UA77393C2 - Non-viral vector for introduction of nucleic acid and a process for preparation thereof, condensed complex polypeptide/nucleic acid and a process for insertion of nucleic acid of interest, into eukaryotic cell - Google Patents
Non-viral vector for introduction of nucleic acid and a process for preparation thereof, condensed complex polypeptide/nucleic acid and a process for insertion of nucleic acid of interest, into eukaryotic cell Download PDFInfo
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- UA77393C2 UA77393C2 UA2002076053A UA2002076053A UA77393C2 UA 77393 C2 UA77393 C2 UA 77393C2 UA 2002076053 A UA2002076053 A UA 2002076053A UA 2002076053 A UA2002076053 A UA 2002076053A UA 77393 C2 UA77393 C2 UA 77393C2
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- polypeptide
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Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930533.6A GB9930533D0 (en) | 1999-12-23 | 1999-12-23 | Nucleic acid delivery |
| PCT/GB2000/004767 WO2001048233A1 (en) | 1999-12-23 | 2000-12-12 | Viral core protein-cationic lipid-nucleic acid-delivery complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77393C2 true UA77393C2 (en) | 2006-12-15 |
Family
ID=10866964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002076053A UA77393C2 (en) | 1999-12-23 | 2000-12-12 | Non-viral vector for introduction of nucleic acid and a process for preparation thereof, condensed complex polypeptide/nucleic acid and a process for insertion of nucleic acid of interest, into eukaryotic cell |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20030153081A1 (de) |
| EP (2) | EP1566445A3 (de) |
| JP (1) | JP2003518388A (de) |
| CN (1) | CN100354426C (de) |
| AT (1) | ATE318322T1 (de) |
| AU (1) | AU781356B2 (de) |
| CA (1) | CA2395454A1 (de) |
| CZ (1) | CZ298353B6 (de) |
| DE (1) | DE60026164T2 (de) |
| DK (1) | DK1244805T3 (de) |
| ES (1) | ES2258986T3 (de) |
| GB (1) | GB9930533D0 (de) |
| PT (1) | PT1244805E (de) |
| RU (1) | RU2267536C2 (de) |
| UA (1) | UA77393C2 (de) |
| WO (1) | WO2001048233A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0118517D0 (en) * | 2001-07-30 | 2001-09-19 | Mitsubishi Tokyo Pharm Inc | Compound |
| FR2829136B1 (fr) * | 2001-08-29 | 2006-11-17 | Aventis Pharma Sa | Derives lipidiques d'aminoglycosides |
| EP1430074B1 (de) * | 2001-08-29 | 2009-05-06 | Aventis Pharma S.A. | Lipid-aminoglykosid konjugate zur transfektion |
| AU2004246904B2 (en) | 2003-06-18 | 2010-02-04 | Biolab Ltd. | Sphingolipids polyalkylamine conjugates for use in transfection |
| US7906122B2 (en) | 2003-06-18 | 2011-03-15 | Yissum Research Development Company Of The Hebrew University Of Jersusalem | Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination |
| GB0418172D0 (en) * | 2004-08-13 | 2004-09-15 | Ic Vec Ltd | Vector |
| US20090155853A1 (en) * | 2005-11-18 | 2009-06-18 | Gary Nabel | Non-viral gene delivery complex |
| WO2008052766A2 (en) * | 2006-11-03 | 2008-05-08 | Medigene Ag | Cationic colloidal carriers for delivery of active agents to the blood-brain barrier in the course of neuroinflammatory diseases |
| WO2008056623A1 (en) * | 2006-11-09 | 2008-05-15 | Daiichi Sankyo Company, Limited | Composition for introduction of nucleic acid |
| EP2105145A1 (de) * | 2008-03-27 | 2009-09-30 | ETH Zürich | Verfahren zur muskelspezifischen Abgabe lipidkonjugierter Oligonukleotide |
