UA81323C2 - Anthranylamide pyridones that inhibit vegfr-2 and vegfr-3 - Google Patents

Anthranylamide pyridones that inhibit vegfr-2 and vegfr-3 Download PDF

Info

Publication number: UA81323C2
Authority: UA; Ukraine
Prior art keywords: compounds; diseases; general formula; halo; well
Prior art date: 2003-06-13

Application number

UAA200512752A

Other languages

English (en)

Ukrainian (uk)

Inventor

Andreas Hut

Martin Kruger

Rolf Bolmann

Karl-Heinz Thierauch

Andreas Menrad

Martin Haberey

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-13

Filing date

2004-09-06

Publication date

2007-12-25

2004-09-06 Application filed by Schering Ag filed Critical Schering Ag

2007-12-25 Publication of UA81323C2 publication Critical patent/UA81323C2/uk

Links

108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 title abstract 2
108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 title abstract 2
ZZQFWOJVCQAPCL-UHFFFAOYSA-N anthracen-1-amine;1h-pyridin-2-one Chemical class O=C1C=CC=CN1.C1=CC=C2C=C3C(N)=CC=CC3=CC2=C1 ZZQFWOJVCQAPCL-UHFFFAOYSA-N 0.000 title abstract 2
102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 title 1
102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 title 1
201000010099 disease Diseases 0.000 claims abstract description 22
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 22
150000001875 compounds Chemical class 0.000 claims description 50
239000001257 hydrogen Substances 0.000 claims description 17
229910052739 hydrogen Inorganic materials 0.000 claims description 17
150000003839 salts Chemical class 0.000 claims description 15
229910052760 oxygen Inorganic materials 0.000 claims description 10
239000001301 oxygen Substances 0.000 claims description 10
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 9
125000000217 alkyl group Chemical group 0.000 claims description 9
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239000011737 fluorine Substances 0.000 claims description 7
229940126601 medicinal product Drugs 0.000 claims description 7
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Classifications

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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

UAA200512752A 2003-06-13 2004-09-06 Anthranylamide pyridones that inhibit vegfr-2 and vegfr-3 UA81323C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10327719A DE10327719A1 (de)	2003-06-13	2003-06-13	VEGFR-2 und VEGFR-3 Inhibitorische Anthranylamidpyridone
PCT/EP2004/006236 WO2004111005A1 (fr)	2003-06-13	2004-06-09	Anthranylamide pyridones qui inhibent vegfr-2 et vegfr-3

Publications (1)

Publication Number	Publication Date
UA81323C2 true UA81323C2 (en)	2007-12-25

Family

ID=33520741

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200512752A UA81323C2 (en)	2003-06-13	2004-09-06	Anthranylamide pyridones that inhibit vegfr-2 and vegfr-3

Country Status (18)

