UA79994C2 - Bicyclic inhibitors of hormone sensitive lipases - Google Patents

Bicyclic inhibitors of hormone sensitive lipases Download PDF

Info

Publication number: UA79994C2
Authority: UA; Ukraine
Prior art keywords: mean; benzotriazoles; formula; sna; compounds
Prior art date: 2002-10-12

Application number

UAA200504422A

Other languages

English (en)

Ukrainian (uk)

Inventor

Shtefan Petri

Karl-Heints Baringhaus

Norbert Tennahels

Hunter Muller

Hubert Heuer

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-12

Filing date

2003-09-27

Publication date

2007-08-10

2003-09-27 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2007-08-10 Publication of UA79994C2 publication Critical patent/UA79994C2/uk

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

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Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Animal Behavior & Ethology (AREA)
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Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
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Heart & Thoracic Surgery (AREA)
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Urology & Nephrology (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
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Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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UAA200504422A 2002-10-12 2003-09-27 Bicyclic inhibitors of hormone sensitive lipases UA79994C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10247680A DE10247680B4 (de)	2002-10-12	2002-10-12	Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
PCT/EP2003/010765 WO2004035550A1 (fr)	2002-10-12	2003-09-27	Inhibiteurs bicycliques de la lipase hormono-sensible

Publications (1)

Publication Number	Publication Date
UA79994C2 true UA79994C2 (en)	2007-08-10

Family

ID=32038583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200504422A UA79994C2 (en)	2002-10-12	2003-09-27	Bicyclic inhibitors of hormone sensitive lipases

Country Status (38)

Country	Link
EP (1)	EP1554259B1 (fr)
JP (2)	JP4658607B2 (fr)
KR (1)	KR20050059254A (fr)
CN (1)	CN100366616C (fr)
AR (1)	AR041565A1 (fr)
AT (1)	ATE349433T1 (fr)
AU (1)	AU2003275997B8 (fr)
BR (1)	BR0315257A (fr)
CA (1)	CA2501734C (fr)
CR (1)	CR7717A (fr)
CY (1)	CY1106358T1 (fr)
DE (2)	DE10247680B4 (fr)
DK (1)	DK1554259T3 (fr)
EC (1)	ECSP055729A (fr)
ES (1)	ES2277152T3 (fr)
GT (1)	GT200300214A (fr)
HN (1)	HN2003000316A (fr)
HR (1)	HRP20050325A2 (fr)
IL (1)	IL167907A (fr)
JO (1)	JO2497B1 (fr)
MA (1)	MA27404A1 (fr)
MX (1)	MXPA05003359A (fr)
MY (1)	MY138057A (fr)
NO (1)	NO20052291L (fr)
OA (1)	OA12941A (fr)
PA (1)	PA8585101A1 (fr)
PE (1)	PE20040776A1 (fr)
PL (1)	PL374605A1 (fr)
PT (1)	PT1554259E (fr)
RS (1)	RS51543B (fr)
RU (1)	RU2325385C2 (fr)
SV (1)	SV2004001633A (fr)
TN (1)	TNSN05105A1 (fr)
TW (1)	TWI313265B (fr)
UA (1)	UA79994C2 (fr)
UY (1)	UY28015A1 (fr)
WO (1)	WO2004035550A1 (fr)
ZA (1)	ZA200501757B (fr)

