TW201209163A - Treatment of BCL2 binding component 3 (BBC3) related diseases by inhibition of natural antisense transcript to BBC3 - Google Patents

Treatment of BCL2 binding component 3 (BBC3) related diseases by inhibition of natural antisense transcript to BBC3 Download PDF

Info

Publication number: TW201209163A
Authority: TW; Taiwan
Prior art keywords: bbc3; antisense; polynucleotide; nucleotide; oligonucleotide
Prior art date: 2010-07-12

Application number

TW100124653A

Other languages

English (en)

Chinese (zh)

Inventor

Joseph Collard

Sherman Olga Khorkova

Original Assignee

Opko Curna Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-07-12

Filing date

2011-07-12

Publication date

2012-03-01

2011-07-12 Application filed by Opko Curna Llc filed Critical Opko Curna Llc

2012-03-01 Publication of TW201209163A publication Critical patent/TW201209163A/zh

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 83
201000010099 disease Diseases 0.000 title claims description 74
108020005544 Antisense RNA Proteins 0.000 title claims description 32
102100021572 Bcl-2-binding component 3, isoforms 1/2 Human genes 0.000 title abstract description 34
101000971203 Homo sapiens Bcl-2-binding component 3, isoforms 1/2 Proteins 0.000 title abstract description 34
101000971209 Homo sapiens Bcl-2-binding component 3, isoforms 3/4 Proteins 0.000 title abstract description 34
238000011282 treatment Methods 0.000 title description 35
230000005764 inhibitory process Effects 0.000 title description 4
230000000692 anti-sense effect Effects 0.000 claims abstract description 212
102000040430 polynucleotide Human genes 0.000 claims abstract description 104
108091033319 polynucleotide Proteins 0.000 claims abstract description 104
239000002157 polynucleotide Substances 0.000 claims abstract description 103
239000000074 antisense oligonucleotide Substances 0.000 claims abstract description 78
238000012230 antisense oligonucleotides Methods 0.000 claims abstract description 78
230000014509 gene expression Effects 0.000 claims abstract description 75
230000008685 targeting Effects 0.000 claims abstract description 19
125000003729 nucleotide group Chemical group 0.000 claims description 256
239000002773 nucleotide Substances 0.000 claims description 236
108091034117 Oligonucleotide Proteins 0.000 claims description 234
150000007523 nucleic acids Chemical group 0.000 claims description 162
150000001875 compounds Chemical class 0.000 claims description 149
102000039446 nucleic acids Human genes 0.000 claims description 127
108020004707 nucleic acids Proteins 0.000 claims description 127
230000027455 binding Effects 0.000 claims description 104
108090000623 proteins and genes Proteins 0.000 claims description 98
210000004027 cell Anatomy 0.000 claims description 92
230000006870 function Effects 0.000 claims description 91
238000000034 method Methods 0.000 claims description 83
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 73
102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 70
108091012583 BCL2 Proteins 0.000 claims description 65
239000002253 acid Substances 0.000 claims description 53
230000000295 complement effect Effects 0.000 claims description 51
-1 phosphate triester Chemical class 0.000 claims description 48
235000000346 sugar Nutrition 0.000 claims description 48
230000004048 modification Effects 0.000 claims description 44
238000012986 modification Methods 0.000 claims description 44
239000000203 mixture Substances 0.000 claims description 42
210000001519 tissue Anatomy 0.000 claims description 42
239000004055 small Interfering RNA Substances 0.000 claims description 34
108020004459 Small interfering RNA Proteins 0.000 claims description 32
208000011580 syndromic disease Diseases 0.000 claims description 30
238000000338 in vitro Methods 0.000 claims description 27
108091028043 Nucleic acid sequence Proteins 0.000 claims description 26
239000003814 drug Substances 0.000 claims description 24
238000009396 hybridization Methods 0.000 claims description 23
230000001965 increasing effect Effects 0.000 claims description 23
206010028980 Neoplasm Diseases 0.000 claims description 20
238000001727 in vivo Methods 0.000 claims description 20
125000000217 alkyl group Chemical group 0.000 claims description 19
239000002777 nucleoside Substances 0.000 claims description 16
239000008194 pharmaceutical composition Substances 0.000 claims description 16
230000002441 reversible effect Effects 0.000 claims description 16
235000021419 vinegar Nutrition 0.000 claims description 16
239000000052 vinegar Substances 0.000 claims description 15
230000001105 regulatory effect Effects 0.000 claims description 14
108091093037 Peptide nucleic acid Proteins 0.000 claims description 13
239000012634 fragment Substances 0.000 claims description 12
230000015572 biosynthetic process Effects 0.000 claims description 11
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 11
101150003242 Bbc3 gene Proteins 0.000 claims description 10
108091026890 Coding region Proteins 0.000 claims description 10
229910019142 PO4 Inorganic materials 0.000 claims description 10
150000003833 nucleoside derivatives Chemical class 0.000 claims description 10
235000021317 phosphate Nutrition 0.000 claims description 10
108700028369 Alleles Proteins 0.000 claims description 9
206010061218 Inflammation Diseases 0.000 claims description 9
230000006907 apoptotic process Effects 0.000 claims description 9
201000011510 cancer Diseases 0.000 claims description 9
230000004054 inflammatory process Effects 0.000 claims description 9
238000004519 manufacturing process Methods 0.000 claims description 9
238000003786 synthesis reaction Methods 0.000 claims description 9
RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims description 8
230000002159 abnormal effect Effects 0.000 claims description 8
239000003795 chemical substances by application Substances 0.000 claims description 8
238000006467 substitution reaction Methods 0.000 claims description 8
206010036790 Productive cough Diseases 0.000 claims description 7
210000003802 sputum Anatomy 0.000 claims description 7
208000024794 sputum Diseases 0.000 claims description 7
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 6
206010003246 arthritis Diseases 0.000 claims description 6
230000033228 biological regulation Effects 0.000 claims description 6
230000001939 inductive effect Effects 0.000 claims description 6
210000004962 mammalian cell Anatomy 0.000 claims description 6
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
JZTPOMIFAFKKSK-UHFFFAOYSA-N O-phosphonohydroxylamine Chemical compound NOP(O)(O)=O JZTPOMIFAFKKSK-UHFFFAOYSA-N 0.000 claims description 5
108010029485 Protein Isoforms Proteins 0.000 claims description 5
102000001708 Protein Isoforms Human genes 0.000 claims description 5
125000002619 bicyclic group Chemical group 0.000 claims description 5
230000004663 cell proliferation Effects 0.000 claims description 5
230000002062 proliferating effect Effects 0.000 claims description 5
208000023275 Autoimmune disease Diseases 0.000 claims description 4
206010009900 Colitis ulcerative Diseases 0.000 claims description 4
201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
230000006378 damage Effects 0.000 claims description 4
150000002148 esters Chemical class 0.000 claims description 4
238000002844 melting Methods 0.000 claims description 4
230000008018 melting Effects 0.000 claims description 4
235000015097 nutrients Nutrition 0.000 claims description 4
229940046166 oligodeoxynucleotide Drugs 0.000 claims description 4
239000000546 pharmaceutical excipient Substances 0.000 claims description 4
239000010452 phosphate Substances 0.000 claims description 4
208000011231 Crohn disease Diseases 0.000 claims description 3
208000012902 Nervous system disease Diseases 0.000 claims description 3
208000025966 Neurological disease Diseases 0.000 claims description 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
230000034994 death Effects 0.000 claims description 3
229960002449 glycine Drugs 0.000 claims description 3
230000035772 mutation Effects 0.000 claims description 3
201000008482 osteoarthritis Diseases 0.000 claims description 3
239000001301 oxygen Substances 0.000 claims description 3
229910052760 oxygen Inorganic materials 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
201000000596 systemic lupus erythematosus Diseases 0.000 claims description 3
208000003456 Juvenile Arthritis Diseases 0.000 claims description 2
206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 2
208000003250 Mixed connective tissue disease Diseases 0.000 claims description 2
201000004681 Psoriasis Diseases 0.000 claims description 2
230000007488 abnormal function Effects 0.000 claims description 2
230000032683 aging Effects 0.000 claims description 2
125000005600 alkyl phosphonate group Chemical group 0.000 claims description 2
230000005775 apoptotic pathway Effects 0.000 claims description 2
230000006727 cell loss Effects 0.000 claims description 2
NAGJZTKCGNOGPW-UHFFFAOYSA-N dithiophosphoric acid Chemical compound OP(O)(S)=S NAGJZTKCGNOGPW-UHFFFAOYSA-N 0.000 claims description 2
YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 claims description 2
230000002438 mitochondrial effect Effects 0.000 claims description 2
208000024891 symptom Diseases 0.000 claims description 2
150000003008 phosphonic acid esters Chemical class 0.000 claims 3
DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 claims 2
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 2
QXKAIJAYHKCRRA-JJYYJPOSSA-N D-arabinonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(O)=O QXKAIJAYHKCRRA-JJYYJPOSSA-N 0.000 claims 2
235000013905 glycine and its sodium salt Nutrition 0.000 claims 2
NMGFNBXCWBDSBG-UHFFFAOYSA-N 2-(2-aminooxy-2-oxoethyl)-2-hydroxybutanedioic acid Chemical compound NOC(=O)CC(O)(C(O)=O)CC(O)=O NMGFNBXCWBDSBG-UHFFFAOYSA-N 0.000 claims 1
UPGATMBHQQONPH-UHFFFAOYSA-N 2-aminooxycarbonylbenzoic acid Chemical compound NOC(=O)C1=CC=CC=C1C(O)=O UPGATMBHQQONPH-UHFFFAOYSA-N 0.000 claims 1
208000009137 Behcet syndrome Diseases 0.000 claims 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
101150014361 Delta gene Proteins 0.000 claims 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
230000001086 cytosolic effect Effects 0.000 claims 1
229930182470 glycoside Natural products 0.000 claims 1
150000002338 glycosides Chemical class 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
238000010899 nucleation Methods 0.000 claims 1
230000002093 peripheral effect Effects 0.000 claims 1
230000000379 polymerizing effect Effects 0.000 claims 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
150000003673 urethanes Chemical class 0.000 claims 1
108020000948 Antisense Oligonucleotides Proteins 0.000 abstract description 32
208000037765 diseases and disorders Diseases 0.000 abstract 1
230000009368 gene silencing by RNA Effects 0.000 description 115
108091030071 RNAI Proteins 0.000 description 100
108020004999 messenger RNA Proteins 0.000 description 68
108020004414 DNA Proteins 0.000 description 63
102000053602 DNA Human genes 0.000 description 61
239000002585 base Substances 0.000 description 33
108091032973 (ribonucleotides)n+m Proteins 0.000 description 27
230000037396 body weight Effects 0.000 description 26
230000000694 effects Effects 0.000 description 25
239000002502 liposome Substances 0.000 description 25
102000040650 (ribonucleotides)n+m Human genes 0.000 description 20
102000004169 proteins and genes Human genes 0.000 description 20
238000009472 formulation Methods 0.000 description 19
239000000523 sample Substances 0.000 description 19
238000004458 analytical method Methods 0.000 description 18
229940079593 drug Drugs 0.000 description 18
235000018102 proteins Nutrition 0.000 description 18
108091092562 ribozyme Proteins 0.000 description 18
108090000994 Catalytic RNA Proteins 0.000 description 17
102000053642 Catalytic RNA Human genes 0.000 description 17
108020004705 Codon Proteins 0.000 description 17
241001465754 Metazoa Species 0.000 description 17
230000002255 enzymatic effect Effects 0.000 description 17
230000014616 translation Effects 0.000 description 17
108091081024 Start codon Proteins 0.000 description 16
150000002632 lipids Chemical group 0.000 description 16
150000003839 salts Chemical class 0.000 description 16
239000000243 solution Substances 0.000 description 16
241000894007 species Species 0.000 description 16
238000012228 RNA interference-mediated gene silencing Methods 0.000 description 15
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 15
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 15
239000000047 product Substances 0.000 description 15
241000282414 Homo sapiens Species 0.000 description 14
239000002609 medium Substances 0.000 description 14
230000001225 therapeutic effect Effects 0.000 description 14
238000013519 translation Methods 0.000 description 14
238000006243 chemical reaction Methods 0.000 description 13
239000002243 precursor Substances 0.000 description 13
239000000126 substance Substances 0.000 description 13
238000003776 cleavage reaction Methods 0.000 description 12
230000007017 scission Effects 0.000 description 12
239000013598 vector Substances 0.000 description 12
229930024421 Adenine Natural products 0.000 description 11
241000282412 Homo Species 0.000 description 11
229960000643 adenine Drugs 0.000 description 11
210000004556 brain Anatomy 0.000 description 11
239000000178 monomer Substances 0.000 description 11
238000013518 transcription Methods 0.000 description 11
230000035897 transcription Effects 0.000 description 11
102000004190 Enzymes Human genes 0.000 description 10
108090000790 Enzymes Proteins 0.000 description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
101710163270 Nuclease Proteins 0.000 description 10
230000003197 catalytic effect Effects 0.000 description 10
238000002360 preparation method Methods 0.000 description 10
108090000765 processed proteins & peptides Proteins 0.000 description 10
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 10
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 9
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 9
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 9
239000001963 growth medium Substances 0.000 description 9
230000007246 mechanism Effects 0.000 description 9
229920000768 polyamine Polymers 0.000 description 9
