UA77650C2 - Use of serotonin reuptake inhibitor in combination with deramcyclane - Google Patents

Use of serotonin reuptake inhibitor in combination with deramcyclane Download PDF

Info

Publication number: UA77650C2
Authority: UA; Ukraine
Prior art keywords: serotonin reuptake; reuptake inhibitor; pharmaceutical composition; citalopram; disorder
Prior art date: 1999-12-06

Application number

UA2002065005A

Other languages

English (en)

Ukrainian (uk)

Inventor

Thomas Ivo Franciscus Cramers

Bernard Hendrik Corn Westerink

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-06

Filing date

2000-06-12

Publication date

2007-01-15

2000-06-12 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2007-01-15 Publication of UA77650C2 publication Critical patent/UA77650C2/uk

Links

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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9413—Dopamine
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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UA2002065005A 1999-12-06 2000-06-12 Use of serotonin reuptake inhibitor in combination with deramcyclane UA77650C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16924599P	1999-12-06	1999-12-06
PCT/DK2000/000671 WO2001041701A2 (en)	1999-12-06	2000-12-06	The combination of a serotonin reuptake inhibitor and a 5-ht2c antagonist, inverse agonist or partial agonist

Publications (1)

Publication Number	Publication Date
UA77650C2 true UA77650C2 (en)	2007-01-15

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ID=22614803

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Application Number	Title	Priority Date	Filing Date
UA2002065005A UA77650C2 (en)	1999-12-06	2000-06-12	Use of serotonin reuptake inhibitor in combination with deramcyclane

