UA76124C2 - A crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride, pharmaceutical composition and a method for producing - Google Patents

A crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride, pharmaceutical composition and a method for producing Download PDF

Info

Publication number: UA76124C2
Authority: UA; Ukraine
Prior art keywords: estrogen; animals; methanol; piperidin; methoxyphenyl
Prior art date: 2000-10-20

Application number

UA2003043576A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-20

Filing date

2001-10-18

Publication date

2006-07-17

2001-10-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2006-07-17 Publication of UA76124C2 publication Critical patent/UA76124C2/uk

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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UA2003043576A 2000-10-20 2001-10-18 A crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride, pharmaceutical composition and a method for producing UA76124C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24225200P	2000-10-20	2000-10-20
PCT/US2001/027773 WO2002034741A2 (en)	2000-10-20	2001-10-18	A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL)ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE

Publications (1)

Publication Number	Publication Date
UA76124C2 true UA76124C2 (en)	2006-07-17

Family

ID=22914051

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003043576A UA76124C2 (en)	2000-10-20	2001-10-18	A crystal form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]-phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride, pharmaceutical composition and a method for producing

Country Status (25)

Country	Link
US (1)	US20040014672A1 (no)
EP (1)	EP1328521A2 (no)
JP (1)	JP2004512333A (no)
KR (1)	KR20030037690A (no)
CN (1)	CN1268624C (no)
AR (1)	AR035355A1 (no)
AU (1)	AU2002214534A1 (no)
BR (1)	BR0114792A (no)
CA (1)	CA2426007A1 (no)
CZ (1)	CZ20031098A3 (no)
EA (1)	EA005116B1 (no)
EC (1)	ECSP034560A (no)
HR (1)	HRP20030296A2 (no)
HU (1)	HUP0301403A3 (no)
IL (1)	IL155487A0 (no)
MX (1)	MXPA03003432A (no)
MY (1)	MY125009A (no)
NO (1)	NO20031753L (no)
NZ (1)	NZ525364A (no)
PE (1)	PE20020588A1 (no)
PL (1)	PL360946A1 (no)
SK (1)	SK4902003A3 (no)
UA (1)	UA76124C2 (no)
WO (1)	WO2002034741A2 (no)
ZA (1)	ZA200303061B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007508271A (ja) *	2003-10-10	2007-04-05	シントン・ベスローテン・フェンノートシャップ	固体状態のモンテルカスト
PL1773811T3 (pl) *	2004-07-22	2011-02-28	Lilly Co Eli	Krystaliczny zmienny hydrat soli hemibursztynianowej (s)-6-(4-(2-((3(9h-karbazol-4-iloksy)-2-hydroksypropylo)amino)-2-metylopropylo)fenoksy)-3-pirydynokarboksy amidu
KR20100101655A (ko) *	2007-12-19	2010-09-17	스펙트럼 파마슈티컬즈 인크	안정한 엘사미트루신 염 제제
EP2305238B1 (en)	2009-09-25	2011-12-14	Iasomai aktiebolag	N-acetyl-L-cysteine for the treatment of endometriosis
PL236889B1 (pl) *	2017-10-03	2021-02-22	Univ Warszawski Medyczny	Nowa forma krystaliczna bezwodnego 17-β-estradiolu, sposób jej otrzymywania oraz kompozycja farmaceutyczna zawierająca nową formę krystaliczną bezwodnego 17-β-estradiolu i jej zastosowanie
MX2023011664A (es) *	2021-04-01	2023-10-11	Array Biopharma Inc	Forma cristalina de un inhibidor de shp2.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3989569B2 (ja) *	1995-02-28	2007-10-10	イーライリリーアンドカンパニー	ベンゾチオフェン化合物、中間体、組成物および方法
ZA982877B (en) *	1997-04-09	1999-10-04	Lilly Co Eli	Treatment of central nervous system disorders with selective estrogen receptor modulators.
EP1204656A2 (en) *	1999-07-29	2002-05-15	Eli Lilly And Company	A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene hydrochloride
ES2208384T3 (es) *	1999-07-29	2004-06-16	Eli Lilly And Company	Forma cristalina de clorhidrato de 6 hidroxi-3-(4-(2-(piperidin-1-il)-etoxi)-fenoxi)2--(4-metoxifenil)-benzo(b)tiofeno.

