UA80171C2 - Pyrrolopyrimidine derivatives - Google Patents

Pyrrolopyrimidine derivatives Download PDF

Info

Publication number: UA80171C2
Authority: UA; Ukraine
Prior art keywords: amino; pyrrolo; carbonyl; isopropyl; phenyl
Prior art date: 2002-12-19

Application number

UAA200506094A

Other languages

English (en)

Ukrainian (uk)

Inventor

Joel Thomas Arcari

Jinshan Chen

Susan Lagreca

Matthew Arnold Marx

Matthew David Wessel

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-19

Filing date

2003-08-12

Publication date

2007-08-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32682064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA80171(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-08-12 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2007-08-27 Publication of UA80171C2 publication Critical patent/UA80171C2/uk

Links

150000004944 pyrrolopyrimidines Chemical class 0.000 title description 2
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238000000034 method Methods 0.000 claims abstract description 137
150000003839 salts Chemical class 0.000 claims abstract description 55
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 24
230000003463 hyperproliferative effect Effects 0.000 claims abstract description 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 567
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 263
239000004202 carbamide Substances 0.000 claims description 139
125000000217 alkyl group Chemical group 0.000 claims description 106
125000003118 aryl group Chemical group 0.000 claims description 69
229910052736 halogen Inorganic materials 0.000 claims description 47
150000002367 halogens Chemical class 0.000 claims description 46
125000000623 heterocyclic group Chemical group 0.000 claims description 40
125000001072 heteroaryl group Chemical group 0.000 claims description 39
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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

UAA200506094A 2002-12-19 2003-08-12 Pyrrolopyrimidine derivatives UA80171C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43456802P	2002-12-19	2002-12-19
PCT/IB2003/005841 WO2004056830A1 (fr)	2002-12-19	2003-12-08	Derives de pyrrolopyrimidine

Publications (1)

Publication Number	Publication Date
UA80171C2 true UA80171C2 (en)	2007-08-27

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ID=32682064

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Application Number	Title	Priority Date	Filing Date
UAA200506094A UA80171C2 (en)	2002-12-19	2003-08-12	Pyrrolopyrimidine derivatives

Country Status (34)

Country	Link
US (1)	US7271262B2 (fr)
EP (1)	EP1578751B1 (fr)
JP (1)	JP4057013B2 (fr)
KR (2)	KR20050084402A (fr)
CN (1)	CN1726218A (fr)
AP (1)	AP2005003342A0 (fr)
AR (1)	AR042509A1 (fr)
AT (1)	ATE512965T1 (fr)
AU (1)	AU2003286317A1 (fr)
BR (1)	BR0317524A (fr)
CA (1)	CA2510853C (fr)
EA (1)	EA200500814A1 (fr)
EC (1)	ECSP055867A (fr)
ES (1)	ES2364649T3 (fr)
GT (1)	GT200300289A (fr)
HN (1)	HN2003000416A (fr)
HR (1)	HRP20050560A2 (fr)
IS (1)	IS7872A (fr)
MA (1)	MA27568A1 (fr)
MX (1)	MXPA05006793A (fr)
NL (1)	NL1025068C2 (fr)
NO (1)	NO20052802L (fr)
NZ (1)	NZ540456A (fr)
OA (1)	OA12976A (fr)
PA (1)	PA8591701A1 (fr)
PE (1)	PE20040914A1 (fr)
PL (1)	PL377774A1 (fr)
RS (1)	RS20050469A (fr)
TN (1)	TNSN05165A1 (fr)
TW (1)	TW200423939A (fr)
UA (1)	UA80171C2 (fr)
UY (1)	UY28132A1 (fr)
WO (1)	WO2004056830A1 (fr)
ZA (1)	ZA200504440B (fr)

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ZA200504440B (en)	2006-07-26
AP2005003342A0 (en)	2005-06-30
KR20070087020A (ko)	2007-08-27
HN2003000416A (es)	2006-07-25
MXPA05006793A (es)	2005-09-08
NO20052802D0 (no)	2005-06-09
OA12976A (en)	2006-10-13
NO20052802L (no)	2005-07-19
MA27568A1 (fr)	2005-10-03
KR20050084402A (ko)	2005-08-26
RS20050469A (sr)	2007-11-15
BR0317524A (pt)	2005-11-16
PA8591701A1 (es)	2005-05-24
JP4057013B2 (ja)	2008-03-05
ES2364649T3 (es)	2011-09-08
NZ540456A (en)	2007-11-30
US20050037999A1 (en)	2005-02-17
TNSN05165A1 (fr)	2007-05-14
PE20040914A1 (es)	2005-01-08
IS7872A (is)	2005-05-30
EP1578751B1 (fr)	2011-06-15
US7271262B2 (en)	2007-09-18
NL1025068C2 (nl)	2004-11-16
ATE512965T1 (de)	2011-07-15
AU2003286317A1 (en)	2004-07-14
HRP20050560A2 (en)	2006-02-28
NL1025068A1 (nl)	2004-06-22
JP2006512356A (ja)	2006-04-13
UY28132A1 (es)	2004-07-30
CA2510853A1 (fr)	2004-07-08
EP1578751A1 (fr)	2005-09-28
PL377774A1 (pl)	2006-02-20
CA2510853C (fr)	2009-04-28
TW200423939A (en)	2004-11-16
ECSP055867A (es)	2005-09-20
GT200300289A (es)	2004-09-21
EA200500814A1 (ru)	2006-02-24
CN1726218A (zh)	2006-01-25
WO2004056830A1 (fr)	2004-07-08
AR042509A1 (es)	2005-06-22

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