|
US5472693A
(en)
*
|
1993-02-16 |
1995-12-05 |
The Dow Chemical Company |
Family of anti-carcinoembryonic antigen chimeric antibodies
|
|
US5856135A
(en)
*
|
1993-05-31 |
1999-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human antibody to human interleukin-6
|
|
KR100304333B1
(ko)
*
|
1993-08-24 |
2001-11-30 |
안도 고끼 |
재조합의사람화된항-사람면역결핍바이러스항체
|
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
|
US6214973B1
(en)
|
1993-11-19 |
2001-04-10 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human antibody to human medulloblastoma cells
|
|
WO1995029690A1
(en)
*
|
1994-04-29 |
1995-11-09 |
The Trustees Of The University Of Pennsylvania |
Biologically active peptides and methods of identifying the same
|
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
PT783893E
(pt)
*
|
1994-10-07 |
2012-05-24 |
Chugai Pharmaceutical Co Ltd |
Inibição do crescimento anormal das células sinoviais usando antagonistas de il-6 como componente ativo
|
|
CN1306963C
(zh)
*
|
1994-10-21 |
2007-03-28 |
岸本忠三 |
用于治疗il-6产生所致疾病的药物组合物
|
|
ES2264135T3
(es)
*
|
1995-02-13 |
2006-12-16 |
Chugai Seiyaku Kabushiki Kaisha |
Inhibidor de la descomposicion de proteinas musculares que contienen anticuerpos frente al receptor de il-6.
|
|
DK0923941T3
(da)
|
1996-06-27 |
2006-09-18 |
Chugai Pharmaceutical Co Ltd |
Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler
|
|
SK40599A3
(en)
|
1996-09-26 |
2000-06-12 |
Chugai Pharmaceutical Co Ltd |
Antibody against human parathormone related peptides
|
|
UA76934C2
(en)
|
1996-10-04 |
2006-10-16 |
Chugai Pharmaceutical Co Ltd |
Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
|
|
BR9811094A
(pt)
|
1997-02-12 |
2000-07-18 |
Chugai Pharmaceutical Co Ltd |
Agente terapêutico para tumores linfáticos
|
|
AU736282B2
(en)
|
1997-03-21 |
2001-07-26 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
|
|
WO1998051329A1
(en)
|
1997-05-15 |
1998-11-19 |
Chugai Seiyaku Kabushiki Kaisha |
Cachexia remedy
|
|
AU747883B2
(en)
|
1997-08-15 |
2002-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Preventives and/or remedies for systemic lupus erythematosus containing anti-IL-6 receptor antibody as the active ingredient
|
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
DK1074268T3
(da)
|
1998-03-17 |
2008-04-28 |
Chugai Pharmaceutical Co Ltd |
IL-6-receptorantagonistantistofholdige forebyggende eller terapeutiske midler mod inflammatoriske tarmsygdomme
|
|
US6677436B1
(en)
|
1998-04-03 |
2004-01-13 |
Chugai Seiyaku Kabushiki Kaisha |
Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody
|
|
ATE350060T1
(de)
|
1998-08-24 |
2007-01-15 |
Chugai Pharmaceutical Co Ltd |
Mittel zur vorbeugung oder behandlung von pankreatitis die anti-il-6 receptor antikörper als aktive komponente enthalten
|
|
DE69933044T3
(de)
|
1998-11-27 |
2016-11-24 |
Ucb Pharma, S.A. |
Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
|
|
US7696325B2
(en)
|
1999-03-10 |
2010-04-13 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptide inducing apoptosis
|
|
WO2001016166A2
(en)
*
|
1999-08-27 |
2001-03-08 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
|
|
IL148980A0
(en)
|
1999-10-01 |
2002-11-10 |
Chugai Pharmaceutical Co Ltd |
An antibody to human tissue factor and experimental animals having inserted cells with the gene encoding human tissue factor
|
|
GB0002666D0
(en)
|
2000-02-04 |
2000-03-29 |
Univ London |
Blockade of voltage dependent sodium channels
|
|
US8029793B2
(en)
|
2000-04-28 |
2011-10-04 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for inhibiting cell proliferation
|
|
US8632778B2
(en)
|
2000-08-11 |
2014-01-21 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized anti-interleukin-6 antibody-containing preparations
|
|
AU2002224417A1
(en)
*
|
2000-10-18 |
2002-04-29 |
Immunex Corporation |
Methods for treating il-18 mediated disorders
|
|
RU2287534C2
(ru)
|
2000-10-20 |
2006-11-20 |
Тугаи Сейяку Кабусики Кайся |
Деградированное антитело, являющееся агонистом tpo
|
|
EP2351838A1
(en)
|
2000-10-20 |
2011-08-03 |
Chugai Seiyaku Kabushiki Kaisha |
Crosslinking agonistic antibodies
|
|
EP1327681A4
(en)
|
2000-10-20 |
2004-09-01 |
Chugai Pharmaceutical Co Ltd |
Degraded agonist antibodies
|
|
DE60133029T2
(de)
|
2000-10-25 |
2009-03-12 |
Chugai Seiyaku K.K. |
Mittel zur prävention oder behandlung von psoriasis mit einem il-6-antagonist als wirkstoff
|
|
WO2002036165A1
(fr)
*
|
2000-10-27 |
2002-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Agent à base d'antagoniste d'il-6, faisant baisser le niveau des mmp-3 dans le sang
|
|
WO2002036164A1
(en)
*
|
2000-10-27 |
2002-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient
|
|
JP3986439B2
(ja)
|
