UA99699C2 - Похідні індолкарбоксаміду та фармацевтична композиція, що їх містить - Google Patents

Похідні індолкарбоксаміду та фармацевтична композиція, що їх містить

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Publication number
UA99699C2
UA99699C2 UAA200714940A UAA200714940A UA99699C2 UA 99699 C2 UA99699 C2 UA 99699C2 UA A200714940 A UAA200714940 A UA A200714940A UA A200714940 A UAA200714940 A UA A200714940A UA 99699 C2 UA99699 C2 UA 99699C2
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UA
Ukraine
Prior art keywords
compound
pharmaceutical composition
directed
ikk2
carboxamide derivatives
Prior art date
Application number
UAA200714940A
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English (en)
Russian (ru)
Inventor
Жианг Денг
Джеффри К. Кернс
Ки Жин
Гуолианг Лин
Сишень Лин
Майкл Линденмус
Кристофер Э. Неипп
Хонг НИЕ
Соня М. Томас
Катрин Л. Виддоусон
Original Assignee
Смитклайн Бичам Корпорейшн
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Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of UA99699C2 publication Critical patent/UA99699C2/uk

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
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  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
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  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
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Abstract

Винахід стосується похідних індолкарбоксаміду.Зокрема, винахід спрямовано на сполуки відповідно до формули І:, (I)де R1, R2, R3, U і V визначені нижче, і на їх фармацевтично прийнятні солі.Сполуки за винаходом є інгібіторами ІКК2 і можуть бути використані в лікуванні порушень, пов'язаних з аномальною активністю ІКК2 (також відомої як ІКК), таких як ревматоїдний артрит, астма і COPD (хронічне обструктивне захворювання легень). Відповідно, винахід також спрямований на фармацевтичні композиції, що містять сполуку за винаходом.Винахід також стосується способів інгібування активності ІКК2 і лікування пов'язаних з нею порушень з використанням сполуки за винаходом або фармацевтичної композиції, що містить сполуку за винаходом.
UAA200714940A 2005-06-30 2006-06-28 Похідні індолкарбоксаміду та фармацевтична композиція, що їх містить UA99699C2 (uk)

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US69525605P 2005-06-30 2005-06-30

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UA99699C2 true UA99699C2 (uk) 2012-09-25

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UAA200714940A UA99699C2 (uk) 2005-06-30 2006-06-28 Похідні індолкарбоксаміду та фармацевтична композиція, що їх містить

Country Status (19)

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EP (1) EP1896014A4 (uk)
JP (1) JP5059756B2 (uk)
KR (1) KR20080021077A (uk)
CN (1) CN101247804B (uk)
AR (1) AR055343A1 (uk)
AU (1) AU2006266028B2 (uk)
BR (1) BRPI0611674A2 (uk)
CA (1) CA2613068A1 (uk)
EA (1) EA014083B1 (uk)
IL (1) IL187786A0 (uk)
MA (1) MA29566B1 (uk)
MX (1) MX2007016541A (uk)
NO (1) NO20080457L (uk)
NZ (1) NZ563687A (uk)
PE (1) PE20070173A1 (uk)
TW (1) TWI380973B (uk)
UA (1) UA99699C2 (uk)
WO (1) WO2007005534A2 (uk)
ZA (1) ZA200709948B (uk)

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GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
US20080293802A1 (en) * 2005-12-16 2008-11-27 Smithline Beecham Corporation Chemical Compounds
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
US8815840B2 (en) * 2008-12-19 2014-08-26 Bristol-Myers Squibb Company Carbazole and carboline kinase inhibitors
WO2010102968A1 (en) * 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
JP6509838B2 (ja) * 2013-06-26 2019-05-08 アッヴィ・インコーポレイテッド Ｂｔｋ阻害薬としての一級カルボキサミド類
EA034931B1 (ru) * 2014-10-24 2020-04-08 Бристол-Майерс Сквибб Компани Индолкарбоксамидные соединения

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CA2613068A1 (en) 2007-01-11
KR20080021077A (ko) 2008-03-06
NZ563687A (en) 2011-07-29
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MX2007016541A (es) 2008-03-07
AR055343A1 (es) 2007-08-22
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AU2006266028A1 (en) 2007-01-11
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WO2007005534A3 (en) 2007-04-26
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IL187786A0 (en) 2008-08-07
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MA29566B1 (fr) 2008-06-02
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WO2007005534A8 (en) 2008-01-17

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