UA113174C2 - Стабільна ліофілізована композиція на основі fgf-18 - Google Patents

Стабільна ліофілізована композиція на основі fgf-18

Info

Publication number
UA113174C2
UA113174C2 UAA201314452A UAA201314452A UA113174C2 UA 113174 C2 UA113174 C2 UA 113174C2 UA A201314452 A UAA201314452 A UA A201314452A UA A201314452 A UAA201314452 A UA A201314452A UA 113174 C2 UA113174 C2 UA 113174C2
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UA
Ukraine
Prior art keywords
fgf
stable lyophilized
lyophilized composition
composition
stable
Prior art date
Application number
UAA201314452A
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English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47356563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA113174(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of UA113174C2 publication Critical patent/UA113174C2/uk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Винахід стосується стабільної ліофілізованої композиції, яка містить фактор росту фібробластів FGF-18, полоксамер 188 і цукрозу; способу одержання такої композиції; виробу, який містить вказану композицію і розчинник, які знаходяться в різних відсіках двокамерної системи.
UAA201314452A 2011-06-17 2012-06-15 Стабільна ліофілізована композиція на основі fgf-18 UA113174C2 (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11170437 2011-06-17
PCT/EP2012/061495 WO2012172072A1 (en) 2011-06-17 2012-06-15 Freeze-dried formulations of fgf-18

Publications (1)

Publication Number Publication Date
UA113174C2 true UA113174C2 (xx) 2016-12-26

Family

ID=47356563

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201314452A UA113174C2 (xx) 2011-06-17 2012-06-15 Стабільна ліофілізована композиція на основі fgf-18

Country Status (32)

Country Link
US (2) US9326944B2 (uk)
EP (2) EP2720710B1 (uk)
JP (1) JP5981538B2 (uk)
KR (1) KR102019520B1 (uk)
CN (2) CN107715104A (uk)
AR (1) AR086956A1 (uk)
AU (1) AU2012268987B2 (uk)
BR (1) BR112013032400B1 (uk)
CA (1) CA2836667C (uk)
CL (1) CL2013003618A1 (uk)
CO (1) CO6940377A2 (uk)
CY (1) CY1117933T1 (uk)
DK (1) DK2720710T3 (uk)
EA (1) EA024937B1 (uk)
EC (1) ECSP14013157A (uk)
ES (1) ES2575732T3 (uk)
HR (1) HRP20160566T1 (uk)
HU (1) HUE028355T2 (uk)
IL (1) IL229977A (uk)
MX (1) MX338017B (uk)
MY (1) MY170630A (uk)
PE (1) PE20141265A1 (uk)
PH (1) PH12013502529A1 (uk)
PL (1) PL2720710T3 (uk)
PT (1) PT2720710E (uk)
RS (1) RS54875B1 (uk)
SG (1) SG195021A1 (uk)
SI (1) SI2720710T1 (uk)
TW (1) TWI527590B (uk)
UA (1) UA113174C2 (uk)
WO (1) WO2012172072A1 (uk)
ZA (1) ZA201308698B (uk)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI527590B (zh) * 2011-06-17 2016-04-01 艾瑞斯貿易公司 Ｆｇｆ－１８之凍乾調配物
NZ721597A (en) 2013-12-24 2022-07-01 Ares Trading Sa Fgf-18 formulation in alginate/collagen hydrogels
WO2016120387A1 (en) 2015-01-29 2016-08-04 Ares Trading S.A. Immunoassays for high positively charged proteins
BR112018002404A2 (pt) * 2015-08-13 2018-09-18 Merck Patent Gmbh composição de combinação compreendendo composto de fgf-18
LT3688468T (lt) 2017-09-29 2022-06-27 Merck Patent Gmbh Uždegiminiai biožymenys, skirti atsako į fgf-18 junginį numatymui
EP3687558B1 (en) 2017-09-29 2022-03-16 Merck Patent GmbH Metabolic biomarkers for predicting responsiveness to fgf-18 compound
EP3706710B1 (en) * 2017-11-10 2024-04-10 Novartis AG Extended release formulations for intra-articular applications
IL281333B2 (en) 2018-09-10 2025-11-01 Merck Patent Gmbh A method for reducing risk in a clinical trial
CN109836487B (zh) * 2019-03-01 2022-06-17 重庆派金生物科技有限公司 一种人成纤维细胞生长因子18及其可溶性重组表达方法、制备方法、制剂和应用
CN112121150A (zh) * 2019-06-24 2020-12-25 杭州生物医药创新研究中心 一种成纤维细胞生长因子10冻干粉
PT4034115T (pt) * 2019-09-25 2025-03-25 Lumosa Therapeutics Co Ltd Composição farmacêutica compreendendo conjugado péptido trombolítico-tetra-hidroisoquinolina
CN113304063A (zh) * 2021-04-23 2021-08-27 四川省恩乐生物工程有限公司 一种用于肌肤美容抗衰老的组合物及其制备方法
CN117338705A (zh) * 2022-06-28 2024-01-05 中国医学科学院药物研究所 一种含有奥司他韦的粉液双室袋制剂及其制备方法
CN118310835B (zh) * 2024-04-16 2025-04-11 杭州百凌生物科技有限公司 一种质控品冻干粉及其制备方法和应用