2001-02-07 |
2007-10-03 |
中外製薬株式会社 |
造血器腫瘍の治療剤
|
|
WO2002098370A2
(en)
*
|
2001-03-02 |
2002-12-12 |
Medimmune, Inc. |
Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
|
|
EP3088412B1
(en)
|
2001-03-09 |
2021-05-05 |
Chugai Seiyaku Kabushiki Kaisha |
Protein purification method
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
EP2975382B1
(en)
|
2001-04-17 |
2017-12-27 |
Chugai Seiyaku Kabushiki Kaisha |
Method of quantifying surfactant
|
|
EP1392359B2
(en)
|
2001-05-11 |
2013-03-13 |
Ludwig Institute for Cancer Research Ltd. |
Specific binding proteins and uses thereof
|
|
US20100056762A1
(en)
*
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
AU2003211990A1
(en)
|
2002-02-14 |
2003-09-04 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody-containing solution pharmaceuticals
|
|
GB0208041D0
(en)
*
|
2002-04-08 |
2002-05-22 |
Lonza Biologics Plc |
Method of culturing animal cells
|
|
WO2004022597A1
(ja)
|
2002-09-04 |
2004-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
Gpc3の血中可溶化n端ペプチドに対する抗体
|
|
EP1498137A1
(en)
*
|
2002-04-25 |
2005-01-19 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for lung cancer
|
|
EP1513879B1
(en)
*
|
2002-06-03 |
2018-08-22 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
EP1541165A4
(en)
|
2002-08-27 |
2009-06-24 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR STABILIZING PROTEIN PREPARATION
|
|
ES2558303T3
(es)
|
2002-09-11 |
2016-02-03 |
Chugai Seiyaku Kabushiki Kaisha |
Método de purificación de proteínas
|
|
AU2004212843B2
(en)
*
|
2003-02-24 |
2009-06-25 |
Chugai Seiyaku Kabushiki Kaisha |
Remedy for spinal injury containing interleukin-6 antagonist
|
|
JP2004279086A
(ja)
|
2003-03-13 |
2004-10-07 |
Konica Minolta Holdings Inc |
放射線画像変換パネル及び放射線画像変換パネルの製造方法
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
EP1636270B1
(en)
*
|
2003-06-16 |
2016-07-20 |
UCB Pharma S.A. |
Antibodies specific for sclerostin and methods for increasing bone mineralization
|
|
ATE490787T1
(de)
|
2003-07-15 |
2010-12-15 |
Chugai Pharmaceutical Co Ltd |
Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion
|
|
KR101193708B1
(ko)
|
2003-10-17 |
2012-10-22 |
추가이 세이야쿠 가부시키가이샤 |
중피종 치료제
|
|
CA2548185A1
(en)
|
2003-12-03 |
2005-06-16 |
Chugai Seiyaku Kabushiki Kaisha |
Expression systems using mammalian .beta.-actin promoter
|
|
US8617550B2
(en)
|
2003-12-19 |
2013-12-31 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment of vasculitis with IL-6 antagonist
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
BRPI0506679A
(pt)
*
|
2004-02-11 |
2007-05-15 |
Warner Lambert Co |
métodos de tratar osteoartrite com antagonistas de il-6
|
|
EP1720908A2
(en)
*
|
2004-02-17 |
2006-11-15 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
US7767792B2
(en)
*
|
2004-02-20 |
2010-08-03 |
Ludwig Institute For Cancer Research Ltd. |
Antibodies to EGF receptor epitope peptides
|
|
AR048335A1
(es)
*
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
US8398980B2
(en)
|
2004-03-24 |
2013-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleuken-6 receptor
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
GB0410627D0
(en)
*
|
2004-05-12 |
2004-06-16 |
Scancell Ltd |
Specific binding members
|
|
WO2006046661A1
(ja)
*
|
2004-10-28 |
2006-05-04 |
Osaka University |
インターロイキン-6阻害剤
|
|
JP4818936B2
(ja)
|
2005-01-05 |
2011-11-16 |
中外製薬株式会社 |
細胞の培養方法およびその利用
|
|
PL1859793T3
(pl)
*
|
2005-02-28 |
2011-09-30 |
Eisai R&D Man Co Ltd |
Nowe połączone zastosowanie związku sulfonamidowego w leczeniu choroby nowotworowej
|
|
JP5057967B2
(ja)
|
2005-03-31 |
2012-10-24 |
中外製薬株式会社 |
sc(Fv)2構造異性体
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
PE20061324A1
(es)
|
2005-04-29 |
2007-01-15 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, metodos y usos
|
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
|
KR101360671B1
(ko)
|
2005-06-10 |
2014-02-07 |
추가이 세이야쿠 가부시키가이샤 |
sc(Fv)2를 함유하는 의약조성물
|
|
KR101367544B1
(ko)
|
2005-06-10 |
2014-02-26 |
추가이 세이야쿠 가부시키가이샤 |
메글루민을 함유하는 단백질 제제의 안정화제, 및 그의이용
|
|
CA2618796C
(en)
*
|
2005-08-11 |
2018-01-02 |
Arpi Matossian-Rogers |
Peptides for treatment and diagnosis of autoimmune disease
|
|
RU2446826C2
(ru)
|
2005-10-14 |
2012-04-10 |
Фукуока Юниверсити |
Агенты для подавления повреждения трансплантированных островков после трансплантации островков
|
|
AR058135A1
(es)
*
|
2005-10-21 |
2008-01-23 |
Chugai Pharmaceutical Co Ltd |
Agentes para el tratamiento de cardiopatias
|
|
EP1957531B1
(en)
|
2005-11-07 |
2016-04-13 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
|
US8128934B2
(en)
|
2005-11-14 |
2012-03-06 |
Ribomic, Inc. |
Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
|