108020003175 receptors Proteins 0.000 description 9
102000005962 receptors Human genes 0.000 description 9
238000011160 research Methods 0.000 description 9
239000013603 viral vector Substances 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
239000003184 complementary RNA Substances 0.000 description 8
230000008878 coupling Effects 0.000 description 8
238000010168 coupling process Methods 0.000 description 8
238000005859 coupling reaction Methods 0.000 description 8
229940104302 cytosine Drugs 0.000 description 8
238000002474 experimental method Methods 0.000 description 8
210000002950 fibroblast Anatomy 0.000 description 8
239000002679 microRNA Substances 0.000 description 8
238000003752 polymerase chain reaction Methods 0.000 description 8
239000004094 surface-active agent Substances 0.000 description 8
230000014621 translational initiation Effects 0.000 description 8
RYVNIFSIEDRLSJ-UHFFFAOYSA-N 5-(hydroxymethyl)cytosine Chemical compound NC=1NC(=O)N=CC=1CO RYVNIFSIEDRLSJ-UHFFFAOYSA-N 0.000 description 7
241000124008 Mammalia Species 0.000 description 7
239000003623 enhancer Substances 0.000 description 7
230000000670 limiting effect Effects 0.000 description 7
239000007788 liquid Substances 0.000 description 7
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 7
210000004940 nucleus Anatomy 0.000 description 7
230000035515 penetration Effects 0.000 description 7
230000008569 process Effects 0.000 description 7
102000004196 processed proteins & peptides Human genes 0.000 description 7
VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 description 6
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 6
206010025323 Lymphomas Diseases 0.000 description 6
108700011259 MicroRNAs Proteins 0.000 description 6
239000002202 Polyethylene glycol Substances 0.000 description 6
241000251131 Sphyrna Species 0.000 description 6
206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 6
230000008499 blood brain barrier function Effects 0.000 description 6
210000001218 blood-brain barrier Anatomy 0.000 description 6
229910052799 carbon Inorganic materials 0.000 description 6
229910002091 carbon monoxide Inorganic materials 0.000 description 6
230000004700 cellular uptake Effects 0.000 description 6
238000001514 detection method Methods 0.000 description 6
235000014113 dietary fatty acids Nutrition 0.000 description 6
238000009826 distribution Methods 0.000 description 6
229930195729 fatty acid Natural products 0.000 description 6
239000000194 fatty acid Substances 0.000 description 6
150000004665 fatty acids Chemical class 0.000 description 6
229960002949 fluorouracil Drugs 0.000 description 6
239000001257 hydrogen Substances 0.000 description 6
229910052739 hydrogen Inorganic materials 0.000 description 6
238000011534 incubation Methods 0.000 description 6
125000003835 nucleoside group Chemical group 0.000 description 6
229920001223 polyethylene glycol Polymers 0.000 description 6
229920000642 polymer Polymers 0.000 description 6
238000003753 real-time PCR Methods 0.000 description 6
230000003827 upregulation Effects 0.000 description 6
102100025064 Cellular tumor antigen p53 Human genes 0.000 description 5
101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 5
206010039491 Sarcoma Diseases 0.000 description 5
108091027967 Small hairpin RNA Proteins 0.000 description 5
241000700605 Viruses Species 0.000 description 5
230000001154 acute effect Effects 0.000 description 5
239000002246 antineoplastic agent Substances 0.000 description 5
230000001413 cellular effect Effects 0.000 description 5
230000008859 change Effects 0.000 description 5
239000002299 complementary DNA Substances 0.000 description 5
125000004122 cyclic group Chemical group 0.000 description 5
208000035475 disorder Diseases 0.000 description 5
125000005842 heteroatom Chemical group 0.000 description 5
239000007924 injection Substances 0.000 description 5
238000002347 injection Methods 0.000 description 5
230000003993 interaction Effects 0.000 description 5
230000002452 interceptive effect Effects 0.000 description 5
230000036244 malformation Effects 0.000 description 5
230000003211 malignant effect Effects 0.000 description 5
239000007758 minimum essential medium Substances 0.000 description 5
230000003285 pharmacodynamic effect Effects 0.000 description 5
150000004713 phosphodiesters Chemical class 0.000 description 5
229920001184 polypeptide Polymers 0.000 description 5
125000006239 protecting group Chemical group 0.000 description 5
239000007787 solid Substances 0.000 description 5
230000009885 systemic effect Effects 0.000 description 5
238000002560 therapeutic procedure Methods 0.000 description 5
229940113082 thymine Drugs 0.000 description 5
229940035893 uracil Drugs 0.000 description 5
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
206010003694 Atrophy Diseases 0.000 description 4
206010009944 Colon cancer Diseases 0.000 description 4
206010012289 Dementia Diseases 0.000 description 4
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 4
108091092724 Noncoding DNA Proteins 0.000 description 4
108700026244 Open Reading Frames Proteins 0.000 description 4
208000005587 Refsum Disease Diseases 0.000 description 4
108700008625 Reporter Genes Proteins 0.000 description 4
108091060271 Small temporal RNA Proteins 0.000 description 4
102000039634 Untranslated RNA Human genes 0.000 description 4
108020004417 Untranslated RNA Proteins 0.000 description 4
150000007513 acids Chemical class 0.000 description 4
230000004913 activation Effects 0.000 description 4
150000001413 amino acids Chemical group 0.000 description 4
238000003556 assay Methods 0.000 description 4
230000037444 atrophy Effects 0.000 description 4
125000002091 cationic group Chemical group 0.000 description 4
210000003169 central nervous system Anatomy 0.000 description 4
206010008129 cerebral palsy Diseases 0.000 description 4
235000012000 cholesterol Nutrition 0.000 description 4
229940127089 cytotoxic agent Drugs 0.000 description 4
239000000975 dye Substances 0.000 description 4
239000008187 granular material Substances 0.000 description 4
125000000623 heterocyclic group Chemical group 0.000 description 4
238000001802 infusion Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
201000006417 multiple sclerosis Diseases 0.000 description 4
208000004296 neuralgia Diseases 0.000 description 4
108091027963 non-coding RNA Proteins 0.000 description 4
102000042567 non-coding RNA Human genes 0.000 description 4
230000009871 nonspecific binding Effects 0.000 description 4
YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 4
230000004962 physiological condition Effects 0.000 description 4
239000000843 powder Substances 0.000 description 4
238000012545 processing Methods 0.000 description 4
230000007115 recruitment Effects 0.000 description 4
230000002829 reductive effect Effects 0.000 description 4
238000010839 reverse transcription Methods 0.000 description 4
239000000725 suspension Substances 0.000 description 4
230000000699 topical effect Effects 0.000 description 4
230000003313 weakening effect Effects 0.000 description 4
LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 3
241000894006 Bacteria Species 0.000 description 3
108091032955 Bacterial small RNA Proteins 0.000 description 3
206010006187 Breast cancer Diseases 0.000 description 3
208000026310 Breast neoplasm Diseases 0.000 description 3
201000009030 Carcinoma Diseases 0.000 description 3
208000014311 Cushing syndrome Diseases 0.000 description 3
UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 3
206010011831 Cytomegalovirus infection Diseases 0.000 description 3
YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 3
108010042407 Endonucleases Proteins 0.000 description 3
102000004533 Endonucleases Human genes 0.000 description 3
108700024394 Exon Proteins 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
206010020751 Hypersensitivity Diseases 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
206010049567 Miller Fisher syndrome Diseases 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
206010029260 Neuroblastoma Diseases 0.000 description 3
208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 3
208000002193 Pain Diseases 0.000 description 3
206010033799 Paralysis Diseases 0.000 description 3
208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 3
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 3
230000007022 RNA scission Effects 0.000 description 3
102000000574 RNA-Induced Silencing Complex Human genes 0.000 description 3
108010016790 RNA-Induced Silencing Complex Proteins 0.000 description 3
102000006382 Ribonucleases Human genes 0.000 description 3
108010083644 Ribonucleases Proteins 0.000 description 3
238000002105 Southern blotting Methods 0.000 description 3
208000006011 Stroke Diseases 0.000 description 3
201000004810 Vascular dementia Diseases 0.000 description 3
208000033559 Waldenström macroglobulinemia Diseases 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
208000009956 adenocarcinoma Diseases 0.000 description 3
125000001931 aliphatic group Chemical group 0.000 description 3
229940024606 amino acid Drugs 0.000 description 3
235000001014 amino acid Nutrition 0.000 description 3
201000007201 aphasia Diseases 0.000 description 3
PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 3
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 3
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 3
239000003613 bile acid Substances 0.000 description 3
239000003833 bile salt Substances 0.000 description 3
239000000872 buffer Substances 0.000 description 3
239000002775 capsule Substances 0.000 description 3
230000030833 cell death Effects 0.000 description 3
239000002738 chelating agent Substances 0.000 description 3
239000003153 chemical reaction reagent Substances 0.000 description 3
239000000460 chlorine Substances 0.000 description 3
230000001684 chronic effect Effects 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000004590 computer program Methods 0.000 description 3
125000000753 cycloalkyl group Chemical group 0.000 description 3
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
238000013461 design Methods 0.000 description 3
238000011161 development Methods 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 3
239000003937 drug carrier Substances 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
206010014599 encephalitis Diseases 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
206010015037 epilepsy Diseases 0.000 description 3
238000010195 expression analysis Methods 0.000 description 3
230000037406 food intake Effects 0.000 description 3
239000000499 gel Substances 0.000 description 3
238000001502 gel electrophoresis Methods 0.000 description 3
125000003827 glycol group Chemical group 0.000 description 3
230000002401 inhibitory effect Effects 0.000 description 3
238000002372 labelling Methods 0.000 description 3
208000032839 leukemia Diseases 0.000 description 3
208000020816 lung neoplasm Diseases 0.000 description 3
230000001404 mediated effect Effects 0.000 description 3
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 3
208000005264 motor neuron disease Diseases 0.000 description 3
230000000926 neurological effect Effects 0.000 description 3
210000000056 organ Anatomy 0.000 description 3
239000002245 particle Substances 0.000 description 3
208000033808 peripheral neuropathy Diseases 0.000 description 3
230000000750 progressive effect Effects 0.000 description 3
230000009467 reduction Effects 0.000 description 3
230000010076 replication Effects 0.000 description 3
238000012163 sequencing technique Methods 0.000 description 3
125000006850 spacer group Chemical group 0.000 description 3
125000001424 substituent group Chemical group 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
238000012360 testing method Methods 0.000 description 3
229940124597 therapeutic agent Drugs 0.000 description 3
238000001890 transfection Methods 0.000 description 3
230000009261 transgenic effect Effects 0.000 description 3
239000001226 triphosphate Substances 0.000 description 3
235000011178 triphosphate Nutrition 0.000 description 3
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
JUDOLRSMWHVKGX-UHFFFAOYSA-N 1,1-dioxo-1$l^{6},2-benzodithiol-3-one Chemical compound C1=CC=C2C(=O)SS(=O)(=O)C2=C1 JUDOLRSMWHVKGX-UHFFFAOYSA-N 0.000 description 2
PISWNSOQFZRVJK-XLPZGREQSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2-sulfanylidenepyrimidin-4-one Chemical compound S=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 PISWNSOQFZRVJK-XLPZGREQSA-N 0.000 description 2
FZWGECJQACGGTI-UHFFFAOYSA-N 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one Chemical compound NC1=NC(O)=C2N(C)C=NC2=N1 FZWGECJQACGGTI-UHFFFAOYSA-N 0.000 description 2
HNXQXTQTPAJEJL-UHFFFAOYSA-N 2-aminopteridin-4-ol Chemical compound C1=CN=C2NC(N)=NC(=O)C2=N1 HNXQXTQTPAJEJL-UHFFFAOYSA-N 0.000 description 2
108020005345 3' Untranslated Regions Proteins 0.000 description 2
UJBCLAXPPIDQEE-UHFFFAOYSA-N 5-prop-1-ynyl-1h-pyrimidine-2,4-dione Chemical compound CC#CC1=CNC(=O)NC1=O UJBCLAXPPIDQEE-UHFFFAOYSA-N 0.000 description 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 2
PEHVGBZKEYRQSX-UHFFFAOYSA-N 7-deaza-adenine Chemical compound NC1=NC=NC2=C1C=CN2 PEHVGBZKEYRQSX-UHFFFAOYSA-N 0.000 description 2
LOSIULRWFAEMFL-UHFFFAOYSA-N 7-deazaguanine Chemical compound O=C1NC(N)=NC2=C1CC=N2 LOSIULRWFAEMFL-UHFFFAOYSA-N 0.000 description 2
HCGHYQLFMPXSDU-UHFFFAOYSA-N 7-methyladenine Chemical compound C1=NC(N)=C2N(C)C=NC2=N1 HCGHYQLFMPXSDU-UHFFFAOYSA-N 0.000 description 2
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 description 2
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
208000030507 AIDS Diseases 0.000 description 2
208000035657 Abasia Diseases 0.000 description 2
241000251468 Actinopterygii Species 0.000 description 2
208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
102000002260 Alkaline Phosphatase Human genes 0.000 description 2
108020004774 Alkaline Phosphatase Proteins 0.000 description 2
208000024827 Alzheimer disease Diseases 0.000 description 2
108020004491 Antisense DNA Proteins 0.000 description 2
206010002941 Apallic syndrome Diseases 0.000 description 2
206010003101 Arnold-Chiari Malformation Diseases 0.000 description 2
241000271566 Aves Species 0.000 description 2
102000051485 Bcl-2 family Human genes 0.000 description 2
108700038897 Bcl-2 family Proteins 0.000 description 2
