UA117663C2 - Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози - Google Patents

Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози

Info

Publication number
UA117663C2
UA117663C2 UAA201503972A UAA201503972A UA117663C2 UA 117663 C2 UA117663 C2 UA 117663C2 UA A201503972 A UAA201503972 A UA A201503972A UA A201503972 A UAA201503972 A UA A201503972A UA 117663 C2 UA117663 C2 UA 117663C2
Authority
UA
Ukraine
Prior art keywords
androgens
prostate cancer
treatment
resistant prostate
metastatic castrate
Prior art date
Application number
UAA201503972A
Other languages
English (en)
Inventor
Ісан Чень
Original Assignee
Арагон Фармасьютікалз, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49293921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA117663(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Арагон Фармасьютікалз, Інк. filed Critical Арагон Фармасьютікалз, Інк.
Publication of UA117663C2 publication Critical patent/UA117663C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Винахід стосується способу лікування неметастатичного кастраційно-резистентного раку простати у чоловіків, що включає введення антиандрогену 4-[7-(6-ціано-5-трифторметилпіридин-3-іл)-8-оксо-6-тіоксо-5,7-діазаспіро[3.4]окт-5-ил]-2-фтор-N-метил- бензаміду чоловіку, якому необхідне таке лікування, в комбінації з леупролідом, бузереліном, нафареліном, гістреліном, госереліном або деслореліном.
UAA201503972A 2012-09-26 2013-09-23 Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози UA117663C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261705900P 2012-09-26 2012-09-26
PCT/US2013/061197 WO2014052237A1 (en) 2012-09-26 2013-09-23 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer

Publications (1)

Publication Number Publication Date
UA117663C2 true UA117663C2 (uk) 2018-09-10

Family

ID=49293921

Family Applications (3)

Application Number Title Priority Date Filing Date
UAA201804807A UA124967C2 (uk) 2012-09-26 2013-09-23 Антиандрогени для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
UAA202102785A UA129494C2 (uk) 2012-09-26 2013-09-23 Антиандрогени для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
UAA201503972A UA117663C2 (uk) 2012-09-26 2013-09-23 Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози

Family Applications Before (2)

Application Number Title Priority Date Filing Date
UAA201804807A UA124967C2 (uk) 2012-09-26 2013-09-23 Антиандрогени для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
UAA202102785A UA129494C2 (uk) 2012-09-26 2013-09-23 Антиандрогени для лікування неметастатичного кастраційно-резистентного раку передміхурової залози

Country Status (36)

Country Link
US (8) US9884054B2 (uk)
EP (3) EP3305285B1 (uk)
JP (4) JP6351597B2 (uk)
KR (3) KR20220025231A (uk)
CN (4) CN115737643A (uk)
AU (4) AU2013323861C1 (uk)
BR (1) BR112015006705A8 (uk)
CA (1) CA2885415C (uk)
CL (1) CL2015000715A1 (uk)
CR (1) CR20150140A (uk)
CY (1) CY1123716T1 (uk)
DK (1) DK3305285T3 (uk)
EA (3) EA202190820A1 (uk)
EC (1) ECSP15011764A (uk)
ES (1) ES2836424T3 (uk)
GT (1) GT201500071A (uk)
HK (1) HK1212221A1 (uk)
HR (1) HRP20201721T1 (uk)
HU (1) HUE051211T2 (uk)
IL (3) IL237692B2 (uk)
IN (1) IN2015DN02387A (uk)
LT (1) LT3305285T (uk)
MX (2) MX379847B (uk)
MY (1) MY180834A (uk)
NI (1) NI201500042A (uk)
NZ (3) NZ705815A (uk)
PE (1) PE20150765A1 (uk)
PH (3) PH12018502570B1 (uk)
PT (1) PT3305285T (uk)
RS (1) RS60976B1 (uk)
SG (3) SG10201912719TA (uk)
SI (1) SI3305285T1 (uk)
SM (1) SMT202000573T1 (uk)
UA (3) UA124967C2 (uk)
WO (1) WO2014052237A1 (uk)
ZA (1) ZA201808499B (uk)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10799489B2 (en) 2012-09-26 2020-10-13 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
US11160796B2 (en) 2017-10-16 2021-11-02 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

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SG10201907588XA (en) 2010-02-16 2019-09-27 Aragon Pharmaceuticals Inc Androgen Receptor Modulators And Uses Thereof
EP2791128A4 (en) 2011-12-16 2015-04-22 Olema Pharmaceuticals Inc NOVEL BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF
DK2945628T3 (da) * 2013-01-15 2020-05-04 Aragon Pharmaceuticals Inc Androgen receptormodulator i kombination med abirateronacetat og prednison til behandling af prostatacancer
HUE051888T2 (hu) * 2014-12-05 2021-03-29 Aragon Pharmaceuticals Inc Rákellenes készítmények
US10285948B2 (en) 2014-12-05 2019-05-14 Janssen Pharmaceutica Nv Anticancer compositions
EA201791222A1 (ru) 2014-12-05 2017-09-29 Арагон Фармасьютикалз, Инк. Противораковые композиции
KR101718226B1 (ko) 2015-08-05 2017-03-20 울산대학교 산학협력단 사쿠라소사포닌 화합물을 유효성분으로 포함하는 안드로겐 수용체 관련 질환의 예방 또는 치료용 조성물
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN119606965A (zh) * 2016-07-29 2025-03-14 詹森药业有限公司 治疗前列腺癌的方法
JP2022523094A (ja) * 2019-01-30 2022-04-21 アラゴン ファーマシューティカルズ，インコーポレイテッド 転移性去勢感受性前立腺癌の治療のための抗アンドロゲン剤
EP4054572A1 (en) * 2019-11-04 2022-09-14 Aragon Pharmaceuticals, Inc. Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment

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US10799488B2 (en) 2012-09-26 2020-10-13 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
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USRE49353E1 (en) 2012-09-26 2023-01-03 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
USRE50642E1 (en) 2012-09-26 2025-10-21 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
US11160796B2 (en) 2017-10-16 2021-11-02 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
US11491149B2 (en) 2017-10-16 2022-11-08 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

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