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
TW200803894A
(en)
*
|
2005-11-25 |
2008-01-16 |
Univ Keio |
Prostate cancer therapeutic agents
|
|
US9084777B2
(en)
|
2005-12-28 |
2015-07-21 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized antibody-containing formulations
|
|
CA2637917C
(en)
|
2006-01-27 |
2015-11-24 |
Keio University |
Therapeutic agents for diseases involving choroidal neovascularization
|
|
JP5553506B2
(ja)
|
2006-03-22 |
2014-07-16 |
中外製薬株式会社 |
エリスロポエチン溶液製剤
|
|
US9670269B2
(en)
|
2006-03-31 |
2017-06-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of modifying antibodies for purification of bispecific antibodies
|
|
ES2892925T3
(es)
|
2006-03-31 |
2022-02-07 |
Chugai Pharmaceutical Co Ltd |
Métodos para controlar la farmacocinética en sangre de anticuerpos
|
|
EP2025346B1
(en)
|
2006-04-07 |
2016-08-10 |
Osaka University |
Muscle regeneration promoter
|
|
US8741643B2
(en)
|
2006-04-28 |
2014-06-03 |
Lifescan, Inc. |
Differentiation of pluripotent stem cells to definitive endoderm lineage
|
|
CA2652733C
(en)
*
|
2006-05-25 |
2016-06-21 |
Glaxo Group Limited |
Modified humanised anti-interleukin-18 antibodies
|
|
ES2398076T3
(es)
*
|
2006-06-02 |
2013-03-13 |
Regeneron Pharmaceuticals, Inc. |
Anticuerpos de alta afinidad contra el receptor de IL-6 humano
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
US7919092B2
(en)
|
2006-06-13 |
2011-04-05 |
Oncomed Pharmaceuticals, Inc. |
Antibodies to notch receptors
|
|
CN101573383B
(zh)
|
2006-06-21 |
2015-05-13 |
肿瘤疗法科学股份有限公司 |
靶向肿瘤的针对卷曲同源物10的单克隆抗体及其用途
|
|
EP2057191A1
(en)
|
2006-08-18 |
2009-05-13 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
|
WO2008042611A2
(en)
*
|
2006-09-29 |
2008-04-10 |
Centocor, Inc. |
Method of using il6 antagonists with mitoxantrone for prostate cancer
|
|
WO2008090901A1
(ja)
|
2007-01-23 |
2008-07-31 |
Shinshu University |
慢性拒絶反応抑制剤
|
|
EP2125887A4
(en)
|
2007-01-24 |
2010-11-10 |
Oncomed Pharm Inc |
COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
|
|
US9090693B2
(en)
|
2007-01-25 |
2015-07-28 |
Dana-Farber Cancer Institute |
Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
|
|
CL2008000719A1
(es)
|
2007-03-12 |
2008-09-05 |
Univ Tokushima Chugai Seiyaku |
Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
|
|
US9701747B2
(en)
|
2007-05-21 |
2017-07-11 |
Alderbio Holdings Llc |
Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
|
|
US8062864B2
(en)
|
2007-05-21 |
2011-11-22 |
Alderbio Holdings Llc |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
|
|
HUE032563T2
(en)
|
2007-05-21 |
2017-09-28 |
Alderbio Holdings Llc |
Antibodies to IL-6 and their use
|
|
US8252286B2
(en)
|
2007-05-21 |
2012-08-28 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8404235B2
(en)
*
|
2007-05-21 |
2013-03-26 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US7906117B2
(en)
*
|
2007-05-21 |
2011-03-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
|
|
KR20170036814A
(ko)
*
|
2007-05-21 |
2017-04-03 |
앨더바이오 홀딩스 엘엘씨 |
신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
|
|
US8178101B2
(en)
|
2007-05-21 |
2012-05-15 |
Alderbio Holdings Inc. |
Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
|
|
US20090238825A1
(en)
*
|
2007-05-21 |
2009-09-24 |
Kovacevich Brian R |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
JP5142265B2
(ja)
*
|
2007-05-28 |
2013-02-13 |
独立行政法人産業技術総合研究所 |
抗モータリン抗体のパラトープ及びエピトープ
|
|
US9080145B2
(en)
|
2007-07-01 |
2015-07-14 |
Lifescan Corporation |
Single pluripotent stem cell culture
|
|
EP2174667B1
(en)
*
|
2007-07-26 |
2017-01-04 |
Osaka University |
Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient
|
|
CA3114827C
(en)
|
2007-07-31 |
2023-09-05 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells to pancreatic endocrine
|
|
CN108424454B
(zh)
|
2007-08-14 |
2022-05-31 |
路德维格癌症研究所有限公司 |
靶向egf受体的单克隆抗体175及其衍生物和用途
|
|
CL2008002775A1
(es)
|
2007-09-17 |
2008-11-07 |
Amgen Inc |
Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
|
|
AU2008304748C1
(en)
|
2007-09-26 |
2014-06-12 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant region
|
|
EP2206775B1
(en)
|
2007-09-26 |
2016-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-il-6 receptor antibody
|
|
CN101874042B9
(zh)
|
2007-09-26 |
2019-01-01 |
中外制药株式会社 |
利用cdr的氨基酸取代来改变抗体等电点的方法
|
|
CA2701155C
(en)
|
2007-10-02 |
2016-11-22 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for graft-versus-host disease comprising interleukin 6 receptor inhibitor as active ingredient
|
|
JP4976502B2
(ja)
*
|
2007-10-15 |
2012-07-18 |
中外製薬株式会社 |
抗体の製造方法
|
|
EP2229434B1
(en)
|
2007-11-27 |
2011-09-07 |
Lifescan, Inc. |
Differentiation of human embryonic stem cells
|
|
CA2708532C