206010005003 Bladder cancer Diseases 0.000 description 2
108010006654 Bleomycin Proteins 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
208000003174 Brain Neoplasms Diseases 0.000 description 2
208000014644 Brain disease Diseases 0.000 description 2
ZBEKPPVMYNVMQO-UHFFFAOYSA-N CCCCCCCCCCOP(O)=O Chemical compound CCCCCCCCCCOP(O)=O ZBEKPPVMYNVMQO-UHFFFAOYSA-N 0.000 description 2
241000282472 Canis lupus familiaris Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
206010008342 Cervix carcinoma Diseases 0.000 description 2
208000015321 Chiari malformation Diseases 0.000 description 2
206010008748 Chorea Diseases 0.000 description 2
208000000668 Chronic Pancreatitis Diseases 0.000 description 2
206010010356 Congenital anomaly Diseases 0.000 description 2
IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical group OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 2
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
230000004543 DNA replication Effects 0.000 description 2
CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Chemical group OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
206010058314 Dysplasia Diseases 0.000 description 2
208000032274 Encephalopathy Diseases 0.000 description 2
241000283086 Equidae Species 0.000 description 2
241000282326 Felis catus Species 0.000 description 2
BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Chemical group OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
201000011240 Frontotemporal dementia Diseases 0.000 description 2
241000237858 Gastropoda Species 0.000 description 2
208000007465 Giant cell arteritis Diseases 0.000 description 2
208000032612 Glial tumor Diseases 0.000 description 2
206010018338 Glioma Diseases 0.000 description 2
102000053187 Glucuronidase Human genes 0.000 description 2
108010060309 Glucuronidase Proteins 0.000 description 2
108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
208000007514 Herpes zoster Diseases 0.000 description 2
208000017604 Hodgkin disease Diseases 0.000 description 2
208000010747 Hodgkins lymphoma Diseases 0.000 description 2
108010001336 Horseradish Peroxidase Proteins 0.000 description 2
208000023105 Huntington disease Diseases 0.000 description 2
206010020880 Hypertrophy Diseases 0.000 description 2
208000001953 Hypotension Diseases 0.000 description 2
206010021143 Hypoxia Diseases 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
206010021750 Infantile Spasms Diseases 0.000 description 2
206010061216 Infarction Diseases 0.000 description 2
108020005350 Initiator Codon Proteins 0.000 description 2
108091092195 Intron Proteins 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 2
239000012097 Lipofectamine 2000 Substances 0.000 description 2
DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Chemical group CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 2
206010058467 Lung neoplasm malignant Diseases 0.000 description 2
208000026072 Motor neurone disease Diseases 0.000 description 2
208000001089 Multiple system atrophy Diseases 0.000 description 2
206010028289 Muscle atrophy Diseases 0.000 description 2
206010028570 Myelopathy Diseases 0.000 description 2
201000002481 Myositis Diseases 0.000 description 2
206010061533 Myotonia Diseases 0.000 description 2
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
208000008457 Neurologic Manifestations Diseases 0.000 description 2
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 2
206010033649 Pancreatitis chronic Diseases 0.000 description 2
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 2
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
206010060862 Prostate cancer Diseases 0.000 description 2
208000000236 Prostatic Neoplasms Diseases 0.000 description 2
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 2
241000239226 Scorpiones Species 0.000 description 2
206010040047 Sepsis Diseases 0.000 description 2
241000700584 Simplexvirus Species 0.000 description 2
208000003954 Spinal Muscular Atrophies of Childhood Diseases 0.000 description 2
208000005718 Stomach Neoplasms Diseases 0.000 description 2
101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 description 2
101710172711 Structural protein Proteins 0.000 description 2
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
206010044565 Tremor Diseases 0.000 description 2
208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 2
208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
208000036826 VIIth nerve paralysis Diseases 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
RLXCFCYWFYXTON-JTTSDREOSA-N [(3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-16-yl] N-hexylcarbamate Chemical group C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(OC(=O)NCCCCCC)[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 RLXCFCYWFYXTON-JTTSDREOSA-N 0.000 description 2
DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical group C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
230000009471 action Effects 0.000 description 2
230000003213 activating effect Effects 0.000 description 2
208000002552 acute disseminated encephalomyelitis Diseases 0.000 description 2
238000007792 addition Methods 0.000 description 2
230000001919 adrenal effect Effects 0.000 description 2
208000030597 adult Refsum disease Diseases 0.000 description 2
239000000443 aerosol Substances 0.000 description 2
150000001335 aliphatic alkanes Chemical class 0.000 description 2
125000003342 alkenyl group Chemical group 0.000 description 2
125000005083 alkoxyalkoxy group Chemical group 0.000 description 2
125000000304 alkynyl group Chemical group 0.000 description 2
230000007815 allergy Effects 0.000 description 2
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 2
230000003321 amplification Effects 0.000 description 2
208000000252 angiomatosis Diseases 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
239000003816 antisense DNA Substances 0.000 description 2
125000003118 aryl group Chemical group 0.000 description 2
238000003149 assay kit Methods 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
235000020958 biotin Nutrition 0.000 description 2
239000011616 biotin Substances 0.000 description 2
229960001561 bleomycin Drugs 0.000 description 2
OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 2
210000001124 body fluid Anatomy 0.000 description 2
239000010839 body fluid Substances 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
IVUMCTKHWDRRMH-UHFFFAOYSA-N carprofen Chemical compound C1=CC(Cl)=C[C]2C3=CC=C(C(C(O)=O)C)C=C3N=C21 IVUMCTKHWDRRMH-UHFFFAOYSA-N 0.000 description 2
229960003184 carprofen Drugs 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
239000003054 catalyst Substances 0.000 description 2
238000004113 cell culture Methods 0.000 description 2
230000002490 cerebral effect Effects 0.000 description 2
210000001175 cerebrospinal fluid Anatomy 0.000 description 2
201000010881 cervical cancer Diseases 0.000 description 2
201000001352 cholecystitis Diseases 0.000 description 2
208000029742 colonic neoplasm Diseases 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
230000001054 cortical effect Effects 0.000 description 2
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
238000013211 curve analysis Methods 0.000 description 2
108010082025 cyan fluorescent protein Proteins 0.000 description 2
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
230000009089 cytolysis Effects 0.000 description 2
210000000805 cytoplasm Anatomy 0.000 description 2
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
238000012217 deletion Methods 0.000 description 2
230000037430 deletion Effects 0.000 description 2
150000008266 deoxy sugars Chemical class 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
238000003745 diagnosis Methods 0.000 description 2
239000010432 diamond Substances 0.000 description 2
RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 2
230000029087 digestion Effects 0.000 description 2
239000001177 diphosphate Substances 0.000 description 2
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
235000011180 diphosphates Nutrition 0.000 description 2
238000010494 dissociation reaction Methods 0.000 description 2
230000005593 dissociations Effects 0.000 description 2
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
230000003511 endothelial effect Effects 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
229960001395 fenbufen Drugs 0.000 description 2
ZPAKPRAICRBAOD-UHFFFAOYSA-N fenbufen Chemical compound C1=CC(C(=O)CCC(=O)O)=CC=C1C1=CC=CC=C1 ZPAKPRAICRBAOD-UHFFFAOYSA-N 0.000 description 2
ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 2
238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
239000012737 fresh medium Substances 0.000 description 2
HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
230000004927 fusion Effects 0.000 description 2
206010017758 gastric cancer Diseases 0.000 description 2
230000002068 genetic effect Effects 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000005090 green fluorescent protein Substances 0.000 description 2
201000009277 hairy cell leukemia Diseases 0.000 description 2
210000002216 heart Anatomy 0.000 description 2
206010073071 hepatocellular carcinoma Diseases 0.000 description 2
231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
125000000592 heterocycloalkyl group Chemical group 0.000 description 2
210000001320 hippocampus Anatomy 0.000 description 2
230000036543 hypotension Effects 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
230000007954 hypoxia Effects 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
230000007574 infarction Effects 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000004968 inflammatory condition Effects 0.000 description 2
208000014674 injury Diseases 0.000 description 2
239000000138 intercalating agent Substances 0.000 description 2
238000007917 intracranial administration Methods 0.000 description 2
230000003902 lesion Effects 0.000 description 2
208000036546 leukodystrophy Diseases 0.000 description 2
239000003446 ligand Substances 0.000 description 2
125000005647 linker group Chemical group 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
201000005202 lung cancer Diseases 0.000 description 2
230000001926 lymphatic effect Effects 0.000 description 2
208000003747 lymphoid leukemia Diseases 0.000 description 2
230000036210 malignancy Effects 0.000 description 2
201000001441 melanoma Diseases 0.000 description 2
GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
229930182817 methionine Natural products 0.000 description 2
229960004452 methionine Drugs 0.000 description 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
150000004712 monophosphates Chemical class 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
230000020763 muscle atrophy Effects 0.000 description 2
201000000585 muscular atrophy Diseases 0.000 description 2
230000001613 neoplastic effect Effects 0.000 description 2
210000005036 nerve Anatomy 0.000 description 2
208000021722 neuropathic pain Diseases 0.000 description 2
201000001119 neuropathy Diseases 0.000 description 2
230000007823 neuropathy Effects 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
238000003199 nucleic acid amplification method Methods 0.000 description 2
230000000269 nucleophilic effect Effects 0.000 description 2
239000003921 oil Substances 0.000 description 2
150000002923 oximes Chemical class 0.000 description 2
201000010198 papillary carcinoma Diseases 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
210000001428 peripheral nervous system Anatomy 0.000 description 2
208000005026 persistent vegetative state Diseases 0.000 description 2
239000012071 phase Substances 0.000 description 2
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
150000003017 phosphorus Chemical class 0.000 description 2
230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 2
201000009395 primary hyperaldosteronism Diseases 0.000 description 2
230000035755 proliferation Effects 0.000 description 2
229960002429 proline Drugs 0.000 description 2
ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical group C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
150000003212 purines Chemical class 0.000 description 2
108010054624 red fluorescent protein Proteins 0.000 description 2
230000011514 reflex Effects 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
229920002477 rna polymer Polymers 0.000 description 2
229910052707 ruthenium Inorganic materials 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
230000001568 sexual effect Effects 0.000 description 2
210000001626 skin fibroblast Anatomy 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
206010062261 spinal cord neoplasm Diseases 0.000 description 2
208000002320 spinal muscular atrophy Diseases 0.000 description 2
210000000130 stem cell Anatomy 0.000 description 2
239000008223 sterile water Substances 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
201000011549 stomach cancer Diseases 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
206010042772 syncope Diseases 0.000 description 2
239000003826 tablet Substances 0.000 description 2
XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
150000007944 thiolates Chemical class 0.000 description 2
ZEMGGZBWXRYJHK-UHFFFAOYSA-N thiouracil Chemical compound O=C1C=CNC(=S)N1 ZEMGGZBWXRYJHK-UHFFFAOYSA-N 0.000 description 2
WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
238000011200 topical administration Methods 0.000 description 2
238000012546 transfer Methods 0.000 description 2
230000005945 translocation Effects 0.000 description 2
230000000472 traumatic effect Effects 0.000 description 2
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 2
125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
241001430294 unidentified retrovirus Species 0.000 description 2
238000011144 upstream manufacturing Methods 0.000 description 2
201000005112 urinary bladder cancer Diseases 0.000 description 2
238000010200 validation analysis Methods 0.000 description 2
238000005406 washing Methods 0.000 description 2
210000004885 white matter Anatomy 0.000 description 2
108091005957 yellow fluorescent proteins Proteins 0.000 description 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 1
QGVQZRDQPDLHHV-DPAQBDIFSA-N (3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene-3-thiol Chemical group C1C=C2C[C@@H](S)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 QGVQZRDQPDLHHV-DPAQBDIFSA-N 0.000 description 1