Country	Link
EP (1)	EP1633713A1 (fr)
JP (1)	JP2006527228A (fr)
KR (1)	KR20060021887A (fr)
CN (1)	CN1805936A (fr)
AU (1)	AU2004247377A1 (fr)
BR (1)	BRPI0411360A (fr)
CA (1)	CA2526041A1 (fr)
CR (1)	CR8127A (fr)
DE (1)	DE10327719A1 (fr)
EA (1)	EA200501885A1 (fr)
EC (1)	ECSP066280A (fr)
IL (1)	IL171898A0 (fr)
MX (1)	MXPA05013586A (fr)
NO (1)	NO20060196L (fr)
RS (1)	RS20050831A (fr)
UA (1)	UA81323C2 (fr)
WO (1)	WO2004111005A1 (fr)
ZA (1)	ZA200600291B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20060071812A (ko) *	2004-12-22	2006-06-27	주식회사 엘지생명과학	신규한 3-(2-아미노-6-피리디닐)-4-히드록시페닐 아민유도체
US9376393B2 (en) *	2012-01-05	2016-06-28	Clanotech Ab	Quinoline compounds which are anti-angiogenic integrin alpha5 beta1 inhibitors for use in the treatment of fibrosis or fibrosis-related diseases
CN106496107A (zh) *	2016-08-31	2017-03-15	浙江永宁药业股份有限公司	Vegfr‑2抑制剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9824579D0 (en) *	1998-11-10	1999-01-06	Novartis Ag	Organic compounds
UA71587C2 (uk) *	1998-11-10	2004-12-15	Шерінг Акцієнгезелльшафт	Аміди антранілової кислоти та їхнє застосування як лікарських засобів
DE10023486C1 (de) *	2000-05-09	2002-03-14	Schering Ag	Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
WO2002090352A2 (fr) *	2001-05-08	2002-11-14	Schering Aktiengesellschaft	Anthranylamides pyridine amides selectives en tant qu'inhibateurs vegfr-2 et vegfr-3
GB0126902D0 (en) *	2001-11-08	2002-01-02	Novartis Ag	Organic compounds
DE10228090A1 (de) *	2002-06-19	2004-01-15	Schering Ag	Ausgewählte Anthranylamidpyridinamide und deren Verwendung als Arzneimittel

2003
- 2003-06-13 DE DE10327719A patent/DE10327719A1/de not_active Ceased
2004
- 2004-06-09 EA EA200501885A patent/EA200501885A1/ru unknown
- 2004-06-09 WO PCT/EP2004/006236 patent/WO2004111005A1/fr not_active Ceased
- 2004-06-09 EP EP04739742A patent/EP1633713A1/fr not_active Withdrawn
- 2004-06-09 CN CNA2004800163643A patent/CN1805936A/zh active Pending
- 2004-06-09 CA CA002526041A patent/CA2526041A1/fr not_active Abandoned
- 2004-06-09 BR BRPI0411360-8A patent/BRPI0411360A/pt not_active IP Right Cessation
- 2004-06-09 KR KR1020057023901A patent/KR20060021887A/ko not_active Withdrawn
- 2004-06-09 MX MXPA05013586A patent/MXPA05013586A/es unknown
- 2004-06-09 RS YUP-2005/0831A patent/RS20050831A/sr unknown
- 2004-06-09 AU AU2004247377A patent/AU2004247377A1/en not_active Abandoned
- 2004-06-09 JP JP2006515873A patent/JP2006527228A/ja active Pending
- 2004-09-06 UA UAA200512752A patent/UA81323C2/uk unknown
2005
- 2005-11-10 IL IL171898A patent/IL171898A0/en unknown
- 2005-12-09 CR CR8127A patent/CR8127A/es not_active Application Discontinuation
2006
- 2006-01-12 EC EC2006006280A patent/ECSP066280A/es unknown
- 2006-01-12 ZA ZA200600291A patent/ZA200600291B/en unknown
- 2006-01-12 NO NO20060196A patent/NO20060196L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2526041A1 (fr)	2004-12-23
DE10327719A1 (de)	2005-01-20
AU2004247377A1 (en)	2004-12-23
EA200501885A1 (ru)	2006-06-30
MXPA05013586A (es)	2006-03-09
RS20050831A (sr)	2008-04-04
WO2004111005A1 (fr)	2004-12-23
KR20060021887A (ko)	2006-03-08
JP2006527228A (ja)	2006-11-30
CR8127A (es)	2006-05-29
ZA200600291B (en)	2007-03-28
EP1633713A1 (fr)	2006-03-15
IL171898A0 (en)	2006-04-10
NO20060196L (no)	2006-01-12
BRPI0411360A (pt)	2006-07-25
ECSP066280A (es)	2006-07-28
CN1805936A (zh)	2006-07-19

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UA81323C2 (en)	2007-12-25	Anthranylamide pyridones that inhibit vegfr-2 and vegfr-3
JPH07278148A (ja)	1995-10-24	イミダゾピラゾール誘導体
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