SK15352000A3 - Spôsob výroby cyklických peptidov viazaných k polymérnemu nosiču - Google Patents

Spôsob výroby cyklických peptidov viazaných k polymérnemu nosiču Download PDF

Info

Publication number: SK15352000A3
Authority: SK; Slovakia
Prior art keywords: asp; lys; leu; val; amino acid
Prior art date: 1998-04-15

Application number

SK1535-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Adam W. Sledeski

James J. Mencel

Original Assignee

Aventis Pharmaceuticals Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

1999-04-15

Publication date

2001-04-09

1999-04-15 Application filed by Aventis Pharmaceuticals Products Inc. filed Critical Aventis Pharmaceuticals Products Inc.

2001-04-09 Publication of SK15352000A3 publication Critical patent/SK15352000A3/sk

Links

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238000003818 flash chromatography Methods 0.000 description 1
ZFKJVJIDPQDDFY-UHFFFAOYSA-N fluorescamine Chemical compound C12=CC=CC=C2C(=O)OC1(C1=O)OC=C1C1=CC=CC=C1 ZFKJVJIDPQDDFY-UHFFFAOYSA-N 0.000 description 1
229960003692 gamma aminobutyric acid Drugs 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
108010049041 glutamylalanine Proteins 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
230000035876 healing Effects 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
108010040030 histidinoalanine Proteins 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
102000058004 human PTH Human genes 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
229960002591 hydroxyproline Drugs 0.000 description 1
230000000148 hypercalcaemia Effects 0.000 description 1
208000030915 hypercalcemia disease Diseases 0.000 description 1
230000000705 hypocalcaemia Effects 0.000 description 1
125000001841 imino group Chemical group [H]N=* 0.000 description 1
229960003444 immunosuppressant agent Drugs 0.000 description 1
239000003018 immunosuppressive agent Substances 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
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238000005342 ion exchange Methods 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
238000002156 mixing Methods 0.000 description 1
125000002950 monocyclic group Chemical group 0.000 description 1
125000004370 n-butenyl group Chemical group [H]\C([H])=C(/[H])C([H])([H])C([H])([H])* 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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108020004707 nucleic acids Proteins 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
125000004365 octenyl group Chemical group C(=CCCCCCC)* 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
230000011164 ossification Effects 0.000 description 1
150000002941 palladium compounds Chemical class 0.000 description 1
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230000036961 partial effect Effects 0.000 description 1
238000004810 partition chromatography Methods 0.000 description 1
108010073025 phenylalanylphenylalanine Proteins 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
239000005373 porous glass Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
201000009395 primary hyperaldosteronism Diseases 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
IVRIRQXJSNCSPQ-UHFFFAOYSA-N propan-2-yl carbonochloridate Chemical compound CC(C)OC(Cl)=O IVRIRQXJSNCSPQ-UHFFFAOYSA-N 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000012264 purified product Substances 0.000 description 1
MHZSEPBBOTVGFW-UHFFFAOYSA-N pyrrolidin-1-ylphosphane Chemical compound PN1CCCC1 MHZSEPBBOTVGFW-UHFFFAOYSA-N 0.000 description 1
238000011002 quantification Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000012925 reference material Substances 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
229940043230 sarcosine Drugs 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical class C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 1
229910001488 sodium perchlorate Inorganic materials 0.000 description 1
239000012265 solid product Substances 0.000 description 1
239000006104 solid solution Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
241000894007 species Species 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
238000010998 test method Methods 0.000 description 1
UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
CWMFRHBXRUITQE-UHFFFAOYSA-N trimethylsilylacetylene Chemical compound C[Si](C)(C)C#C CWMFRHBXRUITQE-UHFFFAOYSA-N 0.000 description 1
JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
238000005303 weighing Methods 0.000 description 1
108010027345 wheylin-1 peptide Proteins 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

