UA77669C2 - Method for producing mixture of d-pantothenic acid and salts thereof - Google Patents

Method for producing mixture of d-pantothenic acid and salts thereof Download PDF

Info

Publication number: UA77669C2
Authority: UA; Ukraine
Prior art keywords: pantothenic acid; solution; differs; calcium; fermentation
Prior art date: 2001-02-21

Application number

UA2003098597A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-21

Filing date

2002-02-20

Publication date

2007-01-15

2002-02-20 Application filed by Basf Ag filed Critical Basf Ag

2007-01-15 Publication of UA77669C2 publication Critical patent/UA77669C2/uk

Links

150000003839 salts Chemical class 0.000 title claims abstract description 26
239000000203 mixture Substances 0.000 title claims abstract description 24
GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title abstract description 54
238000004519 manufacturing process Methods 0.000 title abstract description 15
239000011713 pantothenic acid Substances 0.000 claims abstract description 145
229940055726 pantothenic acid Drugs 0.000 claims abstract description 110
244000005700 microbiome Species 0.000 claims abstract description 20
150000001768 cations Chemical class 0.000 claims abstract description 19
238000001035 drying Methods 0.000 claims abstract description 18
241001465754 Metazoa Species 0.000 claims abstract description 12
239000000654 additive Substances 0.000 claims abstract description 9
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract description 5
230000000996 additive effect Effects 0.000 claims abstract description 5
229960000310 isoleucine Drugs 0.000 claims abstract description 5
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract description 5
238000000034 method Methods 0.000 claims description 102
238000000855 fermentation Methods 0.000 claims description 88
230000004151 fermentation Effects 0.000 claims description 88
239000012528 membrane Substances 0.000 claims description 43
229940014662 pantothenate Drugs 0.000 claims description 35
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 24
229910052791 calcium Inorganic materials 0.000 claims description 23
239000011575 calcium Substances 0.000 claims description 23
150000002500 ions Chemical class 0.000 claims description 23
230000008569 process Effects 0.000 claims description 23
230000015572 biosynthetic process Effects 0.000 claims description 18
239000001963 growth medium Substances 0.000 claims description 18
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 16
229910052749 magnesium Inorganic materials 0.000 claims description 16
239000011777 magnesium Substances 0.000 claims description 16
239000000725 suspension Substances 0.000 claims description 13
239000007900 aqueous suspension Substances 0.000 claims description 12
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 9
239000000920 calcium hydroxide Substances 0.000 claims description 9
229910001861 calcium hydroxide Inorganic materials 0.000 claims description 9
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 7
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 7
FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 7
239000011591 potassium Substances 0.000 claims description 7
229960002079 calcium pantothenate Drugs 0.000 claims description 6
230000005684 electric field Effects 0.000 claims description 6
239000003014 ion exchange membrane Substances 0.000 claims description 6
238000006386 neutralization reaction Methods 0.000 claims description 6
241000894006 Bacteria Species 0.000 claims description 5
230000033228 biological regulation Effects 0.000 claims description 5
ONSCBWDZUUNMMK-UBKPKTQASA-L magnesium;3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [Mg+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O ONSCBWDZUUNMMK-UBKPKTQASA-L 0.000 claims description 5
239000007787 solid Substances 0.000 claims description 5
239000000126 substance Substances 0.000 claims description 5
229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 4
239000001095 magnesium carbonate Substances 0.000 claims description 4
229910000021 magnesium carbonate Inorganic materials 0.000 claims description 4
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 4
239000000347 magnesium hydroxide Substances 0.000 claims description 4
229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 4
241000233866 Fungi Species 0.000 claims description 3
240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical class NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 3
238000007493 shaping process Methods 0.000 claims description 3
241000894007 species Species 0.000 claims description 3
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
239000000292 calcium oxide Substances 0.000 claims description 2
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
238000005342 ion exchange Methods 0.000 claims description 2
229910001414 potassium ion Inorganic materials 0.000 claims description 2
238000012545 processing Methods 0.000 claims description 2
229910001415 sodium ion Inorganic materials 0.000 claims description 2
238000012876 topography Methods 0.000 claims 1
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract description 98
235000019161 pantothenic acid Nutrition 0.000 abstract description 49
238000000909 electrodialysis Methods 0.000 abstract description 23
239000004474 valine Substances 0.000 abstract description 4
