UA78979C2 - Pharmaceutical composition comprising catechin compound for treating neoplastic diseases - Google Patents

Pharmaceutical composition comprising catechin compound for treating neoplastic diseases Download PDF

Info

Publication number: UA78979C2
Authority: UA; Ukraine
Prior art keywords: proline; lysine; ascorbic acid; combination; cells
Prior art date: 2002-01-08

Application number

UA20040705480A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-08

Filing date

2002-01-31

Publication date

2007-05-10

2002-01-31 Application filed filed Critical

2007-05-10 Publication of UA78979C2 publication Critical patent/UA78979C2/uk

Links

ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 title claims abstract description 25
235000005487 catechin Nutrition 0.000 title claims abstract description 25
201000010099 disease Diseases 0.000 title claims abstract description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 18
229950001002 cianidanol Drugs 0.000 title claims abstract description 11
-1 catechin compound Chemical class 0.000 title claims abstract description 7
239000008194 pharmaceutical composition Substances 0.000 title claims 2
230000001613 neoplastic effect Effects 0.000 title abstract description 10
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 78
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract description 44
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 42
239000004472 Lysine Substances 0.000 claims abstract description 42
235000010323 ascorbic acid Nutrition 0.000 claims abstract description 39
229960005070 ascorbic acid Drugs 0.000 claims abstract description 39
239000011668 ascorbic acid Substances 0.000 claims abstract description 39
239000000203 mixture Substances 0.000 claims abstract description 21
238000011282 treatment Methods 0.000 claims description 14
239000003963 antioxidant agent Substances 0.000 claims description 11
235000006708 antioxidants Nutrition 0.000 claims description 11
230000003078 antioxidant effect Effects 0.000 claims description 8
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 7
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 6
235000019152 folic acid Nutrition 0.000 claims description 5
XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 claims description 4
239000011724 folic acid Substances 0.000 claims description 4
TVLSKGDBUQMDPR-UHFFFAOYSA-N 2,3-Dimethoxy-5-methyl-6-(3-methyl-2-buten-1-yl)-1,4-benzenediol Chemical class COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC TVLSKGDBUQMDPR-UHFFFAOYSA-N 0.000 claims description 3
108010024636 Glutathione Proteins 0.000 claims description 3
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 3
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 3
235000021466 carotenoid Nutrition 0.000 claims description 3
150000001747 carotenoids Chemical class 0.000 claims description 3
229960000304 folic acid Drugs 0.000 claims description 3
229960003180 glutathione Drugs 0.000 claims description 3
235000003969 glutathione Nutrition 0.000 claims description 3
229910052711 selenium Inorganic materials 0.000 claims description 3
239000011669 selenium Substances 0.000 claims description 3
229930003799 tocopherol Natural products 0.000 claims description 3
239000011732 tocopherol Substances 0.000 claims description 3
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WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims description 2
PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims description 2
WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims description 2
229940093797 bioflavonoids Drugs 0.000 claims description 2
229960004203 carnitine Drugs 0.000 claims description 2
229940030275 epigallocatechin gallate Drugs 0.000 claims description 2
235000019136 lipoic acid Nutrition 0.000 claims description 2
229960002663 thioctic acid Drugs 0.000 claims description 2
AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 2
LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 claims 1
GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 claims 1