SK1535-2000A 1998-04-15 1999-04-15 Spôsob výroby cyklických peptidov viazaných k polymérnemu nosiču SK15352000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8189798P	1998-04-15	1998-04-15
PCT/US1999/008435 WO1999052933A1 (en)	1998-04-15	1999-04-15	Process for the preparation of resin-bound cyclic peptides

Publications (1)

Publication Number	Publication Date
SK15352000A3 true SK15352000A3 (sk)	2001-04-09

Family

ID=22167111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1535-2000A SK15352000A3 (sk)	1998-04-15	1999-04-15	Spôsob výroby cyklických peptidov viazaných k polymérnemu nosiču

Country Status (20)

Country	Link
US (1)	US6569993B1 (cs)
EP (1)	EP1093458A4 (cs)
JP (1)	JP2002511483A (cs)
KR (1)	KR20010085236A (cs)
CN (2)	CN1163504C (cs)
AP (1)	AP1117A (cs)
AU (1)	AU744812B2 (cs)
BG (1)	BG104903A (cs)
BR (1)	BR9909634A (cs)
CA (1)	CA2325572A1 (cs)
CZ (1)	CZ20003798A3 (cs)
EA (1)	EA200001071A1 (cs)
HU (1)	HUP0101629A2 (cs)
IL (1)	IL138338A0 (cs)
NO (1)	NO20005165L (cs)
OA (1)	OA11501A (cs)
PL (1)	PL347103A1 (cs)
SK (1)	SK15352000A3 (cs)
UA (1)	UA72460C2 (cs)
WO (1)	WO1999052933A1 (cs)

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US20040082783A1 (en) *	2002-08-06	2004-04-29	Schafmeister Christian E.	Bis (amino acid) molecular scaffolds
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BRPI0719885B8 (pt)	2006-10-13	2021-05-25	Lilly Co Eli	peptídeos peguilados como moduladores de receptores de pth, seus usos, e composição.
DK2118123T3 (en) *	2007-01-31	2016-01-25	Dana Farber Cancer Inst Inc	Stabilized p53 peptides and uses thereof
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US8592377B2 (en)	2007-03-28	2013-11-26	President And Fellows Of Harvard College	Stitched polypeptides
DE112009000300T5 (de)	2008-02-08	2011-01-20	Aileron Therapeutics, Inc., Cambridge	Therapeutische Peptidomimetische Makrocyclen
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CN102203126A (zh)	2008-09-22	2011-09-28	爱勒让治疗公司	用于制备纯化的多肽组合物的方法
US9175047B2 (en)	2009-01-14	2015-11-03	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
CN102712675A (zh)	2009-09-22	2012-10-03	爱勒让治疗公司	拟肽大环化合物
ES2711526T3 (es)	2010-08-13	2019-05-06	Aileron Therapeutics Inc	Macrociclos peptidomiméticos
TW201806968A (zh)	2011-10-18	2018-03-01	艾利倫治療公司	擬肽巨環化合物
EP2819688A4 (en)	2012-02-15	2015-10-28	Aileron Therapeutics Inc	TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt)	2012-02-15	2018-10-09	Aileron Therapeutics, Inc.	macrociclos peptidomiméticos
WO2014071241A1 (en)	2012-11-01	2014-05-08	Aileron Therapeutics, Inc.	Disubstituted amino acids and methods of preparation and use thereof
AU2015320545C1 (en)	2014-09-24	2020-05-14	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and formulations thereof
EP3197478A4 (en)	2014-09-24	2018-05-30	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
WO2016154058A1 (en)	2015-03-20	2016-09-29	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
CN106146648B (zh) *	2015-03-26	2020-06-12	深圳翰宇药业股份有限公司	一种甲状旁腺激素类似物的合成方法
US10059741B2 (en)	2015-07-01	2018-08-28	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
WO2017044633A1 (en)	2015-09-10	2017-03-16	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles as modulators of mcl-1
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1999
- 1999-04-15 CZ CZ20003798A patent/CZ20003798A3/cs unknown
- 1999-04-15 UA UA2000116453A patent/UA72460C2/uk unknown
- 1999-04-15 HU HU0101629A patent/HUP0101629A2/hu unknown
- 1999-04-15 AP APAP/P/2000/001972A patent/AP1117A/en active
- 1999-04-15 CN CNB998119709A patent/CN1163504C/zh not_active Expired - Fee Related
- 1999-04-15 EP EP99917595A patent/EP1093458A4/en not_active Withdrawn
- 1999-04-15 EA EA200001071A patent/EA200001071A1/ru unknown
- 1999-04-15 KR KR1020007011446A patent/KR20010085236A/ko not_active Ceased
- 1999-04-15 AU AU35679/99A patent/AU744812B2/en not_active Ceased
- 1999-04-15 JP JP2000543489A patent/JP2002511483A/ja active Pending
- 1999-04-15 BR BR9909634-0A patent/BR9909634A/pt not_active IP Right Cessation
- 1999-04-15 SK SK1535-2000A patent/SK15352000A3/sk unknown
- 1999-04-15 CN CNA2004100386677A patent/CN1552737A/zh active Pending
- 1999-04-15 WO PCT/US1999/008435 patent/WO1999052933A1/en not_active Ceased
- 1999-04-15 PL PL99347103A patent/PL347103A1/xx not_active Application Discontinuation
- 1999-04-15 CA CA002325572A patent/CA2325572A1/en not_active Abandoned
- 1999-04-15 IL IL13833899A patent/IL138338A0/xx unknown
- 1999-11-18 US US09/442,989 patent/US6569993B1/en not_active Expired - Fee Related
2000
- 2000-10-13 NO NO20005165A patent/NO20005165L/no not_active Application Discontinuation
- 2000-10-13 OA OA1200000283A patent/OA11501A/en unknown
- 2000-11-02 BG BG104903A patent/BG104903A/bg unknown

