UA81319C2 - 3-fluoro-piperidines as nmda/nr2b antagonists - Google Patents

3-fluoro-piperidines as nmda/nr2b antagonists Download PDF

Info

Publication number: UA81319C2
Authority: UA; Ukraine
Prior art keywords: pharmaceutically acceptable; compound; acceptable salt; compound according; formula
Prior art date: 2003-06-04

Application number

UAA200511411A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-04

Filing date

2004-05-28

Publication date

2007-12-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33511734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA81319(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-05-28 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2007-12-25 Publication of UA81319C2 publication Critical patent/UA81319C2/uk

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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UAA200511411A 2003-06-04 2004-05-28 3-fluoro-piperidines as nmda/nr2b antagonists UA81319C2 (en)

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US47593803P	2003-06-04	2003-06-04
PCT/US2004/017175 WO2004108705A1 (en)	2003-06-04	2004-05-28	3-fluoro-piperidines as nmda/nr2b antagonists

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JP (1)	JP3927228B2 (de)
KR (1)	KR20060017839A (de)
CN (1)	CN1798744A (de)
AR (1)	AR044579A1 (de)
AT (1)	ATE403651T1 (de)
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TW (1)	TW200510378A (de)
UA (1)	UA81319C2 (de)
WO (1)	WO2004108705A1 (de)
ZA (1)	ZA200509000B (de)

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WO2008128996A1 (en) *	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
US20100316678A1 (en) *	2007-06-28	2010-12-16	Cnsbio Pty Ltd.	Combination methods and compositions for treatment of neuropathic pain
AU2011216950A1 (en)	2010-02-16	2012-08-23	Pfizer Inc.	(R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors
ES2627541T3 (es)	2012-04-20	2017-07-28	Ucb Pharma, S.A.	Métodos para tratar la enfermedad de Parkinson
CN103936663B (zh) *	2013-01-23	2016-12-28	艾琪康医药科技（上海）有限公司	一种1-r1-3,3-二氟(或3-氟)-4-r2-4-氨甲基哌啶及其衍生物的制备方法
US9187506B2 (en)	2014-01-09	2015-11-17	Bristol-Myers Squibb Company	(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders
US9221796B2 (en)	2014-01-09	2015-12-29	Bristol-Myers Squibb Company	Selective NR2B antagonists
EP3152213B1 (de)	2014-06-04	2018-10-31	Rugen Holdings (Cayman) Limited	Difluorethylpyridinderivate als nr2b-rezeptorantagonisten
CA2957898C (en)	2014-09-15	2023-02-21	Rugen Holdings (Cayman) Limited	Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
WO2016049048A1 (en) *	2014-09-22	2016-03-31	Rugen Holdings (Cayman) Limited	Treatment of anxiety disorders and autism spectrum disorders
MX2017008373A (es) *	2014-12-23	2017-10-19	Cerecor Inc	Compuestos, composiciones y metodos.
US10221182B2 (en)	2015-02-04	2019-03-05	Rugen Holdings (Cayman) Limited	3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
US10584127B2 (en) *	2015-06-01	2020-03-10	Rugen Holdings (Cayman) Limited	3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
EA201890946A1 (ru)	2015-10-14	2018-09-28	Бристол-Маерс Сквибб Компани	Селективные антагонисты nr2b
CA3001894A1 (en)	2015-10-14	2017-04-20	Bristol-Myers Squibb Company	Selective nr2b antagonists
AU2017319080B2 (en)	2016-08-31	2020-12-17	Eisai R&D Management Co., Ltd.	Pyrazolo[1,5-a]pyrimidine compound
WO2018098128A1 (en)	2016-11-22	2018-05-31	Rugen Holdings (Cayman) Limited	Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

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WO2002068409A1 (en) *	2001-02-23	2002-09-06	Merck & Co., Inc.	N-substituted nonaryl-heterocyclic nmda/nr2b antagonists

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ES2309540T3 (es)	2008-12-16
PL1648882T3 (pl)	2008-12-31
CN1798744A (zh)	2006-07-05
JP3927228B2 (ja)	2007-06-06
ECSP056192A (es)	2006-04-19
TW200510378A (en)	2005-03-16
AU2004245522A1 (en)	2004-12-16
CA2527093A1 (en)	2004-12-16
KR20060017839A (ko)	2006-02-27
RU2005137704A (ru)	2006-05-27
CL2004001365A1 (es)	2005-05-06
PE20050245A1 (es)	2005-04-13
DK1648882T3 (da)	2008-11-24
SI1648882T1 (sl)	2009-02-28
EP1648882B1 (de)	2008-08-06
NO20060020L (no)	2006-03-03
AR044579A1 (es)	2005-09-21
ATE403651T1 (de)	2008-08-15
CO5700762A2 (es)	2006-11-30
JP2006526650A (ja)	2006-11-24
MY138547A (en)	2009-06-30
MA27781A1 (fr)	2006-02-01
RU2339630C2 (ru)	2008-11-27
AU2004245522B2 (en)	2009-10-29
MXPA05013151A (es)	2006-03-17
EP1648882A1 (de)	2006-04-26
BRPI0410837A (pt)	2006-06-27
PT1648882E (pt)	2008-10-20
DE602004015610D1 (de)	2008-09-18
IS8117A (is)	2005-11-07
WO2004108705A1 (en)	2004-12-16
HRP20080490T3 (en)	2008-11-30
CA2527093C (en)	2009-10-20
ZA200509000B (en)	2006-12-27

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