UA72460C2 - A process for the preparation of polymer- bound cyclic peptides - Google Patents

A process for the preparation of polymer- bound cyclic peptides Download PDF

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Publication number: UA72460C2
Authority: UA; Ukraine
Prior art keywords: peptide; amino acid; avr; polymer; azr
Prior art date: 1998-04-15

Application number

UA2000116453A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Aventic Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

1999-04-15

Publication date

2005-03-15

1999-04-15 Application filed by Aventic Pharmaceuticals Inc filed Critical Aventic Pharmaceuticals Inc

2005-03-15 Publication of UA72460C2 publication Critical patent/UA72460C2/uk

Links

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125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
102000005162 pleiotrophin Human genes 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
201000009395 primary hyperaldosteronism Diseases 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
IVRIRQXJSNCSPQ-UHFFFAOYSA-N propan-2-yl carbonochloridate Chemical compound CC(C)OC(Cl)=O IVRIRQXJSNCSPQ-UHFFFAOYSA-N 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
239000012264 purified product Substances 0.000 description 1
238000011002 quantification Methods 0.000 description 1
230000006340 racemization Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
206010038464 renal hypertension Diseases 0.000 description 1
108010004093 retinal S antigen peptide M Proteins 0.000 description 1
229940043230 sarcosine Drugs 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical class C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
LZTRCELOJRDYMQ-UHFFFAOYSA-N triphenylmethanol Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(O)C1=CC=CC=C1 LZTRCELOJRDYMQ-UHFFFAOYSA-N 0.000 description 1
JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
238000000825 ultraviolet detection Methods 0.000 description 1
229940005605 valeric acid Drugs 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

UA2000116453A 1998-04-15 1999-04-15 A process for the preparation of polymer- bound cyclic peptides UA72460C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8189798P	1998-04-15	1998-04-15
PCT/US1999/008435 WO1999052933A1 (en)	1998-04-15	1999-04-15	Process for the preparation of resin-bound cyclic peptides

Publications (1)

Publication Number	Publication Date
UA72460C2 true UA72460C2 (en)	2005-03-15

Family

ID=22167111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000116453A UA72460C2 (en)	1998-04-15	1999-04-15	A process for the preparation of polymer- bound cyclic peptides

Country Status (20)

Country	Link
US (1)	US6569993B1 (cs)
EP (1)	EP1093458A4 (cs)
JP (1)	JP2002511483A (cs)
KR (1)	KR20010085236A (cs)
CN (2)	CN1163504C (cs)
AP (1)	AP1117A (cs)
AU (1)	AU744812B2 (cs)
BG (1)	BG104903A (cs)
BR (1)	BR9909634A (cs)
CA (1)	CA2325572A1 (cs)
CZ (1)	CZ20003798A3 (cs)
EA (1)	EA200001071A1 (cs)
HU (1)	HUP0101629A2 (cs)
IL (1)	IL138338A0 (cs)
NO (1)	NO20005165L (cs)
OA (1)	OA11501A (cs)
PL (1)	PL347103A1 (cs)
SK (1)	SK15352000A3 (cs)
UA (1)	UA72460C2 (cs)
WO (1)	WO1999052933A1 (cs)

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JP2012503025A (ja)	2008-09-22	2012-02-02	エルロン・セラピューティクス・インコーポレイテッド	精製されたポリペプチド組成物を調製するための方法
JP2012515172A (ja)	2009-01-14	2012-07-05	エルロン・セラピューティクス・インコーポレイテッド	ペプチド模倣大環状分子
WO2011038049A1 (en)	2009-09-22	2011-03-31	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
KR20130099938A (ko)	2010-08-13	2013-09-06	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
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NZ627528A (en)	2012-02-15	2016-05-27	Aileron Therapeutics Inc	Peptidomimetic macrocycles
SG11201503052RA (en)	2012-11-01	2015-05-28	Aileron Therapeutics Inc	Disubstituted amino acids and methods of preparation and use thereof
MX389354B (es)	2014-09-24	2025-03-20	Aileron Therapeutics Inc	Macrociclos peptidomimeticos y formulaciones de los mismos.
MX2017003797A (es)	2014-09-24	2017-06-15	Aileron Therapeutics Inc	Macrociclos peptidomimeticos y usos de los mismos.
WO2016154058A1 (en)	2015-03-20	2016-09-29	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
CN106146648B (zh) *	2015-03-26	2020-06-12	深圳翰宇药业股份有限公司	一种甲状旁腺激素类似物的合成方法
WO2017004548A1 (en)	2015-07-01	2017-01-05	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
JP2018528217A (ja)	2015-09-10	2018-09-27	エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
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1999
- 1999-04-15 SK SK1535-2000A patent/SK15352000A3/sk unknown
- 1999-04-15 HU HU0101629A patent/HUP0101629A2/hu unknown
- 1999-04-15 BR BR9909634-0A patent/BR9909634A/pt not_active IP Right Cessation
- 1999-04-15 AU AU35679/99A patent/AU744812B2/en not_active Ceased
- 1999-04-15 IL IL13833899A patent/IL138338A0/xx unknown
- 1999-04-15 AP APAP/P/2000/001972A patent/AP1117A/en active
- 1999-04-15 PL PL99347103A patent/PL347103A1/xx not_active Application Discontinuation
- 1999-04-15 CN CNB998119709A patent/CN1163504C/zh not_active Expired - Fee Related
- 1999-04-15 CN CNA2004100386677A patent/CN1552737A/zh active Pending
- 1999-04-15 WO PCT/US1999/008435 patent/WO1999052933A1/en not_active Ceased
- 1999-04-15 EA EA200001071A patent/EA200001071A1/ru unknown
- 1999-04-15 KR KR1020007011446A patent/KR20010085236A/ko not_active Ceased
- 1999-04-15 UA UA2000116453A patent/UA72460C2/uk unknown
- 1999-04-15 JP JP2000543489A patent/JP2002511483A/ja active Pending
- 1999-04-15 CA CA002325572A patent/CA2325572A1/en not_active Abandoned
- 1999-04-15 CZ CZ20003798A patent/CZ20003798A3/cs unknown
- 1999-04-15 EP EP99917595A patent/EP1093458A4/en not_active Withdrawn
- 1999-11-18 US US09/442,989 patent/US6569993B1/en not_active Expired - Fee Related
2000
- 2000-10-13 NO NO20005165A patent/NO20005165L/no not_active Application Discontinuation
- 2000-10-13 OA OA1200000283A patent/OA11501A/en unknown
- 2000-11-02 BG BG104903A patent/BG104903A/bg unknown