125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
FQQQSNAVVZSYMB-UHFFFAOYSA-N 1,1-diaminoguanidine Chemical compound NN(N)C(N)=N FQQQSNAVVZSYMB-UHFFFAOYSA-N 0.000 description 1
FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical class C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 description 1
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 1
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 description 1
DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 description 1
UHUHBFMZVCOEOV-UHFFFAOYSA-N 1h-imidazo[4,5-c]pyridin-4-amine Chemical compound NC1=NC=CC2=C1N=CN2 UHUHBFMZVCOEOV-UHFFFAOYSA-N 0.000 description 1
AYRXSINWFIIFAE-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal Chemical compound OCC1OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C1O AYRXSINWFIIFAE-UHFFFAOYSA-N 0.000 description 1
LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 1
QSHACTSJHMKXTE-UHFFFAOYSA-N 2-(2-aminopropyl)-7h-purin-6-amine Chemical compound CC(N)CC1=NC(N)=C2NC=NC2=N1 QSHACTSJHMKXTE-UHFFFAOYSA-N 0.000 description 1
PBUUPFTVAPUWDE-UGZDLDLSSA-N 2-[[(2S,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-yl]sulfanyl]ethanesulfonic acid Chemical compound OS(=O)(=O)CCS[C@H]1CCO[P@](=O)(N(CCCl)CCCl)N1 PBUUPFTVAPUWDE-UGZDLDLSSA-N 0.000 description 1
BRLJKBOXIVONAG-UHFFFAOYSA-N 2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl-methylamino]acetic acid Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(=O)(=O)N(C)CC(O)=O BRLJKBOXIVONAG-UHFFFAOYSA-N 0.000 description 1
GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
XIFVTSIIYVGRHJ-UHFFFAOYSA-N 2-n,2-n,4-n,4-n,6-n-pentamethyl-1,3,5-triazine-2,4,6-triamine Chemical compound CNC1=NC(N(C)C)=NC(N(C)C)=N1 XIFVTSIIYVGRHJ-UHFFFAOYSA-N 0.000 description 1
YNFSUOFXEVCDTC-UHFFFAOYSA-N 2-n-methyl-7h-purine-2,6-diamine Chemical compound CNC1=NC(N)=C2NC=NC2=N1 YNFSUOFXEVCDTC-UHFFFAOYSA-N 0.000 description 1
VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Chemical group C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
YPSXFMHXRZAGTG-UHFFFAOYSA-N 4-methoxy-2-[2-(5-methoxy-2-nitrosophenyl)ethyl]-1-nitrosobenzene Chemical compound COC1=CC=C(N=O)C(CCC=2C(=CC=C(OC)C=2)N=O)=C1 YPSXFMHXRZAGTG-UHFFFAOYSA-N 0.000 description 1
OVONXEQGWXGFJD-UHFFFAOYSA-N 4-sulfanylidene-1h-pyrimidin-2-one Chemical compound SC=1C=CNC(=O)N=1 OVONXEQGWXGFJD-UHFFFAOYSA-N 0.000 description 1
NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 description 1
NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 1
LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical compound BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 description 1
JDBGXEHEIRGOBU-UHFFFAOYSA-N 5-hydroxymethyluracil Chemical compound OCC1=CNC(=O)NC1=O JDBGXEHEIRGOBU-UHFFFAOYSA-N 0.000 description 1
KXBCLNRMQPRVTP-UHFFFAOYSA-N 6-amino-1,5-dihydroimidazo[4,5-c]pyridin-4-one Chemical compound O=C1NC(N)=CC2=C1N=CN2 KXBCLNRMQPRVTP-UHFFFAOYSA-N 0.000 description 1
DCPSTSVLRXOYGS-UHFFFAOYSA-N 6-amino-1h-pyrimidine-2-thione Chemical compound NC1=CC=NC(S)=N1 DCPSTSVLRXOYGS-UHFFFAOYSA-N 0.000 description 1
QNNARSZPGNJZIX-UHFFFAOYSA-N 6-amino-5-prop-1-ynyl-1h-pyrimidin-2-one Chemical compound CC#CC1=CNC(=O)N=C1N QNNARSZPGNJZIX-UHFFFAOYSA-N 0.000 description 1
UGQXLWWNSMGEBY-UHFFFAOYSA-N 6-amino-5-sulfanyl-1h-pyrimidin-2-one Chemical compound NC1=NC(=O)NC=C1S UGQXLWWNSMGEBY-UHFFFAOYSA-N 0.000 description 1
MJQJAROHCVUUKZ-UHFFFAOYSA-N 6-aminopurine-6-thiol Chemical compound NC1(S)N=CN=C2N=CN=C12 MJQJAROHCVUUKZ-UHFFFAOYSA-N 0.000 description 1
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
HRYKDUPGBWLLHO-UHFFFAOYSA-N 8-azaadenine Chemical compound NC1=NC=NC2=NNN=C12 HRYKDUPGBWLLHO-UHFFFAOYSA-N 0.000 description 1
LPXQRXLUHJKZIE-UHFFFAOYSA-N 8-azaguanine Chemical compound NC1=NC(O)=C2NN=NC2=N1 LPXQRXLUHJKZIE-UHFFFAOYSA-N 0.000 description 1
229960005508 8-azaguanine Drugs 0.000 description 1
FJNCXZZQNBKEJT-UHFFFAOYSA-N 8beta-hydroxymarrubiin Natural products O1C(=O)C2(C)CCCC3(C)C2C1CC(C)(O)C3(O)CCC=1C=COC=1 FJNCXZZQNBKEJT-UHFFFAOYSA-N 0.000 description 1
206010065040 AIDS dementia complex Diseases 0.000 description 1
206010052075 Acquired epileptic aphasia Diseases 0.000 description 1
208000000197 Acute Cholecystitis Diseases 0.000 description 1
208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 1
206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
208000024341 Aicardi syndrome Diseases 0.000 description 1
241000282979 Alces alces Species 0.000 description 1
208000022309 Alcoholic Liver disease Diseases 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
208000031277 Amaurotic familial idiocy Diseases 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
201000003076 Angiosarcoma Diseases 0.000 description 1
206010003062 Apraxia Diseases 0.000 description 1
208000022316 Arachnoid cyst Diseases 0.000 description 1
241000239290 Araneae Species 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
241000796533 Arna Species 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
208000036640 Asperger disease Diseases 0.000 description 1
201000006062 Asperger syndrome Diseases 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
206010003571 Astrocytoma Diseases 0.000 description 1
206010003591 Ataxia Diseases 0.000 description 1
206010003594 Ataxia telangiectasia Diseases 0.000 description 1
208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
206010003805 Autism Diseases 0.000 description 1
208000020706 Autistic disease Diseases 0.000 description 1
206010003840 Autonomic nervous system imbalance Diseases 0.000 description 1
208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
208000008035 Back Pain Diseases 0.000 description 1
206010004146 Basal cell carcinoma Diseases 0.000 description 1
208000006373 Bell palsy Diseases 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
241001674044 Blattodea Species 0.000 description 1
201000004940 Bloch-Sulzberger syndrome Diseases 0.000 description 1
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
206010006074 Brachial plexus injury Diseases 0.000 description 1
208000004020 Brain Abscess Diseases 0.000 description 1
208000024806 Brain atrophy Diseases 0.000 description 1
206010048409 Brain malformation Diseases 0.000 description 1
206010006458 Bronchitis chronic Diseases 0.000 description 1
206010006491 Brown-Sequard syndrome Diseases 0.000 description 1
206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 description 1
COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
QCMYYKRYFNMIEC-UHFFFAOYSA-N COP(O)=O Chemical class COP(O)=O QCMYYKRYFNMIEC-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
208000022526 Canavan disease Diseases 0.000 description 1
241000283707 Capra Species 0.000 description 1
241001070941 Castanea Species 0.000 description 1
235000014036 Castanea Nutrition 0.000 description 1
206010064012 Central pain syndrome Diseases 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
206010008027 Cerebellar atrophy Diseases 0.000 description 1
206010065559 Cerebral arteriosclerosis Diseases 0.000 description 1
206010053684 Cerebrohepatorenal syndrome Diseases 0.000 description 1
241000282994 Cervidae Species 0.000 description 1
206010008479 Chest Pain Diseases 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 1
206010008614 Cholecystitis acute Diseases 0.000 description 1
206010008617 Cholecystitis chronic Diseases 0.000 description 1
239000004380 Cholic acid Substances 0.000 description 1
208000005243 Chondrosarcoma Diseases 0.000 description 1
201000009047 Chordoma Diseases 0.000 description 1
208000006332 Choriocarcinoma Diseases 0.000 description 1
108010077544 Chromatin Proteins 0.000 description 1
208000000094 Chronic Pain Diseases 0.000 description 1
208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 description 1
206010010071 Coma Diseases 0.000 description 1
108020004394 Complementary RNA Proteins 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
241001137251 Corvidae Species 0.000 description 1
208000009798 Craniopharyngioma Diseases 0.000 description 1
208000009283 Craniosynostoses Diseases 0.000 description 1
206010049889 Craniosynostosis Diseases 0.000 description 1
208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
241000938605 Crocodylia Species 0.000 description 1
MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
208000012514 Cumulative Trauma disease Diseases 0.000 description 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
206010011732 Cyst Diseases 0.000 description 1
206010063057 Cystitis noninfective Diseases 0.000 description 1
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
241000701022 Cytomegalovirus Species 0.000 description 1
206010048843 Cytomegalovirus chorioretinitis Diseases 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N D-Maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
IMXSCCDUAFEIOE-UHFFFAOYSA-N D-Octopin Natural products OC(=O)C(C)NC(C(O)=O)CCCN=C(N)N IMXSCCDUAFEIOE-UHFFFAOYSA-N 0.000 description 1
UNXHWFMMPAWVPI-QWWZWVQMSA-N D-Threitol Natural products OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 description 1
HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
SHZGCJCMOBCMKK-SVZMEOIVSA-N D-fucopyranose Chemical compound C[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O SHZGCJCMOBCMKK-SVZMEOIVSA-N 0.000 description 1
NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
IMXSCCDUAFEIOE-RITPCOANSA-N D-octopine Chemical compound [O-]C(=O)[C@@H](C)[NH2+][C@H](C([O-])=O)CCCNC(N)=[NH2+] IMXSCCDUAFEIOE-RITPCOANSA-N 0.000 description 1
230000004544 DNA amplification Effects 0.000 description 1
230000005778 DNA damage Effects 0.000 description 1
231100000277 DNA damage Toxicity 0.000 description 1
230000006820 DNA synthesis Effects 0.000 description 1
108010092160 Dactinomycin Proteins 0.000 description 1
201000003863 Dandy-Walker Syndrome Diseases 0.000 description 1
WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 description 1
208000016192 Demyelinating disease Diseases 0.000 description 1
241000702421 Dependoparvovirus Species 0.000 description 1
206010012559 Developmental delay Diseases 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
208000006402 Ductal Carcinoma Diseases 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
238000012286 ELISA Assay Methods 0.000 description 1
239000012594 Earle’s Balanced Salt Solution Substances 0.000 description 1
201000009051 Embryonal Carcinoma Diseases 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
206010014561 Emphysema Diseases 0.000 description 1
206010014567 Empty Sella Syndrome Diseases 0.000 description 1
206010014733 Endometrial cancer Diseases 0.000 description 1
206010014759 Endometrial neoplasm Diseases 0.000 description 1
201000009273 Endometriosis Diseases 0.000 description 1
108010067770 Endopeptidase K Proteins 0.000 description 1
241000792859 Enema Species 0.000 description 1
206010014967 Ependymoma Diseases 0.000 description 1
YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
208000000461 Esophageal Neoplasms Diseases 0.000 description 1
208000032027 Essential Thrombocythemia Diseases 0.000 description 1
241000206602 Eukaryota Species 0.000 description 1
208000006168 Ewing Sarcoma Diseases 0.000 description 1
108060002716 Exonuclease Proteins 0.000 description 1
208000024720 Fabry Disease Diseases 0.000 description 1
208000004929 Facial Paralysis Diseases 0.000 description 1
208000002091 Febrile Seizures Diseases 0.000 description 1
201000008808 Fibrosarcoma Diseases 0.000 description 1
206010016654 Fibrosis Diseases 0.000 description 1
BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
241000700662 Fowlpox virus Species 0.000 description 1
208000024412 Friedreich ataxia Diseases 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
241000233866 Fungi Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
208000007882 Gastritis Diseases 0.000 description 1
208000015872 Gaucher disease Diseases 0.000 description 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
229930182566 Gentamicin Natural products 0.000 description 1
208000007223 Gerstmann syndrome Diseases 0.000 description 1
201000010915 Glioblastoma multiforme Diseases 0.000 description 1
208000010055 Globoid Cell Leukodystrophy Diseases 0.000 description 1
206010018364 Glomerulonephritis Diseases 0.000 description 1
206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
229930186217 Glycolipid Natural products 0.000 description 1
206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
206010019196 Head injury Diseases 0.000 description 1
206010019233 Headaches Diseases 0.000 description 1
208000001258 Hemangiosarcoma Diseases 0.000 description 1
208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
206010063491 Herpes zoster oticus Diseases 0.000 description 1
241000238631 Hexapoda Species 0.000 description 1
101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 description 1
101001087394 Homo sapiens Tyrosine-protein phosphatase non-receptor type 1 Proteins 0.000 description 1
108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 description 1
241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
208000037171 Hypercorticoidism Diseases 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 1
XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 1
206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
208000010159 IgA glomerulonephritis Diseases 0.000 description 1
208000007031 Incontinentia pigmenti Diseases 0.000 description 1
102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 description 1
208000035899 Infantile spasms syndrome Diseases 0.000 description 1
208000022559 Inflammatory bowel disease Diseases 0.000 description 1
206010022158 Injury to brachial plexus due to birth trauma Diseases 0.000 description 1
229930010555 Inosine Natural products 0.000 description 1
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
102100034343 Integrase Human genes 0.000 description 1
101710203526 Integrase Proteins 0.000 description 1
208000018650 Intervertebral disc disease Diseases 0.000 description 1
201000008450 Intracranial aneurysm Diseases 0.000 description 1
206010022773 Intracranial pressure increased Diseases 0.000 description 1
201000008645 Joubert syndrome Diseases 0.000 description 1
208000027747 Kennedy disease Diseases 0.000 description 1
208000006541 Klippel-Feil syndrome Diseases 0.000 description 1
