UA75587C2 - Use of enoxaparin for treating cerebral ischemia - Google Patents
Use of enoxaparin for treating cerebral ischemia Download PDFInfo
- Publication number
- UA75587C2 UA75587C2 UA2002076399A UA2002076399A UA75587C2 UA 75587 C2 UA75587 C2 UA 75587C2 UA 2002076399 A UA2002076399 A UA 2002076399A UA 2002076399 A UA2002076399 A UA 2002076399A UA 75587 C2 UA75587 C2 UA 75587C2
- Authority
- UA
- Ukraine
- Prior art keywords
- enoxaparin
- cerebral ischemia
- rats
- study
- treatment
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 229960000610 enoxaparin Drugs 0.000 title claims abstract description 21
- 206010008118 cerebral infarction Diseases 0.000 title claims abstract description 11
- 201000006474 Brain Ischemia Diseases 0.000 title claims abstract description 10
- 206010008120 Cerebral ischaemia Diseases 0.000 title claims abstract description 10
- 229940126601 medicinal product Drugs 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000012876 topography Methods 0.000 claims 1
- 241000700159 Rattus Species 0.000 description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 239000000203 mixture Substances 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000009509 cortical damage Effects 0.000 description 4
- 208000028867 ischemia Diseases 0.000 description 4
- 230000000926 neurological effect Effects 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 210000001715 carotid artery Anatomy 0.000 description 3
- 210000003657 middle cerebral artery Anatomy 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 206010051055 Deep vein thrombosis Diseases 0.000 description 2
- 206010047249 Venous thrombosis Diseases 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 229940127215 low-molecular weight heparin Drugs 0.000 description 2
- 238000010984 neurological examination Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PKDBCJSWQUOKDO-UHFFFAOYSA-M 2,3,5-triphenyltetrazolium chloride Chemical compound [Cl-].C1=CC=CC=C1C(N=[N+]1C=2C=CC=CC=2)=NN1C1=CC=CC=C1 PKDBCJSWQUOKDO-UHFFFAOYSA-M 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- 208000001738 Nervous System Trauma Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000006931 brain damage Effects 0.000 description 1
- 231100000874 brain damage Toxicity 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 201000008247 brain infarction Diseases 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 210000001168 carotid artery common Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000007428 craniotomy Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000042 effect on ischemia Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 description 1
- 229960003132 halothane Drugs 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 230000037000 normothermia Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0000137A FR2803522B1 (fr) | 2000-01-06 | 2000-01-06 | Nouvelle application therapeutique de l'enoxaparine |
| PCT/FR2001/000014 WO2001049298A2 (fr) | 2000-01-06 | 2001-01-03 | Nouvelle application therapeutique de l"enoxaparine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA75587C2 true UA75587C2 (en) | 2006-05-15 |
Family
ID=8845669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002076399A UA75587C2 (en) | 2000-01-06 | 2001-03-01 | Use of enoxaparin for treating cerebral ischemia |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1248638B1 (pl) |
| JP (1) | JP2003519185A (pl) |
| KR (1) | KR20020069240A (pl) |
| CN (1) | CN1400905A (pl) |
| AR (1) | AR026804A1 (pl) |
| AT (1) | ATE344671T1 (pl) |
| AU (1) | AU784656B2 (pl) |
| BR (1) | BR0107442A (pl) |
| CA (1) | CA2396178A1 (pl) |
