TW200716111A - Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors - Google Patents

Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors

Info

Publication number: TW200716111A
Authority: TW; Taiwan
Prior art keywords: hydroxysteroid dehydrogenase; inhibitors; dehydrogenase type; triazolopyridine; beta
Prior art date: 2005-06-09

Application number

TW095120401A

Other languages

English (en)

Inventor

James J Li

Lawrence G Hamann

hai-xia Wang

Zhe-Ming Ruan

Christopher B Cooper

Jun Li

Jeffrey A Robl

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-08

Publication date

2007-05-01

2006-06-08 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2007-05-01 Publication of TW200716111A publication Critical patent/TW200716111A/zh

Links

102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 title abstract 4
108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 title abstract 4
239000003112 inhibitor Substances 0.000 title abstract 4
OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyridine Compounds (AREA)

TW095120401A 2005-06-09 2006-06-08 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors TW200716111A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68899305P	2005-06-09	2005-06-09
US11/448,947 US7579360B2 (en)	2005-06-09	2006-06-07	Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors

Publications (1)

Publication Number	Publication Date
TW200716111A true TW200716111A (en)	2007-05-01

Family

ID=37574243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095120401A TW200716111A (en)	2005-06-09	2006-06-08	Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors

Country Status (26)

Country	Link
US (2)	US7579360B2 (zh)
EP (1)	EP1888582B1 (zh)
JP (1)	JP4994368B2 (zh)
KR (1)	KR20080019276A (zh)
CN (1)	CN102558176A (zh)
AR (1)	AR054385A1 (zh)
AT (1)	ATE487717T1 (zh)
AU (1)	AU2006257924B2 (zh)
BR (1)	BRPI0611773A2 (zh)
CA (1)	CA2611529C (zh)
CY (1)	CY1111148T1 (zh)
DE (1)	DE602006018135D1 (zh)
DK (1)	DK1888582T3 (zh)
EA (1)	EA013017B1 (zh)
GE (1)	GEP20105073B (zh)
HR (1)	HRP20110073T1 (zh)
IL (1)	IL187812A (zh)
MX (1)	MX2007015285A (zh)
NO (1)	NO20076055L (zh)
NZ (1)	NZ563457A (zh)
PE (1)	PE20070164A1 (zh)
PL (1)	PL1888582T3 (zh)
PT (1)	PT1888582E (zh)
SI (1)	SI1888582T1 (zh)
TW (1)	TW200716111A (zh)
WO (1)	WO2006135795A1 (zh)

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Also Published As

Publication number	Publication date
KR20080019276A (ko)	2008-03-03
DK1888582T3 (da)	2011-02-28
IL187812A0 (en)	2008-08-07
CN102558176A (zh)	2012-07-11
CA2611529C (en)	2013-12-03
AU2006257924B2 (en)	2012-03-08
MX2007015285A (es)	2008-02-22
US7579360B2 (en)	2009-08-25
US20090203668A1 (en)	2009-08-13
CA2611529A1 (en)	2006-12-21
CY1111148T1 (el)	2015-06-11
NO20076055L (no)	2008-03-05
AU2006257924A1 (en)	2006-12-21
EP1888582A1 (en)	2008-02-20
GEP20105073B (en)	2010-09-10
ATE487717T1 (de)	2010-11-15
US20060287357A1 (en)	2006-12-21
WO2006135795A1 (en)	2006-12-21
SI1888582T1 (sl)	2011-03-31
PT1888582E (pt)	2011-01-14
BRPI0611773A2 (pt)	2010-09-28
PL1888582T3 (pl)	2011-05-31
HK1112463A1 (zh)	2008-09-05
JP2008543776A (ja)	2008-12-04
JP4994368B2 (ja)	2012-08-08
AR054385A1 (es)	2007-06-20
PE20070164A1 (es)	2007-03-11
EA013017B1 (ru)	2010-02-26
DE602006018135D1 (de)	2010-12-23
EP1888582B1 (en)	2010-11-10
IL187812A (en)	2012-02-29
NZ563457A (en)	2010-06-25
EA200800006A1 (ru)	2008-06-30
US8148396B2 (en)	2012-04-03
HRP20110073T1 (hr)	2011-02-28

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