TWI338685B - N3 alkylated benzimid azole derivatives as mek inhibitors - Google Patents

N3 alkylated benzimid azole derivatives as mek inhibitors Download PDF

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Publication number
TWI338685B
TWI338685B TW092105718A TW92105718A TWI338685B TW I338685 B TWI338685 B TW I338685B TW 092105718 A TW092105718 A TW 092105718A TW 92105718 A TW92105718 A TW 92105718A TW I338685 B TWI338685 B TW I338685B
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group
fluoro
anilino
alkyl
bromo
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TW092105718A
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TW200407129A (en
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M Wallace Eli
P Lyssikatos Joseph
L Marlow Allison
Brian Hurley T
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Array Biopharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Communicable Diseases (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW092105718A 2002-03-13 2003-03-13 N3 alkylated benzimid azole derivatives as mek inhibitors TWI338685B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36400702P 2002-03-13 2002-03-13

Publications (2)

Publication Number Publication Date
TW200407129A TW200407129A (en) 2004-05-16
TWI338685B true TWI338685B (en) 2011-03-11

Family

ID=28041856

Family Applications (3)

Application Number Title Priority Date Filing Date
TW092105718A TWI338685B (en) 2002-03-13 2003-03-13 N3 alkylated benzimid azole derivatives as mek inhibitors
TW099113360A TWI350285B (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors
TW099113379A TWI343377B (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW099113360A TWI350285B (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors
TW099113379A TWI343377B (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors

Country Status (35)

Country Link
US (11) US20030232869A1 (2)
EP (5) EP2130536B1 (2)
JP (4) JP4093966B2 (2)
KR (3) KR100984613B1 (2)
CN (4) CN101633644B (2)
AR (3) AR038971A1 (2)
AT (1) ATE449605T1 (2)
AU (2) AU2003218157C1 (2)
BE (1) BE2019C510I2 (2)
BR (1) BR122018007328B8 (2)
CA (1) CA2478374C (2)
CL (2) CL2012002380A1 (2)
CY (3) CY1109727T1 (2)
DE (1) DE60330227D1 (2)
DK (4) DK2275102T3 (2)
DO (4) DOP2003000613A (2)
ES (5) ES2549159T3 (2)
FR (1) FR19C1014I2 (2)
HU (2) HUE025767T2 (2)
IL (4) IL163995A0 (2)
IS (4) IS2748B (2)
LT (1) LTC1482932I2 (2)
LU (1) LUC00100I2 (2)
MX (1) MXPA04008893A (2)
NL (1) NL300974I2 (2)
NZ (1) NZ535158A (2)
PA (1) PA8569301A1 (2)
PL (5) PL233493B1 (2)
PT (4) PT2275102E (2)
SG (3) SG2013013339A (2)
SI (4) SI2130537T1 (2)
TW (3) TWI338685B (2)
UA (1) UA77765C2 (2)
WO (1) WO2003077914A1 (2)
ZA (1) ZA200407220B (2)

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DE602004020741D1 (de) * 2003-02-26 2009-06-04 Kowa Co Mittel zur behandlung der allergischen kontaktdermatitis
CA2532067C (en) 2003-07-24 2010-12-21 Stephen Douglas Barrett N-methyle-substituted benzamidazoles
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US7144907B2 (en) * 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
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US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) * 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
CA2546353A1 (en) 2003-11-19 2005-06-09 Array Biopharma Inc. Bicyclic inhibitors of mek and methods of use thereof
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HRP20110498T1 (hr) 2005-10-07 2011-08-31 Exelixis Azetidini kao inhibitori mek za liječenje proliferativnih bolesti
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RU2418790C3 (ru) * 2005-12-21 2022-03-14 Астразенека Аб Новая гидросульфатная соль
CA2534243A1 (fr) 2006-01-25 2007-07-25 Hydro Quebec Particules d'oxyde metallique enrobees a faible taux de dissolution, procedes de preparation et utilisation dans les systemes electrochimiques
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