Also Published As

Publication number	Publication date
CN1552737A (zh)	2004-12-08
CA2325572A1 (en)	1999-10-21
BG104903A (bg)	2001-07-31
CZ20003798A3 (cs)	2001-08-15
HUP0101629A2 (en)	2003-03-28
KR20010085236A (ko)	2001-09-07
AU3567999A (en)	1999-11-01
OA11501A (en)	2004-05-14
AP1117A (en)	2002-11-02
AU744812B2 (en)	2002-03-07
NO20005165D0 (no)	2000-10-13
EP1093458A1 (en)	2001-04-25
EA200001071A1 (ru)	2001-08-27
CN1163504C (zh)	2004-08-25
US6569993B1 (en)	2003-05-27
NO20005165L (no)	2000-12-15
IL138338A0 (en)	2001-10-31
AP2000001972A0 (en)	2000-12-31
JP2002511483A (ja)	2002-04-16
CN1323313A (zh)	2001-11-21
WO1999052933A1 (en)	1999-10-21
BR9909634A (pt)	2001-10-16
SK15352000A3 (sk)	2001-04-09
PL347103A1 (en)	2002-03-25
EP1093458A4 (en)	2001-07-18

Publication	Publication Date	Title
UA72460C2 (en)	2005-03-15	A process for the preparation of polymer- bound cyclic peptides
Beyermann et al.	1990	Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl) piperidine deblocking
US5767239A (en)	1998-06-16	Process for preparing cardiodilatin fragments; highly purified cardiodilatin fragments and intermediate products for the preparation of same
US4304715A (en)	1981-12-08	Enkephalin analogues
US4420424A (en)	1983-12-13	New peptides and a process for their preparation
EP0597997B1 (en)	1998-05-20	Lanthionine bridged peptides
US4198398A (en)	1980-04-15	Enkephalin analogues
US4439360A (en)	1984-03-27	Retro-inverso analogues of C-terminal penta and hexapeptides of Substance P
NO166532B (no)	1991-04-29	Fremgangsmaate for fremstilling av peptidet h-arg-x-z-y-tyr-r.
CH637111A5 (fr)	1983-07-15	Composes polypeptidiques a activite thymique ou antagoniste et leurs procedes de synthese.
EP0037516A1 (en)	1981-10-14	N-omega substituted derivatives of 1-Desamino-vasopressin analogs
US4465625A (en)	1984-08-14	Pentapeptides and process for their preparation
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US6268339B1 (en)	2001-07-31	Lanthionine bridged peptides
US20100216973A1 (en)	2010-08-26	Methods for the specific preparation of lysobactin fragments
JPH051798B2 (cs)	1993-01-11
US4474765A (en)	1984-10-02	Biologically active peptides
WO2003042163A1 (de)	2003-05-22	N-methyl-homocysteine und ihre verwendung sowie verfahren zu ihrer herstellung
GB2118190A (en)	1983-10-26	Peptides with sauvagine-like activity
IE66493B1 (en)	1996-01-10	Peptides which inhibit blood coagulation processes for the preparation thereof and the use thereof
JPH05336987A (ja)	1993-12-21	酵素的ペプチド合成
NO177100B (no)	1995-04-10	Peptider