| CZ (1) | CZ20022303A3 (pl) |
| DE (1) | DE60124373T2 (pl) |
| DK (1) | DK1248638T3 (pl) |
| EA (1) | EA006035B1 (pl) |
| EE (1) | EE200200374A (pl) |
| ES (1) | ES2275648T3 (pl) |
| FR (1) | FR2803522B1 (pl) |
| HK (1) | HK1052649A1 (pl) |
| HR (1) | HRP20020573A2 (pl) |
| HU (1) | HUP0204040A3 (pl) |
| IL (1) | IL150477A0 (pl) |
| MX (1) | MXPA02006672A (pl) |
| NO (1) | NO20023243D0 (pl) |
| NZ (1) | NZ520283A (pl) |
| PL (1) | PL357192A1 (pl) |
| PT (1) | PT1248638E (pl) |
| SK (1) | SK9612002A3 (pl) |
| UA (1) | UA75587C2 (pl) |
| WO (1) | WO2001049298A2 (pl) |
| YU (1) | YU51802A (pl) |
| ZA (1) | ZA200205415B (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2231358C2 (ru) * | 2002-06-11 | 2004-06-27 | Научно-исследовательский институт кардиологии Томского научного центра СО РАМН | Способ лечения острого коронарного синдрома без подъема сегмента st |
| CN100582123C (zh) * | 2006-10-20 | 2010-01-20 | 江苏江山制药有限公司 | 依诺肝素及其制备方法 |
| AR063530A1 (es) * | 2006-10-30 | 2009-01-28 | Aventis Pharma Sa | Procedimiento de utilizacion de enoxaparina sodica para la preparacion de un medicamento |
| ITMI20091445A1 (it) * | 2009-08-07 | 2011-02-08 | Inalco S P A A Socio Unico | Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008595A1 (en) * | 1992-10-13 | 1994-04-28 | Virginia Commonwealth University | Use of non-anticoagulant heparin for treating ischemia/reperfusion injury |
| US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
-
2000
- 2000-01-06 FR FR0000137A patent/FR2803522B1/fr not_active Expired - Fee Related
-
2001
- 2001-01-03 MX MXPA02006672A patent/MXPA02006672A/es active IP Right Grant
- 2001-01-03 JP JP2001549666A patent/JP2003519185A/ja active Pending
- 2001-01-03 HU HU0204040A patent/HUP0204040A3/hu unknown
- 2001-01-03 HK HK03104944.6A patent/HK1052649A1/zh unknown
- 2001-01-03 AT AT01903859T patent/ATE344671T1/de not_active IP Right Cessation
- 2001-01-03 CA CA002396178A patent/CA2396178A1/fr not_active Abandoned
- 2001-01-03 DE DE60124373T patent/DE60124373T2/de not_active Expired - Fee Related
- 2001-01-03 EP EP01903859A patent/EP1248638B1/fr not_active Expired - Lifetime
- 2001-01-03 KR KR1020027008754A patent/KR20020069240A/ko not_active Ceased
- 2001-01-03 YU YU51802A patent/YU51802A/sh unknown
- 2001-01-03 HR HR20020573A patent/HRP20020573A2/hr not_active Application Discontinuation
- 2001-01-03 AU AU31830/01A patent/AU784656B2/en not_active Ceased
- 2001-01-03 SK SK961-2002A patent/SK9612002A3/sk not_active Application Discontinuation
- 2001-01-03 EA EA200200750A patent/EA006035B1/ru not_active IP Right Cessation
- 2001-01-03 CZ CZ20022303A patent/CZ20022303A3/cs unknown
- 2001-01-03 EE EEP200200374A patent/EE200200374A/xx unknown
- 2001-01-03 BR BR0107442-3A patent/BR0107442A/pt not_active IP Right Cessation
- 2001-01-03 WO PCT/FR2001/000014 patent/WO2001049298A2/fr not_active Ceased
- 2001-01-03 ES ES01903859T patent/ES2275648T3/es not_active Expired - Lifetime
- 2001-01-03 NZ NZ520283A patent/NZ520283A/en unknown
- 2001-01-03 PL PL01357192A patent/PL357192A1/pl unknown
- 2001-01-03 PT PT01903859T patent/PT1248638E/pt unknown
- 2001-01-03 DK DK01903859T patent/DK1248638T3/da active
- 2001-01-03 CN CN01803471A patent/CN1400905A/zh active Pending
- 2001-01-03 IL IL15047701A patent/IL150477A0/xx unknown
- 2001-01-05 AR ARP010100054A patent/AR026804A1/es unknown
- 2001-03-01 UA UA2002076399A patent/UA75587C2/uk unknown
-
2002
- 2002-07-04 NO NO20023243A patent/NO20023243D0/no not_active Application Discontinuation
- 2002-07-05 ZA ZA200205415A patent/ZA200205415B/xx unknown
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