TWI519320B - 冷凍乾燥阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）調配物 - Google Patents

冷凍乾燥阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）調配物 Download PDF

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Publication number: TWI519320B
Authority: TW; Taiwan
Prior art keywords: freeze; aripiprazole; dried; suspension; spray
Prior art date: 2011-06-07

Application number

TW101120275A

Other languages

English (en)

Chinese (zh)

Other versions

TW201302246A (zh

Inventor

平岡祥吾

Original Assignee

大塚製藥股份有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-06-07

Filing date

2012-06-06

Publication date

2016-02-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46420491&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI519320(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-06-06 Application filed by 大塚製藥股份有限公司 filed Critical 大塚製藥股份有限公司

2013-01-16 Publication of TW201302246A publication Critical patent/TW201302246A/zh

2016-02-01 Application granted granted Critical

2016-02-01 Publication of TWI519320B publication Critical patent/TWI519320B/zh

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CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title claims description 200
229960004372 aripiprazole Drugs 0.000 title claims description 200
239000000203 mixture Substances 0.000 title claims description 121
238000009472 formulation Methods 0.000 title claims description 118
239000000725 suspension Substances 0.000 claims description 191
239000002245 particle Substances 0.000 claims description 184
239000007921 spray Substances 0.000 claims description 107
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 79
238000000034 method Methods 0.000 claims description 61
239000008187 granular material Substances 0.000 claims description 46
239000012931 lyophilized formulation Substances 0.000 claims description 26
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
238000007710 freezing Methods 0.000 claims description 23
238000001035 drying Methods 0.000 claims description 19
230000008014 freezing Effects 0.000 claims description 17
238000005507 spraying Methods 0.000 claims description 17
239000000375 suspending agent Substances 0.000 claims description 16
239000001768 carboxy methyl cellulose Substances 0.000 claims description 12
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 10
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 10
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 10
238000004519 manufacturing process Methods 0.000 claims description 10
239000003002 pH adjusting agent Substances 0.000 claims description 10
238000001238 wet grinding Methods 0.000 claims description 9
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
229930195725 Mannitol Natural products 0.000 claims description 8
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 8
239000006172 buffering agent Substances 0.000 claims description 8
239000003795 chemical substances by application Substances 0.000 claims description 8
239000000594 mannitol Substances 0.000 claims description 8
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238000002156 mixing Methods 0.000 claims description 8
239000008215 water for injection Substances 0.000 claims description 8
230000008961 swelling Effects 0.000 claims description 7
229910000162 sodium phosphate Inorganic materials 0.000 claims description 6
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 6
238000011084 recovery Methods 0.000 claims description 5
239000001488 sodium phosphate Substances 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 3
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150000004682 monohydrates Chemical class 0.000 claims description 2
230000037452 priming Effects 0.000 claims 1
239000000843 powder Substances 0.000 description 72
238000004108 freeze drying Methods 0.000 description 49
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
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235000011008 sodium phosphates Nutrition 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
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125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
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APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 3
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GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 description 2
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VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
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BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 2
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JVAZJLFFSJARQM-RMPHRYRLSA-N (2r,3r,4s,5s,6r)-2-hexoxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound CCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JVAZJLFFSJARQM-RMPHRYRLSA-N 0.000 description 1
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
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GZTUEENHJMPCPO-UHFFFAOYSA-N C1CO1.C(C)(C)(CC(C)(C)C)C1=CC=C(C=C1)O Chemical compound C1CO1.C(C)(C)(CC(C)(C)C)C1=CC=C(C=C1)O GZTUEENHJMPCPO-UHFFFAOYSA-N 0.000 description 1
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FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
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GUTXTARXLVFHDK-UHFFFAOYSA-N Haloperidol decanoate Chemical compound C1CC(OC(=O)CCCCCCCCC)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 GUTXTARXLVFHDK-UHFFFAOYSA-N 0.000 description 1
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238000012792 lyophilization process Methods 0.000 description 1
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238000010951 particle size reduction Methods 0.000 description 1
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239000010452 phosphate Substances 0.000 description 1
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239000011148 porous material Substances 0.000 description 1
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RYVMUASDIZQXAA-UHFFFAOYSA-N pyranoside Natural products O1C2(OCC(C)C(OC3C(C(O)C(O)C(CO)O3)O)C2)C(C)C(C2(CCC3C4(C)CC5O)C)C1CC2C3CC=C4CC5OC(C(C1O)O)OC(CO)C1OC(C1OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OCC(O)C(O)C1O RYVMUASDIZQXAA-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Psychiatry (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Oil, Petroleum & Natural Gas (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TW101120275A 2011-06-07 2012-06-06 冷凍乾燥阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）調配物 TWI519320B (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201161494088P	2011-06-07	2011-06-07

