UA124237C2 - Заміщені індазоли, придатні для лікування і попередження алергійних і/або запальних захворювань у тварин - Google Patents

Заміщені індазоли, придатні для лікування і попередження алергійних і/або запальних захворювань у тварин Download PDF

Info

Publication number
UA124237C2
UA124237C2 UAA201812729A UAA201812729A UA124237C2 UA 124237 C2 UA124237 C2 UA 124237C2 UA A201812729 A UAA201812729 A UA A201812729A UA A201812729 A UAA201812729 A UA A201812729A UA 124237 C2 UA124237 C2 UA 124237C2
Authority
UA
Ukraine
Prior art keywords
trifluoromethyl
carboxamide
indazol
alkyl
hydroxypropan
Prior art date
Application number
UAA201812729A
Other languages
English (en)
Ukrainian (uk)
Inventor
Джеральд Беддіс
Джеральд БЕДДИС
Едріан Фостер
Эдриан ФОСТЕР
Ульріх Боте
Ульрих Боте
Ніколє Шмідт
Николе Шмидт
Ульф Бьомер
Ульф Бёмер
Райнхард Нуббемейер
Марія Де Лурдес Мот'є
Мария Де Лурдес Мотье
Original Assignee
Байєр Енімал Хелс Гмбх
Байер Энимал Хелс Гмбх
Байєр Фарма Акцієнгезелльшафт
Байер Фарма Акциенгезелльшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байєр Енімал Хелс Гмбх, Байер Энимал Хелс Гмбх, Байєр Фарма Акцієнгезелльшафт, Байер Фарма Акциенгезелльшафт filed Critical Байєр Енімал Хелс Гмбх
Publication of UA124237C2 publication Critical patent/UA124237C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
UAA201812729A 2016-06-01 2017-05-29 Заміщені індазоли, придатні для лікування і попередження алергійних і/або запальних захворювань у тварин UA124237C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16172544 2016-06-01
PCT/EP2017/062876 WO2017207481A1 (fr) 2016-06-01 2017-05-29 Indazoles substitués utiles pour le traitement et la prévention de maladies allergiques et/ou inflammatoires chez des animaux

Publications (1)

Publication Number Publication Date
UA124237C2 true UA124237C2 (uk) 2021-08-11

Family

ID=56097024

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201812729A UA124237C2 (uk) 2016-06-01 2017-05-29 Заміщені індазоли, придатні для лікування і попередження алергійних і/або запальних захворювань у тварин

Country Status (25)

Country Link
US (3) US20200216413A1 (fr)
EP (1) EP3464266B1 (fr)
JP (1) JP7004677B2 (fr)
KR (1) KR102547834B1 (fr)
CN (3) CN119367364A (fr)
AU (1) AU2017272505B9 (fr)
BR (1) BR112018074927A2 (fr)
CA (1) CA3025847A1 (fr)
CL (1) CL2018003432A1 (fr)
CO (1) CO2018013029A2 (fr)
DK (1) DK3464266T3 (fr)
DO (1) DOP2018000262A (fr)
ES (1) ES2898771T3 (fr)
IL (1) IL263132B (fr)
MX (1) MX394560B (fr)
MY (1) MY199070A (fr)
PH (1) PH12018502530A1 (fr)
PL (1) PL3464266T3 (fr)
PT (1) PT3464266T (fr)
RU (1) RU2743170C2 (fr)
SG (1) SG11201809470RA (fr)
SI (1) SI3464266T1 (fr)
TW (1) TWI781935B (fr)
UA (1) UA124237C2 (fr)
WO (1) WO2017207481A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
WO2017148902A1 (fr) 2016-03-03 2017-09-08 Bayer Pharma Aktiengesellschaft Nouveaux indazoles substitués en 2, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour produire des médicaments
EP3448849B1 (fr) 2016-04-29 2020-05-13 Bayer Pharma Aktiengesellschaft Synthèse d'indazoles
WO2017186689A1 (fr) 2016-04-29 2017-11-02 Bayer Pharma Aktiengesellschaft Synthèse d'indazoles
SG10202011653WA (en) 2016-06-01 2020-12-30 Bayer Pharma AG Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
MX394560B (es) 2016-06-01 2025-03-24 Bayer Pharma AG Uso de indazoles sustituidos para el tratamiento y la prevencion de enfermedades en animales.
CN111194319A (zh) 2017-10-19 2020-05-22 拜耳动物保健有限责任公司 稠合的杂芳族吡咯烷酮类化合物用于治疗和预防动物中的疾病的用途
CN110835338A (zh) * 2018-08-17 2020-02-25 浙江海正药业股份有限公司 咪唑并吡啶类衍生物及其制备方法和其在医药上的用途
US12496340B2 (en) 2019-05-23 2025-12-16 The University Of Montana Vaccine adjuvants based on TLR receptor ligands
AU2020352311B2 (en) * 2019-09-24 2023-11-09 Wuhan Createrna Science And Technology Co., Ltd. IRAK inhibitor and preparation method therefor and use thereof
EP3800188A1 (fr) 2019-10-02 2021-04-07 Bayer AG Pyrazolopyrimidines substituées en tant qu'inhibiteurs d'irak4
WO2021119159A1 (fr) 2019-12-10 2021-06-17 Kymera Therapeutics, Inc. Agents de dégradation d'irak et leurs utilisations
JP7429032B2 (ja) * 2019-12-24 2024-02-07 学校法人順天堂 間質性肺炎モデル非ヒト動物の作製方法
CN113521079A (zh) * 2020-04-20 2021-10-22 上海领泰生物医药科技有限公司 Irak4抑制剂在治疗ali/ards中的应用
CN115300627B (zh) * 2021-05-08 2024-01-26 中南大学湘雅医院 钠-葡萄糖共转运蛋白2抑制剂的应用、一种药物组合物及其应用
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途
CN121773108A (zh) * 2023-06-29 2026-03-31 同和药品株式会社 新的羧酰胺衍生物化合物及包含该化合物的药物组合物

