UA80543C2 - Method for the preparation of o-desmethylvenlafaxine - Google Patents

Method for the preparation of o-desmethylvenlafaxine Download PDF

Info

Publication number: UA80543C2
Authority: UA; Ukraine
Prior art keywords: thiolate; carried out; venlafaxine; alcohol; reaction
Prior art date: 2001-12-04

Application number

UA20040705306A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-04

Filing date

2002-03-12

Publication date

2007-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23309595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA80543(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-03-12 Application filed by Wyeth Corp filed Critical Wyeth Corp

2007-10-10 Publication of UA80543C2 publication Critical patent/UA80543C2/uk

Links

KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethylvenlafaxine Chemical compound C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 title claims abstract description 12
238000000034 method Methods 0.000 title claims description 31
238000002360 preparation method Methods 0.000 title description 2
-1 thiolate anion Chemical class 0.000 claims abstract description 18
PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims abstract description 17
229960004688 venlafaxine Drugs 0.000 claims abstract description 16
230000001335 demethylating effect Effects 0.000 claims abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 23
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 21
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 12
125000004432 carbon atom Chemical group C* 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 8
239000002904 solvent Substances 0.000 claims description 8
WNAHIZMDSQCWRP-UHFFFAOYSA-N dodecane-1-thiol Chemical compound CCCCCCCCCCCCS WNAHIZMDSQCWRP-UHFFFAOYSA-N 0.000 claims description 7
239000002202 Polyethylene glycol Substances 0.000 claims description 5
150000004703 alkoxides Chemical class 0.000 claims description 5
239000000203 mixture Substances 0.000 claims description 5
229920001223 polyethylene glycol Polymers 0.000 claims description 5
150000007944 thiolates Chemical class 0.000 claims description 5
230000017858 demethylation Effects 0.000 claims description 4
238000010520 demethylation reaction Methods 0.000 claims description 4
239000011541 reaction mixture Substances 0.000 claims description 4
150000001335 aliphatic alkanes Chemical class 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 3
230000003472 neutralizing effect Effects 0.000 claims description 3
229940068918 polyethylene glycol 400 Drugs 0.000 claims description 3
150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
125000003710 aryl alkyl group Chemical group 0.000 claims description 2
NBTOZLQBSIZIKS-UHFFFAOYSA-N methoxide Chemical compound [O-]C NBTOZLQBSIZIKS-UHFFFAOYSA-N 0.000 claims description 2
YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 claims description 2
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
RMVRSNDYEFQCLF-UHFFFAOYSA-M benzenethiolate Chemical compound [S-]C1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-M 0.000 claims 1
238000012876 topography Methods 0.000 claims 1
238000004519 manufacturing process Methods 0.000 abstract 1
RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 6
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 4
238000001914 filtration Methods 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000012065 filter cake Substances 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
XRZRPHKMCVBSLA-UHFFFAOYSA-M sodium;dodecane-1-thiolate Chemical compound [Na+].CCCCCCCCCCCC[S-] XRZRPHKMCVBSLA-UHFFFAOYSA-M 0.000 description 3
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000006386 neutralization reaction Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
239000000010 aprotic solvent Substances 0.000 description 1
UENWRTRMUIOCKN-UHFFFAOYSA-N benzyl thiol Chemical compound SCC1=CC=CC=C1 UENWRTRMUIOCKN-UHFFFAOYSA-N 0.000 description 1
125000001743 benzylic group Chemical group 0.000 description 1
150000004946 bicyclic arenes Chemical class 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
210000005056 cell body Anatomy 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
GPAYUJZHTULNBE-UHFFFAOYSA-N diphenylphosphine Chemical compound C=1C=CC=CC=1PC1=CC=CC=C1 GPAYUJZHTULNBE-UHFFFAOYSA-N 0.000 description 1
HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
229910000041 hydrogen chloride Inorganic materials 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
150000004947 monocyclic arenes Chemical class 0.000 description 1
125000002950 monocyclic group Chemical group 0.000 description 1
239000003586 protic polar solvent Substances 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000000967 suction filtration Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

UA20040705306A 2001-12-04 2002-03-12 Method for the preparation of o-desmethylvenlafaxine UA80543C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US33495301P	2001-12-04	2001-12-04
PCT/US2002/038403 WO2003048104A1 (en)	2001-12-04	2002-12-03	Methods for preparing o-desmethylvenlafaxine

Publications (1)

