NO20080457L - Kjemiske forbindelser - Google Patents

Kjemiske forbindelser

Info

Publication number
NO20080457L
NO20080457L NO20080457A NO20080457A NO20080457L NO 20080457 L NO20080457 L NO 20080457L NO 20080457 A NO20080457 A NO 20080457A NO 20080457 A NO20080457 A NO 20080457A NO 20080457 L NO20080457 L NO 20080457L
Authority
NO
Norway
Prior art keywords
compound
ikk2
directed
compounds
formula
Prior art date
Application number
NO20080457A
Other languages
English (en)
Inventor
Qi Jin
Christopher E Neipp
Sonia M Thomas
Jeffrey K Kerns
Michael Lindenmuth
Xichen Lin
Hong Nie
Jianghe Deng
Guoliang Lin
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20080457L publication Critical patent/NO20080457L/no

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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
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  • Hospice & Palliative Care (AREA)
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Abstract

Foreliggende oppfinnelse er rettet mot nye indolkarboksamidderivater. Spesifikt er oppfinnelsen rettet mot forbindelser ifølge formel I: Formel (I) hvor RI, R2, R3, U og V er definert nedenfor, og mot farmasøytisk akseptable salter derav. Forbindelsene ifølge oppfinnelsen er inhibitorer av IKK2 og kan være nyttige i behandlingen av forstyrrelser assosiert med uheldig IKK2 (også kjent som IKKP) aktivitet, slik som reumatoid artritt, astma og COPD (kronisk obstruktiv lungesykdom). Oppfinnelsen er følgelig ytterligere rettet mot farmasøytiske sammensetninger omfattende en forbindelse ifølge oppfinnelsen. Oppfinnelsen er også ytterligere rettet mot fremgangsmåter for å inhibere IKK2-aktivitet og behandling av forstyrrelser assosiert dermed, ved anvendelse av en forbindelse ifølge foreliggende oppfinnelse eller en farmasøytisk sammensetning omfattende en forbindelse ifølge oppfinnelsen.
NO20080457A 2005-06-30 2008-01-24 Kjemiske forbindelser NO20080457L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69525605P 2005-06-30 2005-06-30
PCT/US2006/025402 WO2007005534A2 (en) 2005-06-30 2006-06-28 Chemical compounds

Publications (1)

Publication Number Publication Date
NO20080457L true NO20080457L (no) 2008-01-29

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ID=37605008

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NO20080457A NO20080457L (no) 2005-06-30 2008-01-24 Kjemiske forbindelser

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EP (1) EP1896014A4 (no)
JP (1) JP5059756B2 (no)
KR (1) KR20080021077A (no)
CN (1) CN101247804B (no)
AR (1) AR055343A1 (no)
AU (1) AU2006266028B2 (no)
BR (1) BRPI0611674A2 (no)
CA (1) CA2613068A1 (no)
EA (1) EA014083B1 (no)
IL (1) IL187786A0 (no)
MA (1) MA29566B1 (no)
MX (1) MX2007016541A (no)
NO (1) NO20080457L (no)
NZ (1) NZ563687A (no)
PE (1) PE20070173A1 (no)
TW (1) TWI380973B (no)
UA (1) UA99699C2 (no)
WO (1) WO2007005534A2 (no)
ZA (1) ZA200709948B (no)

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WO2010102968A1 (en) * 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
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EA200800183A1 (ru) 2008-08-29
MA29566B1 (fr) 2008-06-02
EP1896014A2 (en) 2008-03-12
WO2007005534A2 (en) 2007-01-11
AU2006266028A1 (en) 2007-01-11
MX2007016541A (es) 2008-03-07
UA99699C2 (ru) 2012-09-25
ZA200709948B (en) 2009-03-25
IL187786A0 (en) 2008-08-07
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JP2009500338A (ja) 2009-01-08
EA014083B1 (ru) 2010-08-30
PE20070173A1 (es) 2007-03-14
WO2007005534A8 (en) 2008-01-17
CN101247804A (zh) 2008-08-20
KR20080021077A (ko) 2008-03-06
TW200738588A (en) 2007-10-16
AR055343A1 (es) 2007-08-22
CA2613068A1 (en) 2007-01-11
CN101247804B (zh) 2012-09-26
JP5059756B2 (ja) 2012-10-31
WO2007005534A3 (en) 2007-04-26

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