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20004714A3 (cs) 1998-07-01 2001-09-12 The Procter & Gamble Company Způsob odstraňování vody z vláknitého rouna za použití oscilačního reverzního proudu dopadajícího plynu
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
WO2004013102A1 (fr) * 2002-07-31 2004-02-12 Schering Aktiengesellschaft Anthranylamidopyrimidines inhibant vegfr-2 et vegfr-3
CN100393698C (zh) 2003-06-25 2008-06-11 第一药品(株) 三环衍生物或其药学上可接受的盐、其制备以及包含它们的药物组合物
US8084457B2 (en) 2003-09-15 2011-12-27 Lead Discovery Center Gmbh Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
WO2005082866A2 (fr) 2004-02-20 2005-09-09 Pfizer Limited Derives de triazole substitues utilises en tant qu'antagonistes de l'oxytocine
US20080161365A1 (en) 2004-12-08 2008-07-03 Pfizer Inc. Methylene Derivatives
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
GT200600411A (es) 2005-09-13 2007-05-21 Novartis Ag Combinaciones que comprenden un inhibidor del receptor del factor de crecimiento endotelial vascular
SG10202003901UA (en) 2005-12-13 2020-05-28 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
US7745477B2 (en) 2006-02-07 2010-06-29 Hoffman-La Roche Inc. Heteroaryl and benzyl amide compounds
EP1986643A1 (fr) 2006-02-10 2008-11-05 Summit Corporation Plc Traitement de la dystrophie musculaire de duchenne
TW200801012A (en) 2006-04-26 2008-01-01 Piramed Ltd Phosphoinositide 3-kinase inhibitor compounds and methods of use
JP5258563B2 (ja) 2006-06-29 2013-08-07 日産化学工業株式会社 αアミノ酸誘導体及びそれを有効成分として含む医薬
EP2061786A2 (fr) 2006-09-07 2009-05-27 Biogen Idec MA Inc. Modulateurs de la kinase associée au récepteur de l'interleukine-1
WO2009117421A2 (fr) 2008-03-17 2009-09-24 Kalypsys, Inc. Modulateurs hétérocycliques de gpr119 pour le traitement d’une maladie
US20100094000A1 (en) 2008-09-03 2010-04-15 Takeda Pharmaceutical Company Limited Pyrazole compounds
JP5656880B2 (ja) 2009-03-09 2015-01-21 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｐｉ３キナーゼの阻害剤としての４−オキサジアゾール−２−イル−インダゾール
WO2011153588A1 (fr) 2010-06-10 2011-12-15 Biota Scientific Management Pty Ltd Inhibiteurs de polymérase virale
WO2012061926A1 (fr) 2010-11-08 2012-05-18 Zalicus Pharmaceuticals Ltd. Composés de bisarylsulfone et de dialkylarylsulfone en tant que bloquants du canal calcique
US8507499B2 (en) 2010-12-06 2013-08-13 Confluence Life Sciences, Inc. Substituted indole/indazole-pyrimidinyl compounds
BR112013015460B1 (pt) 2010-12-20 2022-01-25 Merck Serono S.A. Derivados de indazolil triazol, kit, e composição farmacêutica
WO2012087772A1 (fr) 2010-12-21 2012-06-28 Schering Corporation Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
WO2012107475A1 (fr) 2011-02-10 2012-08-16 Syngenta Participations Ag Dérivés de pyrazole microbiocides
EP2489663A1 (fr) 2011-02-16 2012-08-22 Almirall, S.A. Composés en tant qu'inhibiteurs de la syk kinase
MX2013009393A (es) 2011-02-18 2013-08-29 Vertex Pharma Piperidinamidas cromano-espirociclicas como moduladores de canales de iones.
US8575336B2 (en) * 2011-07-27 2013-11-05 Pfizer Limited Indazoles
WO2013042137A1 (fr) * 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Hétérocycles bicycliques convenant comme inhibiteurs de l'irak4
WO2013106254A1 (fr) 2012-01-11 2013-07-18 Dow Agrosciences Llc Compositions pesticides et procédés qui leur sont associés
AU2013224302B2 (en) 2012-02-21 2017-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
HK1206723A1 (en) 2012-05-21 2016-01-15 Bayer Pharma Aktiengesellschaft Thienopyrimidines
WO2015017336A1 (fr) * 2013-07-29 2015-02-05 OmniGen Research, L.L.C. Combinaison médicamenteuse et procédé d'administration à un animal
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
EP3092226B1 (fr) 2014-01-10 2019-03-13 Aurigene Discovery Technologies Limited Composés d'imidazole utilisables en tant qu'inhibiteurs de l'irak4
AU2015275730A1 (en) 2014-06-20 2016-12-15 Aurigene Discovery Technologies Limited Substituted indazole compounds as IRAK4 inhibitors
CN104093061B (zh) * 2014-07-18 2020-06-02 北京智谷睿拓技术服务有限公司 内容分享方法和装置
JO3705B1 (ar) * 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
TW201701879A (zh) * 2015-04-30 2017-01-16 拜耳製藥公司 Ｉｒａｋ４抑制劑組合
EP3448849B1 (fr) * 2016-04-29 2020-05-13 Bayer Pharma Aktiengesellschaft Synthèse d'indazoles
WO2017186689A1 (fr) * 2016-04-29 2017-11-02 Bayer Pharma Aktiengesellschaft Synthèse d'indazoles
SG10202011653WA (en) 2016-06-01 2020-12-30 Bayer Pharma AG Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
MX394560B (es) 2016-06-01 2025-03-24 Bayer Pharma AG Uso de indazoles sustituidos para el tratamiento y la prevencion de enfermedades en animales.