Publications (2)

Publication Number	Publication Date
TW201302246A TW201302246A (zh)	2013-01-16
TWI519320B true TWI519320B (zh)	2016-02-01

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ID=46420491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW101120275A TWI519320B (zh)	2011-06-07	2012-06-06	冷凍乾燥阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）調配物

Country Status (30)

Country	Link
US (4)	US11154507B2 (fr)
EP (1)	EP2717859B1 (fr)
JP (1)	JP6012637B2 (fr)
KR (1)	KR102014124B1 (fr)
CN (3)	CN106389357A (fr)
AR (2)	AR086682A1 (fr)
AU (1)	AU2012267810B2 (fr)
BR (1)	BR112013031459B1 (fr)
CA (1)	CA2837693C (fr)
CO (1)	CO6842019A2 (fr)
CY (1)	CY1118561T1 (fr)
DK (1)	DK2717859T3 (fr)
EA (1)	EA023951B1 (fr)
ES (1)	ES2599479T3 (fr)
HR (1)	HRP20161357T1 (fr)
HU (1)	HUE031723T2 (fr)
IL (1)	IL229467A (fr)
JO (1)	JO3410B1 (fr)
LT (1)	LT2717859T (fr)
MX (1)	MX354473B (fr)
MY (1)	MY166052A (fr)
PH (1)	PH12013502377A1 (fr)
PL (1)	PL2717859T3 (fr)
PT (1)	PT2717859T (fr)
SG (1)	SG195046A1 (fr)
SI (1)	SI2717859T1 (fr)
TW (1)	TWI519320B (fr)
UA (1)	UA112186C2 (fr)
WO (1)	WO2012169662A1 (fr)
ZA (1)	ZA201308868B (fr)

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US20050032811A1 (en) *	2003-08-06	2005-02-10	Josiah Brown	Methods for administering aripiprazole
JOP20200109A1 (ar)	2012-04-23	2017-06-16	Otsuka Pharma Co Ltd	مستحضر قابل للحقن
WO2016100940A1 (fr)	2014-12-19	2016-06-23	The Broad Institute, Inc.	Ligands des récepteurs dopaminergiques d2
KR102699521B1 (ko) *	2015-10-15	2024-08-26	르 라보레또레 쎄르비에르	악성 종양의 치료를 위한 조합물 요법
CN105663057A (zh) *	2015-12-30	2016-06-15	中国药科大学	阿立哌唑长效混悬剂及其制备方法
WO2018020325A1 (fr)	2016-07-28	2018-02-01	Mylan Laboratories Ltd,	Procédé de préparation d'une formulation d'aripiprazole stérile
WO2021233402A1 (fr) *	2020-05-21	2021-11-25	江苏先声药业有限公司	Composition pharmaceutique contenant du brexpiprazole et son procédé de préparation
CN112656767A (zh) *	2021-01-22	2021-04-16	烟台东诚药业集团股份有限公司	一种依诺肝素钠注射制剂及其制备方法
EP4043008A1 (fr)	2021-02-15	2022-08-17	Warszawskie Zaklady Farmaceutyczne Polfa S.A.	Procédé de préparation d'une composition pharmaceutique comprenant de l'aripiprazole
CN118201600A (zh) *	2021-11-10	2024-06-14	广东东阳光药业股份有限公司	一种喹啉类药物的组合物
JP2023151957A (ja) *	2022-04-01	2023-10-16	理研ビタミン株式会社	薬物含有粒子の製造方法
JP2024016759A (ja) *	2022-07-26	2024-02-07	ニプロ株式会社	アリピプラゾール懸濁液の製造方法
GR1010656B (el) *	2023-03-23	2024-03-21	Φαρματεν Α.Β.Ε.Ε.,	Φαρμακευτικο σκευασμα που περιλαμβανει εναν ατυπο αντιψυχωσικο παραγοντα και μεθοδος για την παρασκευη αυτου