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DE102005002130A1 (de)	2005-01-17	2006-07-27	Sanofi-Aventis Deutschland Gmbh	Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel
DE102005026808A1 (de)	2005-06-09	2006-12-14	Sanofi-Aventis Deutschland Gmbh	Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026762A1 (de)	2005-06-09	2006-12-21	Sanofi-Aventis Deutschland Gmbh	Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026809A1 (de)	2005-06-09	2006-12-14	Sanofi-Aventis Deutschland Gmbh	Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005048897A1 (de) *	2005-10-12	2007-04-19	Sanofi-Aventis Deutschland Gmbh	Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049954A1 (de)	2005-10-19	2007-05-31	Sanofi-Aventis Deutschland Gmbh	Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049953A1 (de)	2005-10-19	2007-04-26	Sanofi-Aventis Deutschland Gmbh	Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
FR2915199B1 (fr) *	2007-04-18	2010-01-22	Sanofi Aventis	Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
FR2915197B1 (fr)	2007-04-18	2009-06-12	Sanofi Aventis Sa	Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2915198B1 (fr) *	2007-04-18	2009-12-18	Sanofi Aventis	Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
UY31968A (es)	2008-07-09	2010-01-29	Sanofi Aventis	Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
SG172301A1 (en) *	2008-12-24	2011-07-28	Bial Portela & Ca Sa	Pharmaceutical compounds
US8329904B2 (en)	2009-05-12	2012-12-11	Hoffmann-La Roche Inc.	Azacyclic derivatives
US8440710B2 (en)	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
US8097634B2 (en)	2010-04-15	2012-01-17	Hoffmann-La Roche Inc.	Azacyclic derivatives
WO2011140296A1 (fr) *	2010-05-05	2011-11-10	Infinity Pharmaceuticals	Triazoles utilisés comme inhibiteurs d'acides gras synthase (fasn)
US8722721B2 (en) *	2011-03-16	2014-05-13	Hoffmann-La Roche Inc.	SEC-hydroxycyclohexyl derivatives
US8703807B2 (en) *	2011-03-17	2014-04-22	Hoffmann-La Roche Inc.	Azaspirodecanone compounds
US8809384B2 (en) *	2011-03-25	2014-08-19	Hoffmann-La Roche Inc.	Azaspirodecanone compounds
UA119247C2 (uk)	2013-09-06	2019-05-27	РОЙВЕНТ САЙЕНСИЗ ҐмбГ	Спіроциклічні сполуки як інгібітори триптофангідроксилази
GB201321740D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
WO2015089137A1 (fr)	2013-12-11	2015-06-18	Karos Pharmaceuticals, Inc.	Acylguanidines comme inhibiteurs de la tryptophan hydroxylase
WO2016109501A1 (fr)	2014-12-30	2016-07-07	Karos Pharmaceuticals, Inc.	Composés amides utilisés en tant qu'inhibiteurs de la tryptophane hydroxylase
US9611201B2 (en)	2015-03-05	2017-04-04	Karos Pharmaceuticals, Inc.	Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
KR20210102887A (ko)	2018-11-14	2021-08-20	알타반트 사이언시스 게엠베하	말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제

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CA1126999A (fr) *	1978-10-20	1982-07-06	Michael J. Simons	Utilisation de derives de l'azole a groupe carbomoyl disubstitue en n,n, sur de l'azote cyclique, comme precurseurs pour la retenue du developpement dans des elements photographiques
US5369086A (en) *	1993-04-28	1994-11-29	Zeneca Limited	N-benzotriazoles
DE19942354A1 (de) *	1999-09-04	2001-03-08	Aventis Pharma Gmbh	Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln
MXPA03010129A (es) *	2001-05-05	2004-03-10	Smithkline Beecham Plc	N-aroilaminas-ciclicas.
KR20040068240A (ko) *	2001-12-14	2004-07-30	노보 노르디스크 에이/에스	호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용

