TWI222863B - Synergistic pharmaceutical compositions comprising anthracycline derivatives and anticancer agents - Google Patents

Synergistic pharmaceutical compositions comprising anthracycline derivatives and anticancer agents Download PDF

Info

Publication number: TWI222863B
Authority: TW; Taiwan
Prior art keywords: cancer; application; item; drug; range
Prior art date: 1999-04-29

Application number

TW089106805A

Other languages

English (en)

Chinese (zh)

Inventor

Maria Cristina Geroni

Marina Ripamonti

Michele Caruso

Antonio Suarato

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-29

Filing date

2000-04-12

Publication date

2004-11-01

2000-04-12 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

2004-11-01 Application granted granted Critical

2004-11-01 Publication of TWI222863B publication Critical patent/TWI222863B/zh

Links

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OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
229960002066 vinorelbine Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TW089106805A 1999-04-29 2000-04-12 Synergistic pharmaceutical compositions comprising anthracycline derivatives and anticancer agents TWI222863B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9909925.1A GB9909925D0 (en)	1999-04-29	1999-04-29	Combined preparations comprising anthracycline derivatives

Publications (1)

Publication Number	Publication Date
TWI222863B true TWI222863B (en)	2004-11-01

Family

ID=10852508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW089106805A TWI222863B (en)	1999-04-29	2000-04-12	Synergistic pharmaceutical compositions comprising anthracycline derivatives and anticancer agents

Country Status (16)

Country	Link
US (2)	US6537990B1 (de)
EP (3)	EP1977753A1 (de)
JP (1)	JP2002543112A (de)
CN (5)	CN1222294C (de)
AR (1)	AR023616A1 (de)
AT (2)	ATE398457T1 (de)
AU (1)	AU4397700A (de)
DE (2)	DE60004348T2 (de)
DK (1)	DK1173187T3 (de)
ES (2)	ES2307867T3 (de)
GB (1)	GB9909925D0 (de)
HK (1)	HK1045462B (de)
MY (1)	MY136610A (de)
PT (1)	PT1173187E (de)
TW (1)	TWI222863B (de)
WO (1)	WO2000066093A2 (de)

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GB9916882D0 (en) *	1999-07-19	1999-09-22	Pharmacia & Upjohn Spa	Antitumor synergistic composition
GB9920548D0 (en) *	1999-08-31	1999-11-03	Rhone Poulenc Rorer Sa	Treatment of hepatocellular carcinoma
US20030133939A1 (en) *	2001-01-17	2003-07-17	Genecraft, Inc.	Binding domain-immunoglobulin fusion proteins
US7754208B2 (en)	2001-01-17	2010-07-13	Trubion Pharmaceuticals, Inc.	Binding domain-immunoglobulin fusion proteins
US7829084B2 (en)	2001-01-17	2010-11-09	Trubion Pharmaceuticals, Inc.	Binding constructs and methods for use thereof
ATE554756T1 (de) *	2001-03-14	2012-05-15	Bristol Myers Squibb Co	Kombination aus epothilon-analog und chemotherapeutika zur behandlung von proliferativen erkrankungen
CA2383259A1 (en)	2002-04-23	2003-10-23	Celator Technologies Inc.	Synergistic compositions
US20080075762A1 (en) *	2001-10-03	2008-03-27	Paul Tardi	Compositions for delivery of drug combinations
WO2003061566A2 (en) *	2002-01-24	2003-07-31	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Anti-cancer combination and use thereof
TWI323662B (en) *	2002-11-15	2010-04-21	Telik Inc	Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
JP2006519209A (ja) *	2003-02-26	2006-08-24	ファルマシア・イタリア・ソシエタ・ペル・アツィオーニ	ネモルビシン（ｎｅｍｏｒｕｂｉｃｉｎ）の肝臓内投与により肝臓癌を治療するための方法
MXPA05009849A (es) *	2003-03-18	2005-12-06	Pharmacia Italia Spa	Terapia combinada que comprende nemorubicina y un inhibidor de la ciclooxigenasa-2.
CN100500212C (zh) *	2005-04-06	2009-06-17	山东蓝金生物工程有限公司	一种抗实体肿瘤药物组合物
AU2006272555B2 (en)	2005-07-25	2012-03-08	Aptevo Research And Development Llc	B-cell reduction using CD37-specific and CD20-specific binding molecules
US7776832B2 (en) *	2006-04-21	2010-08-17	Gem Pharmaceuticals, Llc	Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
CN105837690A (zh)	2006-06-12	2016-08-10	新兴产品开发西雅图有限公司	具有效应功能的单链多价结合蛋白
US20090004134A1 (en) *	2006-09-08	2009-01-01	Obeid Michel Sarkis	Kit for treating a health condition by inducing translocation of an erp57 protein to a cellular membrane
EP2109462A1 (de) *	2007-01-29	2009-10-21	Nerviano Medical Sciences S.r.l.	Antitumor-kombination mit einem morpholinyl-anthracyclin und einem antikörper
US8940334B2 (en)	2007-05-11	2015-01-27	Nerviano Medical Sciences S.R.L.	Pharmaceutical composition of an anthracycline
US20110021517A1 (en) *	2008-02-26	2011-01-27	Nerviano Medical Sciences S.R.L.	Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents
NZ603059A (en) *	2008-04-11	2014-07-25	Emergent Product Dev Seattle	Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
US8690833B2 (en)	2011-01-31	2014-04-08	Vascular Pathways, Inc.	Intravenous catheter and insertion device with reduced blood spatter
KR20170110083A (ko)	2014-12-23	2017-10-10	인털렉츄얼 프라퍼티 어쏘시에이츠, 엘엘씨	경피 투여를 위한 방법 및 제형
HK1251480A1 (zh)	2015-09-21	2019-02-01	Aptevo Research And Development Llc	Cd3结合多肽
EP4324460A3 (de)	2017-09-15	2024-04-24	Dyve Biosciences, Inc.	Natriumhydrogencarbonat zur verwendung in der behandlung von gicht und verwandten erkrankungen