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US5217954A (en) * 1990-04-04 1993-06-08 Scios Nova Inc. Formulations for stabilizing fibroblast growth factor
GB9015824D0 (en) 1990-07-18 1990-09-05 Erba Carlo Spa Stable pharmaceutical compositions containing a fibroblast growth factor
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US20010056066A1 (en) * 1996-07-26 2001-12-27 Smithkline Beecham Corporation Method of treating immune cell mediated systemic diseases
UA75316C2 (uk) * 1996-10-16 2006-04-17 Займодженетікс, Інк. Гомологи з фактором росту фібробласта
CN1184673A (zh) * 1996-12-13 1998-06-17 中国医科大学 Fgf粗提多肽生长因子混合物及其提取工艺
JP2002527401A (ja) * 1998-10-13 2002-08-27 カイロン コーポレイション Ｆｇｆの脈管形成的に有効な単位用量および投与方法
ATE539157T1 (de) 1999-12-02 2012-01-15 Zymogenetics Inc Methoden welche auf zellen zielen, die die fibroblasten wachtumsfaktor-rezeptoren-3 oder -2 exprimieren
CN1303714A (zh) * 2000-01-13 2001-07-18 重庆多泰制药有限公司 Ii型胶原蛋白口服胃溶制剂
WO2002017956A2 (en) * 2000-08-31 2002-03-07 Chiron Corporation Stabilized fgf formulations containing reducing agents
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Also Published As

Publication number Publication date
HRP20160566T1 (hr) 2016-06-17
JP5981538B2 (ja) 2016-08-31
PL2720710T3 (pl) 2016-09-30
EA201490032A1 (ru) 2014-05-30
NZ617992A (en) 2015-09-25
TW201302217A (zh) 2013-01-16
PT2720710E (pt) 2016-06-17
MX2013014894A (es) 2014-09-01
MX338017B (es) 2016-03-29
EP3056211A1 (en) 2016-08-17
CA2836667C (en) 2020-01-14
ZA201308698B (en) 2016-02-24
KR102019520B1 (ko) 2019-11-04
EP2720710B1 (en) 2016-03-23
SI2720710T1 (sl) 2016-07-29
PE20141265A1 (es) 2014-09-29
DK2720710T3 (en) 2016-06-27
IL229977A (en) 2017-01-31
BR112013032400A2 (pt) 2016-11-22
EA024937B1 (ru) 2016-11-30
CN107715104A (zh) 2018-02-23
AR086956A1 (es) 2014-02-05
ECSP14013157A (es) 2014-02-28
CY1117933T1 (el) 2017-05-17
MY170630A (en) 2019-08-21
PH12013502529A1 (en) 2014-01-27
HUE028355T2 (en) 2016-12-28
CL2013003618A1 (es) 2014-07-04
BR112013032400B1 (pt) 2021-07-20
US9326944B2 (en) 2016-05-03
RS54875B1 (sr) 2016-10-31
AU2012268987B2 (en) 2016-09-08
ES2575732T3 (es) 2016-06-30
TWI527590B (zh) 2016-04-01
US20140121162A1 (en) 2014-05-01
CA2836667A1 (en) 2012-12-20
KR20140041600A (ko) 2014-04-04
CO6940377A2 (es) 2014-05-09
US20160228374A1 (en) 2016-08-11
CN103619347A (zh) 2014-03-05
EP2720710A1 (en) 2014-04-23
SG195021A1 (en) 2013-12-30
WO2012172072A1 (en) 2012-12-20
JP2014522807A (ja) 2014-09-08

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