(en)
|
2007-12-05 |
2018-06-05 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-il31ra antibody and use thereof
|
|
WO2009075344A1
(ja)
|
2007-12-12 |
2009-06-18 |
Japan As Represented By Director General Of Agency Of National Cancer Center |
M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
WO2009095489A2
(en)
*
|
2008-02-01 |
2009-08-06 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
KR101731474B1
(ko)
|
2008-02-21 |
2017-05-11 |
얀센 바이오테크 인코포레이티드 |
세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
|
|
KR102057826B1
(ko)
|
2008-04-11 |
2019-12-20 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
US8623648B2
(en)
|
2008-04-24 |
2014-01-07 |
Janssen Biotech, Inc. |
Treatment of pluripotent cells
|
|
BRPI0910482A2
(pt)
*
|
2008-04-29 |
2019-09-24 |
Abbott Lab |
imunoglobinas de domínio variável duplo e usos das mesmas
|
|
WO2009140348A2
(en)
|
2008-05-13 |
2009-11-19 |
Novimmune Sa |
Anti-il-6/il-6r antibodies and methods of use thereof
|
|
BRPI0913366A8
(pt)
|
2008-06-03 |
2017-07-11 |
Abbott Lab |
Imunoglobulinas de domínio variável duplo e seus usos
|
|
PE20100092A1
(es)
|
2008-06-03 |
2010-03-12 |
Abbott Lab |
Inmunoglobulina con dominio variable dual y usos de la misma
|
|
TWI528973B
(zh)
|
2008-06-05 |
2016-04-11 |
Chugai Pharmaceutical Co Ltd |
Nerve infiltration inhibitor
|
|
US8188235B2
(en)
*
|
2008-06-18 |
2012-05-29 |
Pfizer Inc. |
Antibodies to IL-6 and their uses
|
|
PL2310492T3
(pl)
|
2008-06-30 |
2015-12-31 |
Janssen Biotech Inc |
Różnocowanie pluripotencjalnych komórek macierzystych
|
|
NZ603698A
(en)
|
2008-07-08 |
2014-03-28 |
Abbvie Inc |
Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
|
|
CN104402998A
(zh)
|
2008-07-08 |
2015-03-11 |
昂考梅德药品有限公司 |
分离的抗体
|
|
US9132189B2
(en)
|
2008-07-08 |
2015-09-15 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
PL2346988T3
(pl)
|
2008-10-31 |
2017-10-31 |
Janssen Biotech Inc |
Różnicowanie ludzkich zarodkowych komórek macierzystych do linii endokrynnej trzustki
|
|
ES2642070T3
(es)
|
2008-11-20 |
2017-11-15 |
Janssen Biotech, Inc. |
Cultivo de células madre pluripotentes en microportadores
|
|
ES2584053T3
(es)
|
2008-11-20 |
2016-09-23 |
Janssen Biotech, Inc. |
Métodos y composiciones para la unión de células y cultivo en sustratos planos
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US8323649B2
(en)
|
2008-11-25 |
2012-12-04 |
Alderbio Holdings Llc |
Antibodies to IL-6 and use thereof
|
|
US8337847B2
(en)
|
2008-11-25 |
2012-12-25 |
Alderbio Holdings Llc |
Methods of treating anemia using anti-IL-6 antibodies
|
|
US9212223B2
(en)
|
2008-11-25 |
2015-12-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8992920B2
(en)
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
US9452227B2
(en)
|
2008-11-25 |
2016-09-27 |
Alderbio Holdings Llc |
Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
WO2010107110A1
(ja)
|
2009-03-19 |
2010-09-23 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
TWI682995B
(zh)
|
2009-03-19 |
2020-01-21 |
日商中外製藥股份有限公司 |
抗體恆定區域改變體
|
|
WO2010115995A2
(en)
|
2009-04-10 |
2010-10-14 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
NZ595461A
(en)
|
2009-04-10 |
2013-01-25 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
EP2424566A4
(en)
*
|
2009-05-01 |
2013-07-31 |
Abbvie Inc |
IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE
|
|
KR20120024763A
(ko)
|
2009-05-15 |
2012-03-14 |
추가이 세이야쿠 가부시키가이샤 |
항axl 항체
|
|
KR102058901B1
(ko)
|
2009-07-20 |
2019-12-24 |
얀센 바이오테크 인코포레이티드 |
인간 배아 줄기 세포의 분화
|
|
AU2010278067B2
(en)
*
|
2009-07-31 |
2016-10-27 |
Shin Maeda |
Cancer metastasis inhibitor
|
|
US10150808B2
(en)
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
|
TW201118166A
(en)
|
2009-09-24 |
2011-06-01 |
Chugai Pharmaceutical Co Ltd |
HLA class I-recognizing antibodies
|
|
AU2010306677B2
(en)
*
|
2009-10-15 |
2013-05-23 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
WO2011051231A1
(en)
|
2009-10-26 |
2011-05-05 |
F. Hoffmann-La Roche Ag |
Method for the production of a glycosylated immunoglobulin
|
|
UY32979A
(es)
*
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
WO2011066374A2
(en)
|
2009-11-24 |
2011-06-03 |
Alder Biopharmaceuticals, Inc. |
Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
|
|
US9775921B2
(en)
|
2009-11-24 |
2017-10-03 |
Alderbio Holdings Llc |
Subcutaneously administrable composition containing anti-IL-6 antibody
|
|
WO2011080796A1
(en)
|
2009-12-28 |
2011-07-07 |
Oncotherapy Science, Inc. |
Anti-cdh3 antibodies and uses thereof
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
MX2012008085A
(es)
*
|
2010-01-13 |
2012-09-12 |
Oncomed Pharm Inc |
Agentes de union notch1 y metodos de uso de los mismos.