Publication Number	Publication Date
UA80543C2 true UA80543C2 (en)	2007-10-10

Family

ID=23309595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040705306A UA80543C2 (en)	2001-12-04	2002-03-12	Method for the preparation of o-desmethylvenlafaxine

Country Status (28)

Country	Link
US (4)	US6689912B2 (de)
EP (1)	EP1451143B9 (de)
JP (1)	JP4342312B2 (de)
KR (1)	KR100939650B1 (de)
CN (1)	CN1319934C (de)
AR (1)	AR037622A1 (de)
AT (1)	ATE403641T1 (de)
AU (1)	AU2002357049B2 (de)
BR (1)	BR0214701A (de)
CA (1)	CA2466779C (de)
CO (1)	CO5580816A2 (de)
DE (1)	DE60228118D1 (de)
DK (1)	DK1451143T3 (de)
EC (1)	ECSP045135A (de)
ES (1)	ES2311647T4 (de)
HU (1)	HUP0402269A3 (de)
IL (3)	IL162253A0 (de)
MX (1)	MXPA04005309A (de)
NO (1)	NO20042680L (de)
NZ (1)	NZ533316A (de)
PL (1)	PL369299A1 (de)
PT (1)	PT1451143E (de)
RU (1)	RU2317286C2 (de)
SI (1)	SI1451143T1 (de)
TW (1)	TWI260982B (de)
UA (1)	UA80543C2 (de)
WO (1)	WO2003048104A1 (de)
ZA (1)	ZA200405250B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6342533B1 (en) *	1998-12-01	2002-01-29	Sepracor, Inc.	Derivatives of (−)-venlafaxine and methods of preparing and using the same
CA2368083A1 (en) *	1999-04-06	2000-10-12	Sepracor Inc.	Derivatives of venlafaxine and methods of preparing and using the same
EA011451B1 (ru) *	2001-02-12	2009-04-28	Уайт	Новая соль сукцинат о-десметилвенлафаксина
UA80543C2 (en) *	2001-12-04	2007-10-10	Wyeth Corp	Method for the preparation of o-desmethylvenlafaxine
EP1904046A4 (de) *	2005-07-06	2008-10-01	Sepracor Inc	Kombinationen von eszopiclon und o-desmethylvenlafaxin und verfahren zur behandlung der menopause und von stimmungsschwankungen; angstzuständen und kognitiven störungen
WO2007067501A1 (en) *	2005-12-05	2007-06-14	Wyeth	Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
WO2007071404A1 (en) *	2005-12-20	2007-06-28	Synthon B.V.	Process for making desvenlafaxine
EP2007708A1 (de)	2006-04-17	2008-12-31	Teva Pharmaceutical Industries Ltd	Substanziell reines o-desmethylvenlafaxin und herstellungsverfahren dafür
MX2007016179A (es) *	2006-04-17	2008-03-11	Teva Pharma	Formas cristalinas de o-desmetilvenlafaxina.
WO2008035369A2 (en) *	2006-06-30	2008-03-27	Alembic Limited	Novel form of o-desmethyl venlafaxine
US20090069601A1 (en) *	2006-07-26	2009-03-12	Valerie Niddam-Hildesheim	Processes for the synthesis of O-desmethylvenlafaxine
US20080221356A1 (en) *	2006-07-26	2008-09-11	Valerie Niddam-Hildesheim	Processes for the synthesis of O-desmethylvenlafaxine
JP4763788B2 (ja) *	2006-07-26	2011-08-31	テバファーマシューティカルインダストリーズリミティド	Ｏ−デスメチルベンラファキシンの合成方法
WO2008013994A2 (en)	2006-07-26	2008-01-31	Teva Pharmaceutical Industries Ltd.	Processes for the synthesis of o-desmethylvenlafaxine
WO2008013995A2 (en) *	2006-07-26	2008-01-31	Teva Pharmaceutical Industries Ltd.	Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine
US20080183016A1 (en) *	2006-07-26	2008-07-31	Valerie Niddam-Hildesheim	Process for the synthesis of O-desmethylvenlafaxine
US20090137846A1 (en) *	2006-07-26	2009-05-28	Valerie Niddam-Hildesheim	Processes for the synthesis of O-Desmethylvenlafaxine
ES2334765B1 (es) *	2006-08-04	2010-12-20	Medichem, S.A.	Proceso mejorado para sintetizar la base libre de la desvenlafaxina ysales o solvatos de la misma.
AU2008211711A1 (en) *	2007-01-31	2008-08-07	Generics [Uk] Limited	Process for the preparation of O-desmethyl venlafaxine
WO2008112313A2 (en) *	2007-03-14	2008-09-18	Teva Pharmaceutical Industries Ltd.	Processes for preparing solid states of o-desmethylvenlafaxine succinate
US20100210719A1 (en) *	2007-07-12	2010-08-19	Dr. Reddy's Laboratories Ltd.	O-desmethylvenlafaxine
IN2007CH01519A (de) *	2007-07-16	2009-09-11	Matrix Lab Ltd
