UA101002C2 - ПРОИЗВОДНЫЕ ТЕТРАГИДРОИМИДАЗО[1,5-а]ПИРАЗИНА, СПОСОБ ПОЛУЧЕНИЯ И ИХ МЕДИЦИНСКОЕ ПРИМЕНЕНИЕ - Google Patents

ПРОИЗВОДНЫЕ ТЕТРАГИДРОИМИДАЗО[1,5-а]ПИРАЗИНА, СПОСОБ ПОЛУЧЕНИЯ И ИХ МЕДИЦИНСКОЕ ПРИМЕНЕНИЕ

Info

Publication number
UA101002C2
UA101002C2 UAA201008000A UAA201008000A UA101002C2 UA 101002 C2 UA101002 C2 UA 101002C2 UA A201008000 A UAA201008000 A UA A201008000A UA A201008000 A UAA201008000 A UA A201008000A UA 101002 C2 UA101002 C2 UA 101002C2
Authority
UA
Ukraine
Prior art keywords
imidazo
tetrahydro
preparation methods
pyrazine derivatives
medical uses
Prior art date
Application number
UAA201008000A
Other languages
English (en)
Ukrainian (uk)
Inventor
Пенг Чо Танг
Фанглонг Янг
Джянг Фан
Ху Фенг
Янг Ванг
Тао Янг
Original Assignee
Джянгсу Хенгруй Медисин Ко., Лтд.
Шанхай Хенгруй Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джянгсу Хенгруй Медисин Ко., Лтд., Шанхай Хенгруй Фармасьютикал Ко., Лтд. filed Critical Джянгсу Хенгруй Медисин Ко., Лтд.
Publication of UA101002C2 publication Critical patent/UA101002C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Описываются производные тетрагидроимидазо[1,5-а]пиразина формулы (I), способы их получения, фармацевтические композиции, которые содержат производные, и их использование в качестве медикаментов, особенно в качестве ингибитора дипептидилпептидазы IV, где заместители в формуле (I) являются такими, как определено в описании.
UAA201008000A 2007-12-26 2008-11-27 ПРОИЗВОДНЫЕ ТЕТРАГИДРОИМИДАЗО[1,5-а]ПИРАЗИНА, СПОСОБ ПОЛУЧЕНИЯ И ИХ МЕДИЦИНСКОЕ ПРИМЕНЕНИЕ UA101002C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA2007103023359A CN101468988A (zh) 2007-12-26 2007-12-26 哌嗪类衍生物,其制备方法及其在医药上的应用
PCT/CN2008/001936 WO2009082881A1 (en) 2007-12-26 2008-11-27 Tetrahydro-imidazo[1,5-a]pyrazine derivatives, preparation methods and medical uses thereof

Publications (1)

Publication Number Publication Date
UA101002C2 true UA101002C2 (ru) 2013-02-25

Family

ID=40823770

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201008000A UA101002C2 (ru) 2007-12-26 2008-11-27 ПРОИЗВОДНЫЕ ТЕТРАГИДРОИМИДАЗО[1,5-а]ПИРАЗИНА, СПОСОБ ПОЛУЧЕНИЯ И ИХ МЕДИЦИНСКОЕ ПРИМЕНЕНИЕ

Country Status (15)

Country Link
US (2) US8207161B2 (ru)
EP (1) EP2230241B1 (ru)
JP (1) JP5481008B2 (ru)
KR (1) KR101685103B1 (ru)
CN (2) CN101468988A (ru)
AU (1) AU2008342461B2 (ru)
BR (1) BRPI0821440A2 (ru)
CA (1) CA2706735C (ru)
ES (1) ES2529435T3 (ru)
MX (1) MX2010006438A (ru)
PT (1) PT2230241E (ru)
RU (1) RU2483070C2 (ru)
UA (1) UA101002C2 (ru)
WO (1) WO2009082881A1 (ru)
ZA (1) ZA201004154B (ru)