|
|
AR080428A1
(es)
|
2010-01-20 |
2012-04-11 |
Chugai Pharmaceutical Co Ltd |
Formulaciones liquidas estabilizadas contentivas de anticuerpos
|
|
EP2542667A4
(en)
|
2010-03-01 |
2013-07-31 |
Janssen Biotech Inc |
PROCESS FOR CLEANING CELLS OBTAINED FROM PLURIPOTENTIAL STEM CELLS
|
|
EP2543388A4
(en)
|
2010-03-04 |
2013-11-27 |
Dainippon Sumitomo Pharma Co |
MEDICINAL PRODUCT FOR INFLAMMATORY ENDURANCE
|
|
JP5889181B2
(ja)
|
2010-03-04 |
2016-03-22 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
EP2552967A4
(en)
|
2010-04-02 |
2014-10-08 |
Amunix Operating Inc |
BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE
|
|
WO2011128096A1
(en)
|
2010-04-16 |
2011-10-20 |
Roche Diagnostics Gmbh |
Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
RU2663339C1
(ru)
|
2010-05-12 |
2018-08-03 |
Янссен Байотек, Инк. |
Дифференцирование эмбриональных стволовых клеток человека
|
|
SMT202000095T1
(it)
|
2010-05-14 |
2020-03-13 |
Amgen Inc |
Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
|
|
JP6051049B2
(ja)
|
2010-05-28 |
2016-12-21 |
中外製薬株式会社 |
抗腫瘍t細胞応答増強剤
|
|
WO2011149046A1
(ja)
|
2010-05-28 |
2011-12-01 |
独立行政法人国立がん研究センター |
膵癌治療剤
|
|
US8858944B2
(en)
|
2010-06-02 |
2014-10-14 |
Sumitomo Dainippon Pharma Co., Ltd. |
Treatment drug for autoimmune diseases and allergic diseases
|
|
CA2801107A1
(en)
|
2010-06-07 |
2011-12-15 |
F. Hoffman-La Roche Ag |
Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
|
|
AR081434A1
(es)
*
|
2010-06-10 |
2012-08-29 |
Lilly Co Eli |
Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo
|
|
US8735546B2
(en)
|
2010-08-03 |
2014-05-27 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
WO2012019168A2
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
PE20140229A1
(es)
|
2010-08-26 |
2014-03-27 |
Abbvie Inc |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
CN103221536B
(zh)
|
2010-08-31 |
2016-08-31 |
詹森生物科技公司 |
人胚胎干细胞的分化
|
|
RU2013120302A
(ru)
|
2010-10-01 |
2014-11-20 |
Модерна Терапьютикс, Инк. |
Сконструированные нуклеиновые кислоты и способы их применения
|
|
CN105399831A
(zh)
|
2010-10-29 |
2016-03-16 |
伊缪诺金公司 |
非拮抗性egfr结合分子及其免疫偶联物
|
|
CN103298489A
(zh)
*
|
2010-10-29 |
2013-09-11 |
伊缪诺金公司 |
新型egfr结合分子及其免疫偶联物
|
|
TWI603738B
(zh)
|
2010-11-08 |
2017-11-01 |
建南德克公司 |
皮下投予抗-il-6受體抗體
|
|
PH12016502073B1
(en)
|
2010-11-17 |
2024-04-05 |
Chugai Pharmaceutical Co Ltd |
Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
|
|
US9304134B2
(en)
|
2010-11-23 |
2016-04-05 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of anemia
|
|
TWI812066B
(zh)
|
2010-11-30 |
2023-08-11 |
日商中外製藥股份有限公司 |
具有鈣依存性的抗原結合能力之抗體
|
|
PL3395836T3
(pl)
|
2011-01-28 |
2021-12-13 |
Sanofi Biotechnology |
Ludzkie przeciwciała przeciwko pcsk9 do zastosowania w sposobach leczenia konkretnych grup osobników
|
|
CN112812184A
(zh)
|
2011-02-25 |
2021-05-18 |
中外制药株式会社 |
FcγRIIb特异性Fc抗体
|
|
EP2681242B1
(en)
|
2011-03-01 |
2018-01-24 |
Amgen Inc. |
Sclerostin and dkk-1 bispecific binding agents
|
|
WO2012135035A1
(en)
|
2011-03-25 |
2012-10-04 |
Amgen Inc. |
Anti - sclerostin antibody crystals and formulations thereof
|
|
EP2691101A2
(en)
|
2011-03-31 |
2014-02-05 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
US9309305B2
(en)
|
2011-06-10 |
2016-04-12 |
National Research Council Of Canada |
Anti-ricin antibodies and uses thereof
|
|
US10400029B2
(en)
|
2011-06-28 |
2019-09-03 |
Inhibrx, Lp |
Serpin fusion polypeptides and methods of use thereof
|
|
CN110551223A
(zh)
|
2011-06-28 |
2019-12-10 |
英伊布里克斯有限合伙公司 |
丝氨酸蛋白酶抑制蛋白融合多肽及其使用方法
|
|
US9574005B2
(en)
|
2011-07-19 |
2017-02-21 |
Chugai Seiyaku Kabushiki Kaisha |
Stable Protein-containing preparation containing argininamide or analogous compound thereof
|
|
AR087305A1
(es)
|
2011-07-28 |
2014-03-12 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
|
|
WO2013017656A1
(en)
|
2011-08-02 |
2013-02-07 |
Medizinische Universität Wien |
Antagonists of ribonucleases for treating obesity
|
|
CA2842432C
(en)
|
2011-08-04 |
2022-10-04 |
Amgen Inc. |
Method for treating bone gap defects
|
|
EP2739652B1
(en)
|
2011-08-04 |
2017-04-05 |
Medizinische Universität Innsbruck |
Cahgt1p inhibitors for use in the treatment of candidiasis
|
|
KR101993488B1
(ko)
|
2011-09-01 |
2019-06-26 |
추가이 세이야쿠 가부시키가이샤 |
한외여과에 의해 고도로 농축된 항체를 포함하는 조성물의 제조 방법
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US10138302B2
(en)
|
2011-09-23 |
2018-11-27 |
Ablynx N.V. |
Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
|
|
DE102011083811A1
(de)
*
|
2011-09-30 |
2013-04-04 |
Airbus Operations Gmbh |
Sitzvorrichtung für ein Luft- oder Raumfahrzeug
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
WO2013059548A1
(en)
|
2011-10-19 |
2013-04-25 |
Sanofi |