WO2009034434A2 (en) *	2007-09-10	2009-03-19	Cadila Pharmaceuticals Limited	An improved process for the preparation of o-desmethylvenlafaxine
US20110118357A1 (en) *	2007-10-26	2011-05-19	Generics Limited	Process for preparing o-desmethylvenlafaxine
KR101343027B1 (ko) *	2007-11-26	2013-12-18	테바 파마슈티컬 인더스트리즈 리미티드	Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
WO2009084038A2 (en) *	2007-12-28	2009-07-09	Ind-Swift Laboratories Limited	Improved process for the preparation of 0-desmethyl-venlafaxine
EP2252574A1 (de) *	2008-03-06	2010-11-24	Teva Pharmaceutical Industries Ltd.	Verfahren zur herstellung von dimer-unreinheitsfreiem o-desmethylvenlafaxin
EP2119696A1 (de)	2008-05-16	2009-11-18	Krka	Zubereitung von O-Desmethylvenlafaxin-Salzen
EP2119695A1 (de)	2008-05-16	2009-11-18	Krka	Zubereitung von O-Desmethylvenlafaxin-Salzen
US20110112200A1 (en) *	2008-06-16	2011-05-12	Valerie Niddam-Hildesheim	Solid states of o-desmethylvenlafaxine salts
US20100016638A1 (en) *	2008-07-21	2010-01-21	Zdenko Hamersak	Method for preparation of o-desmethylvenlafaxine using polythiolates
US20110263718A1 (en) *	2008-07-30	2011-10-27	Generics [Uk] Limited	Process for the preparation of o-desmethylvenlafaxine
CZ301503B6 (cs)	2008-11-27	2010-03-24	Zentiva, A. S.	Zpusob prípravy desvenlafaxinu a jeho solí
CZ301820B6 (cs)	2009-02-06	2010-06-30	Zentiva, K.S.	Nové soli desvenlafaxinu a zpusob jejich prípravy
CZ2009454A3 (cs)	2009-07-15	2010-11-10	Zentiva, K. S.	Zpusob prípravy desvenlafaxinu a jeho solí
JP2012532923A (ja)	2009-07-16	2012-12-20	シプラ・リミテッド	Ｏ−デスメチルベンラファキシンの製造方法及びそれに使用される中間体
US20110098506A1 (en) *	2009-10-26	2011-04-28	Intas Pharmaceuticals Limited	Method of preparing o-desmethylvenlafaxine
US20110184067A1 (en) *	2010-01-25	2011-07-28	Intas Pharmaceuticals Ltd.	O-desmethylvenlafaxine succinate polymorph & process for preparing thereof
CA2795023A1 (en)	2010-03-29	2011-10-06	Pliva Hrvatska D.O.O.	Crystal forms of o-desmethylvenlafaxine fumarate
CZ303249B6 (cs)	2010-04-06	2012-06-20	Zentiva, K.S.	Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
EP2394976A1 (de)	2010-06-11	2011-12-14	LEK Pharmaceuticals d.d.	Verfahren zur Demethylierung aromatischer Methylether unter Verwendung von 3-Mercaptopropionsäure
US10464873B2 (en)	2017-02-09	2019-11-05	R L Finechem Private Limited	Process for preparation of 1-[2-(dimethyl amino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof
CN109232189B (zh) *	2018-09-25	2021-10-08	杭州盛弗泰新材料科技有限公司	一种高纯度1-羟基芘的制备方法
CN109665966A (zh) *	2018-11-01	2019-04-23	山东蒲济医药科技有限公司	一种琥珀酸去甲文拉法辛化合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2741009A1 (de) *	1976-09-22	1978-03-23	Sandoz Ag	4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
US4535186A (en)	1983-04-19	1985-08-13	American Home Products Corporation	2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
CA1227304A (en)	1984-08-01	1987-09-29	Raymond C. Francis	Delignification of pulp
GB8902209D0 (en)	1989-02-01	1989-03-22	Wyeth John And Brother Limited	Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6342533B1 (en) *	1998-12-01	2002-01-29	Sepracor, Inc.	Derivatives of (−)-venlafaxine and methods of preparing and using the same
US6197828B1 (en) *	1998-12-01	2001-03-06	Sepracor, Inc.	Derivatives of (+)-venlafaxine and methods of preparing and using the same
CA2368083A1 (en)	1999-04-06	2000-10-12	Sepracor Inc.	Derivatives of venlafaxine and methods of preparing and using the same
AU5738700A (en)	1999-06-15	2001-01-02	American Home Products Corporation	Enantiomers of o-desmethyl venlafaxine
JP2004504026A (ja)	2000-07-18	2004-02-12	バイエル　アクチェンゲゼルシャフト	ヒトｄｅｓｃ１様セリンプロテアーゼの調節
EA011451B1 (ru) *	2001-02-12	2009-04-28	Уайт	Новая соль сукцинат о-десметилвенлафаксина
UA80543C2 (en) *	2001-12-04	2007-10-10	Wyeth Corp	Method for the preparation of o-desmethylvenlafaxine

