UA99637C2 - Производные пиридина, замещенные гетероциклическим кольцом и фосфоноксиметильной группой, и содержащее их противогрибковое средство - Google Patents

Производные пиридина, замещенные гетероциклическим кольцом и фосфоноксиметильной группой, и содержащее их противогрибковое средство

Info

Publication number
UA99637C2
UA99637C2 UAA201008001A UAA201008001A UA99637C2 UA 99637 C2 UA99637 C2 UA 99637C2 UA A201008001 A UAA201008001 A UA A201008001A UA A201008001 A UAA201008001 A UA A201008001A UA 99637 C2 UA99637 C2 UA 99637C2
Authority
UA
Ukraine
Prior art keywords
group
rrepresents
atom
hydrogen atom
antifungal agent
Prior art date
Application number
UAA201008001A
Other languages
English (en)
Ukrainian (uk)
Inventor
Масаюки МАЦУКУРА
Original Assignee
Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйсай Ар Энд Ди Менеджмент Ко., Лтд. filed Critical Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Publication of UA99637C2 publication Critical patent/UA99637C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Данное изобретение касается противогрибкового средства, имеющего превосходное противогрибковое действие и превосходные физические свойства, а именно растворимость в воде и безопасность водных растворов, это также касается утилизации отходов.Согласно данному изобретению, описано соединение и его соли, представленные формулой (I). В этой формуле Rпредставляет собой атом водорода, атом галогена, аминогруппу, алкильную группу, гидроксиалкильную группу, цианоалкильную группу, алкоксигруппу, алкоксиалкильную группу и т.д.; Rпредставляет собой атом водорода, алкильную группу, аминогруппу и т.д.; один из X и Υ представляет собой атом азота, а другой представляет собой атом азота
UAA201008001A 2007-12-27 2008-12-26 Производные пиридина, замещенные гетероциклическим кольцом и фосфоноксиметильной группой, и содержащее их противогрибковое средство UA99637C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007336977 2007-12-27

Publications (1)

Publication Number Publication Date
UA99637C2 true UA99637C2 (ru) 2012-09-10

Family

ID=40824334

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201008001A UA99637C2 (ru) 2007-12-27 2008-12-26 Производные пиридина, замещенные гетероциклическим кольцом и фосфоноксиметильной группой, и содержащее их противогрибковое средство

Country Status (17)

Country Link
US (1) US8513287B2 (ru)
EP (1) EP2223926B1 (ru)
JP (1) JP5244821B2 (ru)
KR (1) KR101548759B1 (ru)
CN (1) CN101918417B (ru)
AU (1) AU2008344341B9 (ru)
BR (1) BRPI0821653B8 (ru)
CA (1) CA2710786C (ru)
ES (1) ES2456819T3 (ru)
IL (1) IL206470A (ru)
NZ (1) NZ586259A (ru)
RU (1) RU2485131C2 (ru)
SA (1) SA108290840B1 (ru)
TW (1) TW200934788A (ru)
UA (1) UA99637C2 (ru)
WO (1) WO2009084621A1 (ru)
ZA (1) ZA201004396B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932272B2 (en) * 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
WO2006106711A1 (ja) 2005-03-30 2006-10-12 Eisai R & D Management Co., Ltd. ピリジン誘導体を含有する抗真菌剤
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
WO2008035726A1 (en) 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
CN101622251B (zh) 2007-04-27 2012-07-04 卫材R&D管理有限公司 杂环取代吡啶衍生物的盐或其结晶
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
WO2010032874A1 (ja) * 2008-09-19 2010-03-25 住友化学株式会社 農業用組成物
US8188119B2 (en) * 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd ((ホスホノオキシ)メチル)ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
WO2011051198A2 (de) * 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridin-derivate als pflanzenschutzmittel
WO2012060448A1 (ja) 2010-11-05 2012-05-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗真菌剤としての併用医薬組成物
EP3720438B1 (en) 2017-12-07 2023-08-30 Amplyx Pharmaceuticals, Inc. Heterocycle substituted pyridine derivative antifungal agents
JP2021530445A (ja) 2018-06-25 2021-11-11 アンプリックス ファーマシューティカルズ,インク. 複素環およびアミノ基によって置換されたピリジン誘導体
CN110776505A (zh) * 2018-07-29 2020-02-11 朱允涛 一种氘代的异恶唑类化合物的制备方法和用途
EA202190590A1 (ru) * 2018-08-31 2021-07-16 Ампликс Фармасьютикалз, Инк. Соединения и способы лечения грибковых инфекций
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2020247804A1 (en) * 2019-06-07 2020-12-10 Amplyx Pharmaceuticals, Inc. Heterocycle substituted pyridine derivative antifungal agents
MX2022010804A (es) 2020-03-04 2023-01-16 Amplyx Pharmaceuticals Inc Uso de compuestos en el tratamiento de infecciones fungicas.
MX2022016179A (es) * 2020-06-17 2023-04-20 Amplyx Pharmaceuticals Inc Compuestos y metodos para tratar infecciones fungicas.
CN119013269A (zh) * 2022-06-13 2024-11-22 辰欣药业股份有限公司 一种炔基吡啶类化合物的晶型及其制备方法