229960004295 valine Drugs 0.000 abstract description 4
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract description 3
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract description 3
239000007795 chemical reaction product Substances 0.000 abstract 1
230000025078 regulation of biosynthetic process Effects 0.000 abstract 1
239000000243 solution Substances 0.000 description 150
108090000623 proteins and genes Proteins 0.000 description 41
238000007792 addition Methods 0.000 description 35
239000002609 medium Substances 0.000 description 32
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 26
239000000047 product Substances 0.000 description 26
210000004027 cell Anatomy 0.000 description 23
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 18
239000008103 glucose Substances 0.000 description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 17
239000001110 calcium chloride Substances 0.000 description 16
229910001628 calcium chloride Inorganic materials 0.000 description 16
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 14
238000000926 separation method Methods 0.000 description 14
229940041514 candida albicans extract Drugs 0.000 description 13
238000005341 cation exchange Methods 0.000 description 13
239000002243 precursor Substances 0.000 description 13
239000012138 yeast extract Substances 0.000 description 13
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
-1 for example Chemical compound 0.000 description 12
LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 11
230000001954 sterilising effect Effects 0.000 description 11
238000004659 sterilization and disinfection Methods 0.000 description 11
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
229910052799 carbon Inorganic materials 0.000 description 10
235000013923 monosodium glutamate Nutrition 0.000 description 10
239000011573 trace mineral Substances 0.000 description 10
235000013619 trace mineral Nutrition 0.000 description 10
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
150000001450 anions Chemical class 0.000 description 9
239000012141 concentrate Substances 0.000 description 9
230000000694 effects Effects 0.000 description 9
239000004223 monosodium glutamate Substances 0.000 description 9
239000012266 salt solution Substances 0.000 description 9
108090000790 Enzymes Proteins 0.000 description 8
102000004190 Enzymes Human genes 0.000 description 8
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
238000010494 dissociation reaction Methods 0.000 description 8
230000005593 dissociations Effects 0.000 description 8
229940088598 enzyme Drugs 0.000 description 8
239000012634 fragment Substances 0.000 description 8
238000001694 spray drying Methods 0.000 description 8
235000010469 Glycine max Nutrition 0.000 description 7
239000002253 acid Substances 0.000 description 7
150000007513 acids Chemical class 0.000 description 7
229910021529 ammonia Inorganic materials 0.000 description 7
239000003011 anion exchange membrane Substances 0.000 description 7
239000001301 oxygen Substances 0.000 description 7
229910052760 oxygen Inorganic materials 0.000 description 7
239000013612 plasmid Substances 0.000 description 7
238000003786 synthesis reaction Methods 0.000 description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 6
244000068988 Glycine max Species 0.000 description 6
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
230000008901 benefit Effects 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
230000007423 decrease Effects 0.000 description 6
239000000706 filtrate Substances 0.000 description 6
238000001914 filtration Methods 0.000 description 6
230000001965 increasing effect Effects 0.000 description 6
229910052757 nitrogen Inorganic materials 0.000 description 6
230000002018 overexpression Effects 0.000 description 6
239000011734 sodium Substances 0.000 description 6
229910052708 sodium Inorganic materials 0.000 description 6
239000001509 sodium citrate Substances 0.000 description 6
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 6
229910000147 aluminium phosphate Inorganic materials 0.000 description 5
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
229910052921 ammonium sulfate Inorganic materials 0.000 description 5
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QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Food Science & Technology (AREA)
Animal Husbandry (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Sustainable Development (AREA)
Molecular Biology (AREA)
Physiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fodder In General (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UA2003098597A 2001-02-21 2002-02-20 Method for producing mixture of d-pantothenic acid and salts thereof UA77669C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10108223A DE10108223A1 (de)	2001-02-21	2001-02-21	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
PCT/EP2002/001766 WO2002066666A2 (de)	2001-02-21	2002-02-20	Verfahren zur herstellung von d-pantothensäure und/oder deren salze als zusatz zu tierfuttermitteln

Publications (1)

Publication Number	Publication Date
UA77669C2 true UA77669C2 (en)	2007-01-15

Family

ID=7674921

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003098597A UA77669C2 (en)	2001-02-21	2002-02-20	Method for producing mixture of d-pantothenic acid and salts thereof