2002
- 2002-10-12 DE DE10247680A patent/DE10247680B4/de not_active Expired - Fee Related
2003
- 2003-09-27 WO PCT/EP2003/010765 patent/WO2004035550A1/fr not_active Ceased
- 2003-09-27 OA OA1200500103A patent/OA12941A/en unknown
- 2003-09-27 KR KR1020057006312A patent/KR20050059254A/ko not_active Ceased
- 2003-09-27 RU RU2005114394/04A patent/RU2325385C2/ru not_active IP Right Cessation
- 2003-09-27 PT PT03808700T patent/PT1554259E/pt unknown
- 2003-09-27 CN CNB038241420A patent/CN100366616C/zh not_active Expired - Fee Related
- 2003-09-27 DK DK03808700T patent/DK1554259T3/da active
- 2003-09-27 BR BR0315257-0A patent/BR0315257A/pt not_active IP Right Cessation
- 2003-09-27 DE DE50306134T patent/DE50306134D1/de not_active Expired - Lifetime
- 2003-09-27 UA UAA200504422A patent/UA79994C2/uk unknown
- 2003-09-27 JP JP2004544048A patent/JP4658607B2/ja not_active Expired - Fee Related
- 2003-09-27 HR HR20050325A patent/HRP20050325A2/xx not_active Application Discontinuation
- 2003-09-27 CA CA2501734A patent/CA2501734C/fr not_active Expired - Fee Related
- 2003-09-27 PL PL03374605A patent/PL374605A1/xx not_active Application Discontinuation
- 2003-09-27 RS YUP-2005/0207A patent/RS51543B/sr unknown
- 2003-09-27 MX MXPA05003359A patent/MXPA05003359A/es active IP Right Grant
- 2003-09-27 EP EP03808700A patent/EP1554259B1/fr not_active Expired - Lifetime
- 2003-09-27 AU AU2003275997A patent/AU2003275997B8/en not_active Ceased
- 2003-09-27 AT AT03808700T patent/ATE349433T1/de active
- 2003-09-27 ES ES03808700T patent/ES2277152T3/es not_active Expired - Lifetime
- 2003-09-29 JO JO2003123A patent/JO2497B1/en active
- 2003-09-29 GT GT200300214A patent/GT200300214A/es unknown
- 2003-10-08 TW TW092127898A patent/TWI313265B/zh active
- 2003-10-08 SV SV2003001633A patent/SV2004001633A/es not_active Application Discontinuation
- 2003-10-09 AR ARP030103676A patent/AR041565A1/es unknown
- 2003-10-09 PA PA20038585101A patent/PA8585101A1/es unknown
- 2003-10-09 HN HN2003000316A patent/HN2003000316A/es unknown
- 2003-10-09 PE PE2003001028A patent/PE20040776A1/es not_active Application Discontinuation
- 2003-10-10 UY UY28015A patent/UY28015A1/es unknown
- 2003-10-10 MY MYPI20033883A patent/MY138057A/en unknown
2005
- 2005-03-01 ZA ZA200501757A patent/ZA200501757B/en unknown
- 2005-03-07 CR CR7717A patent/CR7717A/es unknown
- 2005-04-07 IL IL167907A patent/IL167907A/en not_active IP Right Cessation
- 2005-04-11 TN TNP2005000105A patent/TNSN05105A1/en unknown
- 2005-04-11 MA MA28213A patent/MA27404A1/fr unknown
- 2005-04-11 EC EC2005005729A patent/ECSP055729A/es unknown
- 2005-05-10 NO NO20052291A patent/NO20052291L/no not_active Application Discontinuation
2007
- 2007-03-06 CY CY20071100315T patent/CY1106358T1/el unknown
2010
- 2010-10-08 JP JP2010228107A patent/JP2011026342A/ja not_active Abandoned

