UA66840C2 - 6,9-дизаміщені 2-[транс-(4-аміноциклогексил)аміно]пурини, фармацевтична композиція та способи лікування проліферативного розладу, попередження апоптозу нервових клітин, захисту нервових клітин від руйнування - Google Patents

6,9-дизаміщені 2-[транс-(4-аміноциклогексил)аміно]пурини, фармацевтична композиція та способи лікування проліферативного розладу, попередження апоптозу нервових клітин, захисту нервових клітин від руйнування

Info

Publication number: UA66840C2
Authority: UA; Ukraine
Prior art keywords: formula; inhibiting; admixture; association; pharmaceutically acceptable
Prior art date: 1998-02-26

Application number

UA2000095501A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Дженніфєр А. Дюмон

Алан Дж. Бітонті

Алан Дж. Битонти

Девід Р. Борчердінг

Нортон П. Піт

Х. Ренделл Мансон

Патрік В.К. Шам

Original Assignee

Авентіс Фармасьютікалз Інк.

Авентис Фармасьютикалз Инк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

1999-02-18

Publication date

2004-06-15

1999-02-18 Application filed by Авентіс Фармасьютікалз Інк., Авентис Фармасьютикалз Инк. filed Critical Авентіс Фармасьютікалз Інк.

1999-02-18 Priority claimed from PCT/US1999/003450 external-priority patent/WO1999043675A1/en

2004-06-15 Publication of UA66840C2 publication Critical patent/UA66840C2/uk

Links

-1 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines Chemical class 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
108091007914 CDKs Proteins 0.000 abstract 1
101100439046 Caenorhabditis elegans cdk-2 gene Proteins 0.000 abstract 1
102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 1
108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
230000006369 cell cycle progression Effects 0.000 abstract 1
125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
210000002569 neuron Anatomy 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UA2000095501A 1998-02-26 1999-02-18 6,9-дизаміщені 2-[транс-(4-аміноциклогексил)аміно]пурини, фармацевтична композиція та способи лікування проліферативного розладу, попередження апоптозу нервових клітин, захисту нервових клітин від руйнування UA66840C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3097598A	1998-02-26	1998-02-26
PCT/US1999/003450 WO1999043675A1 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (1)

Publication Number	Publication Date
UA66840C2 true UA66840C2 (uk)	2004-06-15

Family

ID=21856977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000095501A UA66840C2 (uk)	1998-02-26	1999-02-18	6,9-дизаміщені 2-[транс-(4-аміноциклогексил)аміно]пурини, фармацевтична композиція та способи лікування проліферативного розладу, попередження апоптозу нервових клітин, захисту нервових клітин від руйнування

Country Status (13)

Country	Link
KR (1)	KR100568657B1 (de)
AR (1)	AR018121A1 (de)
AT (1)	ATE252583T1 (de)
DE (1)	DE69912248T2 (de)
DK (1)	DK1056744T3 (de)
ES (1)	ES2207182T3 (de)
ID (1)	ID25444A (de)
NZ (1)	NZ506235A (de)
OA (1)	OA11455A (de)
PT (1)	PT1056744E (de)
RU (1)	RU2200162C2 (de)
TW (1)	TWI225060B (de)
UA (1)	UA66840C2 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4232155A (en) *	1979-09-13	1980-11-04	Bristol-Myers Company	Purine compounds
AU7296896A (en) *	1995-11-01	1997-05-22	Novartis Ag	Purine derivatives and processes for their preparation
FR2741881B1 (fr) *	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

1999
- 1999-02-18 UA UA2000095501A patent/UA66840C2/uk unknown
- 1999-02-18 PT PT99908220T patent/PT1056744E/pt unknown
- 1999-02-18 AT AT99908220T patent/ATE252583T1/de active
- 1999-02-18 KR KR1020007009424A patent/KR100568657B1/ko not_active Expired - Fee Related
- 1999-02-18 DK DK99908220T patent/DK1056744T3/da active
- 1999-02-18 DE DE69912248T patent/DE69912248T2/de not_active Expired - Lifetime
- 1999-02-18 ES ES99908220T patent/ES2207182T3/es not_active Expired - Lifetime
- 1999-02-18 NZ NZ506235A patent/NZ506235A/xx active IP Right Revival
- 1999-02-18 ID IDW20001617A patent/ID25444A/id unknown
- 1999-02-18 RU RU2000124410/04A patent/RU2200162C2/ru not_active IP Right Cessation
- 1999-02-24 TW TW088102764A patent/TWI225060B/zh not_active IP Right Cessation
- 1999-02-25 AR ARP990100781A patent/AR018121A1/es active IP Right Grant
2000
- 2000-08-25 OA OA1200000233A patent/OA11455A/en unknown

Also Published As

Publication number	Publication date
NZ506235A (en)	2003-02-28
ES2207182T3 (es)	2004-05-16
PT1056744E (pt)	2004-03-31
OA11455A (en)	2003-12-05
TWI225060B (en)	2004-12-11
AR018121A1 (es)	2001-10-31
ID25444A (id)	2000-10-05
DE69912248T2 (de)	2004-04-22
DE69912248D1 (de)	2003-11-27
HK1030949A1 (en)	2001-05-25
ATE252583T1 (de)	2003-11-15
KR100568657B1 (ko)	2006-04-07
DK1056744T3 (da)	2004-02-23
KR20010041318A (ko)	2001-05-15
RU2200162C2 (ru)	2003-03-10

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UA66840C2 (uk)	2004-06-15	6,9-дизаміщені 2-[транс-(4-аміноциклогексил)аміно]пурини, фармацевтична композиція та способи лікування проліферативного розладу, попередження апоптозу нервових клітин, захисту нервових клітин від руйнування
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