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Country	Link
US (4)	US20020103249A1 (de)
EP (2)	EP1237553B1 (de)
JP (1)	JP2003516326A (de)
KR (1)	KR100832026B1 (de)
CN (2)	CN1433313A (de)
AT (1)	ATE314849T1 (de)
AU (2)	AU1850801A (de)
BG (1)	BG106895A (de)
BR (1)	BR0016385A (de)
CA (1)	CA2393470A1 (de)
CO (1)	CO5251409A1 (de)
CY (1)	CY1105014T1 (de)
CZ (1)	CZ20021961A3 (de)
DE (1)	DE60025398T2 (de)
DK (1)	DK1237553T3 (de)
EA (1)	EA006391B1 (de)
ES (1)	ES2255519T3 (de)
HR (1)	HRP20020527A2 (de)
HU (1)	HUP0203586A3 (de)
IL (2)	IL149994A0 (de)
IS (1)	IS2227B (de)
ME (1)	MEP6208A (de)
MX (1)	MXPA02005613A (de)
NO (1)	NO20022657L (de)
NZ (1)	NZ545907A (de)
PL (1)	PL356402A1 (de)
PT (1)	PT1237553E (de)
SK (1)	SK7962002A3 (de)
TR (1)	TR200201512T2 (de)
UA (1)	UA77650C2 (de)
WO (2)	WO2001041766A1 (de)
YU (1)	YU41902A (de)
ZA (1)	ZA200204391B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR021155A1 (es) *	1999-07-08	2002-06-12	Lundbeck & Co As H	Tratamiento de desordenes neuroticos
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
US6589996B2 (en)	2000-03-17	2003-07-08	Orion Corporation	Treatment of disorders relating to the serotonergic system
US6335371B1 (en) *	2000-11-28	2002-01-01	Orion Corporation	Method for inducing cognition enhancement
US6335372B1 (en) *	2000-11-28	2002-01-01	Orion Corporation	Treatment of obsessive compulsive disorder
AU2002218338A1 (en) *	2000-11-28	2002-06-11	Orion Corporation	Treatment of psychiatric disorders with trimethyl-bicyclo(2.2.1)heptane derivatives
FI20002612A0 (fi) *	2000-11-28	2000-11-28	Orion Yhtymae Oyj	Yhdistelmäterapia serotoniinivälityksen häiriöiden hoitamiseksi
CA2445843A1 (en) *	2001-05-01	2002-11-07	H. Lundbeck A/S	The use of enantiomeric pure escitalopram
GB0118892D0 (en) *	2001-08-02	2001-09-26	Vernalis Res Ltd	Method of treatment
SE0201544D0 (sv)	2002-05-17	2002-05-17	Biovitrum Ab	Novel compounds and thier use
UA80055C2 (en) *	2003-05-27	2007-08-10	Forest Laboratories	Combination of nmda-receptor antagonist and selective inhibitor of serotonin reuptake for a depression and other pscihiatric disorders treatment
US20050234093A1 (en) *	2003-06-25	2005-10-20	H. Lundbeck A/S	Treatment of depression and other affective disorders
AR047553A1 (es) *	2003-07-04	2006-01-25	Lundbeck & Co As H	La combinacion de un inhibidor de reabsorcion de serotonina y agomelatina
EP1500391A1 (de) *	2003-07-24	2005-01-26	Neuro3D	Medizinische Verwendung von Bicycloheptan-Derivaten
SG146683A1 (en)	2003-09-17	2008-10-30	Janssen Pharmaceutica Nv	Fused heterocyclic compounds as serotonin receptor modulators
US7884096B2 (en)	2003-12-02	2011-02-08	Pharmaneuroboost N.V.	Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
US7855195B2 (en)	2003-12-02	2010-12-21	Pharmaneuroboost N.V.	Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists
US8304431B2 (en) *	2003-12-02	2012-11-06	Pharmaneuroboost N.V.	Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
US20050203130A1 (en) *	2003-12-02	2005-09-15	Erik Buntinx	Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
EP1713486A4 (de) *	2003-12-02	2009-04-29	Sheldon Leslie James	Kombinationstherapie für demenz, depression und apathie
US20050241110A1 (en) *	2004-04-09	2005-11-03	Bruce Baker	Ergonomic handles, especially for garden tools
US7598255B2 (en)	2005-08-04	2009-10-06	Janssen Pharmaceutica Nv	Pyrimidine compounds as serotonin receptor modulators
US20090054510A1 (en) *	2006-03-22	2009-02-26	H. Lundbeck A/S	Method for identifying compounds for the treatment of depression
MY150647A (en)	2006-06-16	2014-02-14	Lundbeck & Co As H	1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
US20080081067A1 (en) *	2006-10-03	2008-04-03	Gupta Manishkumar	Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
ES2653852T3 (es) *	2007-08-03	2018-02-09	Richter Gedeon Nyrt.	Composiciones farmacéuticas que contienen ligandos del receptor de dopamina y procedimientos de tratamiento usando ligandos del receptor de dopamina
EP2236511A4 (de)	2007-12-21	2011-04-13	Alla Chem Llc	Liganden von alpha-adrenoceptoren und von dopamin-, histamin-, imidazolin- und serotoninrezeptoren und anwendung davon
