UA68324C2 - Dimers of "cloverleaf" peptide (variants), method for their production (variants) and pharmaceutical composition (variants) - Google Patents

Dimers of "cloverleaf" peptide (variants), method for their production (variants) and pharmaceutical composition (variants) Download PDF

Info

Publication number
UA68324C2
UA68324C2 UA97020840A UA97020840A UA68324C2 UA 68324 C2 UA68324 C2 UA 68324C2 UA 97020840 A UA97020840 A UA 97020840A UA 97020840 A UA97020840 A UA 97020840A UA 68324 C2 UA68324 C2 UA 68324C2
Authority
UA
Ukraine
Prior art keywords
peptide
clover
fact
monomers
ite
Prior art date
Application number
UA97020840A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of UA68324C2 publication Critical patent/UA68324C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
UA97020840A 1994-08-26 1995-08-25 Dimers of "cloverleaf" peptide (variants), method for their production (variants) and pharmaceutical composition (variants) UA68324C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK98394 1994-08-26
PCT/DK1995/000343 WO1996006861A1 (en) 1994-08-26 1995-08-25 Trefoil peptide dimer

Publications (1)

Publication Number Publication Date
UA68324C2 true UA68324C2 (en) 2004-08-16

Family

ID=8099704

Family Applications (1)

Application Number Title Priority Date Filing Date
UA97020840A UA68324C2 (en) 1994-08-26 1995-08-25 Dimers of "cloverleaf" peptide (variants), method for their production (variants) and pharmaceutical composition (variants)

Country Status (21)

Country Link
EP (2) EP0777687B1 (pl)
JP (3) JPH10504720A (pl)
KR (1) KR100255911B1 (pl)
CN (1) CN1070867C (pl)
AT (1) ATE329929T1 (pl)
AU (1) AU694796B2 (pl)
BR (1) BR9508773A (pl)
CA (1) CA2196876C (pl)
CZ (2) CZ289705B6 (pl)
DE (1) DE69535060T2 (pl)
DK (1) DK0777687T3 (pl)
ES (1) ES2267104T3 (pl)
FI (1) FI119989B (pl)
HU (1) HU226921B1 (pl)
MX (1) MX9701239A (pl)
NO (1) NO323642B1 (pl)
PL (1) PL184516B1 (pl)
PT (1) PT777687E (pl)
RU (1) RU2162857C2 (pl)
UA (1) UA68324C2 (pl)
WO (1) WO1996006861A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221840B1 (en) * 1991-02-14 2001-04-24 The General Hospital Corporation Intestinal trefoil proteins
US6063755A (en) 1991-02-14 2000-05-16 The General Hospital Corporation Intestinal trefoil proteins
US6337195B1 (en) 1995-06-06 2002-01-08 Human Genome Sciences, Inc. Colon specific genes and proteins
US6525018B1 (en) 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
WO1999010377A1 (en) 1997-08-25 1999-03-04 The General Hospital Corporation Receptor for intestinal trefoil factor
EP1292675A2 (en) * 2000-05-26 2003-03-19 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating colon cancer
EP1341817A2 (en) * 2000-12-08 2003-09-10 Novo Nordisk A/S Tff peptides
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
EP1842858A3 (en) * 2001-04-24 2008-04-02 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
MXPA03009772A (es) * 2001-04-24 2004-02-23 Gen Hospital Corp Metodos y composiciones para tratar lesiones orales y del esofago.
EP1401481A1 (en) * 2001-06-14 2004-03-31 Novo Nordisk A/S Mucosal repair by tff dimer peptides
RU2224797C2 (ru) * 2002-04-04 2004-02-27 Эльдаров Михаил Анатольевич Рекомбинантная плазмидная днк pacyclans для переноса и экспрессии в клетках escherichia coli гена l-аспарагиназы erwinia carotovora (ecar-lans) и способ получения рекомбинантной ecar-lans из биомассы штамма e.coli-продуцента
WO2003068817A1 (en) * 2002-02-11 2003-08-21 Novo Nordisk A/S Management of mucosal viscosity by tff monomer peptides
AU2003224773B2 (en) * 2002-03-26 2010-08-26 The General Hospital Corporation Combination therapy using trefoil peptides
ES2642214T3 (es) 2004-01-21 2017-11-15 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
CN103096917A (zh) 2010-06-04 2013-05-08 三叶草私人有限公司 用于治疗慢性肺病的三叶因子(tff)
CN102526702A (zh) * 2010-12-23 2012-07-04 中国医学科学院基础医学研究所 小肽tff3治疗代谢综合征的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO884054D0 (no) * 1988-09-13 1988-09-13 Bio Tech As Nytt pentapeptid og fremgangsmaate for fremstilling derav.
DE69232619T2 (de) * 1991-02-14 2002-09-12 The General Hospital Corp., Charlestown Intestinale kleeblatt-proteine