Also Published As

Publication number	Publication date
CN1552737A (zh)	2004-12-08
AU744812B2 (en)	2002-03-07
PL347103A1 (en)	2002-03-25
CA2325572A1 (en)	1999-10-21
HUP0101629A2 (en)	2003-03-28
CZ20003798A3 (cs)	2001-08-15
EP1093458A4 (en)	2001-07-18
CN1163504C (zh)	2004-08-25
US6569993B1 (en)	2003-05-27
BR9909634A (pt)	2001-10-16
JP2002511483A (ja)	2002-04-16
EP1093458A1 (en)	2001-04-25
AU3567999A (en)	1999-11-01
BG104903A (bg)	2001-07-31
IL138338A0 (en)	2001-10-31
OA11501A (en)	2004-05-14
UA72460C2 (en)	2005-03-15
NO20005165L (no)	2000-12-15
KR20010085236A (ko)	2001-09-07
EA200001071A1 (ru)	2001-08-27
NO20005165D0 (no)	2000-10-13
CN1323313A (zh)	2001-11-21
AP1117A (en)	2002-11-02
AP2000001972A0 (en)	2000-12-31
WO1999052933A1 (en)	1999-10-21

Publication	Publication Date	Title
SK15352000A3 (sk)	2001-04-09	Spôsob výroby cyklických peptidov viazaných k polymérnemu nosiču
US6472505B1 (en)	2002-10-29	Peptide parathyroid hormone analogs
JP2679786B2 (ja)	1997-11-19	非ペプチド結合を有するペプチド合成方法
JP2002533299A (ja)	2002-10-08	環状ペプチドの合成
JPH06504795A (ja)	1994-06-02	新規アミリン拮抗剤ペプチドおよびその使用
US5681928A (en)	1997-10-28	Betides and methods for screening peptides using same
EP0597997B1 (en)	1998-05-20	Lanthionine bridged peptides
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