CA2817256A1 - Arn non codants associes a polycomb - Google Patents

Arn non codants associes a polycomb Download PDF

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Publication number
CA2817256A1
CA2817256A1 CA2817256A CA2817256A CA2817256A1 CA 2817256 A1 CA2817256 A1 CA 2817256A1 CA 2817256 A CA2817256 A CA 2817256A CA 2817256 A CA2817256 A CA 2817256A CA 2817256 A1 CA2817256 A1 CA 2817256A1
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Prior art keywords
nucleic acid
rna
seq
inhibitory nucleic
nos
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Abandoned
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CA2817256A
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Inventor
Jeannie T. Lee
Jing Zhao
Kavitha Sarma
Mark Borowsky
Toshiro Kendrick Ohsumi
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General Hospital Corp
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General Hospital Corp
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Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CA2817256A1 publication Critical patent/CA2817256A1/fr
Abandoned legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Abstract

Cette invention concerne de longs ARN non codants (ARNlnc), des banques de ces ARNnc qui se lient à des modificateurs de chromatine, tels que le complexe 2 de répression de Polycomb, des acides nucléiques inhibiteurs et des procédés et des compositions pour le ciblage des ARNlnc.
CA2817256A 2010-11-12 2011-11-12 Arn non codants associes a polycomb Abandoned CA2817256A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41286210P 2010-11-12 2010-11-12
US61/412,862 2010-11-12
US201061425174P 2010-12-20 2010-12-20
US61/425,174 2010-12-20
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