Country Status (23)

Country	Link
US (1)	US7824891B2 (es)
EP (1)	EP1362118B1 (es)
JP (1)	JP2004531236A (es)
KR (1)	KR20030075204A (es)
CN (1)	CN1294273C (es)
AT (1)	ATE342372T1 (es)
AU (1)	AU2002250978B2 (es)
BR (1)	BR0207474A (es)
CA (1)	CA2438949A1 (es)
CZ (1)	CZ20032223A3 (es)
DE (2)	DE10108223A1 (es)
EE (1)	EE200300406A (es)
ES (1)	ES2274967T3 (es)
HU (1)	HUP0303304A3 (es)
IL (1)	IL157496A0 (es)
IN (1)	IN2003CH01315A (es)
MX (1)	MX240870B (es)
NO (1)	NO20033707L (es)
PL (1)	PL363989A1 (es)
RU (1)	RU2292397C2 (es)
SK (1)	SK10452003A3 (es)
UA (1)	UA77669C2 (es)
WO (1)	WO2002066666A2 (es)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10108225A1 (de)	2001-02-21	2002-10-10	Basf Ag	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
DE10344200A1 (de) *	2003-09-22	2005-05-04	Basf Ag	Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
ES2991621T3 (es) *	2016-03-07	2024-12-04	Glycom As	Separación de oligosacáridos de caldo de fermentación
MX2020002990A (es) *	2017-09-19	2020-07-22	Evogene Ltd	Genes y aislados bacterianos para conferir resistencia a insectos.
CN111621541B (zh) *	2019-02-27	2025-10-31	广安摩珈生物科技有限公司	使用电渗析技术拆分光学异构体的方法
CN116200320A (zh) *	2022-12-30	2023-06-02	浙江工业大学	一种辅因子平衡的高产d-泛酸的基因工程菌、构建及应用

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GB562267A (en) *	1941-08-08	1944-06-26	Hoffmann La Roche	Process for the manufacture of a crystallised, non-hygroscopic calcium salt of d-pantothenic acid
EP0493060A3 (en)	1990-12-25	1993-04-14	Takeda Chemical Industries, Ltd.	Production method of d-pantothenic acid and plasmids and microorganisms thereof
JP3710497B2 (ja) *	1992-09-25	2005-10-26	ビーエーエスエフアクチェンゲゼルシャフト	Ｄ−パント酸、ｄ−パントテン酸およびそれらの塩の製造法
RU2054415C1 (ru) *	1994-03-02	1996-02-20	Товарищество с ограниченной ответственностью "Пант"	Кетопантотенат кальция, обладающий ацетилирующей активностью d-пантотената кальция
DK0822989T3 (da) *	1995-04-21	2001-04-17	Takeda Chemical Industries Ltd	Fremgangsmåde til fremstilling af D-pantothenat
RU2231552C2 (ru)	1997-10-04	2004-06-27	Форшунгсцентрум Юлих Гмбх	Способ микробиологического получения аминокислот семейства аспартатов и/или глутаматов и используемые в способе средства
AT407050B (de)	1997-12-29	2000-11-27	Chemie Linz Gmbh	Verfahren zur herstellung von l-asparaginsäure
US6110342A (en) *	1998-07-21	2000-08-29	Archer Daniels Midland Company	Process for production of amino acid hydrochloride and caustic via electrodialysis water splitting
DE19855313A1 (de) *	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
PT1050219E (pt) *	1999-05-05	2003-04-30	Degussa	Aditivos alimentares para animais contendo acido d-pantotenico e/ou seus sais e processo para a sua preparacao
EP2163629B1 (en) *	1999-09-21	2017-03-08	Basf Se	Methods and microorganisms for production of panto-compounds
US8232081B2 (en) *	1999-09-21	2012-07-31	Basf Se	Methods and microorganisms for production of panto-compounds
FR2799754A1 (fr) *	1999-10-18	2001-04-20	Roquette Freres	Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation
DE10021515A1 (de) *	2000-05-03	2001-11-08	Degussa	Verfahren zur Herstellung von Erdalkalisalzen der D-Pantothensäure
BR0113399A (pt) *	2000-09-20	2003-07-15	Basf Ag	Processo para a preparação de um suplemento de ração animal, suplemento de ração animal, e, uso do mesmo
CN100529068C (zh)	2001-01-19	2009-08-19	巴斯福股份公司	用于提高泛酸产量的微生物和方法
KR20040004496A (ko)	2001-01-19	2004-01-13	바스프 악티엔게젤샤프트	판토테네이트 생산의 증가 방법