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB919073A (en) 1960-09-15 1963-02-20 Farmaceutici Italia Benzylamine derivatives
JPS542325A (en) 1977-06-07 1979-01-09 Sankyo Co Ltd Agricultural and horticultural pesticide
US4551532A (en) 1980-05-08 1985-11-05 Takeda Chemical Industries, Ltd. Ethylene glycol derivatives having anti-protozoan, anti-fungal and anti-tumor activity
JPS57179192A (en) 1981-04-27 1982-11-04 Takeda Chem Ind Ltd Ethylene glycol derivative
JPS5973575A (ja) 1982-10-05 1984-04-25 Shionogi & Co Ltd プロピニルアミノイソオキサゾ−ル誘導体
JPS5984824A (ja) 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
GB8311003D0 (en) 1983-04-22 1983-05-25 Shell Int Research Aniline compounds
EP0124067B1 (de) 1983-05-04 1986-12-17 CASSELLA Aktiengesellschaft 2-(Aminoalkyl)-pyrrol-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
WO1986003203A1 (fr) 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Derives de thienylthiazole
JP2556849B2 (ja) 1986-02-13 1996-11-27 三共株式会社 グリセリン誘導体
US5070082A (en) 1986-10-23 1991-12-03 American Cyanamid Company Solubilized pro-drugs
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
IL89028A0 (en) 1988-01-29 1989-08-15 Lilly Co Eli Quinoline,quinazoline and cinnoline derivatives
US5034393A (en) 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
US5371086A (en) 1991-03-15 1994-12-06 The Green Cross Corporation Aminopyridine compounds
JP3161470B2 (ja) 1991-05-31 2001-04-25 松下電器産業株式会社 部品認識装置、部品実装機およびデータ作成機
US5208247A (en) 1991-08-01 1993-05-04 American Cyanamid Company Pyridinium compounds which are useful as antagonists of platelet activating factor
EP0533130A1 (de) 1991-09-19 1993-03-24 Hoechst Aktiengesellschaft 2-Hydroxymethylpyridine, die entsprechenden Pyridin-N-oxide und ihre Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung
DE69230397T2 (de) 1991-10-01 2000-06-08 Dainippon Ink And Chemicals, Inc. Fluorbenzonitrile und sie enthaltende flüssigkristalline gemische
DK0610396T3 (da) 1991-10-23 2001-01-29 Baylor College Medicine Fingeraftryksidentifikation af bakteriestammer med anvendelse af repetitiv DNA-sekvensamplifikation
IT1251708B (it) 1991-12-11 1995-05-20 Novamont Spa Procedimento per la preparazione di acidi carbossilici o loro esteri mediante scissione ossidativa di acidi grassi insaturi o loro esteri.
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
US6399044B1 (en) * 1993-04-29 2002-06-04 Merck Patent Gesellschaft Mit Skin-coloring powder mixture
AU674613B2 (en) 1993-09-28 1997-01-02 Otsuka Pharmaceutical Co., Ltd. Quinoxaline derivative as antidiabetic agent
BR9408475A (pt) 1994-01-07 1997-08-26 Dowelanco Pesticidas de n-(4-pirimidinil) amidas
IL112778A0 (en) 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
DE4434637A1 (de) 1994-09-28 1996-04-04 Hoechst Schering Agrevo Gmbh Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
ES2169773T3 (es) 1995-04-11 2002-07-16 Mitsui Chemicals Inc Derivados de tiofeno sustituido y fungicidas agricolas y horticolas que contienen dichos derivados como ingrediente activo.
US5710171A (en) 1995-05-24 1998-01-20 Merck & Co., Inc. Bisphenyl inhibitors of farnesyl-protein transferase
US6080767A (en) 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
