UA70961C2 - Трициклические d3-пиперидины, композиция на их основе и способ их получения (варианты) - Google Patents

Трициклические d3-пиперидины, композиция на их основе и способ их получения (варианты)

Info

Publication number
UA70961C2
UA70961C2 UA2001032000A UA01032000A UA70961C2 UA 70961 C2 UA70961 C2 UA 70961C2 UA 2001032000 A UA2001032000 A UA 2001032000A UA 01032000 A UA01032000 A UA 01032000A UA 70961 C2 UA70961 C2 UA 70961C2
Authority
UA
Ukraine
Prior art keywords
preparation
piperidines
tricyclic
variants
composition based
Prior art date
Application number
UA2001032000A
Other languages
English (en)
Ukrainian (uk)
Inventor
Людо Едмон Жозефін Кенніс
Людо Эдмон Жозефин Кеннис
Жозефус Каролус МЕРТЕНС
Міреї Брекен
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of UA70961C2 publication Critical patent/UA70961C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение касается соединений общей формулы (І), их N-оксидных форм, фармацевтически приемлемых аддитивных солей и стереохимически изомерных форм, где Alk представляет собой С1-6алкандиил; n представляет собой 1 или 2; Х представляет собой -О-, -S-, -S(=O)- или -S(=O)2-; каждый R1 независимо представляет собой водород, галоген, С1-4алкилокси, нитро, гидрокси или С1-4алкилокси; D представляет собой индол, бензизоксазол, бензизотиазол, 2Н-бензопиранон, феноксифенил, бензамид, бензофенон или бензопиримидинон, которые имеют антагонистическую активность по отношению к центральному -адреноцептору. Также изобретение относится к их препаратам, фармацевтическому применению и композициям.
UA2001032000A 1998-10-06 1999-10-01 Трициклические d3-пиперидины, композиция на их основе и способ их получения (варианты) UA70961C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98203371 1998-10-06
PCT/EP1999/007420 WO2000020423A1 (en) 1998-10-06 1999-10-01 Tricyclic δ3-piperidines as pharmaceuticals

Publications (1)

Publication Number Publication Date
UA70961C2 true UA70961C2 (ru) 2004-11-15

Family

ID=8234192

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001032000A UA70961C2 (ru) 1998-10-06 1999-10-01 Трициклические d3-пиперидины, композиция на их основе и способ их получения (варианты)

Country Status (27)

