UA68388C2 - Substituted indole derivatives, pharmaceutical composition and method of synthesis (variants) - Google Patents

Substituted indole derivatives, pharmaceutical composition and method of synthesis (variants) Download PDF

Info

Publication number
UA68388C2
UA68388C2 UA2001021382A UA2001021382A UA68388C2 UA 68388 C2 UA68388 C2 UA 68388C2 UA 2001021382 A UA2001021382 A UA 2001021382A UA 2001021382 A UA2001021382 A UA 2001021382A UA 68388 C2 UA68388 C2 UA 68388C2
Authority
UA
Ukraine
Prior art keywords
general formula
hexahydro
trans
methyl
hydroxy
Prior art date
Application number
UA2001021382A
Other languages
English (en)
Ukrainian (uk)
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of UA68388C2 publication Critical patent/UA68388C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA2001021382A 1998-07-31 1999-07-22 Substituted indole derivatives, pharmaceutical composition and method of synthesis (variants) UA68388C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19834714A DE19834714A1 (de) 1998-07-31 1998-07-31 Neue 2,3,3a,4,9,9a-Hexahydro-8-hydroxy-1H-ben[f]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/005222 WO2000007986A1 (de) 1998-07-31 1999-07-22 Neue 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1h-benz[f]indole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
UA68388C2 true UA68388C2 (en) 2004-08-16

Family

ID=7876092

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001021382A UA68388C2 (en) 1998-07-31 1999-07-22 Substituted indole derivatives, pharmaceutical composition and method of synthesis (variants)

Country Status (29)

Country Link
US (1) US6051583A (id)
EP (1) EP1100780B1 (id)
JP (1) JP2002522418A (id)
KR (1) KR20010072142A (id)
CN (1) CN1147470C (id)
AT (1) ATE360611T1 (id)
AU (1) AU763834B2 (id)
BG (1) BG105178A (id)
BR (1) BR9912605A (id)
CA (1) CA2336783C (id)
CO (1) CO5080748A1 (id)
DE (2) DE19834714A1 (id)
EA (1) EA003370B1 (id)
EE (1) EE200100062A (id)
ES (1) ES2285851T3 (id)
HU (1) HUP0103518A3 (id)
ID (1) ID28292A (id)
IL (1) IL140863A0 (id)
MY (1) MY133085A (id)
NO (1) NO20010513L (id)
NZ (1) NZ510246A (id)
PL (1) PL345808A1 (id)
SK (1) SK1502001A3 (id)
TR (1) TR200100316T2 (id)
TW (1) TW464643B (id)
UA (1) UA68388C2 (id)
WO (1) WO2000007986A1 (id)
YU (1) YU5501A (id)
ZA (1) ZA200007770B (id)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0002666D0 (en) * 2000-02-04 2000-03-29 Univ London Blockade of voltage dependent sodium channels
EP1458386B1 (en) * 2001-12-27 2007-04-18 Ortho-McNeil Pharmaceutical, Inc. Aroyl pyrrole heteroeryl and methanols useful for treating a central nervous system disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69030665T2 (de) * 1989-07-13 1997-10-02 Pharmacia & Upjohn Co., Kalamazoo, Mich. (1,2n) und (3,2n)-karbozyklische-2-amino-tetralinderivate
JPH06507906A (ja) * 1991-05-20 1994-09-08 ジ・アップジョン・カンパニー カルボキサミド−（３，２ｎ）−カルボサイクリック−２−アミノテトラリン誘導体
GB9612153D0 (en) * 1996-06-11 1996-08-14 Smithkline Beecham Plc Compounds

Also Published As

Publication number Publication date
AU5162699A (en) 2000-02-28
CN1310707A (zh) 2001-08-29
YU5501A (sh) 2003-04-30
HK1038017A1 (en) 2002-03-01
CO5080748A1 (es) 2001-09-25
HUP0103518A3 (en) 2002-12-28
BG105178A (bg) 2001-12-29
NZ510246A (en) 2003-08-29
ES2285851T3 (es) 2007-11-16
BR9912605A (pt) 2001-05-02
US6051583A (en) 2000-04-18
CA2336783C (en) 2009-04-28
ID28292A (id) 2001-05-10
IL140863A0 (en) 2002-02-10
DE19834714A1 (de) 2000-02-03
MY133085A (en) 2007-10-31
HUP0103518A2 (hu) 2002-01-28
AU763834B2 (en) 2003-07-31
EP1100780A1 (de) 2001-05-23
TW464643B (en) 2001-11-21
WO2000007986A1 (de) 2000-02-17
ZA200007770B (en) 2002-01-17
ATE360611T1 (de) 2007-05-15
PL345808A1 (en) 2002-01-02
EA003370B1 (ru) 2003-04-24
JP2002522418A (ja) 2002-07-23
EP1100780B1 (de) 2007-04-25
TR200100316T2 (tr) 2001-07-23
NO20010513D0 (no) 2001-01-30
CA2336783A1 (en) 2000-02-17
DE59914314D1 (de) 2007-06-06
KR20010072142A (ko) 2001-07-31
CN1147470C (zh) 2004-04-28
EE200100062A (et) 2002-06-17
EA200100107A1 (ru) 2001-08-27
NO20010513L (no) 2001-01-30
SK1502001A3 (en) 2001-09-11

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