208000028226 Krabbe disease Diseases 0.000 description 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
208000005870 Lafora disease Diseases 0.000 description 1
208000014161 Lafora myoclonic epilepsy Diseases 0.000 description 1
201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 description 1
201000005802 Landau-Kleffner Syndrome Diseases 0.000 description 1
239000005639 Lauric acid Substances 0.000 description 1
208000006136 Leigh Disease Diseases 0.000 description 1
208000017507 Leigh syndrome Diseases 0.000 description 1
208000018142 Leiomyosarcoma Diseases 0.000 description 1
241000270322 Lepidosauria Species 0.000 description 1
208000009625 Lesch-Nyhan syndrome Diseases 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
208000009829 Lewy Body Disease Diseases 0.000 description 1
201000002832 Lewy body dementia Diseases 0.000 description 1
OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
108060001084 Luciferase Proteins 0.000 description 1
239000005089 Luciferase Substances 0.000 description 1
208000016604 Lyme disease Diseases 0.000 description 1
208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
208000002569 Machado-Joseph Disease Diseases 0.000 description 1
208000002720 Malnutrition Diseases 0.000 description 1
208000021964 McLeod neuroacanthocytosis syndrome Diseases 0.000 description 1
208000026486 McLeod syndrome Diseases 0.000 description 1
208000007054 Medullary Carcinoma Diseases 0.000 description 1
208000000172 Medulloblastoma Diseases 0.000 description 1
201000002571 Melkersson-Rosenthal syndrome Diseases 0.000 description 1
208000027530 Meniere disease Diseases 0.000 description 1
201000009906 Meningitis Diseases 0.000 description 1
208000008948 Menkes Kinky Hair Syndrome Diseases 0.000 description 1
208000012583 Menkes disease Diseases 0.000 description 1
206010027406 Mesothelioma Diseases 0.000 description 1
LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
208000019695 Migraine disease Diseases 0.000 description 1
201000002169 Mitochondrial myopathy Diseases 0.000 description 1
201000002983 Mobius syndrome Diseases 0.000 description 1
208000034167 Moebius syndrome Diseases 0.000 description 1
208000019430 Motor disease Diseases 0.000 description 1
208000002678 Mucopolysaccharidoses Diseases 0.000 description 1
208000005647 Mumps Diseases 0.000 description 1
241001529936 Murinae Species 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
208000021642 Muscular disease Diseases 0.000 description 1
206010028424 Myasthenic syndrome Diseases 0.000 description 1
102100026784 Myelin proteolipid protein Human genes 0.000 description 1
208000036572 Myoclonic epilepsy Diseases 0.000 description 1
208000002033 Myoclonus Diseases 0.000 description 1
201000009623 Myopathy Diseases 0.000 description 1
208000010316 Myotonia congenita Diseases 0.000 description 1
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
206010051606 Necrotising colitis Diseases 0.000 description 1
108010025020 Nerve Growth Factor Proteins 0.000 description 1
102000007072 Nerve Growth Factors Human genes 0.000 description 1
206010029240 Neuritis Diseases 0.000 description 1
208000009905 Neurofibromatoses Diseases 0.000 description 1
208000005890 Neuroma Diseases 0.000 description 1
208000002537 Neuronal Ceroid-Lipofuscinoses Diseases 0.000 description 1
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
208000014060 Niemann-Pick disease Diseases 0.000 description 1
238000000636 Northern blotting Methods 0.000 description 1
108020003217 Nuclear RNA Proteins 0.000 description 1
102000043141 Nuclear RNA Human genes 0.000 description 1
KRIMDSNQQXJAIF-UHFFFAOYSA-N OP(O)(=O)ON=C=S Chemical class OP(O)(=O)ON=C=S KRIMDSNQQXJAIF-UHFFFAOYSA-N 0.000 description 1
206010068106 Occipital neuralgia Diseases 0.000 description 1
241000282943 Odocoileus Species 0.000 description 1
206010030155 Oesophageal carcinoma Diseases 0.000 description 1
239000012124 Opti-MEM Substances 0.000 description 1
208000003435 Optic Neuritis Diseases 0.000 description 1
241000700629 Orthopoxvirus Species 0.000 description 1
206010031127 Orthostatic hypotension Diseases 0.000 description 1
206010033128 Ovarian cancer Diseases 0.000 description 1
206010061535 Ovarian neoplasm Diseases 0.000 description 1
229930012538 Paclitaxel Natural products 0.000 description 1
206010061902 Pancreatic neoplasm Diseases 0.000 description 1
206010033645 Pancreatitis Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
208000017493 Pelizaeus-Merzbacher disease Diseases 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
208000027190 Peripheral T-cell lymphomas Diseases 0.000 description 1
IAJOBQBIJHVGMQ-UHFFFAOYSA-N Phosphinothricin Natural products CP(O)(=O)CCC(N)C(O)=O IAJOBQBIJHVGMQ-UHFFFAOYSA-N 0.000 description 1
IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
208000000609 Pick Disease of the Brain Diseases 0.000 description 1
208000007641 Pinealoma Diseases 0.000 description 1
208000007913 Pituitary Neoplasms Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
206010036105 Polyneuropathy Diseases 0.000 description 1
229920000388 Polyphosphate Polymers 0.000 description 1
108010076039 Polyproteins Proteins 0.000 description 1
206010052469 Postictal paralysis Diseases 0.000 description 1
201000010769 Prader-Willi syndrome Diseases 0.000 description 1
208000032236 Predisposition to disease Diseases 0.000 description 1
208000032319 Primary lateral sclerosis Diseases 0.000 description 1
208000024777 Prion disease Diseases 0.000 description 1
208000037534 Progressive hemifacial atrophy Diseases 0.000 description 1
208000033526 Proximal spinal muscular atrophy type 3 Diseases 0.000 description 1
201000001263 Psoriatic Arthritis Diseases 0.000 description 1
208000036824 Psoriatic arthropathy Diseases 0.000 description 1
206010037601 Pyelonephritis chronic Diseases 0.000 description 1
108091034057 RNA (poly(A)) Proteins 0.000 description 1
238000002123 RNA extraction Methods 0.000 description 1
238000010802 RNA extraction kit Methods 0.000 description 1
230000026279 RNA modification Effects 0.000 description 1
208000032831 Ramsay Hunt syndrome Diseases 0.000 description 1
206010071141 Rasmussen encephalitis Diseases 0.000 description 1
208000004160 Rasmussen subacute encephalitis Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
108700005075 Regulator Genes Proteins 0.000 description 1
208000006265 Renal cell carcinoma Diseases 0.000 description 1
206010038584 Repetitive strain injury Diseases 0.000 description 1
208000005793 Restless legs syndrome Diseases 0.000 description 1
201000000582 Retinoblastoma Diseases 0.000 description 1
208000006289 Rett Syndrome Diseases 0.000 description 1
JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 description 1
108091029810 SaRNA Proteins 0.000 description 1
208000021811 Sandhoff disease Diseases 0.000 description 1
208000034189 Sclerosis Diseases 0.000 description 1
201000010208 Seminoma Diseases 0.000 description 1
108091081021 Sense strand Proteins 0.000 description 1
238000012300 Sequence Analysis Methods 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
208000009106 Shy-Drager Syndrome Diseases 0.000 description 1
208000021386 Sjogren Syndrome Diseases 0.000 description 1
206010041067 Small cell lung cancer Diseases 0.000 description 1
238000003723 Smelting Methods 0.000 description 1
201000003696 Sotos syndrome Diseases 0.000 description 1
206010041415 Spastic paralysis Diseases 0.000 description 1
206010042265 Sturge-Weber Syndrome Diseases 0.000 description 1
241000282887 Suidae Species 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
208000027522 Sydenham chorea Diseases 0.000 description 1
206010042928 Syringomyelia Diseases 0.000 description 1
206010042953 Systemic sclerosis Diseases 0.000 description 1
208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 description 1
206010043118 Tardive Dyskinesia Diseases 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
208000024313 Testicular Neoplasms Diseases 0.000 description 1
206010057644 Testis cancer Diseases 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
239000004473 Threonine Substances 0.000 description 1
208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
208000024770 Thyroid neoplasm Diseases 0.000 description 1
208000010641 Tooth disease Diseases 0.000 description 1
208000035317 Total hypoxanthine-guanine phosphoribosyl transferase deficiency Diseases 0.000 description 1
102000007238 Transferrin Receptors Human genes 0.000 description 1
108010033576 Transferrin Receptors Proteins 0.000 description 1
206010052779 Transplant rejections Diseases 0.000 description 1
208000030886 Traumatic Brain injury Diseases 0.000 description 1
208000026911 Tuberous sclerosis complex Diseases 0.000 description 1
102100033001 Tyrosine-protein phosphatase non-receptor type 1 Human genes 0.000 description 1
108090000848 Ubiquitin Proteins 0.000 description 1
102000044159 Ubiquitin Human genes 0.000 description 1
206010046298 Upper motor neurone lesion Diseases 0.000 description 1
208000008385 Urogenital Neoplasms Diseases 0.000 description 1
206010063661 Vascular encephalopathy Diseases 0.000 description 1
206010047115 Vasculitis Diseases 0.000 description 1
OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 description 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
201000006791 West syndrome Diseases 0.000 description 1
208000027207 Whipple disease Diseases 0.000 description 1
206010049644 Williams syndrome Diseases 0.000 description 1
208000018839 Wilson disease Diseases 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
201000004525 Zellweger Syndrome Diseases 0.000 description 1
208000036813 Zellweger spectrum disease Diseases 0.000 description 1
HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical group CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
230000001594 aberrant effect Effects 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
XVIYCJDWYLJQBG-UHFFFAOYSA-N acetic acid;adamantane Chemical compound CC(O)=O.C1C(C2)CC3CC1CC2C3 XVIYCJDWYLJQBG-UHFFFAOYSA-N 0.000 description 1
230000021736 acetylation Effects 0.000 description 1
238000006640 acetylation reaction Methods 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
102000005421 acetyltransferase Human genes 0.000 description 1
108020002494 acetyltransferase Proteins 0.000 description 1
229960004150 aciclovir Drugs 0.000 description 1
239000003377 acid catalyst Substances 0.000 description 1
RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
239000012190 activator Substances 0.000 description 1
201000010442 acute cervicitis Diseases 0.000 description 1
208000021841 acute erythroid leukemia Diseases 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
210000000577 adipose tissue Anatomy 0.000 description 1
201000005255 adrenal gland hyperfunction Diseases 0.000 description 1
201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
230000002411 adverse Effects 0.000 description 1
206010064930 age-related macular degeneration Diseases 0.000 description 1
239000000556 agonist Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000001336 alkenes Chemical class 0.000 description 1
125000003282 alkyl amino group Chemical group 0.000 description 1
125000002877 alkyl aryl group Chemical group 0.000 description 1
230000029936 alkylation Effects 0.000 description 1
238000005804 alkylation reaction Methods 0.000 description 1
201000009961 allergic asthma Diseases 0.000 description 1
229960000473 altretamine Drugs 0.000 description 1
125000004103 aminoalkyl group Chemical group 0.000 description 1
125000005122 aminoalkylamino group Chemical group 0.000 description 1
XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
229960001220 amsacrine Drugs 0.000 description 1
XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
229940124599 anti-inflammatory drug Drugs 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940037157 anticorticosteroids Drugs 0.000 description 1
239000003472 antidiabetic agent Substances 0.000 description 1
229940125708 antidiabetic agent Drugs 0.000 description 1
239000003443 antiviral agent Substances 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
206010003074 arachnoiditis Diseases 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
229960003121 arginine Drugs 0.000 description 1
235000009697 arginine Nutrition 0.000 description 1
238000003491 array Methods 0.000 description 1
206010003230 arteritis Diseases 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
125000003710 aryl alkyl group Chemical group 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
229960005261 aspartic acid Drugs 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
230000001363 autoimmune Effects 0.000 description 1
201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
230000005784 autoimmunity Effects 0.000 description 1
210000003403 autonomic nervous system Anatomy 0.000 description 1
208000031375 autosomal dominant myotonia congenita Diseases 0.000 description 1
229960002756 azacitidine Drugs 0.000 description 1
229940125717 barbiturate Drugs 0.000 description 1
HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000037429 base substitution Effects 0.000 description 1
108700000711 bcl-X Proteins 0.000 description 1
102000055104 bcl-X Human genes 0.000 description 1
239000011324 bead Substances 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 1
HAVZTGSQJIEKPI-UHFFFAOYSA-N benzothiadiazine Chemical compound C1=CC=C2C=NNSC2=C1 HAVZTGSQJIEKPI-UHFFFAOYSA-N 0.000 description 1
102000005936 beta-Galactosidase Human genes 0.000 description 1
108010005774 beta-Galactosidase Proteins 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
229940093761 bile salts Drugs 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000008236 biological pathway Effects 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
229910052797 bismuth Inorganic materials 0.000 description 1
JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
238000010322 bone marrow transplantation Methods 0.000 description 1
229910052796 boron Inorganic materials 0.000 description 1
201000006431 brachial plexus neuropathy Diseases 0.000 description 1
208000029028 brain injury Diseases 0.000 description 1
210000000133 brain stem Anatomy 0.000 description 1
208000026555 breast adenosis Diseases 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
229960002092 busulfan Drugs 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