WO2010006231A1 (en) *	2008-07-10	2010-01-14	Ore Pharmaceuticals Inc.	Treating inflammation and related conditions with irindalone
ES2565193T3 (es)	2010-07-15	2016-04-01	Sumitomo Dainippon Pharma Co., Ltd.	Compuesto de pirazol
WO2012054815A1 (en)	2010-10-22	2012-04-26	Duke University	Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies
WO2013119800A1 (en)	2012-02-07	2013-08-15	Massachusetts Institute Of Technology	Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
WO2014046544A1 (en)	2012-09-21	2014-03-27	Aapa B.V.	Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators
US9724396B2 (en)	2013-03-15	2017-08-08	Massachusetts Institute Of Technology	Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
US10317418B2 (en)	2015-02-24	2019-06-11	Massachusetts Institute Of Technology	Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
WO2016205631A1 (en) *	2015-06-17	2016-12-22	Massachusetts Institute Of Technology	Serotonin 2c receptor antagonists to prevent and treat stress-related trauma disorders
CN107556206A (zh) *	2016-06-30	2018-01-09	陕西合成药业股份有限公司	一种新型5‑羟色胺再摄取抑制剂类化合物及其制备方法和在医学上的应用
US11478467B2 (en)	2017-05-04	2022-10-25	Sreenivasarao Vepachedu	Targeted drug rescue with novel compositions, combinations, and methods thereof
CN119470729B (zh) *	2025-01-15	2025-04-29	山东英盛生物技术有限公司	一种高效液相色谱-串联质谱法定量检测微量血液中霉酚酸的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
US5155218A (en) *	1990-05-08	1992-10-13	Neurogenetic Corporation	Dna encoding human 5-ht1d receptors
CA2142721A1 (en)	1992-08-20	1994-03-03	Ian T. Forbes	Condensed indole derivatives as 5ht and 5ht antagonists
WO1994014801A1 (en)	1992-12-29	1994-07-07	Smithkline Beecham Plc	Heterocyclic urea derivatives as 5ht2c and 5ht2b antagonists
ES2142397T3 (es) *	1993-02-10	2000-04-16	Yamanouchi Pharma Co Ltd	Derivado de morfolina.
GB9313913D0 (en)	1993-07-06	1993-08-18	Smithkline Beecham Plc	Novel compounds
CA2134038C (en) *	1994-06-16	1997-06-03	David Taiwai Wong	Potentiation of drug response
CA2194984C (en)	1994-07-26	2002-07-02	John Eugene Macor	4-indole derivatives as serotonin agonists and antagonists
US5597826A (en)	1994-09-14	1997-01-28	Pfizer Inc.	Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist
GB9420999D0 (en)	1994-10-18	1994-12-07	Smithkline Beecham Plc	Novel compounds
EP0714663A3 (de) *	1994-11-28	1997-01-15	Lilly Co Eli	Potenzierung von Wirkstoffresponz durch Serotonin 1A Rezeptor Antagonisten
WO1996023769A2 (en)	1995-02-02	1996-08-08	Smithkline Beecham Plc	Heterocyclic compounds possessing 5ht2c receptor antagonist activity
SE9501567D0 (sv) *	1995-04-27	1995-04-27	Astra Ab	A new combination
GB9511355D0 (en)	1995-06-06	1995-08-02	Fujisawa Pharmaceutical Co	Urea derivatives
GB9514384D0 (en) *	1995-07-13	1995-09-13	American Home Prod	Medical treatment
GB9517559D0 (en)	1995-08-26	1995-10-25	Smithkline Beecham Plc	Novel compounds
FR2744449B1 (fr)	1996-02-02	1998-04-24	Pf Medicament	Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
GB9607219D0 (en)	1996-04-04	1996-06-12	Smithkline Beecham Plc	Novel compounds
NZ329954A (en)	1996-04-12	1999-07-29	Janssen Pharmaceutica Nv	Isoxazolidine tetracyclic and tricyclic ring system derivatives and medicaments
EP0813873B1 (de)	1996-06-19	2002-02-13	Akzo Nobel N.V.	Pharmazeutische Zusammensetzungen mit Mirtazapin und einem oder mehreren selektiven Serotonin-Aufnahme Inhibitoren
US5958429A (en) *	1996-08-16	1999-09-28	Eli Lilly And Company	Potentiation of serotonin response
SE9703375D0 (sv)	1997-09-18	1997-09-18	Astra Ab	A new combination
US6960577B2 (en) *	1998-05-22	2005-11-01	Eli Lilly And Company	Combination therapy for treatment of refractory depression
HK1040055B (zh) *	1998-05-22	2005-04-01	伊莱利利公司	奥氮平和氟西汀在制备治疗对抗治疗的严重抑郁症的药物中的应用
BR9911068A (pt) *	1998-05-29	2001-02-06	Lilly Co Eli	Terapia combinada para tratamento de distúrbios bipolares
DE19827750C1 (de) *	1998-06-22	1999-07-29	Centeon Pharma Gmbh	Verfahren zum Abtrennen von HIV aus einer Flüssigkeit
DE19900673A1 (de) *	1999-01-11	2000-07-13	Basf Ag	Verwendung von Bindungspartnern für 5-HT5-Rezeptoren zur Behandlung neurodegenerativer und neuropsychiatrischer Störungen
US20070259952A1 (en) *	2006-05-02	2007-11-08	H. Lundbeck A/S	Uses of escitalopram