| WO2010042751A2 (en) * | 2008-10-08 | 2010-04-15 | Chimeros Inc. | Chimeric therapeutics, compositions, and methods for using same |
| EP4241767B1 (de) | 2008-11-10 | 2024-10-23 | Arbutus Biopharma Corporation | Neuartige lipide und zusammensetzungen zur verabreichung von therapeutika |
| WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
| JP2014527072A (ja) | 2011-09-09 | 2014-10-09 | バイオメド リアルティー， エル．ピー． | ウイルスタンパク質の集合を制御するための方法および組成物 |
| ES3065854T3 (en) | 2011-12-07 | 2026-05-08 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| IL316479A (en) | 2014-06-25 | 2024-12-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle compositions for nucleic acid delivery |
| JP2018526321A (ja) | 2015-04-27 | 2018-09-13 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ |
| HUE067372T2 (hu) | 2015-06-29 | 2024-10-28 | Acuitas Therapeutics Inc | Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására |
| US10829787B2 (en) * | 2015-10-14 | 2020-11-10 | Life Technologies Corporation | Ribonucleoprotein transfection agents |
| RS63986B1 (sr) | 2015-10-28 | 2023-03-31 | Acuitas Therapeutics Inc | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| WO2017212006A1 (en) * | 2016-06-09 | 2017-12-14 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| CN109475640B (zh) | 2016-06-09 | 2023-03-10 | 库瑞瓦格欧洲公司 | 核酸被运载物的混合载运体 |
| CA3031702A1 (en) | 2016-07-27 | 2018-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Immolative cell-penetrating complexes for nucleic acid delivery |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| BR112019014314A2 (pt) | 2017-01-11 | 2020-02-18 | The Trustees Of The University Of Pennsylvania | Composição, e, método de indução de uma resposta imune adaptativa contra vírus zika. |
| WO2018191657A1 (en) | 2017-04-13 | 2018-10-18 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
| CA3061326A1 (en) | 2017-04-27 | 2018-11-01 | The Johns Hopkins University | Nucleoside-modified mrna-lipid nanoparticle lineage vaccine for hepatitis c virus |
| ES2981244T3 (es) | 2017-04-28 | 2024-10-07 | Acuitas Therapeutics Inc | Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos |
| US11639329B2 (en) | 2017-08-16 | 2023-05-02 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US11542225B2 (en) | 2017-08-17 | 2023-01-03 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| WO2019036030A1 (en) | 2017-08-17 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS |
| EP4501322A3 (de) | 2017-08-17 | 2025-04-16 | Acuitas Therapeutics, Inc. | Lipide zur verwendung in lipidnanopartikelformulierungen |
| IL281615B2 (en) | 2018-09-21 | 2026-01-01 | Acuitas Therapeutics Inc | Systems and methods for producing lipid nanoparticles and liposomes |
| US12583816B2 (en) | 2018-10-18 | 2026-03-24 | Acuitas Therapeutics, Inc. | Lipids for lipid nanoparticle delivery of active agents |
| JP7523449B2 (ja) | 2019-01-11 | 2024-07-26 | アクイタス セラピューティクス インコーポレイテッド | 活性剤の脂質ナノ粒子送達のための脂質 |
| JP7630904B2 (ja) * | 2019-07-23 | 2025-02-18 | 株式会社東芝 | 核酸導入キャリア、核酸導入キャリアセット、核酸導入組成物及び核酸導入方法 |
| CN110408656A (zh) * | 2019-07-29 | 2019-11-05 | 成都朴名生物科技有限公司 | 脂多聚物体及其制备方法、采用脂多聚物体将基因编辑质粒导入真核细胞的方法 |
| CN110452303B (zh) * | 2019-08-08 | 2022-03-04 | 中国科学院武汉病毒研究所 | 共价连接核酸和肽或蛋白的方法及应用 |
| CN111394313A (zh) * | 2020-04-01 | 2020-07-10 | 河南科技学院 | 一种人造细胞及其制备方法 |
| JP7798855B2 (ja) | 2020-07-16 | 2026-01-14 | アクイタス セラピューティクス インコーポレイテッド | 脂質ナノ粒子に使用するためのカチオン性脂質 |