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GB9105705D0 (en)	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
CN1074923C (zh)	1993-11-19	2001-11-21	詹森药业有限公司	微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
GB9718986D0 (en)	1997-09-09	1997-11-12	Danbiosyst Uk	Controlled release microsphere delivery system
US7521068B2 (en) *	1998-11-12	2009-04-21	Elan Pharma International Ltd.	Dry powder aerosols of nanoparticulate drugs
MY129350A (en)	2001-04-25	2007-03-30	Bristol Myers Squibb Co	Aripiprazole oral solution
AR033485A1 (es)	2001-09-25	2003-12-26	Otsuka Pharma Co Ltd	Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US20050019607A1 (en) *	2003-06-30	2005-01-27	Franky So	OLED device with mixed emissive layer
US20050032811A1 (en) *	2003-08-06	2005-02-10	Josiah Brown	Methods for administering aripiprazole
TWI371274B (en) *	2003-10-23	2012-09-01	Bristol Myers Squibb Co	Process for making sterile aripiprazole of desired mean particle size
UA82561C2 (uk)	2003-10-23	2008-04-25	Оцука Фармасьютикалз Ко., Лтд.	Стерильна ін'єкційна композиція арипіпразолу з контрольованим вивільненням, спосіб її виготовлення та спосіб лікування шизофренії
EP1732107A4 (fr)	2004-03-30	2009-05-13	Fujitsu Microelectronics Ltd	Procede de correction de donnees d"exposition a un faisceau d"electrons
US7731873B2 (en)	2005-08-09	2010-06-08	Coopervision International Holding Company, Lp	Contact lens mold assemblies and systems and methods of producing same
CA2622758A1 (fr) *	2005-09-15	2007-03-29	Elan Pharma International, Limited	Formulations aripiprazoliques nanoparticulaires
SI2170279T1 (en) *	2007-07-31	2018-04-30	Otsuka Pharmaceutical Co., Ltd.	Methods for producing aripiprazole suspension and freeze-dried formulation