2000
- 2000-06-12 UA UA2002065005A patent/UA77650C2/uk unknown
- 2000-12-04 WO PCT/DK2000/000667 patent/WO2001041766A1/en not_active Ceased
- 2000-12-04 AU AU18508/01A patent/AU1850801A/en not_active Abandoned
- 2000-12-05 CO CO00092734A patent/CO5251409A1/es unknown
- 2000-12-06 CZ CZ20021961A patent/CZ20021961A3/cs unknown
- 2000-12-06 MX MXPA02005613A patent/MXPA02005613A/es not_active Application Discontinuation
- 2000-12-06 AU AU18511/01A patent/AU1851101A/en not_active Abandoned
- 2000-12-06 US US09/731,411 patent/US20020103249A1/en not_active Abandoned
- 2000-12-06 HR HRP20020527 patent/HRP20020527A2/hr not_active Application Discontinuation
- 2000-12-06 CN CN00818827A patent/CN1433313A/zh active Pending
- 2000-12-06 EP EP00981174A patent/EP1237553B1/de not_active Expired - Lifetime
- 2000-12-06 TR TR2002/01512T patent/TR200201512T2/xx unknown
- 2000-12-06 IL IL14999400A patent/IL149994A0/xx active IP Right Grant
- 2000-12-06 EA EA200200649A patent/EA006391B1/ru not_active IP Right Cessation
- 2000-12-06 BR BR0016385-6A patent/BR0016385A/pt not_active Application Discontinuation
- 2000-12-06 ME MEP-62/08A patent/MEP6208A/xx unknown
- 2000-12-06 PT PT00981174T patent/PT1237553E/pt unknown
- 2000-12-06 PL PL00356402A patent/PL356402A1/xx not_active Application Discontinuation
- 2000-12-06 DE DE60025398T patent/DE60025398T2/de not_active Expired - Fee Related
- 2000-12-06 CN CNA2008101499473A patent/CN101406465A/zh active Pending
- 2000-12-06 WO PCT/DK2000/000671 patent/WO2001041701A2/en not_active Ceased
- 2000-12-06 DK DK00981174T patent/DK1237553T3/da active
- 2000-12-06 HU HU0203586A patent/HUP0203586A3/hu unknown
- 2000-12-06 SK SK796-2002A patent/SK7962002A3/sk unknown
- 2000-12-06 KR KR1020027007231A patent/KR100832026B1/ko not_active Expired - Fee Related
- 2000-12-06 ES ES00981174T patent/ES2255519T3/es not_active Expired - Lifetime
- 2000-12-06 NZ NZ545907A patent/NZ545907A/en unknown
- 2000-12-06 JP JP2001542871A patent/JP2003516326A/ja not_active Withdrawn
- 2000-12-06 YU YU41902A patent/YU41902A/sh unknown
- 2000-12-06 AT AT00981174T patent/ATE314849T1/de not_active IP Right Cessation
- 2000-12-06 EP EP08021043A patent/EP2036564A1/de not_active Withdrawn
- 2000-12-06 CA CA002393470A patent/CA2393470A1/en not_active Abandoned
2002
- 2002-05-31 ZA ZA200204391A patent/ZA200204391B/xx unknown
- 2002-05-31 IS IS6404A patent/IS2227B/is unknown
- 2002-06-03 IL IL149994A patent/IL149994A/en not_active IP Right Cessation
- 2002-06-05 NO NO20022657A patent/NO20022657L/no not_active Application Discontinuation
- 2002-06-06 US US10/165,196 patent/US20030032636A1/en not_active Abandoned