2002
- 2002-03-12 UA UA20040705306A patent/UA80543C2/uk unknown
- 2002-11-26 US US10/304,871 patent/US6689912B2/en not_active Expired - Fee Related
- 2002-11-27 TW TW091134427A patent/TWI260982B/zh not_active IP Right Cessation
- 2002-12-03 DK DK02804479T patent/DK1451143T3/da active
- 2002-12-03 WO PCT/US2002/038403 patent/WO2003048104A1/en not_active Ceased
- 2002-12-03 EP EP02804479A patent/EP1451143B9/de not_active Expired - Lifetime
- 2002-12-03 JP JP2003549297A patent/JP4342312B2/ja not_active Expired - Fee Related
- 2002-12-03 CN CNB028242386A patent/CN1319934C/zh not_active Expired - Fee Related
- 2002-12-03 HU HU0402269A patent/HUP0402269A3/hu active IP Right Revival
- 2002-12-03 PT PT02804479T patent/PT1451143E/pt unknown
- 2002-12-03 DE DE60228118T patent/DE60228118D1/de not_active Expired - Lifetime
- 2002-12-03 CA CA2466779A patent/CA2466779C/en not_active Expired - Lifetime
- 2002-12-03 AT AT02804479T patent/ATE403641T1/de not_active IP Right Cessation
- 2002-12-03 NZ NZ533316A patent/NZ533316A/en unknown
- 2002-12-03 IL IL16225302A patent/IL162253A0/xx active IP Right Grant
- 2002-12-03 PL PL02369299A patent/PL369299A1/xx unknown
- 2002-12-03 AU AU2002357049A patent/AU2002357049B2/en not_active Ceased
- 2002-12-03 ES ES02804479T patent/ES2311647T4/es not_active Expired - Lifetime
- 2002-12-03 BR BR0214701-7A patent/BR0214701A/pt not_active Application Discontinuation
- 2002-12-03 AR ARP020104669A patent/AR037622A1/es unknown
- 2002-12-03 SI SI200230743T patent/SI1451143T1/sl unknown
- 2002-12-03 RU RU2004120284/04A patent/RU2317286C2/ru not_active IP Right Cessation
- 2002-12-03 KR KR1020047008512A patent/KR100939650B1/ko not_active Expired - Fee Related
- 2002-12-03 MX MXPA04005309A patent/MXPA04005309A/es active IP Right Grant
2003
- 2003-12-31 US US10/750,196 patent/US20040158101A1/en not_active Abandoned
2004
- 2004-05-31 IL IL162253A patent/IL162253A/en not_active IP Right Cessation
- 2004-06-01 CO CO04050957A patent/CO5580816A2/es active IP Right Grant
- 2004-06-04 EC EC2004005135A patent/ECSP045135A/es unknown
- 2004-06-25 NO NO20042680A patent/NO20042680L/no not_active Application Discontinuation
- 2004-07-01 ZA ZA2004/05250A patent/ZA200405250B/en unknown
2007
- 2007-06-01 US US11/756,772 patent/US7435854B2/en not_active Expired - Fee Related
2008
- 2008-09-11 US US12/208,990 patent/US20090018365A1/en not_active Abandoned
- 2008-09-11 IL IL194034A patent/IL194034A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR20050044671A (ko)	2005-05-12
US20040158101A1 (en)	2004-08-12
HK1065778A1 (en)	2005-03-04
EP1451143B9 (de)	2009-08-12
PT1451143E (pt)	2008-10-21
AU2002357049A1 (en)	2003-06-17
US6689912B2 (en)	2004-02-10
JP4342312B2 (ja)	2009-10-14
CN1319934C (zh)	2007-06-06
EP1451143B1 (de)	2008-08-06
EP1451143A1 (de)	2004-09-01
DK1451143T3 (da)	2008-11-10
SI1451143T1 (sl)	2008-12-31
MXPA04005309A (es)	2004-09-13
IL162253A0 (en)	2005-11-20
NO20042680L (no)	2004-06-25
CN1625546A (zh)	2005-06-08
PL369299A1 (en)	2005-04-18
IL162253A (en)	2009-02-11
HUP0402269A2 (hu)	2005-02-28
TWI260982B (en)	2006-09-01
KR100939650B1 (ko)	2010-02-05
US20070225525A1 (en)	2007-09-27
HUP0402269A3 (en)	2010-06-28
CA2466779C (en)	2013-11-19
NZ533316A (en)	2005-12-23
CO5580816A2 (es)	2005-11-30
AR037622A1 (es)	2004-11-17
JP2005511681A (ja)	2005-04-28
ES2311647T3 (es)	2009-02-16
ATE403641T1 (de)	2008-08-15
WO2003048104A1 (en)	2003-06-12
US20090018365A1 (en)	2009-01-15
CA2466779A1 (en)	2003-06-12
US7435854B2 (en)	2008-10-14
DE60228118D1 (de)	2008-09-18
US20030105358A1 (en)	2003-06-05
ZA200405250B (en)	2005-12-28
BR0214701A (pt)	2004-08-31
RU2004120284A (ru)	2005-04-10
IL194034A (en)	2010-12-30
ECSP045135A (es)	2004-07-23
RU2317286C2 (ru)	2008-02-20
AU2002357049B2 (en)	2009-07-16
ES2311647T4 (es)	2009-11-10
TW200301102A (en)	2003-07-01