Also Published As

Publication number Publication date
EP0777687B1 (en) 2006-06-14
DE69535060D1 (de) 2006-07-27
NO970844D0 (no) 1997-02-25
CA2196876C (en) 2007-04-17
KR100255911B1 (ko) 2000-05-01
FI119989B (fi) 2009-05-29
JP2007161720A (ja) 2007-06-28
BR9508773A (pt) 1997-12-30
AU694796B2 (en) 1998-07-30
DK0777687T3 (da) 2006-10-16
HUT77917A (hu) 1998-10-28
PL184516B1 (pl) 2002-11-29
CN1070867C (zh) 2001-09-12
CZ289864B6 (cs) 2002-04-17
JP4156829B2 (ja) 2008-09-24
CZ289705B6 (cs) 2002-03-13
CZ54897A3 (en) 1997-08-13
NO970844L (no) 1997-04-28
EP1739091A1 (en) 2007-01-03
JPH10504720A (ja) 1998-05-12
FI970783A0 (fi) 1997-02-25
AU3341595A (en) 1996-03-22
ATE329929T1 (de) 2006-07-15
CA2196876A1 (en) 1996-03-07
WO1996006861A1 (en) 1996-03-07
JP2002191385A (ja) 2002-07-09
HU226921B1 (en) 2010-03-01
NO323642B1 (no) 2007-06-18
PL318785A1 (en) 1997-07-07
EP0777687A1 (en) 1997-06-11
DE69535060T2 (de) 2006-12-28
CN1156459A (zh) 1997-08-06
FI970783L (fi) 1997-02-25
PT777687E (pt) 2006-10-31
ES2267104T3 (es) 2007-03-01
RU2162857C2 (ru) 2001-02-10
MX9701239A (es) 1997-05-31

Similar Documents

Publication Publication Date Title
UA68324C2 (en) Dimers of "cloverleaf" peptide (variants), method for their production (variants) and pharmaceutical composition (variants)
EP0293357B1 (fr) Expression de la proapolipoprotéine A-I humaine
UA70283C2 (en) Peptide (variants), a pharmaceutical composition cpeptide (variants), a pharmaceutical composition composed of peptide and a method for the preparatioomposed of peptide and a method for the preparation thereof (variants) n thereof (variants)
FI87800C (fi) Foerfarande foer framstaellning av glukagon i jaest
KR20150008870A (ko) 락토페린 융합 단백질 및 그의 제조방법
WO2023227133A1 (zh) 人胰淀素类似物、其衍生物及用途
CN113150172A (zh) Glp-1r/gipr双靶点激动剂融合蛋白及其制备方法与应用
EP0362259B1 (en) Method of producing cystatin c or modifications hereof and dna-sequence for use when carrying out the method
Li et al. Optimized functional and structural design of dual-target LMRAP, a bifunctional fusion protein with a 25-amino-acid antitumor peptide and GnRH Fc fragment
CN104693300B (zh) 改良型聚乙二醇化重组人干扰素α2b
US10179802B2 (en) Conotoxin peptide κ-CPTX-BTL04, preparation method therefor, and uses thereof
US11980671B2 (en) Use of bacterial voltage gated ion channels for human therapies
CN106146667B (zh) 一种Exendin-4融合蛋白及其制备方法与用途
US10246490B2 (en) Conotoxin peptide κ-CPTX-BTL02, preparation method therefor, and uses thereof
KR20180114684A (ko) 신규한 Stx2e 에피토프 단백질 및 이를 포함하는 백신 조성물
JP5019442B2 (ja) 心筋の収縮を抑制するグラモストラ・スパチュラタ由来のポリペプチドおよびその遺伝子。
US20180162909A1 (en) Conotoxin peptide k-cptx-btl03, preparation method therefor, and uses thereof
EP4606898A1 (en) Cell surface large-display technology using extracellular membrane lipoprotein prsa display system
EP3738978A1 (en) In-vivo release sustained recombinant coagulation factor viii and preparation method therefor
JP2002534960A (ja) ワクチン
KR970009354B1 (ko) 모티린형 폴리펩티드 및 그 용도
CN111094357A (zh) 一类新的Bcl10聚合抑制剂及其应用
CN119431515A (zh) 一种穿膜蛋白及其应用
EP1602726A2 (en) Human tachykinin-related splice variants and compositions thereof
KR101752775B1 (ko) 단백질의 재설계를 위한 허용 위치 선별 및 이를 이용한 변형된 단백질의 제조 방법