- 2002-07-02 BG BG106895A patent/BG106895A/bg unknown
2006
- 2006-03-28 CY CY20061100431T patent/CY1105014T1/el unknown
- 2006-10-05 US US11/539,100 patent/US20070105843A1/en not_active Abandoned
2009
- 2009-03-18 US US12/406,226 patent/US20090176808A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20020060987A (ko)	2002-07-19
TR200201512T2 (tr)	2002-09-23
IL149994A (en)	2007-07-24
YU41902A (sh)	2005-06-10
CO5251409A1 (es)	2003-02-28
NO20022657D0 (no)	2002-06-05
KR100832026B1 (ko)	2008-05-23
HUP0203586A2 (hu)	2003-03-28
PT1237553E (pt)	2006-05-31
US20090176808A1 (en)	2009-07-09
WO2001041701A2 (en)	2001-06-14
CA2393470A1 (en)	2001-06-14
EA006391B1 (ru)	2005-12-29
MXPA02005613A (es)	2002-12-13
MEP6208A (en)	2010-02-10
EA200200649A1 (ru)	2002-12-26
EP2036564A1 (de)	2009-03-18
CN1433313A (zh)	2003-07-30
BR0016385A (pt)	2003-02-18
WO2001041766A1 (en)	2001-06-14
NZ545907A (en)	2007-07-27
HUP0203586A3 (en)	2005-02-28
CN101406465A (zh)	2009-04-15
IS2227B (is)	2007-04-15
CY1105014T1 (el)	2009-11-04
NO20022657L (no)	2002-07-26
ZA200204391B (en)	2003-11-26
US20070105843A1 (en)	2007-05-10
US20020103249A1 (en)	2002-08-01
DE60025398T2 (de)	2006-08-03
EP1237553A2 (de)	2002-09-11
PL356402A1 (en)	2004-06-28
BG106895A (bg)	2003-04-30
ES2255519T3 (es)	2006-07-01
US20030032636A1 (en)	2003-02-13
AU1851101A (en)	2001-06-18
SK7962002A3 (en)	2002-09-10
ATE314849T1 (de)	2006-02-15
DK1237553T3 (da)	2006-05-15
IS6404A (is)	2002-05-31
CZ20021961A3 (cs)	2002-11-13
AU1850801A (en)	2001-06-18
JP2003516326A (ja)	2003-05-13
EP1237553B1 (de)	2006-01-04
DE60025398D1 (de)	2006-03-30
IL149994A0 (en)	2002-12-01
WO2001041701A3 (en)	2001-12-13
HRP20020527A2 (en)	2004-12-31

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JP2007504181A (ja)	2007-03-01	セロトニン再取り込み阻害剤およびロキサピンの併用
KR20060072127A (ko)	2006-06-27	세로토닌 재흡수 억제제 및 록사핀의 조합
KR20060124639A (ko)	2006-12-05	세로토닌 재흡수 억제제 및 히스타민 ３ 수용체안타고니스트, 역 아고니스트 또는 부분 아고니스트의 조합
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EP1782813A1 (de)	2007-05-09	Kombination aus einem Serotonin-wiederaufnahme-inhibitor und einem 5-ht2c-antagonist, -inverse Agonist oder einem -partiellen agonisten
Chadda et al.	2020	Treatment of Depression
HK1055682A (en)	2004-01-21	The combination of a serotonin reuptake inhibitor and a 5-ht2c antagonist, inverse agonist or partial agonist
JP2007504180A (ja)	2007-03-01	セロトニン再取り込み阻害剤およびアモキサピンの併用
AU2009202463A1 (en)	2009-07-09	Not Given
UA81248C2 (en)	2007-12-25	Combination therapy wherein a serotonin reuptake inhibitor is used and compounds, which are a gabab receptor antagonist, inverse agonist or partial agonist