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CN101899048B (zh) * 2009-05-27 2013-04-17 上海恒瑞医药有限公司 (R)-7-[3-氨基-4-(2,4,5-三氟-苯基)-丁酰]-3-三氟甲基-5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸甲酯的盐
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103087067A (zh) * 2012-08-02 2013-05-08 盛世泰科生物医药技术(苏州)有限公司 作为二肽基酶抑制剂的化合物及其组合物，以及它们的用途
CN106892926B (zh) * 2012-10-16 2019-09-06 江苏盛迪医药有限公司 一种dpp-iv抑制剂的中间体、其制备方法和通过其制备dpp-iv抑制剂的方法
TWI500613B (zh) 2012-10-17 2015-09-21 Cadila Healthcare Ltd 新穎之雜環化合物
CN105142621A (zh) 2012-10-24 2015-12-09 国家健康科学研究所 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂
RU2674977C2 (ru) * 2013-10-30 2018-12-14 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Производные пиразолопиримидона или пирролотриазона, способ их получения и их фармацевтические применения
CN103664962A (zh) * 2013-12-20 2014-03-26 南京华威医药科技开发有限公司 哌嗪类衍生物
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CN103910734B (zh) * 2014-03-28 2016-01-13 南京华威医药科技开发有限公司 一种具有哌嗪结构的dpp-4抑制剂
EP3273981B1 (en) 2015-03-24 2020-04-29 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of diabetes
KR101709127B1 (ko) 2015-06-16 2017-02-22 경동제약 주식회사 Dpp-iv 억제제의 제조를 위한 신규 중간체, 이의 제조방법 및 이를 이용한 dpp-iv 억제제의 제조방법
CN108658990B (zh) * 2017-03-31 2021-03-23 南京科技职业学院 一类新型咪唑并[1,5-a]吡嗪类布鲁顿激酶抑制剂
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WO2019195846A1 (en) 2018-04-06 2019-10-10 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
CN108383845B (zh) * 2018-04-26 2020-11-06 盛世泰科生物医药技术(苏州)有限公司 盛格列汀盐的晶型和无定形及其制备方法和用途
CN113620957B (zh) * 2020-05-08 2022-04-19 盛世泰科生物医药技术(苏州)有限公司 一种胺甲基吡嗪类化合物的制备方法
CN113773323B (zh) * 2020-06-10 2023-05-12 江苏恒瑞医药股份有限公司 3r-氨基取代丁酰胺衍生物的制备方法
JP7777131B2 (ja) 2020-10-02 2025-11-27 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム 転写活性化タンパク質のイミダゾピペラジン阻害剤
KR20230080441A (ko) 2020-10-02 2023-06-07 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 전사 활성화 단백질의 이미다조피페라진 억제제
CN114478536B (zh) * 2020-10-28 2024-12-13 上海森辉医药有限公司 四氢吡嗪稠环衍生物的制备方法
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Also Published As

Publication number Publication date
RU2483070C2 (ru) 2013-05-27
ES2529435T3 (es) 2015-02-20
US20120220766A1 (en) 2012-08-30
PT2230241E (pt) 2015-02-10
JP5481008B2 (ja) 2014-04-23
US8513411B2 (en) 2013-08-20
EP2230241A1 (en) 2010-09-22
ZA201004154B (en) 2011-08-31
EP2230241A4 (en) 2011-06-22
MX2010006438A (es) 2010-10-13
CA2706735C (en) 2016-04-12
AU2008342461A2 (en) 2010-09-09
AU2008342461A1 (en) 2009-07-09
CN101641361A (zh) 2010-02-03
BRPI0821440A2 (pt) 2015-06-16
CN101468988A (zh) 2009-07-01
US20100273786A1 (en) 2010-10-28
HK1134817A1 (en) 2010-05-14
EP2230241B1 (en) 2014-11-26
WO2009082881A1 (en) 2009-07-09
KR20110002003A (ko) 2011-01-06
KR101685103B1 (ko) 2016-12-09
AU2008342461B2 (en) 2013-09-05
RU2010125703A (ru) 2012-02-10
JP2011508735A (ja) 2011-03-17
CN101641361B (zh) 2012-02-08
CA2706735A1 (en) 2009-07-09
US8207161B2 (en) 2012-06-26

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