Compositions and methods for treating cancer using jak2 inhibitor
|
|
SG10201603411WA
(en)
|
2011-10-28 |
2016-07-28 |
Teva Pharmaceuticals Australia Pty Ltd |
Polypeptide constructs and uses thereof
|
|
JO3370B1
(ar)
|
2011-11-10 |
2019-03-13 |
Regeneron Pharma |
طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
|
|
US9233171B2
(en)
|
2011-11-21 |
2016-01-12 |
Immunogen, Inc. |
Method of treatment of tumors that are resistant to EGFR antibody therapies by EGFR antibody cytotoxic agent conjugate
|
|
WO2013081612A1
(en)
*
|
2011-11-30 |
2013-06-06 |
Abbvie Biotherapeutics Inc. |
Vectors and host cells comprising a modified sv40 promoter for protein expression
|
|
BR112014014258A2
(pt)
*
|
2011-12-13 |
2020-10-27 |
Nordic Nanovector As. |
molécula de anticorpo que se liga a cd37 humano; anticorpo; molécula de dna; vetor de expressão; célula hospedeira; método para produzir um anticorpo; composição farmacêutica; método de esgotamento de células b que expressam cd37 dentre uma população de células; radioimunoconjugado que se liga a cd37 humano; método de tratamento de uma malignidade de célula b; kit para a produção do radioimunoconjugado; e preparação injetável de anticorpo hh1 quimérico ou humanizado para uso no pré-tratamento de uma malignidade de célula b
|
|
CN104114572A
(zh)
|
2011-12-16 |
2014-10-22 |
现代治疗公司 |
经修饰的核苷、核苷酸和核酸组合物
|
|
KR102203056B1
(ko)
|
2011-12-22 |
2021-01-14 |
얀센 바이오테크 인코포레이티드 |
인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화
|
|
SG11201403718YA
(en)
|
2011-12-28 |
2014-07-30 |
Amgen Inc |
Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
|
|
AR089529A1
(es)
|
2011-12-30 |
2014-08-27 |
Abbvie Inc |
Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
|
|
WO2013138586A1
(en)
|
2012-03-15 |
2013-09-19 |
Janssen Biotech, Inc. |
Human anti-cd27 antibodies, methods and uses
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
AU2013243948A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins associated with human disease
|
|
JP6224077B2
(ja)
|
2012-04-17 |
2017-11-01 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
改変された核酸を用いてポリペプチドを発現させるための方法
|
|
KR101510831B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
항 il-6r 및 tnfr2을 포함하는 이중특이적 단백질을 발현하는 미니서클 벡터를 포함하는 줄기세포 치료제
|
|
KR101510830B1
(ko)
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
생리활성 단백질을 발현하는 미니서클을 이용하여 형질전환된 줄기세포를 통한 치료법
|
|
KR101510302B1
(ko)
*
|
2012-05-11 |
2015-04-10 |
가톨릭대학교 산학협력단 |
Il-6 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제
|
|
AU2013271581B2
(en)
|
2012-06-08 |
2018-08-09 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells into pancreatic endocrine cells
|
|
US9925260B2
(en)
|
2012-07-05 |
2018-03-27 |
Ucb Pharma S.A. |
Treatment for bone diseases
|
|
WO2014042251A1
(ja)
|
2012-09-13 |
2014-03-20 |
中外製薬株式会社 |
遺伝子ノックイン非ヒト動物
|
|
US9487590B2
(en)
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
KR20180008921A
(ko)
|
2012-11-01 |
2018-01-24 |
애브비 인코포레이티드 |
항-vegf/dll4 이원 가변 도메인 면역글로불린 및 이의 용도
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
WO2014081507A1
(en)
|
2012-11-26 |
2014-05-30 |
Moderna Therapeutics, Inc. |
Terminally modified rna
|
|
JP6557147B2
(ja)
|
2012-12-31 |
2019-08-07 |
ヤンセン バイオテツク,インコーポレーテツド |
Hb9調節物を用いたヒト胚性幹細胞の膵臓内分泌細胞への分化
|
|
RU2687379C2
(ru)
|
2012-12-31 |
2019-05-13 |
Янссен Байотек, Инк. |
Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки
|
|
US10370644B2
(en)
|
2012-12-31 |
2019-08-06 |
Janssen Biotech, Inc. |
Method for making human pluripotent suspension cultures and cells derived therefrom
|
|
BR112015015770A2
(pt)
|
2012-12-31 |
2017-07-11 |
Janssen Biotech Inc |
cultivo de células-tronco embrionárias humanas na interface ar-líquido para diferenciação em células pancreáticas endócrinas
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
CN105324396A
(zh)
|
2013-03-15 |
2016-02-10 |
艾伯维公司 |
针对IL-1β和/或IL-17的双重特异性结合蛋白
|
|
ES2774976T3
(es)
|
2013-04-29 |
2020-07-23 |
Teva Pharmaceuticals Australia Pty Ltd |
Anticuerpos anti-CD38 y fusiones con interferón alfa-2b atenuado
|
|
US11117975B2
(en)
|
2013-04-29 |
2021-09-14 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
|
|
EP3009518B1
(en)
*
|
2013-06-11 |
2020-08-12 |
National Center of Neurology and Psychiatry |
Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
|
|
CN105378480B
(zh)
|
2013-07-04 |
2018-06-12 |
豪夫迈·罗氏有限公司 |
检测血清样品中抗药物抗体的干扰抑制性免疫测定
|
|
JP6534615B2
(ja)
|
2013-09-27 |
2019-06-26 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
JP2016538829A
(ja)
|
2013-10-03 |
2016-12-15 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
低密度リポタンパク質受容体をコードするポリヌクレオチド
|
|
MX2016006226A
(es)
|
2013-11-12 |
2016-09-07 |
Sanofi Biotechnology |
Regimenes de dosificacion para uso con inhibidores de pcsk9.