WO1997027852A1 (en) 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9605437D0 (en) 1996-03-15 1996-05-15 Iaf Biochem Int Cytomegalovirus inhibiting compounds
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
EP0944582B1 (de) 1996-12-11 2003-07-02 Abbott GmbH & Co. KG Ketobenzamide als calpain-inhibitoren
CA2285548C (en) 1997-04-04 2006-07-11 Pfizer Products Inc. Nicotinamide derivatives
US20020111495A1 (en) 1997-04-04 2002-08-15 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
EP0986384B1 (en) 1997-05-07 2012-02-22 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
WO1998050385A1 (en) 1997-05-08 1998-11-12 Merck Sharp & Dohme Limited SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS
DE19727117A1 (de) 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19732033A1 (de) 1997-07-25 1999-01-28 Bayer Ag Triazolinthion-phosphorsäure-Derivate
US6407116B1 (en) 1997-09-16 2002-06-18 Takeda Chemical Industries, Inc. Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs
TW390963B (en) 1997-09-26 2000-05-21 Shinetsu Handotai Kk Method and apparatus for detecting heavy metals in silicon wafer bulk withhigh sensitivity
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
EP1037633B1 (en) 1997-12-11 2003-09-10 Biochem Pharma Inc. Antiviral compounds
AU754965B2 (en) * 1997-12-31 2002-11-28 University Of Kansas, The Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
NZ507760A (en) 1998-03-26 2002-10-25 Japan Tobacco Inc Amide derivatives and nociceptin antagonists
KR100672186B1 (ko) 1998-03-31 2007-01-19 아카디아 파마슈티칼스 인코포레이티드 무스카린 수용체에 대해 활성을 갖는 화합물
PE20000942A1 (es) 1998-07-31 2000-09-28 Lilly Co Eli Derivados de amida, carbamato y urea
BR9912729A (pt) 1998-08-04 2001-05-02 Astrazeneca Ab Derivado de amida, processo para prepará-lo, e, uso do mesmo
JP2000178243A (ja) 1998-12-14 2000-06-27 Teijin Ltd ビフェニルアミジン誘導体
US6235728B1 (en) * 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
DE60001218D1 (de) 1999-02-22 2003-02-20 Shire Biochem Inc [1,8]-naphthyridinderivate derivate mit antiviraler wirkung
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6636831B1 (en) 1999-04-09 2003-10-21 Inroad, Inc. System and process for voice-controlled information retrieval
US6319944B1 (en) 1999-05-10 2001-11-20 Merck & Co., Inc. Aryl amidines, compositions containing such compounds and methods of use
CH1196397H1 (de) 1999-06-02 2007-05-31 Nps Pharma Inc Metabotrope Glutamatrezeptorantagonisten zur Behandlung von Krankheiten des zentralen Nervensystems.
GB9919588D0 (en) 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
EP1214292B1 (en) 1999-09-24 2007-06-13 Genentech, Inc. Tyrosine derivatives
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
JP4831907B2 (ja) 1999-10-08 2011-12-07 アフィニアム・ファーマシューティカルズ・インコーポレイテッド FabI阻害剤
GB9923710D0 (en) 1999-10-08 1999-12-08 Proteus Molecular Design Chemical compounds
WO2001036003A2 (en) 1999-11-15 2001-05-25 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles
CA2397575A1 (en) 2000-01-13 2001-07-19 Tularik Inc. Antibacterial agents
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
JP2003529589A (ja) 2000-03-31 2003-10-07 ユーロ−セルティック エス. ア. アミノピリジンならびにこれらの鎮痙薬およびナトリウムチャンネル遮断薬としての使用
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