| CA3242402A1 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| CN114656422B (zh) * | 2022-04-22 | 2023-05-23 | 重庆理工大学 | 一种新型氮杂冠醚化合物及其阳离子脂质体、制备方法与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1322987A (en) * | 1969-12-29 | 1973-07-11 | Richter Gedeon Vegyeszet | On,n-diacylhydroxylamine derivatives and preparation |
| US4189431A (en) * | 1975-08-04 | 1980-02-19 | The Board of Trustees of Leland Stanford Junior University | Alkinyl terminating groups in biogenetic-like cyclizations to steroids |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| IL112372A (en) * | 1994-02-07 | 2001-08-26 | Res Dev Foundation | Non-viral vector for the delivery of genetic information to cells |
| US5510510A (en) * | 1994-05-10 | 1996-04-23 | Bristol-Meyers Squibb Company | Inhibitors of farnesyl protein transferase |
| EP0874910A4 (de) * | 1995-06-07 | 1999-04-21 | Life Technologies Inc | Durch peptide erhöhte kationische lipid transfektionen |
| US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| CN1181422A (zh) * | 1996-10-31 | 1998-05-13 | 上海市肿瘤研究所 | 与生长因子受体结合的多肽所构建的基因转移载体 |
| JP2002539134A (ja) * | 1999-03-09 | 2002-11-19 | アクゾ・ノベル・エヌ・ベー | 減数分裂の阻害のための２２ｒ−ヒドロキシコレスタ−８，１４−ジエン誘導体 |
-
1999
- 1999-12-23 GB GBGB9930533.6A patent/GB9930533D0/en not_active Ceased
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2000
- 2000-12-12 DE DE60026164T patent/DE60026164T2/de not_active Expired - Fee Related
- 2000-12-12 DK DK00981481T patent/DK1244805T3/da active
- 2000-12-12 CA CA002395454A patent/CA2395454A1/en not_active Abandoned
- 2000-12-12 EP EP04077588A patent/EP1566445A3/de not_active Withdrawn
- 2000-12-12 CZ CZ20022193A patent/CZ298353B6/cs not_active IP Right Cessation
- 2000-12-12 EP EP00981481A patent/EP1244805B1/de not_active Expired - Lifetime
- 2000-12-12 AT AT00981481T patent/ATE318322T1/de not_active IP Right Cessation
- 2000-12-12 RU RU2002119560/13A patent/RU2267536C2/ru not_active IP Right Cessation
- 2000-12-12 PT PT00981481T patent/PT1244805E/pt unknown
- 2000-12-12 ES ES00981481T patent/ES2258986T3/es not_active Expired - Lifetime
- 2000-12-12 US US10/168,909 patent/US20030153081A1/en not_active Abandoned
- 2000-12-12 JP JP2001548745A patent/JP2003518388A/ja active Pending
- 2000-12-12 AU AU18716/01A patent/AU781356B2/en not_active Ceased
- 2000-12-12 UA UA2002076053A patent/UA77393C2/uk unknown
- 2000-12-12 WO PCT/GB2000/004767 patent/WO2001048233A1/en not_active Ceased
- 2000-12-12 CN CNB008191468A patent/CN100354426C/zh not_active Expired - Fee Related
-
2008
- 2008-10-30 US US12/261,999 patent/US20090209037A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002119560A (ru) | 2004-03-27 |
| EP1244805B1 (de) | 2006-02-22 |
| RU2267536C2 (ru) | 2006-01-10 |
| ES2258986T3 (es) | 2006-09-16 |
| ATE318322T1 (de) | 2006-03-15 |
| AU781356B2 (en) | 2005-05-19 |
| CZ20022193A3 (cs) | 2003-02-12 |
| CZ298353B6 (cs) | 2007-09-05 |
| US20030153081A1 (en) | 2003-08-14 |
| PT1244805E (pt) | 2006-07-31 |
| JP2003518388A (ja) | 2003-06-10 |
| CN100354426C (zh) | 2007-12-12 |
| DE60026164T2 (de) | 2006-11-16 |
| US20090209037A1 (en) | 2009-08-20 |
| AU1871601A (en) | 2001-07-09 |
| DE60026164D1 (de) | 2006-04-27 |
| EP1566445A2 (de) | 2005-08-24 |
| CA2395454A1 (en) | 2001-07-05 |
| EP1566445A3 (de) | 2005-08-31 |
| EP1244805A1 (de) | 2002-10-02 |
| GB9930533D0 (en) | 2000-02-16 |
| WO2001048233A1 (en) | 2001-07-05 |
| CN1434870A (zh) | 2003-08-06 |
| DK1244805T3 (da) | 2006-06-26 |
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