|
|
US9017678B1
(en)
|
2014-07-15 |
2015-04-28 |
Kymab Limited |
Method of treating rheumatoid arthritis using antibody to IL6R
|
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
|
BR112016013347B1
(pt)
|
2013-12-26 |
2023-12-12 |
Mitsubishi Tanabe Pharma Corporation |
Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos
|
|
BR112016014824A2
(pt)
|
2013-12-27 |
2017-09-19 |
Chugai Pharmaceutical Co Ltd |
Método para purificar anticorpo que tem ponto isoelétrico baixo
|
|
EP2898896A1
(en)
|
2014-01-22 |
2015-07-29 |
Université Pierre et Marie Curie (Paris 6) |
Agents for use in the treatment of retinal inflammation
|
|
WO2015116852A1
(en)
|
2014-01-29 |
2015-08-06 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating rheumatoid arthritis by administering an il-6r antibody
|
|
TWI731535B
(zh)
|
2014-03-21 |
2021-06-21 |
美商艾伯維有限公司 |
抗-egfr抗體及抗體藥物結合物
|
|
UA119352C2
(uk)
|
2014-05-01 |
2019-06-10 |
Тева Фармасьютикалз Острейліа Пті Лтд |
Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
|
|
US10006006B2
(en)
|
2014-05-16 |
2018-06-26 |
Janssen Biotech, Inc. |
Use of small molecules to enhance MAFA expression in pancreatic endocrine cells
|
|
JP6858559B2
(ja)
|
2014-08-20 |
2021-04-14 |
中外製薬株式会社 |
蛋白質溶液の粘度測定方法
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
CA2963712A1
(en)
|
2014-10-21 |
2016-04-28 |
Ablynx Nv |
Treatment of il-6r related diseases
|
|
CA2965414C
(en)
|
2014-10-29 |
2024-01-09 |
Teva Pharmaceuticals Australia Pty Ltd |
Interferon .alpha.2.beta. variants
|
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
|
MA41142A
(fr)
|
2014-12-12 |
2017-10-17 |
Amgen Inc |
Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
|
|
EP4400516A1
(en)
|
2014-12-15 |
2024-07-17 |
The Regents of the University of California |
Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
|
|
EP3234120B1
(en)
|
2014-12-15 |
2025-09-03 |
The Regents of the University of California |
Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
|
|
CN107207607B
(zh)
|
2014-12-19 |
2021-05-04 |
中外制药株式会社 |
抗-c5抗体及使用方法
|
|
KR101860280B1
(ko)
|
2014-12-19 |
2018-05-21 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
|
|
CN114773470A
(zh)
|
2015-02-05 |
2022-07-22 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用
|
|
JP6130983B2
(ja)
|
2015-02-27 |
2017-05-17 |
中外製薬株式会社 |
Il−6関連疾患治療用組成物
|
|
AR104050A1
(es)
|
2015-03-26 |
2017-06-21 |
Chugai Pharmaceutical Co Ltd |
Proceso de producción con iones de cobre controlados
|
|
JP7082484B2
(ja)
|
2015-04-01 |
2022-06-08 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
JP6875683B2
(ja)
|
2015-05-19 |
2021-05-26 |
国立研究開発法人国立精神・神経医療研究センター |
多発性硬化症(ms)患者の新規治療適用判断方法
|
|
JP7128460B2
(ja)
|
2015-06-04 |
2022-08-31 |
国立研究開発法人国立精神・神経医療研究センター |
Il-6阻害剤を有効成分とする精神疾患治療剤
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
|
JP2018523684A
(ja)
|
2015-08-18 |
2018-08-23 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗pcsk9阻害抗体
|
|
DK3368571T5
(da)
|
2015-10-30 |
2024-09-30 |
Univ California |
Transformerende, vækstfaktor-beta-responsive polypeptider og fremgangsmåder til anvendelse deraf
|
|
IL319993A
(en)
|
2015-11-03 |
2025-06-01 |
Sanofi Biotechnology |
Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same
|
|
US11359009B2
(en)
|
2015-12-25 |
2022-06-14 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
|
CN108368166B
(zh)
|
2015-12-28 |
2023-03-28 |
中外制药株式会社 |
提高含fc区多肽纯化效率的方法
|
|
US11484591B2
(en)
|
2016-02-22 |
2022-11-01 |
Ohio State Innovation Foundation |
Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites
|
|
GB201604124D0
(en)
|
2016-03-10 |
2016-04-27 |
Ucb Biopharma Sprl |
Pharmaceutical formulation
|
|
US11072666B2
(en)
|
2016-03-14 |
2021-07-27 |
Chugai Seiyaku Kabushiki Kaisha |
Cell injury inducing therapeutic drug for use in cancer therapy
|
|
DK3443073T3
(da)
|
2016-04-14 |
2024-09-02 |
Janssen Biotech Inc |
Differentiering af pluripotente stamceller til intestinale mellemtarmendodermceller
|
|
MA44780A
(fr)
|
2016-04-28 |
2019-03-06 |
Chugai Pharmaceutical Co Ltd |
Préparation contenant un anticorps
|
|
TWI693940B
(zh)
|
2016-08-05 |
2020-05-21 |
日商中外製藥股份有限公司 |
Il-8相關疾病之治療用或預防用組成物
|
|
JP2019530440A
(ja)
|
2016-09-02 |
2019-10-24 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
インターロイキン6受容体α結合単鎖可変断片を含む方法および組成物
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
US10961314B2
(en)
|
2016-09-27 |
2021-03-30 |
Fresenius Kabi Deutschland Gmbh |
Liquid pharmaceutical composition comprising an anti-IL-6 receptor antibody
|
|
KR102051177B1
(ko)
*
|
2016-10-19 |
2019-12-17 |