US6513676B2 (en) 2000-06-21 2003-02-04 Martin L. Clemmons Universal cup holder with food tray accessories
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
CN100467597C (zh) 2000-07-07 2009-03-11 卫材R&D管理有限公司 真菌细胞壁合成基因
EP1300464A4 (en) 2000-07-07 2006-02-01 Eisai Co Ltd GENE OF CELL WALL SYNTHESIS IN MUSHROOMS
WO2002006275A1 (en) 2000-07-17 2002-01-24 Smithkline Beecham P.L.C. Novel processes for the preparation of 4-phenylpiperidine derivatives
DE10039477A1 (de) 2000-08-08 2002-02-21 Aventis Cropscience Gmbh Heterocyclylalkylazol-Derivate und ihre Verwendung als Schädlingsbekämpfungsmittel
NZ524421A (en) 2000-09-15 2005-02-25 Anormed Inc Chemokine receptor binding heterocyclic compounds
IL154004A0 (en) 2000-09-18 2003-07-31 Du Pont Pyridinyl amides and imides for use as fungicides
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
WO2002060875A1 (en) 2001-01-31 2002-08-08 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
KR20030070150A (ko) 2001-01-31 2003-08-27 화이자 프로덕츠 인크. Pde4 이소자임 억제제로서 유용한 에테르 유도체
EP1229034B1 (en) 2001-01-31 2005-04-13 Pfizer Products Inc. Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes
CZ20031903A3 (cs) 2001-01-31 2004-07-14 Pfizer Products Inc. Amidové deriváty thiazolyl-, oxazolyl-, pyrrolyl- a imidazolyl karboxylových kyselin užitečné jako inhibitory isozymů PDE4
JP2002275159A (ja) 2001-03-16 2002-09-25 Japan Tobacco Inc Hcp阻害剤及びhcp阻害活性を有する化合物
SI1373263T1 (en) 2001-04-05 2005-04-30 Torrent Pharmaceuticals Ltd Heterocyclic compounds for aging-related and diabetic vascular complications
GB0109122D0 (en) 2001-04-11 2001-05-30 Smithkline Beecham Spa Novel compounds
EP1275653A1 (en) 2001-07-10 2003-01-15 Bayer CropScience S.A. Oxazolopyridines and their use as fungicides
EP1275301A1 (en) 2001-07-10 2003-01-15 Bayer CropScience S.A. Trisubstituted heterocyclic compounds and their use as fungicides
WO2003006628A2 (en) 2001-07-13 2003-01-23 Virtual Drug Development, Inc. Nad synthetase inhibitors and uses thereof
AU2002340010A1 (en) 2001-09-26 2003-04-07 Bayer Corporation Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors
US20040198773A1 (en) 2001-09-26 2004-10-07 Barry Hart Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors
DE10149370A1 (de) 2001-10-06 2003-04-10 Merck Patent Gmbh Pyrazolderivate
KR100437972B1 (ko) 2001-10-27 2004-07-02 한국과학기술연구원 피롤리디논 유도체, 이의 제조 방법 및 이를 포함하는제약 조성물
EP1440072A4 (en) 2001-10-30 2005-02-02 Conforma Therapeutic Corp PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
EP1451156A4 (en) 2001-11-27 2005-05-25 Merck & Co Inc 4-AMINOCHINOLINVERBINDUNGEN
MXPA04004982A (es) 2001-11-27 2004-08-11 Hoffmann La Roche Derivados de benzotiazol.
DE10201764A1 (de) 2002-01-18 2003-07-31 Bayer Cropscience Ag Substituierte 4-Aminopyridin-Derivate
US20030191158A1 (en) 2002-02-11 2003-10-09 Magee Thomas V. Nicotinamide derivatives and a tiotropium salt in combination for the treatment of diseases
GB0203193D0 (en) 2002-02-11 2002-03-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
MXPA04007737A (es) 2002-02-11 2004-10-15 Pfizer Derivados de nicotinamida utiles como inhibidores de fosfodesterasas 4.
CN100369898C (zh) 2002-02-12 2008-02-20 史密丝克莱恩比彻姆公司 用作p38抑制剂的烟酰胺衍生物
CA2478587C (en) 2002-03-08 2011-05-17 Basf Aktiengesellschaft Fungicidal mixtures based on prothioconazole and containing an insecticide