238000004422 calculation algorithm Methods 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
229940077731 carbohydrate nutrients Drugs 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001721 carbon Chemical group 0.000 description 1
208000002458 carcinoid tumor Diseases 0.000 description 1
229960004203 carnitine Drugs 0.000 description 1
208000003295 carpal tunnel syndrome Diseases 0.000 description 1
150000001767 cationic compounds Chemical class 0.000 description 1
230000032677 cell aging Effects 0.000 description 1
230000006721 cell death pathway Effects 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000006041 cell recruitment Effects 0.000 description 1
108091092328 cellular RNA Proteins 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
210000001638 cerebellum Anatomy 0.000 description 1
208000012056 cerebral malformation Diseases 0.000 description 1
206010008323 cervicitis Diseases 0.000 description 1
238000012412 chemical coupling Methods 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
239000005081 chemiluminescent agent Substances 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
229940044683 chemotherapy drug Drugs 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
229960004630 chlorambucil Drugs 0.000 description 1
JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
229960002155 chlorothiazide Drugs 0.000 description 1
208000006990 cholangiocarcinoma Diseases 0.000 description 1
BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
235000019416 cholic acid Nutrition 0.000 description 1
229960002471 cholic acid Drugs 0.000 description 1
208000012601 choreatic disease Diseases 0.000 description 1
210000003483 chromatin Anatomy 0.000 description 1
230000002759 chromosomal effect Effects 0.000 description 1
208000007451 chronic bronchitis Diseases 0.000 description 1
201000003988 chronic cervicitis Diseases 0.000 description 1
201000003139 chronic cystitis Diseases 0.000 description 1
208000023652 chronic gastritis Diseases 0.000 description 1
201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 description 1
201000006368 chronic pyelonephritis Diseases 0.000 description 1
230000007882 cirrhosis Effects 0.000 description 1
208000019425 cirrhosis of liver Diseases 0.000 description 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
229960004316 cisplatin Drugs 0.000 description 1
206010009887 colitis Diseases 0.000 description 1
238000003340 combinatorial analysis Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000002131 composite material Substances 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
239000013068 control sample Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
210000000877 corpus callosum Anatomy 0.000 description 1
239000003246 corticosteroid Substances 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
229960000956 coumarin Drugs 0.000 description 1
235000001671 coumarin Nutrition 0.000 description 1
238000005336 cracking Methods 0.000 description 1
210000003792 cranial nerve Anatomy 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000001186 cumulative effect Effects 0.000 description 1
235000021438 curry Nutrition 0.000 description 1
229920005565 cyclic polymer Polymers 0.000 description 1
229960004397 cyclophosphamide Drugs 0.000 description 1
208000031513 cyst Diseases 0.000 description 1
208000002445 cystadenocarcinoma Diseases 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
229960002433 cysteine Drugs 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
229960000684 cytarabine Drugs 0.000 description 1
UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 1
208000001763 cytomegalovirus retinitis Diseases 0.000 description 1
229960003901 dacarbazine Drugs 0.000 description 1
229960000640 dactinomycin Drugs 0.000 description 1
108700007153 dansylsarcosine Proteins 0.000 description 1
229960000975 daunorubicin Drugs 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
238000007872 degassing Methods 0.000 description 1
230000007850 degeneration Effects 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
229940124447 delivery agent Drugs 0.000 description 1
239000003398 denaturant Substances 0.000 description 1
CFCUWKMKBJTWLW-UHFFFAOYSA-N deoliosyl-3C-alpha-L-digitoxosyl-MTM Natural products CC=1C(O)=C2C(O)=C3C(=O)C(OC4OC(C)C(O)C(OC5OC(C)C(O)C(OC6OC(C)C(O)C(C)(O)C6)C5)C4)C(C(OC)C(=O)C(O)C(C)O)CC3=CC2=CC=1OC(OC(C)C1O)CC1OC1CC(O)C(O)C(C)O1 CFCUWKMKBJTWLW-UHFFFAOYSA-N 0.000 description 1
KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
239000005549 deoxyribonucleoside Substances 0.000 description 1
238000011033 desalting Methods 0.000 description 1
239000003599 detergent Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
GPRLSGONYQIRFK-DYCDLGHISA-N deuteron Chemical compound [2H+] GPRLSGONYQIRFK-DYCDLGHISA-N 0.000 description 1
208000013257 developmental and epileptic encephalopathy Diseases 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
239000000032 diagnostic agent Substances 0.000 description 1
229940039227 diagnostic agent Drugs 0.000 description 1
229910003460 diamond Inorganic materials 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
229960003529 diazepam Drugs 0.000 description 1
229960000452 diethylstilbestrol Drugs 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000000539 dimer Substances 0.000 description 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
150000002009 diols Chemical class 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
GTZOYNFRVVHLDZ-UHFFFAOYSA-N dodecane-1,1-diol Chemical group CCCCCCCCCCCC(O)O GTZOYNFRVVHLDZ-UHFFFAOYSA-N 0.000 description 1
229960004679 doxorubicin Drugs 0.000 description 1
239000006196 drop Substances 0.000 description 1
238000007876 drug discovery Methods 0.000 description 1
229940088679 drug related substance Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000012636 effector Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
201000002491 encephalomyelitis Diseases 0.000 description 1
201000009274 endometriosis of uterus Diseases 0.000 description 1
239000007920 enema Substances 0.000 description 1
229940079360 enema for constipation Drugs 0.000 description 1
108700004025 env Genes Proteins 0.000 description 1
101150030339 env gene Proteins 0.000 description 1
230000007515 enzymatic degradation Effects 0.000 description 1
208000002854 epidermolysis bullosa simplex superficialis Diseases 0.000 description 1
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
201000004101 esophageal cancer Diseases 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
102000013165 exonuclease Human genes 0.000 description 1
239000013613 expression plasmid Substances 0.000 description 1
239000013604 expression vector Substances 0.000 description 1
239000000284 extract Substances 0.000 description 1
208000002980 facial hemiatrophy Diseases 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
229960000961 floxuridine Drugs 0.000 description 1
LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 description 1
229960004369 flufenamic acid Drugs 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000000799 fluorescence microscopy Methods 0.000 description 1
238000001506 fluorescence spectroscopy Methods 0.000 description 1
239000007850 fluorescent dye Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
235000019152 folic acid Nutrition 0.000 description 1
239000011724 folic acid Substances 0.000 description 1
229960000304 folic acid Drugs 0.000 description 1
235000008191 folinic acid Nutrition 0.000 description 1
239000011672 folinic acid Substances 0.000 description 1
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
108020001507 fusion proteins Proteins 0.000 description 1
102000037865 fusion proteins Human genes 0.000 description 1
FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
229960002963 ganciclovir Drugs 0.000 description 1
SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
229960005277 gemcitabine Drugs 0.000 description 1
238000003633 gene expression assay Methods 0.000 description 1
230000030279 gene silencing Effects 0.000 description 1
238000012226 gene silencing method Methods 0.000 description 1
201000011349 geniculate herpes zoster Diseases 0.000 description 1
101150025688 ggact gene Proteins 0.000 description 1
210000004907 gland Anatomy 0.000 description 1
208000005017 glioblastoma Diseases 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
125000004383 glucosinolate group Chemical group 0.000 description 1
IAJOBQBIJHVGMQ-BYPYZUCNSA-N glufosinate-P Chemical compound CP(O)(=O)CC[C@H](N)C(O)=O IAJOBQBIJHVGMQ-BYPYZUCNSA-N 0.000 description 1
229960002989 glutamic acid Drugs 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
125000003563 glycoside group Chemical group 0.000 description 1
230000013595 glycosylation Effects 0.000 description 1
238000006206 glycosylation reaction Methods 0.000 description 1
239000004519 grease Substances 0.000 description 1
210000004884 grey matter Anatomy 0.000 description 1
230000012010 growth Effects 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
229960004198 guanidine Drugs 0.000 description 1
229940029575 guanosine Drugs 0.000 description 1
208000021245 head disease Diseases 0.000 description 1
231100000869 headache Toxicity 0.000 description 1
210000002443 helper t lymphocyte Anatomy 0.000 description 1
201000002222 hemangioblastoma Diseases 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
208000008675 hereditary spastic paraplegia Diseases 0.000 description 1
UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 description 1
238000010842 high-capacity cDNA reverse transcription kit Methods 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
229960002885 histidine Drugs 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
208000003906 hydrocephalus Diseases 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
150000001261 hydroxy acids Chemical class 0.000 description 1
XAKRTGZVYPZHCO-UHFFFAOYSA-O hydroxy-methoxy-oxophosphanium Chemical group CO[P+](O)=O XAKRTGZVYPZHCO-UHFFFAOYSA-O 0.000 description 1
229960002899 hydroxyprogesterone Drugs 0.000 description 1
208000013403 hyperactivity Diseases 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
229960001680 ibuprofen Drugs 0.000 description 1
229960000908 idarubicin Drugs 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
238000010324 immunological assay Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000007901 in situ hybridization Methods 0.000 description 1
238000000099 in vitro assay Methods 0.000 description 1
208000023692 inborn mitochondrial myopathy Diseases 0.000 description 1
210000003000 inclusion body Anatomy 0.000 description 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
150000002475 indoles Chemical class 0.000 description 1
229960000905 indomethacin Drugs 0.000 description 1
239000012678 infectious agent Substances 0.000 description 1
210000004969 inflammatory cell Anatomy 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
229910001411 inorganic cation Inorganic materials 0.000 description 1
229960003786 inosine Drugs 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000009878 intermolecular interaction Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
201000005851 intracranial arteriosclerosis Diseases 0.000 description 1
201000009941 intracranial hypertension Diseases 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000007914 intraventricular administration Methods 0.000 description 1
230000034727 intrinsic apoptotic signaling pathway Effects 0.000 description 1
229960004768 irinotecan Drugs 0.000 description 1
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
210000004153 islets of langerhan Anatomy 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
208000017476 juvenile neuronal ceroid lipofuscinosis Diseases 0.000 description 1
201000004815 juvenile spinal muscular atrophy Diseases 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
238000004898 kneading Methods 0.000 description 1
206010023497 kuru Diseases 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229910052746 lanthanum Inorganic materials 0.000 description 1
FZLIPJUXYLNCLC-UHFFFAOYSA-N lanthanum atom Chemical compound [La] FZLIPJUXYLNCLC-UHFFFAOYSA-N 0.000 description 1
208000004343 lateral medullary syndrome Diseases 0.000 description 1
201000010901 lateral sclerosis Diseases 0.000 description 1
201000003723 learning disability Diseases 0.000 description 1
229960003136 leucine Drugs 0.000 description 1
229960001691 leucovorin Drugs 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
229960005287 lincomycin Drugs 0.000 description 1
OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
239000008206 lipophilic material Substances 0.000 description 1
206010024627 liposarcoma Diseases 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
230000007762 localization of cell Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
208000037841 lung tumor Diseases 0.000 description 1
206010025135 lupus erythematosus Diseases 0.000 description 1
208000012804 lymphangiosarcoma Diseases 0.000 description 1
230000001589 lymphoproliferative effect Effects 0.000 description 1
229960003646 lysine Drugs 0.000 description 1
235000018977 lysine Nutrition 0.000 description 1
230000002101 lytic effect Effects 0.000 description 1
201000000564 macroglobulinemia Diseases 0.000 description 1
208000002780 macular degeneration Diseases 0.000 description 1
229950000547 mafosfamide Drugs 0.000 description 1
230000005291 magnetic effect Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
230000001071 malnutrition Effects 0.000 description 1
235000000824 malnutrition Nutrition 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
230000008774 maternal effect Effects 0.000 description 1
208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 description 1
238000005259 measurement Methods 0.000 description 1
208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
229960001924 melphalan Drugs 0.000 description 1
238000011880 melting curve analysis Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
206010027191 meningioma Diseases 0.000 description 1
229960001428 mercaptopurine Drugs 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
229960003105 metformin Drugs 0.000 description 1
AWIJRPNMLHPLNC-UHFFFAOYSA-N methanethioic s-acid Chemical compound SC=O AWIJRPNMLHPLNC-UHFFFAOYSA-N 0.000 description 1