Also Published As

Publication number Publication date
TW201808933A (zh) 2018-03-16
KR102547834B1 (ko) 2023-06-26
MY199070A (en) 2023-10-12
US20200216413A1 (en) 2020-07-09
BR112018074927A2 (pt) 2019-03-12
SI3464266T1 (sl) 2021-12-31
US20260085057A1 (en) 2026-03-26
AU2017272505A1 (en) 2018-11-15
CN109219603A (zh) 2019-01-15
CA3025847A1 (fr) 2017-12-07
AU2017272505A8 (en) 2018-11-29
PL3464266T3 (pl) 2022-01-24
DOP2018000262A (es) 2019-02-28
RU2018145860A3 (fr) 2020-07-09
IL263132A (en) 2018-12-31
KR20190015252A (ko) 2019-02-13
CO2018013029A2 (es) 2018-12-28
CN109219603B (zh) 2025-06-27
WO2017207481A1 (fr) 2017-12-07
JP2019520348A (ja) 2019-07-18
CL2018003432A1 (es) 2019-03-22
AU2017272505B2 (en) 2021-10-07
US20220204474A1 (en) 2022-06-30
SG11201809470RA (en) 2018-11-29
PT3464266T (pt) 2021-11-23
EP3464266A1 (fr) 2019-04-10
DK3464266T3 (da) 2021-11-22
MX2018014899A (es) 2019-04-24
ES2898771T3 (es) 2022-03-08
JP7004677B2 (ja) 2022-01-21
EP3464266B1 (fr) 2021-10-20
PH12018502530A1 (en) 2019-10-21
WO2017207481A8 (fr) 2018-11-22
NZ747414A (en) 2025-06-27
TWI781935B (zh) 2022-11-01
US12459916B2 (en) 2025-11-04
RU2743170C2 (ru) 2021-02-15
IL263132B (en) 2022-04-01
MX394560B (es) 2025-03-24
CN120531733A (zh) 2025-08-26
RU2018145860A (ru) 2020-07-09
AU2017272505B9 (en) 2021-10-28
CN119367364A (zh) 2025-01-28

Similar Documents

Publication Publication Date Title
UA124237C2 (uk) Заміщені індазоли, придатні для лікування і попередження алергійних і/або запальних захворювань у тварин
TWI703147B (zh) 用於治療胃腸發炎性疾病之jak抑制劑化合物之前藥
ES2816060T3 (es) Aza-aril 1H-pirazol-1-il-bencenosulfonamidas como antagonistas de CCR(9)
UA123916C2 (uk) Застосування 2-заміщених індазолів для лікування і профілактики аутоімунних захворювань
JP2022504638A (ja) 統合的ストレス経路のプロドラッグ調節剤
CN105960237B (zh) Ccr6化合物
TW201819380A (zh) 作為抗病毒劑之稠合四環吡啶酮化合物
CN102131800A (zh) 5元和6元杂环化合物
TW201736345A (zh) 2-羥吲哚化合物
JP2022095809A (ja) ヒストン脱アセチル化酵素阻害剤とプログラム細胞死リガンド１（ｐｄ－ｌ１）阻害剤とを含む医薬組み合わせ物及びその使用方法
ZA200604926B (en) Methods of treating acute inflammation in animals with p38 MAP kinase inhibitors
RU2757014C1 (ru) Композиции для предупреждения или лечения волчанки
HK1260442A1 (en) Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
HK1260442B (zh) 用於治疗和预防动物的过敏性和/或炎症性疾病的取代吲唑
CN108697684A (zh) 趋化因子受体的调节剂