UA79296C2 - Substituted heterocyclic derivatives and method for treatment with use thereof - Google Patents

Substituted heterocyclic derivatives and method for treatment with use thereof Download PDF

Info

Publication number: UA79296C2
Authority: UA; Ukraine
Prior art keywords: compound; room temperature; vacuo; inhibitor; mixture
Prior art date: 2002-07-09

Application number

UAA200501187A

Other languages

English (en)

Ukrainian (uk)

Inventor

Peter T W Cheng

Sean Chen

Charles Z Ding

Thimothy F Herpin

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-09

Filing date

2003-08-07

Publication date

2007-06-11

2003-08-07 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2007-06-11 Publication of UA79296C2 publication Critical patent/UA79296C2/uk

Links

238000000034 method Methods 0.000 title claims description 57
125000000623 heterocyclic group Chemical group 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 369
125000000217 alkyl group Chemical group 0.000 claims abstract description 45
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 22
150000002367 halogens Chemical class 0.000 claims abstract description 20
125000003545 alkoxy group Chemical group 0.000 claims abstract description 19
229910052736 halogen Inorganic materials 0.000 claims abstract description 18
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 18
239000003472 antidiabetic agent Substances 0.000 claims abstract description 13
125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 11
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235000020824 obesity Nutrition 0.000 claims abstract description 7
-1 amino, substituted amino Chemical group 0.000 claims description 112
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125000003118 aryl group Chemical group 0.000 claims description 33
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NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 16
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RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 4
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150000001420 substituted heterocyclic compounds Chemical class 0.000 claims description 4
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Classifications

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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

UAA200501187A 2002-07-09 2003-08-07 Substituted heterocyclic derivatives and method for treatment with use thereof UA79296C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39455302P	2002-07-09	2002-07-09
PCT/US2003/021331 WO2004004655A2 (en)	2002-07-09	2003-07-08	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method

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US (2)	US6875782B2 (sr)
EP (1)	EP1531810B1 (sr)
JP (1)	JP4541883B2 (sr)
KR (1)	KR101120337B1 (sr)
CN (1)	CN1665500A (sr)
AT (1)	ATE543497T1 (sr)
AU (1)	AU2003248861B2 (sr)
BR (1)	BR0312503A (sr)
CA (1)	CA2490972C (sr)
ES (1)	ES2380319T3 (sr)
GE (1)	GEP20084475B (sr)
HR (1)	HRP20050001A2 (sr)
IL (1)	IL165809A (sr)
IS (1)	IS7629A (sr)
MX (1)	MXPA05000279A (sr)
NO (1)	NO329328B1 (sr)
NZ (1)	NZ537251A (sr)
PL (1)	PL375230A1 (sr)
RS (1)	RS20050002A (sr)
RU (1)	RU2325381C2 (sr)
UA (1)	UA79296C2 (sr)
WO (1)	WO2004004655A2 (sr)
ZA (1)	ZA200500029B (sr)

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2003
- 2003-07-08 US US10/616,283 patent/US6875782B2/en not_active Expired - Lifetime
- 2003-07-08 AT AT03763345T patent/ATE543497T1/de active
- 2003-07-08 RS YUP-2005/0002A patent/RS20050002A/sr unknown
- 2003-07-08 NZ NZ537251A patent/NZ537251A/en not_active IP Right Cessation
- 2003-07-08 AU AU2003248861A patent/AU2003248861B2/en not_active Ceased
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- 2003-07-08 CN CN038160382A patent/CN1665500A/zh active Pending
- 2003-07-08 JP JP2004520018A patent/JP4541883B2/ja not_active Expired - Fee Related
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- 2003-07-08 PL PL03375230A patent/PL375230A1/xx not_active Application Discontinuation
- 2003-07-08 KR KR1020057000362A patent/KR101120337B1/ko not_active Expired - Fee Related
- 2003-07-08 BR BRPI0312503-3A patent/BR0312503A/pt not_active IP Right Cessation
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- 2003-07-08 HR HR20050001A patent/HRP20050001A2/hr not_active Application Discontinuation
- 2003-07-08 RU RU2005103395/04A patent/RU2325381C2/ru not_active IP Right Cessation
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- 2003-07-08 MX MXPA05000279A patent/MXPA05000279A/es active IP Right Grant
- 2003-08-07 UA UAA200501187A patent/UA79296C2/uk unknown
2004
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- 2004-12-17 NO NO20045529A patent/NO329328B1/no not_active IP Right Cessation
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Also Published As

Publication number	Publication date
JP4541883B2 (ja)	2010-09-08
RU2005103395A (ru)	2005-08-10
BR0312503A (pt)	2007-06-26
ZA200500029B (en)	2006-06-28
IL165809A0 (en)	2006-01-15
EP1531810A4 (en)	2008-05-28
IL165809A (en)	2010-05-17
US20050119312A1 (en)	2005-06-02
HRP20050001A2 (en)	2005-08-31
CA2490972A1 (en)	2004-01-15
CN1665500A (zh)	2005-09-07
US6875782B2 (en)	2005-04-05
WO2004004655A2 (en)	2004-01-15
WO2004004655A3 (en)	2004-10-14
ATE543497T1 (de)	2012-02-15
US20040063762A1 (en)	2004-04-01
AU2003248861B2 (en)	2009-01-22
CA2490972C (en)	2012-05-29
EP1531810A2 (en)	2005-05-25
NO329328B1 (no)	2010-09-27
ES2380319T3 (es)	2012-05-10
RS20050002A (sr)	2007-09-21
NO20045529L (no)	2005-02-03
AU2003248861A1 (en)	2004-01-23
JP2006501187A (ja)	2006-01-12
KR101120337B1 (ko)	2012-02-29
GEP20084475B (en)	2008-09-10
MXPA05000279A (es)	2005-03-31
US7507757B2 (en)	2009-03-24
RU2325381C2 (ru)	2008-05-27
IS7629A (is)	2005-01-05
NZ537251A (en)	2007-02-23
EP1531810B1 (en)	2012-02-01
KR20050025951A (ko)	2005-03-14
PL375230A1 (en)	2005-11-28

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