WDWDWGRYHDPSDS-UHFFFAOYSA-N methanimine Chemical compound N=C WDWDWGRYHDPSDS-UHFFFAOYSA-N 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
239000004530 micro-emulsion Substances 0.000 description 1
238000002493 microarray Methods 0.000 description 1
208000004141 microcephaly Diseases 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
206010027599 migraine Diseases 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 1
210000003470 mitochondria Anatomy 0.000 description 1
229960004857 mitomycin Drugs 0.000 description 1
229960001156 mitoxantrone Drugs 0.000 description 1
KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
238000006011 modification reaction Methods 0.000 description 1
230000009149 molecular binding Effects 0.000 description 1
230000004001 molecular interaction Effects 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
210000002161 motor neuron Anatomy 0.000 description 1
206010028093 mucopolysaccharidosis Diseases 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
206010065579 multifocal motor neuropathy Diseases 0.000 description 1
208000010805 mumps infectious disease Diseases 0.000 description 1
201000006938 muscular dystrophy Diseases 0.000 description 1
230000000869 mutational effect Effects 0.000 description 1
206010028417 myasthenia gravis Diseases 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
GZCNJTFELNTSAB-UHFFFAOYSA-N n'-(7h-purin-6-yl)hexane-1,6-diamine Chemical compound NCCCCCCNC1=NC=NC2=C1NC=N2 GZCNJTFELNTSAB-UHFFFAOYSA-N 0.000 description 1
239000002105 nanoparticle Substances 0.000 description 1
201000003631 narcolepsy Diseases 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
208000004995 necrotizing enterocolitis Diseases 0.000 description 1
210000005170 neoplastic cell Anatomy 0.000 description 1
210000001577 neostriatum Anatomy 0.000 description 1
210000000653 nervous system Anatomy 0.000 description 1
230000004770 neurodegeneration Effects 0.000 description 1
208000015122 neurodegenerative disease Diseases 0.000 description 1
201000004931 neurofibromatosis Diseases 0.000 description 1
230000002232 neuromuscular Effects 0.000 description 1
230000016273 neuron death Effects 0.000 description 1
230000017511 neuron migration Effects 0.000 description 1
201000007607 neuronal ceroid lipofuscinosis 3 Diseases 0.000 description 1
239000003900 neurotrophic factor Substances 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
239000012457 nonaqueous media Substances 0.000 description 1
238000007899 nucleic acid hybridization Methods 0.000 description 1
231100000862 numbness Toxicity 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
230000035764 nutrition Effects 0.000 description 1
208000015380 nutritional deficiency disease Diseases 0.000 description 1
239000002674 ointment Substances 0.000 description 1
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
210000004248 oligodendroglia Anatomy 0.000 description 1
238000006384 oligomerization reaction Methods 0.000 description 1
238000002515 oligonucleotide synthesis Methods 0.000 description 1
239000010450 olivine Substances 0.000 description 1
229910052609 olivine Inorganic materials 0.000 description 1
210000001328 optic nerve Anatomy 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
201000008968 osteosarcoma Diseases 0.000 description 1
230000002018 overexpression Effects 0.000 description 1
238000012261 overproduction Methods 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
125000003544 oxime group Chemical group 0.000 description 1
229960001592 paclitaxel Drugs 0.000 description 1
208000005877 painful neuropathy Diseases 0.000 description 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
208000008443 pancreatic carcinoma Diseases 0.000 description 1
208000002593 pantothenate kinase-associated neurodegeneration Diseases 0.000 description 1
208000004019 papillary adenocarcinoma Diseases 0.000 description 1
244000045947 parasite Species 0.000 description 1
208000035824 paresthesia Diseases 0.000 description 1
230000001314 paroxysmal effect Effects 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
244000052769 pathogen Species 0.000 description 1
230000037361 pathway Effects 0.000 description 1
230000006320 pegylation Effects 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
239000003961 penetration enhancing agent Substances 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
ONTNXMBMXUNDBF-UHFFFAOYSA-N pentatriacontane-17,18,19-triol Chemical compound CCCCCCCCCCCCCCCCC(O)C(O)C(O)CCCCCCCCCCCCCCCC ONTNXMBMXUNDBF-UHFFFAOYSA-N 0.000 description 1
229960002340 pentostatin Drugs 0.000 description 1
FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 description 1
201000006195 perinatal necrotizing enterocolitis Diseases 0.000 description 1
208000029308 periodic paralysis Diseases 0.000 description 1
210000005259 peripheral blood Anatomy 0.000 description 1
239000011886 peripheral blood Substances 0.000 description 1
206010034674 peritonitis Diseases 0.000 description 1
239000008251 pharmaceutical emulsion Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
229960005190 phenylalanine Drugs 0.000 description 1
229960002895 phenylbutazone Drugs 0.000 description 1
VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
150000003009 phosphonic acids Chemical class 0.000 description 1
XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
150000008300 phosphoramidites Chemical class 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
125000004437 phosphorous atom Chemical group 0.000 description 1
229910001392 phosphorus oxide Inorganic materials 0.000 description 1
229940068041 phytic acid Drugs 0.000 description 1
239000000467 phytic acid Substances 0.000 description 1
235000002949 phytic acid Nutrition 0.000 description 1
239000000049 pigment Substances 0.000 description 1
208000024724 pineal body neoplasm Diseases 0.000 description 1
208000010916 pituitary tumor Diseases 0.000 description 1
239000013612 plasmid Substances 0.000 description 1
229960003171 plicamycin Drugs 0.000 description 1
238000006068 polycondensation reaction Methods 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
108010040003 polyglutamine Proteins 0.000 description 1
102000054765 polymorphisms of proteins Human genes 0.000 description 1
208000005987 polymyositis Diseases 0.000 description 1
208000019629 polyneuritis Diseases 0.000 description 1
239000001205 polyphosphate Substances 0.000 description 1
235000011176 polyphosphates Nutrition 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 1
208000037955 postinfectious encephalomyelitis Diseases 0.000 description 1
229960003101 pranoprofen Drugs 0.000 description 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
229960004618 prednisone Drugs 0.000 description 1
230000002265 prevention Effects 0.000 description 1
208000030266 primary brain neoplasm Diseases 0.000 description 1
230000037452 priming Effects 0.000 description 1
230000000861 pro-apoptotic effect Effects 0.000 description 1
CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
229960000624 procarbazine Drugs 0.000 description 1
206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
210000004129 prosencephalon Anatomy 0.000 description 1
230000004952 protein activity Effects 0.000 description 1
238000003498 protein array Methods 0.000 description 1
239000001397 quillaja saponaria molina bark Substances 0.000 description 1
150000003254 radicals Chemical group 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000008707 rearrangement Effects 0.000 description 1
239000000018 receptor agonist Substances 0.000 description 1
229940044601 receptor agonist Drugs 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
230000014493 regulation of gene expression Effects 0.000 description 1
238000007634 remodeling Methods 0.000 description 1
230000010410 reperfusion Effects 0.000 description 1
230000003252 repetitive effect Effects 0.000 description 1
125000006853 reporter group Chemical group 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
108091008146 restriction endonucleases Proteins 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
238000003757 reverse transcription PCR Methods 0.000 description 1
201000009410 rhabdomyosarcoma Diseases 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
239000002342 ribonucleoside Substances 0.000 description 1
229930182490 saponin Natural products 0.000 description 1
150000007949 saponins Chemical class 0.000 description 1
229910052594 sapphire Inorganic materials 0.000 description 1
239000010980 sapphire Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000007632 sclerotherapy Methods 0.000 description 1
238000012216 screening Methods 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
208000018964 sebaceous gland cancer Diseases 0.000 description 1
230000028327 secretion Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
208000002477 septooptic dysplasia Diseases 0.000 description 1
230000009919 sequestration Effects 0.000 description 1
229960001153 serine Drugs 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
238000004088 simulation Methods 0.000 description 1
239000002356 single layer Substances 0.000 description 1
230000037380 skin damage Effects 0.000 description 1
201000002859 sleep apnea Diseases 0.000 description 1
208000000587 small cell lung carcinoma Diseases 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
206010041232 sneezing Diseases 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
JJICLMJFIKGAAU-UHFFFAOYSA-M sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate Chemical compound [Na+].NC1=NC([O-])=C2N=CN(COC(CO)CO)C2=N1 JJICLMJFIKGAAU-UHFFFAOYSA-M 0.000 description 1
RMLUKZWYIKEASN-UHFFFAOYSA-M sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate Chemical compound [Na+].O=C1[N-]C(N)=NC2=C1N=CN2COCCO RMLUKZWYIKEASN-UHFFFAOYSA-M 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
238000011895 specific detection Methods 0.000 description 1
210000000278 spinal cord Anatomy 0.000 description 1
208000020431 spinal cord injury Diseases 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000010473 stable expression Effects 0.000 description 1
230000007863 steatosis Effects 0.000 description 1
231100000240 steatosis hepatitis Toxicity 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
239000004575 stone Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000005728 strengthening Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
210000003523 substantia nigra Anatomy 0.000 description 1
239000000758 substrate Substances 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
230000019635 sulfation Effects 0.000 description 1
238000005670 sulfation reaction Methods 0.000 description 1
150000003457 sulfones Chemical group 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
QBXRWOPSPUENQZ-UHFFFAOYSA-N sulfuric acid;thiophene Chemical group C=1C=CSC=1.OS(O)(=O)=O QBXRWOPSPUENQZ-UHFFFAOYSA-N 0.000 description 1
239000000829 suppository Substances 0.000 description 1
229960004492 suprofen Drugs 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
210000004243 sweat Anatomy 0.000 description 1
230000002889 sympathetic effect Effects 0.000 description 1
210000001258 synovial membrane Anatomy 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
229960001603 tamoxifen Drugs 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229960003080 taurine Drugs 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
206010043207 temporal arteritis Diseases 0.000 description 1
NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
229960001278 teniposide Drugs 0.000 description 1
201000003120 testicular cancer Diseases 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
VSAISIQCTGDGPU-UHFFFAOYSA-N tetraphosphorus hexaoxide Chemical compound O1P(O2)OP3OP1OP2O3 VSAISIQCTGDGPU-UHFFFAOYSA-N 0.000 description 1
150000003536 tetrazoles Chemical class 0.000 description 1
210000001103 thalamus Anatomy 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
150000003568 thioethers Chemical class 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
150000003573 thiols Chemical class 0.000 description 1
DENPQNAWGQXKCU-UHFFFAOYSA-N thiophene-2-carboxamide Chemical compound NC(=O)C1=CC=CS1 DENPQNAWGQXKCU-UHFFFAOYSA-N 0.000 description 1
206010048627 thoracic outlet syndrome Diseases 0.000 description 1
229960002898 threonine Drugs 0.000 description 1
230000002992 thymic effect Effects 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
201000002510 thyroid cancer Diseases 0.000 description 1
206010043778 thyroiditis Diseases 0.000 description 1
229960003087 tioguanine Drugs 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
229960000303 topotecan Drugs 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000759 toxicological effect Toxicity 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
208000009174 transverse myelitis Diseases 0.000 description 1
230000008733 trauma Effects 0.000 description 1
230000009529 traumatic brain injury Effects 0.000 description 1
ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
206010044652 trigeminal neuralgia Diseases 0.000 description 1
229960001099 trimetrexate Drugs 0.000 description 1
NOYPYLRCIDNJJB-UHFFFAOYSA-O trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=[NH+]C(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-O 0.000 description 1
125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
208000006961 tropical spastic paraparesis Diseases 0.000 description 1
208000009999 tuberous sclerosis Diseases 0.000 description 1
230000007306 turnover Effects 0.000 description 1
208000032471 type 1 spinal muscular atrophy Diseases 0.000 description 1
208000032527 type III spinal muscular atrophy Diseases 0.000 description 1
229960004441 tyrosine Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
230000002792 vascular Effects 0.000 description 1
229960003636 vidarabine Drugs 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
208000006542 von Hippel-Lindau disease Diseases 0.000 description 1
229960005080 warfarin Drugs 0.000 description 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
229940075420 xanthine Drugs 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW100124653A 2010-07-12 2011-07-12 Treatment of BCL2 binding component 3 (BBC3) related diseases by inhibition of natural antisense transcript to BBC3 TW201209163A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US36353510P	2010-07-12	2010-07-12

