UA61884C2 - 1,3-propane diol derivatives as biologically active compounds - Google Patents

1,3-propane diol derivatives as biologically active compounds Download PDF

Info

Publication number: UA61884C2
Authority: UA; Ukraine
Prior art keywords: acid; octadeca; compound according; mmol; drug
Prior art date: 1995-05-01

Application number

UA97115654A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-01

Filing date

1996-01-05

Publication date

2003-12-15

1996-01-05 Application filed filed Critical

1996-05-01 Priority claimed from PCT/GB1996/001053 external-priority patent/WO1996034846A1/en

2003-12-15 Publication of UA61884C2 publication Critical patent/UA61884C2/uk

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 102
DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical class C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 title claims abstract description 47
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 112
239000000194 fatty acid Substances 0.000 claims abstract description 112
229930195729 fatty acid Natural products 0.000 claims abstract description 112
150000004665 fatty acids Chemical class 0.000 claims abstract description 102
239000003814 drug Substances 0.000 claims abstract description 74
229940079593 drug Drugs 0.000 claims abstract description 71
YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 52
229920000166 polytrimethylene carbonate Polymers 0.000 claims abstract description 23
125000002252 acyl group Chemical group 0.000 claims abstract description 9
235000015097 nutrients Nutrition 0.000 claims abstract description 6
239000001257 hydrogen Substances 0.000 claims abstract description 3
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 3
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 3
125000000373 fatty alcohol group Chemical group 0.000 claims abstract 4
239000000126 substance Substances 0.000 claims description 99
239000000203 mixture Substances 0.000 claims description 83
239000002253 acid Substances 0.000 claims description 63
-1 calcitomin Chemical compound 0.000 claims description 49
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 41
230000000694 effects Effects 0.000 claims description 26
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 24
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
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ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
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ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 4
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JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
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UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
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Classifications

- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

UA97115654A 1995-05-01 1996-01-05 1,3-propane diol derivatives as biologically active compounds UA61884C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9508823.3A GB9508823D0 (en)	1995-05-01	1995-05-01	Drug Derivatives
PCT/GB1996/001053 WO1996034846A1 (en)	1995-05-01	1996-05-01	1,3-propane diol derivatives as bioactive compounds

Publications (1)

Publication Number	Publication Date
UA61884C2 true UA61884C2 (en)	2003-12-15

Family

ID=10773801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA97115654A UA61884C2 (en)	1995-05-01	1996-01-05	1,3-propane diol derivatives as biologically active compounds

Country Status (5)

Country	Link
CN (1)	CN100391930C (ar)
GB (1)	GB9508823D0 (ar)
JO (1)	JO1930B1 (ar)
UA (1)	UA61884C2 (ar)
ZA (3)	ZA963360B (ar)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5994392A (en) *	1988-02-26	1999-11-30	Neuromedica, Inc.	Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
US5919815A (en) *	1996-05-22	1999-07-06	Neuromedica, Inc.	Taxane compounds and compositions
ES2151277T3 (es) *	1996-05-22	2000-12-16	Protarga Inc	Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
ES2252874T3 (es) *	1997-12-12	2006-05-16	Purdue Research Foundation	Utilizacion de acido linoleico conjugado para tratamiento de la diabetes mellitus tipo ii.
US7015249B1 (en)	1997-12-12	2006-03-21	Purdue Research Foundation	Methods and compositions for treating diabetes
US6225444B1 (en)	1998-02-10	2001-05-01	Protarga, Inc.	Neuroprotective peptides and uses thereof
BR0107933A (pt) *	2000-01-28	2004-01-06	Procter & Gamble	Compostos de arginina saborosos e seus usos para saúde cardiovascular
US8288369B2 (en) *	2006-06-27	2012-10-16	University Of South Florida	Delta-tocotrienol treatment and prevention of pancreatic cancer
CN102260177A (zh) *	2010-05-25	2011-11-30	中国医学科学院药物研究所	丙二醇类衍生物、其制备方法和其药物组合物与用途
CN102260178A (zh) *	2010-05-25	2011-11-30	中国医学科学院药物研究所	羟基丙二醇类衍生物、其制备方法和其药物组合物与用途
US9084826B2 (en) *	2012-05-01	2015-07-21	Catabasis Pharmaceuticals, Inc.	Fatty acid conjugates of statin and FXR agonists; compositions and method of uses
CN106957307B (zh) *	2017-03-27	2019-06-28	淮阴工学院	一种丹曲林钠衍生物及其制备方法

1995
- 1995-05-01 GB GBGB9508823.3A patent/GB9508823D0/en active Pending
1996
- 1996-01-05 UA UA97115654A patent/UA61884C2/uk unknown
- 1996-04-26 ZA ZA963360A patent/ZA963360B/xx unknown
- 1996-04-29 ZA ZA963397A patent/ZA963397B/xx unknown
- 1996-04-30 ZA ZA963433A patent/ZA963433B/xx unknown
- 1996-05-01 CN CNB961950625A patent/CN100391930C/zh not_active Expired - Fee Related
- 1996-05-02 JO JO19961930A patent/JO1930B1/ar active

Also Published As

Publication number	Publication date
CN1189148A (zh)	1998-07-29
ZA963397B (en)	1996-08-07
ZA963360B (en)	1996-08-20
GB9508823D0 (en)	1995-06-21
CN100391930C (zh)	2008-06-04
ZA963433B (en)	1996-08-07
JO1930B1 (ar)	1997-01-15

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US6555700B1 (en)	2003-04-29	1,3-propane diol esters and ethers and methods for their use in drug delivery
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US5149695A (en)	1992-09-22	Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
WO1998018751A1 (en)	1998-05-07	Presentation of bioactives
JP5552314B2 (ja)	2014-07-16	新規脂質化合物
UA61884C2 (en)	2003-12-15	1,3-propane diol derivatives as biologically active compounds
JPH06234644A (ja)	1994-08-23	不飽和脂肪酸のエステルおよび該エステルを含有する組成物
AP874A (en)	2000-09-13	Iodinated fatty acid esters, iodinated fatty acids and derivatives thereof, produced by iodohydrination using alkysilylated derivatives and alkaline iodides, and pharmacological activities thereof.
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JPH107556A (ja)	1998-01-13	細胞接着抑制剤