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US4710564A (en) *	1985-01-18	1987-12-01	Microbial Chemistry Research Foundation	Anthracycline compounds
GB2172594B (en)	1985-03-22	1988-06-08	Erba Farmitalia	New morpholino derivatives of daunorubicin and doxorubicin
US5902809A (en) *	1997-07-03	1999-05-11	Paracure, Inc.	Arglabin compounds and therapeutic uses thereof
GB9806324D0 (en) *	1998-03-24	1998-05-20	Pharmacia & Upjohn Spa	Antitumour synergetic composition
GB9820012D0 (en) *	1998-09-14	1998-11-04	Pharmacia & Upjohn Spa	Use of an anthracycline derivative for the treatment of a liver tumor

1999
- 1999-04-29 GB GBGB9909925.1A patent/GB9909925D0/en not_active Ceased
2000
- 2000-04-04 CN CNB008068976A patent/CN1222294C/zh not_active Expired - Fee Related
- 2000-04-04 DK DK00925158T patent/DK1173187T3/da active
- 2000-04-04 AT AT03075776T patent/ATE398457T1/de not_active IP Right Cessation
- 2000-04-04 ES ES03075776T patent/ES2307867T3/es not_active Expired - Lifetime
- 2000-04-04 JP JP2000614978A patent/JP2002543112A/ja active Pending
- 2000-04-04 DE DE60004348T patent/DE60004348T2/de not_active Expired - Lifetime
- 2000-04-04 EP EP08157789A patent/EP1977753A1/de not_active Withdrawn
- 2000-04-04 US US09/926,392 patent/US6537990B1/en not_active Expired - Fee Related
- 2000-04-04 AT AT00925158T patent/ATE246507T1/de not_active IP Right Cessation
- 2000-04-04 CN CNA2003101149091A patent/CN1535688A/zh active Pending
- 2000-04-04 ES ES00925158T patent/ES2204572T3/es not_active Expired - Lifetime
- 2000-04-04 CN CNA2006100597037A patent/CN1853642A/zh active Pending
- 2000-04-04 AU AU43977/00A patent/AU4397700A/en not_active Abandoned
- 2000-04-04 CN CNA2003101149119A patent/CN1507869A/zh active Pending
- 2000-04-04 PT PT00925158T patent/PT1173187E/pt unknown
- 2000-04-04 EP EP00925158A patent/EP1173187B1/de not_active Expired - Lifetime
- 2000-04-04 CN CNA2006100597018A patent/CN1853645A/zh active Pending
- 2000-04-04 HK HK02107029.8A patent/HK1045462B/zh not_active IP Right Cessation
- 2000-04-04 WO PCT/EP2000/002923 patent/WO2000066093A2/en not_active Ceased
- 2000-04-04 EP EP03075776A patent/EP1323423B1/de not_active Expired - Lifetime
- 2000-04-04 DE DE60039260T patent/DE60039260D1/de not_active Expired - Lifetime
- 2000-04-12 TW TW089106805A patent/TWI222863B/zh not_active IP Right Cessation
- 2000-04-26 MY MYPI20001780A patent/MY136610A/en unknown
- 2000-04-27 AR ARP000101989A patent/AR023616A1/es unknown
2002
- 2002-10-31 US US10/284,144 patent/US6586428B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1507869A (zh)	2004-06-30
HK1045462B (zh)	2006-04-28
CN1853645A (zh)	2006-11-01
EP1977753A1 (de)	2008-10-08
WO2000066093A2 (en)	2000-11-09
AR023616A1 (es)	2002-09-04
DK1173187T3 (da)	2003-10-20
ES2307867T3 (es)	2008-12-01
US20030087839A1 (en)	2003-05-08
EP1323423B1 (de)	2008-06-18
JP2002543112A (ja)	2002-12-17
MY136610A (en)	2008-10-31
US6537990B1 (en)	2003-03-25
ATE246507T1 (de)	2003-08-15
EP1323423A1 (de)	2003-07-02
ATE398457T1 (de)	2008-07-15
CN1853642A (zh)	2006-11-01
GB9909925D0 (en)	1999-06-30
AU4397700A (en)	2000-11-17
DE60039260D1 (de)	2008-07-31
ES2204572T3 (es)	2004-05-01
CN1535688A (zh)	2004-10-13
PT1173187E (pt)	2003-10-31
DE60004348T2 (de)	2004-02-26
DE60004348D1 (de)	2003-09-11
US6586428B2 (en)	2003-07-01
CN1349406A (zh)	2002-05-15
EP1173187A2 (de)	2002-01-23
HK1045462A1 (en)	2002-11-29
CN1222294C (zh)	2005-10-12
WO2000066093A3 (en)	2001-01-25
EP1173187B1 (de)	2003-08-06

Legal Events

Date	Code	Title	Description
2012-08-01	MM4A	Annulment or lapse of patent due to non-payment of fees

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