2001
- 2001-10-18 CZ CZ20031098A patent/CZ20031098A3/cs unknown
- 2001-10-18 HU HU0301403A patent/HUP0301403A3/hu unknown
- 2001-10-18 HR HR20030296A patent/HRP20030296A2/hr not_active Application Discontinuation
- 2001-10-18 KR KR10-2003-7005501A patent/KR20030037690A/ko not_active Withdrawn
- 2001-10-18 JP JP2002537732A patent/JP2004512333A/ja active Pending
- 2001-10-18 CA CA002426007A patent/CA2426007A1/en not_active Abandoned
- 2001-10-18 IL IL15548701A patent/IL155487A0/xx unknown
- 2001-10-18 AU AU2002214534A patent/AU2002214534A1/en not_active Abandoned
- 2001-10-18 PE PE2001001040A patent/PE20020588A1/es not_active Application Discontinuation
- 2001-10-18 NZ NZ525364A patent/NZ525364A/en unknown
- 2001-10-18 MX MXPA03003432A patent/MXPA03003432A/es not_active Application Discontinuation
- 2001-10-18 MY MYPI20014862A patent/MY125009A/en unknown
- 2001-10-18 EA EA200300491A patent/EA005116B1/ru not_active IP Right Cessation
- 2001-10-18 CN CNB018175813A patent/CN1268624C/zh not_active Expired - Fee Related
- 2001-10-18 SK SK490-2003A patent/SK4902003A3/sk not_active Application Discontinuation
- 2001-10-18 AR ARP010104895A patent/AR035355A1/es unknown
- 2001-10-18 US US10/399,523 patent/US20040014672A1/en not_active Abandoned
- 2001-10-18 PL PL01360946A patent/PL360946A1/xx unknown
- 2001-10-18 WO PCT/US2001/027773 patent/WO2002034741A2/en not_active Ceased
- 2001-10-18 BR BR0114792-7A patent/BR0114792A/pt not_active IP Right Cessation
- 2001-10-18 EP EP01983079A patent/EP1328521A2/en not_active Withdrawn
- 2001-10-18 UA UA2003043576A patent/UA76124C2/uk unknown
2003
- 2003-04-15 NO NO20031753A patent/NO20031753L/no not_active Application Discontinuation
- 2003-04-16 EC EC2003004560A patent/ECSP034560A/es unknown
- 2003-04-17 ZA ZA200303061A patent/ZA200303061B/en unknown

Also Published As

Publication number	Publication date
HUP0301403A2 (hu)	2003-10-28
PE20020588A1 (es)	2002-07-06
AR035355A1 (es)	2004-05-12
EA005116B1 (ru)	2004-10-28
IL155487A0 (en)	2003-11-23
HUP0301403A3 (en)	2009-05-28
HK1061857A1 (en)	2004-10-08
CN1268624C (zh)	2006-08-09
MXPA03003432A (es)	2003-08-07
JP2004512333A (ja)	2004-04-22
PL360946A1 (en)	2004-09-20
CN1469872A (zh)	2004-01-21
ZA200303061B (en)	2004-07-19
SK4902003A3 (en)	2003-10-07
EA200300491A1 (ru)	2003-08-28
AU2002214534A1 (en)	2002-05-06
BR0114792A (pt)	2003-08-12
WO2002034741A3 (en)	2003-01-03
EP1328521A2 (en)	2003-07-23
WO2002034741A2 (en)	2002-05-02
HRP20030296A2 (en)	2003-06-30
KR20030037690A (ko)	2003-05-14
US20040014672A1 (en)	2004-01-22
NO20031753D0 (no)	2003-04-15
NZ525364A (en)	2005-09-30
CA2426007A1 (en)	2002-05-02
CZ20031098A3 (cs)	2003-08-13
MY125009A (en)	2006-07-31
NO20031753L (no)	2003-04-15
ECSP034560A (es)	2003-06-25

Publication	Publication Date	Title
EP1204655B1 (en)	2003-10-01	A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy] phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
KR100697177B1 (ko)	2007-03-21	신규 결정질 형태의6-히드록시-3-(4-[2-(피페리딘-1-일)에톡시]페녹시)-2-(4-메톡시페닐)벤조[ｂ]티오펜 히드로클로라이드
CZ20031098A3 (cs)	2003-08-13	Nová krystalická forma 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]fenoxy)-2-(4-methoxyfenyl)benzo[b]thiofen hydrochloridu
US6610706B1 (en)	2003-08-26	Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
RU2240318C2 (ru)	2004-11-20	Новая кристаллическая форма 6-гидрокси-3-(4-[2-(пиперидин-1-ил)этокси]фенокси)-2-(4-метоксифенил) бензо[b]тиофена гидрохлорида
RU2240319C2 (ru)	2004-11-20	Новая кристаллическая форма 6-гидрокси-3-(4-[2-(пиперидин-1-ил)этокси]фенокси)-2-(4-метоксифенил) бензо[b]тиофена гидрохлорида
AU780211B2 (en)	2005-03-10	Crystalline form of 6-hydroxy-3-(4-(2-(piperidin-1-yl) ethoxy)phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
US6653479B1 (en)	2003-11-25	Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride
IE83296B1 (en)	2004-02-11	A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
NZ506046A (en)	2002-03-28	A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methanoxyphenyl)benzo[b]thiophene hydrochloride