Publications (1)

Publication Number	Publication Date
TW201209163A true TW201209163A (en)	2012-03-01

Family

ID=45470031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW100124653A TW201209163A (en)	2010-07-12	2011-07-12	Treatment of BCL2 binding component 3 (BBC3) related diseases by inhibition of natural antisense transcript to BBC3

Country Status (2)

Country	Link
TW (1)	TW201209163A (fr)
WO (1)	WO2012009347A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9920317B2 (en)	2010-11-12	2018-03-20	The General Hospital Corporation	Polycomb-associated non-coding RNAs
CA2817256A1 (fr)	2010-11-12	2012-05-18	The General Hospital Corporation	Arn non codants associes a polycomb
AU2013262699A1 (en)	2012-05-16	2015-01-22	Rana Therapeutics, Inc.	Compositions and methods for modulating ATP2A2 expression
EA201492122A1 (ru)	2012-05-16	2015-10-30	Рана Терапьютикс, Инк.	Композиции и способы для модулирования экспрессии utrn
BR112014028631A2 (pt)	2012-05-16	2017-10-17	Rana Therapeutics Inc	composições e métodos para modulação da expressão da família de genes da hemoglobina
US10837014B2 (en)	2012-05-16	2020-11-17	Translate Bio Ma, Inc.	Compositions and methods for modulating SMN gene family expression
SG11201407483YA (en)	2012-05-16	2014-12-30	Rana Therapeutics Inc	Compositions and methods for modulating smn gene family expression
EA201492116A1 (ru)	2012-05-16	2015-05-29	Рана Терапьютикс, Инк.	Композиции и способы для модулирования экспрессии mecp2
WO2016070060A1 (fr)	2014-10-30	2016-05-06	The General Hospital Corporation	Procédés de modulation de la répression génique dépendant d'atrx
US10195213B2 (en)	2015-03-13	2019-02-05	Unity Biotechnology, Inc.	Chemical entities that kill senescent cells for use in treating age-related disease
WO2016149455A2 (fr)	2015-03-17	2016-09-22	The General Hospital Corporation	Interactome arn de complexe répressif polycomb 1 (prc1)
US11584932B2 (en)	2016-11-01	2023-02-21	The Research Foundation For The State University Of New York	5-halouracil-modified microRNAs and their use in the treatment of cancer
WO2021262919A2 (fr)	2020-06-26	2021-12-30	The Research Foundation For The State University Of New York	Microarn modifiés par 5-halogéno-uracile et leur utilisation dans le traitement du cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7202024B2 (en) *	2001-09-17	2007-04-10	Immunogen Inc.	bbc3 Gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression using a bbc3 gene promoter
EP1542016A1 (fr) *	2003-12-11	2005-06-15	Institut Gustave Roussy	PUMA, p53 phosphorylé et p38 MAPK comme marqueurs pour l'apoptose inicieé par VIH dans des cellules T circulantes d'un patient infecté
ES2636470T3 (es) *	2004-04-09	2017-10-05	Genomic Health, Inc.	Marcadores de expresión génica para predecir la respuesta a la quimioterapia
US20060292695A1 (en) *	2005-06-22	2006-12-28	Roslin Institute	Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells

2011
- 2011-07-12 TW TW100124653A patent/TW201209163A/zh unknown
- 2011-07-12 WO PCT/US2011/043694 patent/WO2012009347A2/fr not_active Ceased

Also Published As

Publication number	Publication date
WO2012009347A2 (fr)	2012-01-19
WO2012009347A3 (fr)	2012-04-26

Publication	Publication Date	Title
JP6049623B2 (ja)	2016-12-21	α‐Ｌ‐イズロニダーゼ（ＩＤＵＡ）への天然アンチセンス転写物の阻害によるＩＤＵＡ関連疾患の治療
JP5993744B2 (ja)	2016-09-14	核呼吸因子１（ｎｒｆ１）に対する天然アンチセンス転写物の阻害による核呼吸因子１関連疾患の治療
JP6188686B2 (ja)	2017-08-30	フラタキシン（ｆｘｎ）への天然アンチセンス転写物の阻害によるｆｘｎ関連疾患の治療
JP6025567B2 (ja)	2016-11-16	膜結合転写因子ペプチダーゼ、部位１（ｍｂｔｐｓ１）に対する天然アンチセンス転写物の阻害によるｍｂｔｐｓ１関連性疾患の治療
JP6027893B2 (ja)	2016-11-16	性ホルモン結合グロブリン（ｓｈｂｇ）に対する天然アンチセンス転写物の阻害による性ホルモン結合グロブリン（ｓｈｂｇ）関連疾患の治療
JP5976548B2 (ja)	2016-08-23	Ｐｙｃｒ１に対する天然アンチセンス転写物の阻害によるピロリン−５−カルボン酸レダクターゼ１（ｐｙｃｒ１）関連疾患の治療
JP6073795B2 (ja)	2017-02-01	インターフェロン関連発生制御因子１（ｉｆｒｄ１）への天然アンチセンス転写物の阻害によるｉｆｒｄ１関連疾患の治療
JP5886757B2 (ja)	2016-03-16	インターフェロン調節因子８（ｉｒｆ８）に対する天然アンチセンス転写物の阻害によるインターフェロン調節因子８（ｉｒｆ８）関連疾患の治療
JP5973419B2 (ja)	2016-08-23	コロニー刺激因子３（ｃｓｆ３）に対する天然アンチセンス転写物の阻害によるｃｓｆ３関連疾患の治療
JP5981850B2 (ja)	2016-08-31	ＲＮａｓｅＨ１に対する天然アンチセンス転写物の阻害によるＲＮａｓｅＨ１関連疾患の治療
JP5986998B2 (ja)	2016-09-06	シアリダーゼ４（ｎｅｕ４）への天然アンチセンス転写物の阻害によるｎｅｕ４関連疾患の治療
JP6083735B2 (ja)	2017-02-22	インスリン受容体基質２（ｉｒｓ２）および転写因子３（ｔｆｅ３）に対する天然アンチセンス転写物の阻害によるインスリン受容体基質２（ｉｒｓ２）関連疾患の治療
TWI573871B (zh)	2017-03-11	藉由抑制ｎａｎｏｇ之天然反義轉錄物治療ｎａｎｏｇ相關疾病
JP5982362B2 (ja)	2016-08-31	Ｐａｒ４への天然アンチセンス転写物の阻害によるｐａｒ４関連疾患の治療
TW201209163A (en)	2012-03-01	Treatment of BCL2 binding component 3 (BBC3) related diseases by inhibition of natural antisense transcript to BBC3
TW201200138A (en)	2012-01-01	Treatment of Atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
JP2016106081A (ja)	2016-06-16	‘ｉｑモチーフ含有ｇｔｐアーゼ活性化タンパク質’（ｉｑｇａｐ）に対する天然アンチセンス転写産物の阻害によるｉｑｇａｐ関連疾患の治療
TW201210611A (en)	2012-03-16	Treatment of Nicotinamide Phosphoribosyltransferase (NAMPT) related diseases by inhibition of natural antisense transcript to NAMPT
TW201206450A (en)	2012-02-16	Treatment of Discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG
TW201201819A (en)	2012-01-16	Treatment of BCL2-like 11 (BCL2L11) related diseases by inhibition of natural antisense transcript to BCL2L11
TW201143782A (en)	2011-12-16	Treatment of LIM homeobox 2 (LHX2) related diseases by inhibition of natural antisense transcript to LHX2
CN102762731A (zh)	2012-10-31	通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病