주식회사 엘지화학 |
전압 분배를 이용한 스위치 진단 장치 및 방법
|
|
CN110062620B
(zh)
|
2016-10-31 |
2023-12-05 |
德国费森尤斯卡比有限公司 |
液体药物组合物
|
|
WO2018156180A1
(en)
|
2017-02-24 |
2018-08-30 |
Kindred Biosciences, Inc. |
Anti-il31 antibodies for veterinary use
|
|
WO2018170405A1
(en)
|
2017-03-17 |
2018-09-20 |
Ohio State Innovation Foundation |
Nanoparticles for delivery of chemopreventive agents
|
|
CN110461358A
(zh)
|
2017-03-31 |
2019-11-15 |
公立大学法人奈良县立医科大学 |
可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物
|
|
EP3620531A4
(en)
|
2017-05-02 |
2021-03-17 |
National Center of Neurology and Psychiatry |
METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
|
|
CN107098969B
(zh)
*
|
2017-06-28 |
2018-10-12 |
武汉波睿达生物科技有限公司 |
一种治疗hiv感染的嵌合抗原受体的重组基因构建及其应用
|
|
MY199245A
(en)
|
2017-08-31 |
2023-10-23 |
Hyogo College Medicine |
Il-33 antagonist-containing therapeutic agent for endometriosis
|
|
US20200369774A1
(en)
|
2017-09-13 |
2020-11-26 |
Jiangsu Hengrui Medicine Co., Ltd. |
Il-6r antibody and antigen binding fragment thereof and medical use
|
|
EP3698808B1
(en)
|
2017-10-20 |
2025-01-01 |
Hyogo College Of Medicine |
Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
|
|
AU2018361430B2
(en)
|
2017-11-01 |
2025-08-14 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody variant and isoform with lowered biological activity
|
|
WO2019151418A1
(ja)
|
2018-01-31 |
2019-08-08 |
元一 加藤 |
Il-6阻害剤を含有する喘息の治療剤
|
|
CA3093729A1
(en)
|
2018-03-15 |
2019-09-19 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
|
|
EP3774879B1
(en)
|
2018-03-30 |
2026-01-28 |
Amgen Inc. |
C-terminal antibody variants
|
|
CN112512480B
(zh)
|
2018-05-21 |
2024-10-01 |
中外制药株式会社 |
被封入玻璃容器的冷冻干燥制剂
|
|
CN112243423B
(zh)
|
2018-05-28 |
2022-11-04 |
中外制药株式会社 |
填充喷嘴
|
|
AU2019329958B2
(en)
|
2018-08-29 |
2025-05-29 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for treating subjects having rheumatoid arthritis
|
|
US20220096548A1
(en)
*
|
2019-01-07 |
2022-03-31 |
Hunan Siweikang Therapeutics Co. Ltd. |
Modified immune cells co-expressing chimeric antigen receptor and il-6 antagonist for reducing toxicity and uses thereof in adoptive cell therapy
|
|
BR112021014377A2
(pt)
|
2019-01-31 |
2021-12-28 |
Regeneron Pharma |
Composições e métodos para o tratamento de artrite idiopática juvenil
|
|
JPWO2020202839A1
(2)
|
2019-03-29 |
2020-10-08 |
|
|
|
JP2022527972A
(ja)
|
2019-04-02 |
2022-06-07 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
前悪性病変を有する患者において癌を予測及び予防する方法
|
|
JP7583411B2
(ja)
|
2019-04-10 |
2024-11-14 |
中外製薬株式会社 |
Fc領域改変抗体の精製方法
|
|
IL287220B2
(en)
|
2019-04-17 |
2026-03-01 |
Univ Hiroshima |
A therapeutic agent for urological cancer characterized by administering an IL-6 inhibitor in combination with a CCR2 inhibitor
|
|
AU2020261431A1
(en)
|
2019-04-24 |
2021-12-09 |
Regeneron Pharmaceuticals, Inc. |
Methods of diagnosis and treatment of rheumatoid arthritis
|
|
WO2020243479A1
(en)
|
2019-05-31 |
2020-12-03 |
The Johns Hopkins University |
Bispecific binding agents
|
|
EP3980459A1
(en)
|
2019-06-04 |
2022-04-13 |
Sanofi Biotechnology |
Compositions and methods for treating pain in subj ects with rheumatoid arthritis
|
|
US20200405883A1
(en)
|
2019-06-20 |
2020-12-31 |
Baxalta Incorporated |
Method of treatment with viral-based gene therapy
|
|
CN110483640B
(zh)
*
|
2019-07-16 |
2020-05-01 |
北京汇智和源生物技术有限公司 |
白介素-6r的人源化单克隆抗体、其编码基因及应用
|
|
KR20230022829A
(ko)
|
2020-03-03 |
2023-02-16 |
트웬티에잇-세븐, 인크. |
Rna 결합 단백질 또는 rna 변형 단백질을 표적으로 하는 화합물
|
|
JP2023518812A
(ja)
|
2020-03-23 |
2023-05-08 |
ジェネンテック, インコーポレイテッド |
Covid19肺炎を治療するための、トシリズマブとレムデシビルとの組み合わせ
|
|
JP2023518814A
(ja)
|
2020-03-23 |
2023-05-08 |
ジェネンテック, インコーポレイテッド |
Covid-19肺炎における、il-6アンタゴニストに対する応答を予測するためのバイオマーカー
|
|
JP2023518815A
(ja)
|
2020-03-23 |
2023-05-08 |
ジェネンテック, インコーポレイテッド |
Il6アンタゴニストによるcovid-19肺炎を含む肺炎の治療方法
|
|
WO2021211006A1
(en)
|
2020-04-13 |
2021-10-21 |
Federal State Budgetary Institution Center Of Biomedical Technologies Of Federal Medical And Biological Agency |
Inhaled hexapeptide for treating interleukin-6 related respiratory diseases
|
|
JP2023520249A
(ja)
|
2020-05-15 |
2023-05-16 |
エフ. ホフマン-ラ ロシュ アーゲー |
非経口タンパク質溶液中の可視粒子形成の防止方法
|
|
KR102934248B1
(ko)
*
|
2020-05-18 |
2026-03-04 |
바이오션, 인코포레이티드 |
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
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|
|
|
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|
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|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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