QCRUJHNWBPSKQG-UHFFFAOYSA-N CO[Se](O)=O Chemical compound CO[Se](O)=O QCRUJHNWBPSKQG-UHFFFAOYSA-N 0.000 claims 1
LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 claims 1
XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 claims 1
235000012734 epicatechin Nutrition 0.000 claims 1
DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 claims 1
229940014144 folate Drugs 0.000 claims 1
229940082569 selenite Drugs 0.000 claims 1
MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 claims 1
125000002640 tocopherol group Chemical class 0.000 claims 1
229930003802 tocotrienol Natural products 0.000 claims 1
239000011731 tocotrienol Substances 0.000 claims 1
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235000019148 tocotrienols Nutrition 0.000 claims 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract description 43
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract description 42
238000000034 method Methods 0.000 abstract description 8
210000004027 cell Anatomy 0.000 description 61
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150000001765 catechin Chemical class 0.000 description 18
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239000002609 medium Substances 0.000 description 15
230000004663 cell proliferation Effects 0.000 description 11
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PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 6
108010000684 Matrix Metalloproteinases Proteins 0.000 description 6
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210000002966 serum Anatomy 0.000 description 4
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238000006731 degradation reaction Methods 0.000 description 3
239000012091 fetal bovine serum Substances 0.000 description 3
239000000499 gel Substances 0.000 description 3
235000018977 lysine Nutrition 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000002243 precursor Substances 0.000 description 3
230000002265 prevention Effects 0.000 description 3
235000013930 proline Nutrition 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
102100026802 72 kDa type IV collagenase Human genes 0.000 description 2
201000001320 Atherosclerosis Diseases 0.000 description 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
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CITFYDYEWQIEPX-UHFFFAOYSA-N Flavanol Natural products O1C2=CC(OCC=C(C)C)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C=C1 CITFYDYEWQIEPX-UHFFFAOYSA-N 0.000 description 2
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239000012080 ambient air Substances 0.000 description 2
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150000002215 flavonoids Chemical class 0.000 description 2
235000013305 food Nutrition 0.000 description 2
210000004293 human mammary gland Anatomy 0.000 description 2
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210000005075 mammary gland Anatomy 0.000 description 2
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QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 2
PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 1
229930013783 (-)-epicatechin Natural products 0.000 description 1
235000007355 (-)-epicatechin Nutrition 0.000 description 1
PBZMVAYHJDFHIR-UHFFFAOYSA-N 2-phenyl-3,4-dihydrochromene-2,3-diol Chemical class OC1CC2=CC=CC=C2OC1(O)C1=CC=CC=C1 PBZMVAYHJDFHIR-UHFFFAOYSA-N 0.000 description 1
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SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
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AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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UA20040705480A 2002-01-08 2002-01-31 Pharmaceutical composition comprising catechin compound for treating neoplastic diseases UA78979C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10/041,427 US6939860B2 (en)	2002-01-08	2002-01-08	Composition and method for treatment of neoplastic diseases associated with elevated matrix metalloproteinase activities using catechin compounds
PCT/EP2002/001005 WO2003057211A1 (en)	2002-01-08	2002-01-31	Composition inhibiting matrix-metallproteinases for the treatmentof neoplastic diseases.