Publication	Publication Date	Title
KR100939650B1 (ko)	2010-02-05	Ｏ-데스메틸벤라팍신의 제조방법
CN1239477C (zh)	2006-02-01	酚类的磺化
CN103254095A (zh)	2013-08-21	碘比醇制备过程中的分离、纯化方法
ES2397531T3 (es)	2013-03-07	Procedimiento de producción de derivado de poligliceril éter
CN104086578A (zh)	2014-10-08	一种含糖酰胺基的三硅氧烷及制法
US3660460A (en)	1972-05-02	Process for preparing n n-bis-cyanoethylated derivatives of aliphatic primary amine branched at the alpha-position
TWI243823B (en)	2005-11-21	Phosphonium salts and processes for production of and uses for the same, and phosphines deriving the same and processes for production of the phosphines
WO2001007397A1 (es)	2001-02-01	Procedimiento de obtencion de venlafaxina
CN114845987B (zh)	2024-06-11	用于合成双尾三胺的方法
HK1065778B (en)	2009-03-06	Methods for preparing o-desmethylvenlafaxine
JP2002371088A (ja)	2002-12-26	スルホン酸アミン塩およびその製造方法
KR100601133B1 (ko)	2006-07-19	엔,엔,엔-트리스(3-알킬옥시-2-히드록시프로필)아민화합물의 효율적 제조방법
JP3811819B2 (ja)	2006-08-23	３−ｎ−モノアルキルアミノフェノール又は３−ｎ，ｎ−ジアルキルアミノフェノールの製造法
JPH0641462B2 (ja)	1994-06-01	ロイカルト反応を介して３―アミノ―２，２，４，４―テトラメチルチエタンを製造するための優れた触媒
CN106132973A (zh)	2016-11-16	纯化的亚磷酰二胺的制备
CN104072562A (zh)	2014-10-01	一种乙氧基改性的含糖酰胺基的四硅氧烷及制法
JP2016124788A (ja)	2016-07-11	長鎖ケトアルコールの製造方法およびそれを還元してなる長鎖ジオール
JP2003089664A (ja)	2003-03-28	含フッ素パラシクロファンの製法
JPH06211773A (ja)	1994-08-02	ヒドロキシスルホベタインの製造方法
JP2005047836A (ja)	2005-02-24	１−アルキル−３−ピペリジンエステル類の製造方法
JPWO1995010502A1 (ja)	1996-02-27	３−置換−２，４，５−トリフルオロ安息香酸の製造方法および４−アミノ−３，５，６−トリフルオロフタル酸
WO2001096349A1 (en)	2001-12-20	Water soluble phosphines