Also Published As

Publication number	Publication date
RS51543B (sr)	2011-06-30
CN100366616C (zh)	2008-02-06
DE50306134D1 (de)	2007-02-08
HRP20050325A2 (en)	2005-06-30
DK1554259T3 (da)	2007-05-07
ATE349433T1 (de)	2007-01-15
WO2004035550A1 (fr)	2004-04-29
AU2003275997A1 (en)	2004-05-04
HK1080473A1 (en)	2006-04-28
NO20052291D0 (no)	2005-05-10
RS20050207A (sr)	2007-08-03
MXPA05003359A (es)	2005-06-22
MA27404A1 (fr)	2005-06-01
RU2005114394A (ru)	2006-01-20
BR0315257A (pt)	2005-08-23
AU2003275997B2 (en)	2010-03-25
CA2501734A1 (fr)	2004-04-29
DE10247680A1 (de)	2004-04-22
JP2011026342A (ja)	2011-02-10
EP1554259B1 (fr)	2006-12-27
CN1688555A (zh)	2005-10-26
PA8585101A1 (es)	2004-09-16
CR7717A (es)	2007-09-14
TNSN05105A1 (en)	2007-05-14
CA2501734C (fr)	2011-05-31
GT200300214A (es)	2007-02-05
CY1106358T1 (el)	2011-10-12
SV2004001633A (es)	2004-03-19
JP4658607B2 (ja)	2011-03-23
HN2003000316A (es)	2006-06-12
PE20040776A1 (es)	2004-12-24
KR20050059254A (ko)	2005-06-17
RU2325385C2 (ru)	2008-05-27
ECSP055729A (es)	2005-07-06
UY28015A1 (es)	2004-04-30
ES2277152T3 (es)	2007-07-01
NO20052291L (no)	2005-05-10
PL374605A1 (en)	2005-10-31
OA12941A (en)	2006-10-13
AR041565A1 (es)	2005-05-18
TW200413335A (en)	2004-08-01
JP2006509734A (ja)	2006-03-23
JO2497B1 (en)	2009-10-05
IL167907A (en)	2010-12-30
EP1554259A1 (fr)	2005-07-20
TWI313265B (en)	2009-08-11
MY138057A (en)	2009-04-30
PT1554259E (pt)	2007-02-28
ZA200501757B (en)	2005-09-07
AU2003275997B8 (en)	2010-09-30
DE10247680B4 (de)	2005-09-01

Publication	Publication Date	Title
UA79994C2 (en)	2007-08-10	Bicyclic inhibitors of hormone sensitive lipases
JP4714158B2 (ja)	2011-06-29	ホルモン感受性リパーゼの阻害剤としてのインダゾール誘導体
AU2007263391B2 (en)	2012-05-17	3 -amino-imidazo[1, 2-A]pyridine derivatives as SGLT inhibitors
AU2008314233B2 (en)	2013-06-13	Imidazo[1,2-a]pyrimidine derivatives for treating diseases such as diabetes
DE60008545T2 (de)	2004-12-23	Antibakterielle heterobicyclisch substituierte phenyloxazolidinone
DE60115132T2 (de)	2006-07-06	Thyroid-Rezeptorliganden
RU2414458C2 (ru)	2011-03-20	Производные азола в качестве ингибиторов липаз и фосфолипаз
DE102005049954A1 (de)	2007-05-31	Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102006014685A1 (de)	2007-10-04	Imidazo-pyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholiphasen
DE102005049953A1 (de)	2007-04-26	Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
MX2007015347A (es)	2008-02-15	Derivados de azolopiridin -2- ona como inhibidores de lipasas y fosfolipasas.
EP1874733B1 (fr)	2012-06-20	Derives d'uree cycliques substitues et leur utilisation comme modulateurs du recepteur vanilloide 1
MX2007015267A (es)	2008-02-21	Derivados de benzooxazol-2-ona como inhibidores de lipasas y de fosfolipasas.
NZ564061A (en)	2010-07-30	Benzothiazol-2-one derivatives as lipase and phospholipase inhibitors
US20040127484A1 (en)	2004-07-01	Novel bicyclic inhibitors of hormone sensitive lipase
US5530018A (en)	1996-06-25	Meso-azanoradamantanes
NZ539347A (en)	2006-10-27	Novel bicyclic inhibitors of hormone sensitive lipase
MXPA06008406A (en)	2006-12-13	Indazole derivatives as inhibitors of hormone-sensitive lipases
HK1080473B (en)	2008-07-18	Bicyclic inhibitors of hormone sensitive lipase