Publications (1)

Publication Number	Publication Date
UA78979C2 true UA78979C2 (en)	2007-05-10

Family

ID=21916454

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040705480A UA78979C2 (en)	2002-01-08	2002-01-31	Pharmaceutical composition comprising catechin compound for treating neoplastic diseases

Country Status (29)

Country	Link
US (3)	US6939860B2 (de)
EP (1)	EP1463498B1 (de)
JP (1)	JP4144800B2 (de)
KR (1)	KR20050005408A (de)
CN (1)	CN1612731A (de)
AT (1)	ATE439833T1 (de)
AU (2)	AU2002244690A1 (de)
BR (1)	BR0208052A (de)
CA (1)	CA2469162A1 (de)
CZ (1)	CZ2004853A3 (de)
DE (1)	DE60233433D1 (de)
EE (1)	EE200400031A (de)
ES (1)	ES2332126T3 (de)
HR (1)	HRP20040705A2 (de)
HU (1)	HUP0402421A3 (de)
IL (1)	IL162384A0 (de)
LT (1)	LT5215B (de)
LV (1)	LV13249B (de)
MX (1)	MXPA04006627A (de)
NO (1)	NO20033949L (de)
NZ (1)	NZ533353A (de)
PL (1)	PL371205A1 (de)
RU (1)	RU2284185C2 (de)
SI (1)	SI21871A (de)
SK (1)	SK2772004A3 (de)
TR (1)	TR200401669T1 (de)
UA (1)	UA78979C2 (de)
WO (1)	WO2003057211A1 (de)
ZA (1)	ZA200404915B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8669282B2 (en) *	2000-10-31	2014-03-11	Hill's Pet Nutrition, Inc.	Companion animal compositions including lipoic acid and methods of use thereof
US6939860B2 (en) *	2002-01-08	2005-09-06	Matthias Rath	Composition and method for treatment of neoplastic diseases associated with elevated matrix metalloproteinase activities using catechin compounds
US20050079234A1 (en) *	2003-08-27	2005-04-14	Chiang Yang Chi	Compositions comprising herbs and method for immunomodulation
KR20050070385A (ko) *	2003-12-30	2005-07-07	(주)현덕비엔티	폴리페놀과, 아스코르빈산 또는 그 유도체를 함유하는항암치료 보조용 조성물
WO2006053184A2 (en) *	2004-11-10	2006-05-18	The Trustees Of Columbia University In The City Of New York	Methods for treating or preventing a vascular disease
ES2246737B1 (es) *	2005-06-09	2006-12-01	Jose Juan Rodriguez Jerez	"composicion farmaceutica que comprende lisina y usos correspondientes".
US8338476B2 (en) *	2005-12-29	2012-12-25	Mitsui Norin Co, Ltd.	Compositions and methods of sensitizing methicillin resistant Staphylococcus aureus to beta-lactam antibiotics
US20070265211A1 (en) *	2006-05-12	2007-11-15	Matthias Rath	Novel composition and method effective in inhibiting the atherogenic process
US20100055205A1 (en) *	2008-08-29	2010-03-04	Kristina Mains	Functional consumable compositions for promoting skin health and methods for using the same
EP2179722A1 (de) *	2008-10-24	2010-04-28	Heinrich-Pette-Institut für experimentelle Virologie und Immunologie	Topische Formation zur Vorbeugung der sexuellen Übertragung von Virusinfektionen
CA2742302C (en)	2008-11-04	2018-01-02	Vymedic, Llc	Antiviral supplement formulations
WO2011046199A1 (ja) *	2009-10-16	2011-04-21	株式会社カネカ	還元型補酵素ｑ１０の製造方法、安定化方法及びそれを含有する組成物
JP6091431B2 (ja) *	2011-01-31	2017-03-15	ルコラス−エム．ディー．リミテッド	医薬的使用
KR101829330B1 (ko)	2011-04-13	2018-02-20	(주)아모레퍼시픽	염증성 피부 노화 억제 물질 스크리닝 방법
CN102526170B (zh) *	2011-12-31	2015-04-29	许学志	抗结核杆菌的儿茶提取物组合物、其制备方法及含有它们的药物制剂和应用
BE1023772B9 (fr)	2013-05-17	2017-08-02	Valore	Composition a base d'un complexe de (+)-catechine et d'acide amine pour le traitement et la prevention du cancer
CN104096058A (zh) *	2014-07-02	2014-10-15	胥玲	一种治疗扩张型心肌病的中药药丸
BE1022579A9 (fr) *	2014-11-10	2016-10-06	Valore	Composition antimétastatique comprenant au moins un composé de type flavanol
IT202200013867A1 (it) *	2022-06-30	2023-12-30	Lo Li Pharma Srl	Composizione per il trattamento dell’ infezione da papilloma virus (hpv)
CN118831080B (zh) *	2024-09-24	2024-11-22	上海交通大学医学院附属仁济医院	5-氧脯氨酸在制备预防或治疗心肌病的药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5863949A (en) *	1995-03-08	1999-01-26	Pfizer Inc	Arylsulfonylamino hydroxamic acid derivatives
BR9713182A (pt) *	1996-08-28	1999-11-03	Procter & Gamble	Amidas de ácido fosfìnico como inibidores de metalo protease de matriz
US5962517A (en) *	1997-01-31	1999-10-05	Murad; Howard	Pharmaceutical compositions and methods for treating acne
US5817695A (en) *	1997-12-24	1998-10-06	Pellico; Michael A.	Nutritional product with high fat, low carbohydrate and amino acid imbalance
US6428818B1 (en) *	1999-03-30	2002-08-06	Purdue Research Foundation	Tea catechin formulations and processes for making same
AU768189B2 (en)	1999-06-15	2003-12-04	Nutri-Logics, Inc.	Nutrient formulations for disease reduction, and related treatment and component screening methods
US6939860B2 (en) *	2002-01-08	2005-09-06	Matthias Rath	Composition and method for treatment of neoplastic diseases associated with elevated matrix metalloproteinase activities using catechin compounds
EP1480973B1 (de) *	2002-02-25	2008-02-13	Boehringer Ingelheim Pharmaceuticals Inc.	1,4-disubstituierte benzokondensierte cycloalkyl-harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen

2002
- 2002-01-08 US US10/041,427 patent/US6939860B2/en not_active Expired - Fee Related
- 2002-01-31 KR KR10-2004-7010603A patent/KR20050005408A/ko not_active Ceased
- 2002-01-31 JP JP2003557569A patent/JP4144800B2/ja not_active Expired - Fee Related
- 2002-01-31 MX MXPA04006627A patent/MXPA04006627A/es active IP Right Grant
- 2002-01-31 DE DE60233433T patent/DE60233433D1/de not_active Expired - Lifetime
- 2002-01-31 TR TR2004/01669T patent/TR200401669T1/xx unknown
- 2002-01-31 IL IL16238402A patent/IL162384A0/xx not_active IP Right Cessation
- 2002-01-31 AU AU2002244690A patent/AU2002244690A1/en not_active Abandoned
- 2002-01-31 EE EEP200400031A patent/EE200400031A/xx unknown
- 2002-01-31 AT AT02712877T patent/ATE439833T1/de active
- 2002-01-31 PL PL02371205A patent/PL371205A1/xx unknown
- 2002-01-31 NZ NZ533353A patent/NZ533353A/en unknown
- 2002-01-31 SI SI200220038A patent/SI21871A/sl not_active IP Right Cessation
- 2002-01-31 EP EP02712877A patent/EP1463498B1/de not_active Expired - Lifetime
- 2002-01-31 ES ES02712877T patent/ES2332126T3/es not_active Expired - Lifetime
- 2002-01-31 UA UA20040705480A patent/UA78979C2/uk unknown
- 2002-01-31 CN CNA028269543A patent/CN1612731A/zh active Pending
- 2002-01-31 CZ CZ2004853A patent/CZ2004853A3/cs unknown
- 2002-01-31 BR BR0208052-4A patent/BR0208052A/pt not_active IP Right Cessation
- 2002-01-31 SK SK277-2004A patent/SK2772004A3/sk not_active Application Discontinuation
- 2002-01-31 HR HR20040705A patent/HRP20040705A2/hr not_active Application Discontinuation
- 2002-01-31 HU HU0402421A patent/HUP0402421A3/hu unknown
- 2002-01-31 WO PCT/EP2002/001005 patent/WO2003057211A1/en not_active Ceased
- 2002-01-31 RU RU2004124047/15A patent/RU2284185C2/ru not_active IP Right Cessation
- 2002-01-31 CA CA002469162A patent/CA2469162A1/en not_active Abandoned
2003
- 2003-09-05 NO NO20033949A patent/NO20033949L/no not_active Application Discontinuation
2004
- 2004-06-22 ZA ZA200404915A patent/ZA200404915B/en unknown
- 2004-08-05 LT LT2004074A patent/LT5215B/lt unknown
- 2004-09-06 LV LVP-04-88A patent/LV13249B/en unknown
- 2004-09-15 US US10/942,723 patent/US20050032715A1/en not_active Abandoned
2005
- 2005-08-24 US US11/211,389 patent/US20050281794A1/en not_active Abandoned
2008
- 2008-07-16 AU AU2008203157A patent/AU2008203157A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL371205A1 (en)	2005-06-13
IL162384A0 (en)	2005-11-20
RU2284185C2 (ru)	2006-09-27
ZA200404915B (en)	2006-07-26
EE200400031A (et)	2004-04-15
NO20033949L (no)	2003-11-04
EP1463498B1 (de)	2009-08-19
ATE439833T1 (de)	2009-09-15
LT2004074A (en)	2004-12-27
NO20033949D0 (no)	2003-09-05
RU2004124047A (ru)	2005-04-20
HUP0402421A3 (en)	2008-02-28
US20050281794A1 (en)	2005-12-22
SK2772004A3 (en)	2004-12-01
SI21871A (sl)	2006-04-30
AU2002244690A1 (en)	2003-07-24
AU2008203157A1 (en)	2008-08-07
DE60233433D1 (de)	2009-10-01
JP4144800B2 (ja)	2008-09-03
US6939860B2 (en)	2005-09-06
LT5215B (lt)	2005-05-25
MXPA04006627A (es)	2004-11-10
BR0208052A (pt)	2005-01-04
HUP0402421A2 (hu)	2005-07-28
NZ533353A (en)	2007-04-27
CZ2004853A3 (cs)	2004-12-15
LV13249B (en)	2005-07-20
CA2469162A1 (en)	2003-07-17
CN1612731A (zh)	2005-05-04
TR200401669T1 (tr)	2007-01-22
US20050032715A1 (en)	2005-02-10
EP1463498A1 (de)	2004-10-06
JP2005513166A (ja)	2005-05-12
HRP20040705A2 (en)	2004-10-31
KR20050005408A (ko)	2005-01-13
WO2003057211A1 (en)	2003-07-17
ES2332126T3 (es)	2010-01-27
US20030130201A1 (en)	2003-07-10

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