2012
- 2012-06-03 JO JOP/2012/0141A patent/JO3410B1/ar active
- 2012-06-06 TW TW101120275A patent/TWI519320B/zh active
- 2012-06-06 AR ARP120101990A patent/AR086682A1/es not_active Application Discontinuation
- 2012-06-07 CN CN201610937357.1A patent/CN106389357A/zh active Pending
- 2012-06-07 JP JP2013554727A patent/JP6012637B2/ja active Active
- 2012-06-07 CN CN201280027909.5A patent/CN103596557A/zh active Pending
- 2012-06-07 SG SG2013085568A patent/SG195046A1/en unknown
- 2012-06-07 EP EP12731189.2A patent/EP2717859B1/fr active Active
- 2012-06-07 BR BR112013031459-1A patent/BR112013031459B1/pt active IP Right Grant
- 2012-06-07 ES ES12731189.2T patent/ES2599479T3/es active Active
- 2012-06-07 AU AU2012267810A patent/AU2012267810B2/en active Active
- 2012-06-07 EA EA201391818A patent/EA023951B1/ru not_active IP Right Cessation
- 2012-06-07 CA CA2837693A patent/CA2837693C/fr active Active
- 2012-06-07 PH PH1/2013/502377A patent/PH12013502377A1/en unknown
- 2012-06-07 LT LTEP12731189.2T patent/LT2717859T/lt unknown
- 2012-06-07 CN CN201810450421.2A patent/CN108379231A/zh active Pending
- 2012-06-07 DK DK12731189.2T patent/DK2717859T3/en active
- 2012-06-07 MY MYPI2013702194A patent/MY166052A/en unknown
- 2012-06-07 US US14/124,459 patent/US11154507B2/en active Active
- 2012-06-07 HR HRP20161357TT patent/HRP20161357T1/hr unknown
- 2012-06-07 SI SI201230741A patent/SI2717859T1/sl unknown
- 2012-06-07 WO PCT/JP2012/065180 patent/WO2012169662A1/fr not_active Ceased
- 2012-06-07 KR KR1020147000021A patent/KR102014124B1/ko active Active
- 2012-06-07 PT PT127311892T patent/PT2717859T/pt unknown
- 2012-06-07 MX MX2013014186A patent/MX354473B/es active IP Right Grant
- 2012-06-07 PL PL12731189T patent/PL2717859T3/pl unknown
- 2012-06-07 HU HUE12731189A patent/HUE031723T2/hu unknown
- 2012-07-06 UA UAA201315553A patent/UA112186C2/uk unknown
2013
- 2013-11-17 IL IL229467A patent/IL229467A/en active IP Right Grant
- 2013-11-19 ZA ZA2013/08868A patent/ZA201308868B/en unknown
- 2013-12-30 CO CO13302836A patent/CO6842019A2/es unknown
2016
- 2016-11-03 CY CY20161101125T patent/CY1118561T1/el unknown
2021
- 2021-09-24 US US17/448,862 patent/US20220008341A1/en not_active Abandoned
- 2021-11-29 AR ARP210103281A patent/AR124163A2/es unknown
2023
- 2023-10-09 US US18/483,098 patent/US20240041774A1/en not_active Abandoned
2024
- 2024-11-15 US US18/948,974 patent/US20250064745A1/en active Pending

Also Published As

Publication number	Publication date
PH12013502377A1 (en)	2014-01-06
CY1118561T1 (el)	2017-07-12
LT2717859T (lt)	2016-11-25
SG195046A1 (en)	2013-12-30
PL2717859T3 (pl)	2017-01-31
JP6012637B2 (ja)	2016-10-25
NZ618111A (en)	2015-04-24
PT2717859T (pt)	2016-10-11
US20140112993A1 (en)	2014-04-24
HUE031723T2 (hu)	2017-07-28
DK2717859T3 (en)	2016-11-21
JO3410B1 (ar)	2019-10-20
ES2599479T3 (es)	2017-02-01
IL229467A0 (en)	2014-01-30
US11154507B2 (en)	2021-10-26
EA023951B1 (ru)	2016-07-29
TW201302246A (zh)	2013-01-16
EA201391818A1 (ru)	2014-04-30
US20250064745A1 (en)	2025-02-27
AR086682A1 (es)	2014-01-15
ZA201308868B (en)	2015-02-25
AU2012267810A1 (en)	2013-12-12
AU2012267810B2 (en)	2016-08-11
CN103596557A (zh)	2014-02-19
JP2014516025A (ja)	2014-07-07
UA112186C2 (uk)	2016-08-10
HK1191245A1 (zh)	2014-07-25
CA2837693A1 (fr)	2012-12-13
BR112013031459B1 (pt)	2022-02-22
MX354473B (es)	2018-03-07
CN106389357A (zh)	2017-02-15
EP2717859A1 (fr)	2014-04-16
US20220008341A1 (en)	2022-01-13
EP2717859B1 (fr)	2016-08-31
IL229467A (en)	2017-08-31
CN108379231A (zh)	2018-08-10
AR124163A2 (es)	2023-02-22
US20240041774A1 (en)	2024-02-08
SI2717859T1 (sl)	2017-01-31
MX2013014186A (es)	2014-03-21
KR20140041673A (ko)	2014-04-04
WO2012169662A1 (fr)	2012-12-13
KR102014124B1 (ko)	2019-08-26
MY166052A (en)	2018-05-22
HRP20161357T1 (hr)	2016-12-02
CO6842019A2 (es)	2014-01-20
CA2837693C (fr)	2015-11-03
BR112013031459A2 (pt)	2016-12-06

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