2001
- 2001-02-21 DE DE10108223A patent/DE10108223A1/de not_active Withdrawn
2002
- 2002-02-20 AU AU2002250978A patent/AU2002250978B2/en not_active Ceased
- 2002-02-20 SK SK1045-2003A patent/SK10452003A3/sk not_active Application Discontinuation
- 2002-02-20 DE DE50208413T patent/DE50208413D1/de not_active Expired - Lifetime
- 2002-02-20 CA CA002438949A patent/CA2438949A1/en not_active Abandoned
- 2002-02-20 CZ CZ20032223A patent/CZ20032223A3/cs unknown
- 2002-02-20 AT AT02719874T patent/ATE342372T1/de not_active IP Right Cessation
- 2002-02-20 WO PCT/EP2002/001766 patent/WO2002066666A2/de not_active Ceased
- 2002-02-20 KR KR20037010981A patent/KR20030075204A/ko not_active Ceased
- 2002-02-20 EP EP02719874A patent/EP1362118B1/de not_active Expired - Lifetime
- 2002-02-20 EE EEP200300406A patent/EE200300406A/xx unknown
- 2002-02-20 CN CNB028053303A patent/CN1294273C/zh not_active Expired - Fee Related
- 2002-02-20 ES ES02719874T patent/ES2274967T3/es not_active Expired - Lifetime
- 2002-02-20 PL PL02363989A patent/PL363989A1/xx not_active Application Discontinuation
- 2002-02-20 JP JP2002566370A patent/JP2004531236A/ja active Pending
- 2002-02-20 IL IL15749602A patent/IL157496A0/xx unknown
- 2002-02-20 US US10/468,610 patent/US7824891B2/en not_active Expired - Fee Related
- 2002-02-20 BR BR0207474-5A patent/BR0207474A/pt not_active IP Right Cessation
- 2002-02-20 HU HU0303304A patent/HUP0303304A3/hu unknown
- 2002-02-20 RU RU2003128534/13A patent/RU2292397C2/ru not_active IP Right Cessation
- 2002-02-20 MX MXPA03007383 patent/MX240870B/es active IP Right Grant
- 2002-02-20 UA UA2003098597A patent/UA77669C2/uk unknown
2003
- 2003-08-20 NO NO20033707A patent/NO20033707L/no not_active Application Discontinuation
- 2003-08-21 IN IN1315CH2003 patent/IN2003CH01315A/xx unknown

Also Published As

Publication number	Publication date
US20040072306A1 (en)	2004-04-15
IL157496A0 (en)	2004-03-28
SK10452003A3 (sk)	2004-02-03
WO2002066666A3 (de)	2003-07-17
NO20033707L (no)	2003-10-20
WO2002066666A2 (de)	2002-08-29
ES2274967T3 (es)	2007-06-01
HUP0303304A3 (en)	2007-09-28
HUP0303304A2 (hu)	2004-01-28
CA2438949A1 (en)	2002-08-29
CN1294273C (zh)	2007-01-10
RU2003128534A (ru)	2005-04-10
ATE342372T1 (de)	2006-11-15
MX240870B (es)	2006-10-09
DE50208413D1 (de)	2006-11-23
EE200300406A (et)	2003-12-15
EP1362118B1 (de)	2006-10-11
IN2003CH01315A (en)	2005-11-25
EP1362118A2 (de)	2003-11-19
US7824891B2 (en)	2010-11-02
RU2292397C2 (ru)	2007-01-27
DE10108223A1 (de)	2002-10-10
BR0207474A (pt)	2004-03-02
AU2002250978B2 (en)	2007-03-01
CZ20032223A3 (cs)	2003-11-12
CN1492935A (zh)	2004-04-28
PL363989A1 (en)	2004-11-29
NO20033707D0 (no)	2003-08-20
MXPA03007383A (es)	2004-03-16
JP2004531236A (ja)	2004-10-14
KR20030075204A (ko)	2003-09-22

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