Country Link
US (1) US6352999B1 (ru)
EP (1) EP1119570B1 (ru)
JP (1) JP4590102B2 (ru)
KR (1) KR20010071844A (ru)
CN (1) CN1131868C (ru)
AR (1) AR023679A1 (ru)
AT (1) ATE269337T1 (ru)
AU (1) AU759199B2 (ru)
BG (1) BG64871B1 (ru)
BR (1) BR9913108A (ru)
CA (1) CA2346082C (ru)
CZ (1) CZ20011105A3 (ru)
DE (1) DE69918148T2 (ru)
EE (1) EE04680B1 (ru)
ES (1) ES2222735T3 (ru)
HU (1) HUP0103749A3 (ru)
ID (1) ID28451A (ru)
IL (2) IL142444A0 (ru)
NO (1) NO20011402D0 (ru)
NZ (1) NZ510116A (ru)
PL (1) PL347179A1 (ru)
RU (1) RU2226194C2 (ru)
SK (1) SK285386B6 (ru)
TR (1) TR200100953T2 (ru)
TW (1) TWI244485B (ru)
UA (1) UA70961C2 (ru)
WO (1) WO2000020423A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA69420C2 (ru) * 1998-10-06 2004-09-15 Янссен Фармацевтика Н.В. ТРИЦИКЛИЧЕСКИЕ D3-ПИПЕРИДИНЫ КАК a<sub>2-АНТАГОНИСТЫ
EP1404679A2 (en) * 2001-07-05 2004-04-07 PHARMACIA &amp; UPJOHN COMPANY (hetero)aryl substituted benzofurans as 5-ht ligands
ATE521593T1 (de) * 2002-04-03 2011-09-15 Orion Corp Verwendung eines alfa2-adrenorezeptorantagonisten bei mit dem zns zusammenhängenden erkrankungen
WO2005100355A1 (ja) 2004-04-12 2005-10-27 Taisho Pharmaceutical Co., Ltd. 環状アミン化合物
JP2008530229A (ja) 2005-02-17 2008-08-07 ワイス シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
ES2897946T3 (es) * 2013-07-25 2022-03-03 Dong A St Co Ltd Método para preparar un derivado de benzamida, intermedio novedoso utilizado en la preparación de la benzamida y método para preparar un intermedio novedoso
CN103755715B (zh) * 2013-12-26 2015-12-09 武汉理工大学 苯并呋喃并[2,3-c]吡啶化合物及其合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU926914A1 (ru) * 1980-05-26 1992-04-23 Научно-исследовательский институт фармакологии АМН СССР Производные 1,2,3,4-тетрагидробензофуро[3,2-с]-пиридина или хлоргидрат, обладающие р дом свойств анальгетиков и антагонистов морфина
DE3522959A1 (de) * 1985-06-27 1987-01-08 Merck Patent Gmbh Indolderivate
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
US4971974A (en) * 1988-06-16 1990-11-20 Neurex Corporation Benzothiophenes as appetite suppressants
US5100891A (en) * 1991-01-18 1992-03-31 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
AU735764B2 (en) * 1996-12-06 2001-07-12 Abbott Laboratories Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic compounds
UA52681C2 (ru) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Производные 1,2,3,4-тетрагидро-бензофуро [3,2,-c] пиридина
UA69420C2 (ru) * 1998-10-06 2004-09-15 Янссен Фармацевтика Н.В. ТРИЦИКЛИЧЕСКИЕ D3-ПИПЕРИДИНЫ КАК a<sub>2-АНТАГОНИСТЫ

Also Published As

Publication number Publication date
WO2000020423A1 (en) 2000-04-13
IL142444A (en) 2008-03-20
HUP0103749A2 (hu) 2002-02-28
NO20011402L (no) 2001-03-20
DE69918148D1 (de) 2004-07-22
CN1321158A (zh) 2001-11-07
SK285386B6 (sk) 2006-12-07
BG105334A (bg) 2001-11-30
EE200100210A (et) 2002-06-17
HK1038009A1 (en) 2002-03-01
AU759199B2 (en) 2003-04-10
ATE269337T1 (de) 2004-07-15
ID28451A (id) 2001-05-24
CA2346082A1 (en) 2000-04-13
NZ510116A (en) 2002-10-25
JP2002526547A (ja) 2002-08-20
BR9913108A (pt) 2001-05-08
CN1131868C (zh) 2003-12-24
SK4332001A3 (en) 2001-12-03
JP4590102B2 (ja) 2010-12-01
HUP0103749A3 (en) 2003-03-28
TR200100953T2 (tr) 2001-09-21
ES2222735T3 (es) 2005-02-01
EP1119570B1 (en) 2004-06-16
TWI244485B (en) 2005-12-01
DE69918148T2 (de) 2005-07-28
RU2226194C2 (ru) 2004-03-27
PL347179A1 (en) 2002-03-25
AR023679A1 (es) 2002-09-04
US6352999B1 (en) 2002-03-05
BG64871B1 (bg) 2006-07-31
EP1119570A1 (en) 2001-08-01
EE04680B1 (et) 2006-08-15
AU6334299A (en) 2000-04-26
KR20010071844A (ko) 2001-07-31
CA2346082C (en) 2010-02-16
CZ20011105A3 (cs) 2001-12-12
NO20011402D0 (no) 2001-03-20
IL142444A0 (en) 2002-03-10

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