UA97812C2 - Прививочные макромолекулярные конъюгаты доксорубицина с противоопухолевой активностью и способ их получения - Google Patents

Прививочные макромолекулярные конъюгаты доксорубицина с противоопухолевой активностью и способ их получения

Info

Publication number
UA97812C2
UA97812C2 UAA200903818A UAA200903818A UA97812C2 UA 97812 C2 UA97812 C2 UA 97812C2 UA A200903818 A UAA200903818 A UA A200903818A UA A200903818 A UAA200903818 A UA A200903818A UA 97812 C2 UA97812 C2 UA 97812C2
Authority
UA
Ukraine
Prior art keywords
cancerostatic
connected via
polymeric drug
via spacers
hydroxypropyl
Prior art date
Application number
UAA200903818A
Other languages
English (en)
Ukrainian (uk)
Inventor
Томас Этрих
Петр Хитил
Карел Ульбрих
Томаш Мркван
Бланка Ригова
Original Assignee
Зэнтива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зэнтива, К.С. filed Critical Зэнтива, К.С.
Publication of UA97812C2 publication Critical patent/UA97812C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Полимерное лекарственное средство, в котором канцеростатик, связан при помощи спейсеров, содержащих гидролитически расщепляющие гидразоновые связи, связан с водорастворимым полимерным носителем, полученным на основе сополимера N-(2-гидроксипропил)метакриламида, при этом структура полимерного лекарственного средства состоит из главной цепи N-(2-гидроксипропил)метакриламида, которая несет канцеростатик, и другой цепи N-(2-гидроксипропил)метакриламида - привитой цепи, которая также может нести канцеростатик, при этом указанные привитые цепи связаны с главной цепью связью, которая стабильна в организме, и/или связью, расщепляющей в организме, в частности олигопептидным спейсером, выбранным из группы GlyLeuGly, GlyPheGly, GlyPheLeuGly и GlyLeuPheGly, и способ его получения.
UAA200903818A 2006-09-18 2007-09-18 Прививочные макромолекулярные конъюгаты доксорубицина с противоопухолевой активностью и способ их получения UA97812C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20060592A CZ2006592A3 (cs) 2006-09-18 2006-09-18 Polymerní lécivo a zpusob jeho výroby
PCT/CZ2007/000087 WO2008034391A1 (en) 2006-09-18 2007-09-18 Grafted macromolecular conjugates of doxorubicin with anticancer activity and method of their preparation

Publications (1)

Publication Number Publication Date
UA97812C2 true UA97812C2 (ru) 2012-03-26

Family

ID=38982478

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200903818A UA97812C2 (ru) 2006-09-18 2007-09-18 Прививочные макромолекулярные конъюгаты доксорубицина с противоопухолевой активностью и способ их получения

Country Status (6)

Country Link
US (1) US8603990B2 (ru)
EP (1) EP2063914B1 (ru)
CZ (1) CZ2006592A3 (ru)
EA (1) EA017073B1 (ru)
UA (1) UA97812C2 (ru)
WO (1) WO2008034391A1 (ru)

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* Cited by examiner, † Cited by third party
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BRPI0920655A2 (pt) * 2008-10-07 2019-07-09 Rexahn Pharmaceuticals, Inc. conjugados e hpma-docetaxel ou gencitabina e usos dos mesmos
CZ301288B6 (cs) * 2008-10-23 2009-12-30 Zentiva, A. S Polymerní prípravek se synergickým úcinkem pri lécbe nádorových onemocnení
CZ303072B6 (cs) * 2009-02-13 2012-03-21 Zentiva, K.S. Polymerní konjugáty paclitaxelu a docetaxelu s pH rízeným uvolnováním kancerostatika
KR101721865B1 (ko) * 2009-10-13 2017-04-03 렉산 파마슈티컬스, 인코포레이티드 항암제의 전달을 위한 폴리머 시스템
CZ302830B6 (cs) * 2009-12-15 2011-11-30 Ústav makromolekulární chemie AV CR, v.v.i. Vysokomolekulární polymerní nosice léciv odvozené od dendrimeru a jejich konjugáty s lécivy pro lécbu zejména pevných nádoru
ES2673672T3 (es) 2011-02-11 2018-06-25 The Regents Of The University Of Michigan Composiciones tripeptídicas y su uso para el tratamiento de la diabetes
JP5859118B2 (ja) 2011-05-26 2016-02-10 山東軒竹医薬科技有限公司 チロシンキナーゼ阻害剤としてのキナゾリン誘導体、その調製方法及びその使用
CN103936945B (zh) * 2013-01-23 2017-02-08 中国科学院化学研究所 一类高效抗肿瘤靶向药物载体及其制备方法
CN106995516B (zh) * 2016-01-22 2019-08-02 北京化工大学 肿瘤特异性富集的纳米载药体系及其制备方法
CZ308419B6 (cs) * 2016-04-11 2020-08-12 Ústav makromolekulární chemie AV ČR, v. v. i. Blokový kopolymer pro překonání lékové rezistence nádorů k chemoterapii, jeho polymerní konjugát s léčivem, farmaceutická kompozice je obsahující, způsob jejich přípravy a jejich použití
CN105963706B (zh) * 2016-04-15 2019-03-15 四川大学 一种支化hpma共聚物-dox偶联物及其制备方法和应用
CZ309585B6 (cs) * 2019-12-17 2023-05-03 Ústav makromolekulární chemie AV ČR, v. v. i. Polymerní konjugát s hydrolytickým uvolňováním kancerostatika cytarabinu, způsob jeho přípravy a jeho použití
CN112940248B (zh) * 2021-02-04 2023-07-18 西安交通大学 一种pH响应型金属配位聚前药纳米粒子及其制备方法
CN113908289B (zh) * 2021-10-09 2023-07-25 北京化工大学 一种具有精确调控药物比例的抗肿瘤多元载药体系及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932248A (en) * 1993-11-18 1999-08-03 Paragon Medical Limited Controlled release preparations for cytotoxic or cytostatic drugs
US6060518A (en) * 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
US7279318B1 (en) * 1999-06-09 2007-10-09 Hybrid Systems Limited Modification of biological elements
CZ293787B6 (cs) * 2001-12-20 2004-07-14 Zentiva, A.S. pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii
CZ294996B6 (cs) * 2003-07-16 2005-04-13 Ústav Makromolekulární Chemie Av Čr Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
CZ2005558A3 (cs) * 2005-09-05 2007-04-04 Zentiva, A. S. Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva

Also Published As

Publication number Publication date
WO2008034391A1 (en) 2008-03-27
EA017073B1 (ru) 2012-09-28
CZ298945B6 (cs) 2008-03-19
EP2063914A1 (en) 2009-06-03
EA200900453A1 (ru) 2009-10-30
EP2063914B1 (en) 2018-12-26
US8603990B2 (en) 2013-12-10
US20090306004A1 (en) 2009-12-10
CZ2006592A3 (cs) 2008-03-19

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