GEP20074230B (en) 2002-03-20 2007-11-12 Bristol Myers Squibb Co Phosphate prodrugs of fluorooxindoles
AU2003230829B8 (en) 2002-04-26 2008-12-11 Eli Lilly And Company Triazole derivatives as tachykinin receptor antagonists
SI1501808T1 (sl) 2002-04-26 2008-10-31 Lilly Co Eli Antagonisti tahikininskega receptorja
EP1369420A1 (en) 2002-06-06 2003-12-10 Aventis Pharma Deutschland GmbH Inhibitors of the GPib - vWF interaction
AU2003244181A1 (en) 2002-06-25 2004-01-06 Yamanouchi Pharmaceutical Co., Ltd. Phenoxypyridine derivative or salt thereof
CN1691944A (zh) 2002-08-09 2005-11-02 阿斯利康(瑞典)有限公司 作为代谢型谷氨酸受体-5调节剂的噁二唑
PA8578101A1 (es) 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
GB0222495D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
JP4537855B2 (ja) 2002-10-09 2010-09-08 久光製薬株式会社 抗真菌活性を有する新規ピラゾール化合物
CA2721200A1 (en) 2002-11-22 2004-06-10 Eisai R&D Management Co., Ltd. Methods of screening for compounds that inhibit the biosynthesis of gpi in malaria parasites
AU2003293376A1 (en) 2002-12-10 2004-06-30 Imclone Systems Incorporated Anti-angiogenic compounds and their use in cancer treatment
JP4896518B2 (ja) 2002-12-13 2012-03-14 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド ニコチンアミド系キナーゼ阻害薬
RU2237476C1 (ru) * 2003-02-13 2004-10-10 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Противогрибковая фармацевтическая композиция
TW200500360A (en) 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
DE10315572A1 (de) 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
ATE412642T1 (de) 2003-07-25 2008-11-15 Novartis Ag Inhibitoren von p-38-kinase
US7932272B2 (en) 2003-09-30 2011-04-26 Eisai R&D Management Co., Ltd. Antifungal agent containing heterocyclic compound
JO2525B1 (en) 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
WO2006016548A1 (ja) 2004-08-09 2006-02-16 Eisai R & D Management Co., Ltd. ヘテロ環化合物を含有する新規な抗マラリア剤
JPWO2006016548A1 (ja) 2004-08-09 2008-05-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗マラリア剤
WO2006106711A1 (ja) 2005-03-30 2006-10-12 Eisai R & D Management Co., Ltd. ピリジン誘導体を含有する抗真菌剤
CA2626767C (en) 2005-10-31 2012-01-17 Eisai R&D Management Co., Ltd. Heterocyclic substituted pyridine derivatives and antifungal agent containing same
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
US20070099877A1 (en) 2005-11-02 2007-05-03 Cytovia, Inc. N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP2001298A2 (de) 2006-03-27 2008-12-17 Basf Se Substituierte 5-hetaryl-4-aminopyrimidine
WO2008035726A1 (en) 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
EP2121029A2 (en) 2006-12-05 2009-11-25 Neurogesx, Inc. Prodrugs and methods of making and using the same
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
CN101622251B (zh) 2007-04-27 2012-07-04 卫材R&D管理有限公司 杂环取代吡啶衍生物的盐或其结晶
US20090084621A1 (en) 2007-09-27 2009-04-02 Giovannini Mario R Rack-mounted service center having separately removable housing
WO2009081970A1 (ja) 2007-12-26 2009-07-02 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体の製造方法
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2012176900A (ja) 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd ((ホスホノオキシ)メチル)ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤

Also Published As

Publication number Publication date
US20090233883A1 (en) 2009-09-17
EP2223926B1 (en) 2014-02-12
CN101918417A (zh) 2010-12-15
US8513287B2 (en) 2013-08-20
SA108290840B1 (ar) 2012-05-06
KR20100096207A (ko) 2010-09-01
IL206470A0 (en) 2010-12-30
AU2008344341A1 (en) 2009-07-09
BRPI0821653B1 (pt) 2021-02-17
BRPI0821653A2 (pt) 2015-06-16
WO2009084621A1 (ja) 2009-07-09
AU2008344341B2 (en) 2013-02-14
NZ586259A (en) 2011-05-27
JPWO2009084621A1 (ja) 2011-05-19
KR101548759B1 (ko) 2015-08-31
BRPI0821653B8 (pt) 2021-05-25
BRPI0821653A8 (pt) 2018-07-10
IL206470A (en) 2014-07-31
CA2710786A1 (en) 2009-07-09
RU2485131C2 (ru) 2013-06-20
CA2710786C (en) 2015-12-01
EP2223926A4 (en) 2011-02-09
EP2223926A1 (en) 2010-09-01
AU2008344341B9 (en) 2013-07-04
RU2010126105A (ru) 2011-12-27
ES2456819T3 (es) 2014-04-23
CN101918417B (zh) 2013-11-06
ZA201004396B (en) 2011-03-30
JP5244821B2 (ja) 2013-07-24
TW200934788A (en) 2009-08-16

Similar Documents

Publication Publication Date Title
TW201129556A (en) Novel antiplatelet agent
CY1120066T1 (el) Ενωση κινολονης
CY1121051T1 (el) Περιεχουσα αζωτο ετεροκυκλικη ενωση και γεωργικο/κηπουρικο σποριοκτονο
BRPI0821653B8 (pt) composto de piridina substituída com anel heterocíclico e grupo fosfonoximetila ou um sal do mesmo, composição farmacêutica compreendendo-os e uso dos mesmos para tratar uma doença fungíca
UA105185C2 (ru) Пирролы
JO3114B1 (ar) مركبات بيريدازينون
MY203060A (en) Prophylactic or therapeutic agent for spinal muscular atrophy
TW200732333A (en) An oxime derivative and preparations thereof
MX342064B (es) Novedoso compuesto de imidazo-oxazina o sal del mismo.
MY153045A (en) Oxopyrazine derivative and herbicide
JO2791B1 (en) Acid secretion inhibitor
MX365776B (es) Derivado de sulfuro de alquil fenilo y agente de control de plagas.
MY181947A (en) Tetrazolinone compounds and its use as pesticides
ZA200810739B (en) Pesticide containing novel pyridyl-methanamine derivative or its salt
TNSN07397A1 (en) Acetylene derivatives
NO20081551L (no) Heterocyklisk substituerte pyridinderivater og antisoppmidler inneholdende samme
PH12012500487A1 (en) Herbicidal pyrimidone derivatives
JO3261B1 (ar) مشتق بيريدين أحادي الحلقة
CA2880178C (en) Difluoromethylene compound
MY159870A (en) Piperazine compound capable of inhibiting prostaglandin d synthase
WO2009001784A1 (ja) N-フェニル-メタナミン誘導体及びこれを含有する有害生物防除剤
PH12013501856A1 (en) Novel octahydrothienoquinoline derivative, pharmaceutical composition comprising derivative, and use of these
IN2012DN00871A (ru)
BR112013030570A2 (pt) agente para o controle de ectoparasitas de animais
MY161992A (en) Novel tetrahydroisoquinoline derivative