US5160724A - Barium sulfate contrast medium for x-ray examination of the large intestine - Google Patents

Barium sulfate contrast medium for x-ray examination of the large intestine Download PDF

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Publication number
US5160724A
US5160724A US07/409,296 US40929689A US5160724A US 5160724 A US5160724 A US 5160724A US 40929689 A US40929689 A US 40929689A US 5160724 A US5160724 A US 5160724A
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Prior art keywords
contrast medium
large intestine
barium sulfate
contrast
examination
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Inventor
Yoshito Tonariya
Yukihito Wada
Kazuhiro Yamaguchi
Tomio Yamazaki
Isamu Sakai
Shigeru Yokoi
Mitsuo Togashi
Yukihiro Noguchi
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OHTA SEIYAKU 51 SANJOMACHI OMIYA-SHI SAITAMA-KEN JAPAN KK
Ohta Seiyaku KK
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Ohta Seiyaku KK
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Assigned to OHTA SEIYAKU KABUSHIKI KAISHA, 51, SANJOMACHI, OMIYA-SHI, SAITAMA-KEN, JAPAN reassignment OHTA SEIYAKU KABUSHIKI KAISHA, 51, SANJOMACHI, OMIYA-SHI, SAITAMA-KEN, JAPAN ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: NOGUCHI, YUKIHIRO, SAKAI, ISAMU, TOGASHI, MITSUO, TONARIYA, YOSHITO, WADA, YUKIHITO, YAMAGUCHI, KAZUHIRO, YAMAZAKI, TOMIO, YOKOI, SHIGERU
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0404—X-ray contrast preparations containing barium sulfate

Definitions

  • This invention relates to a barium sulfate contrast medium for enema with double contrast method and computed tomography (X-ray CT) in X-ray examination of the large intestine (colon) practiced in the medical field.
  • X-ray CT computed tomography
  • X-ray CT computed tomography
  • US ultra-sonication examination
  • MRI magnetic resonance examination
  • main current most of large intestine diseases are lesions occurring in mucosa, and for discovery of such lesions, as a matter of course, but also for grasping of characteristics of the lesions, endoscopy and enema X-ray examination have been utilized as the main current.
  • the enema X-ray examination methods known in the prior art may be broadly classified into the filling method, the double contrast method, the compression method, the mucosal relief method, etc., and according to the present standard of Ministry of Health and Welfare of Japan (reevaluation result), it is approved to use 200 to 2000 ml of a 20 to 130 W/V % barium sulfate contrast medium.
  • the barium enema with double contrast method is optimum for imaging of lesions and diagnosis thereof, it holds the primary place in the current examinations.
  • the barium enema with double contrast method is a method, in which barium sulfate which is a positive contrast medium, is coated as a thin layer on the inner walls of the large intestine, and air which is a negative contrast medium is simultaneously insufflated to inflate the large intestine, whereby the state of the large intestine mucosa surface is imaged with contrast on a X-ray film.
  • the enema with double contrast method includes the Fisher method (1923) in which an aqueous barium sulfate suspension with a relatively low concentration (about 40 to 50 W/V %) is injected into the intestine after washing of the intestine, discharged, and then air is insufflated before taking double contrast images, the Welin method (1953) in which an aqueous barium sulfate suspension (about 100 W/V %) is likewise charged into the intestine as a contrast medium after washing of the intestine as the preliminary treatment, and then discharged and again a small amount of the contrast medium is injected with insufflation of air before taking double contrast images and the Brown method (1963) in which the contents of the large intestine are removed without washing of the intestine by carrying out the preliminary treatment which applies strict dietary control and then administers laxative, and double contrast images are taken without accompaniment of discharging of the barium sulfate contrast medium. Further, the Brown method has been improved so as to be well adapted for Japanese
  • the modified Brown method is a method, in which after removal of the large intestine contents by application of a low fat and low residue meals (meals for contrast enema) and then administration of laxatives (saline laxatives and contact evacuant), 200 to 300 ml of an aqueous barium suspension of a relatively higher concentration of about 60 to 80 W/V % is injected into the intestine and, without being discharged, permitted to reach the whole large intestine so far as possible by rotating the patient (change of position) before insufflation of air for fluoroscopic photographing, and according to this method, it has become possible to visualize fine patterns of the large intestine mucosa as fine network patterns.
  • the enema with double contrast method has been almost established according to the modified Brown method, but when propagation as the screening method for large intestine diseases is considered, there remain various problems such as demand of high degree of photographing technique, etc.
  • the contrast medium coated and then formed a solidified layer on intestinal walls is cracked with lapse of time, it is necessary to complete photographing relatively quickly, for which further technical skill is required.
  • the present inventors have made various studies with the aim at developing a contrast medium that is free, due to adequate X-ray transmissibility (radiolucency) and high coating ability, of the blind points in diagnosis as described above caused by contrast medium pooling portions and intestinal tracts overlapping them, and that requires no technical skill which has been a drawback of the enema with double contrast method of the prior art, and achieved the present invention whereby a contrast medium has now been provided that resolves the drawbacks of the prior art.
  • the present inventors have intensively studied first about the relationship between the concentration and the imaging ability of barium sulfate contrast medium, and consequently found that it has an adequate X-ray transmissibility at a barium sulfate concentration of 40 W/V % or less, and that the coating of the contrast medium to the large intestine mucosa is affected more greatly by the kind and the amount of additives rather than the barium sulfate concentration, particularly that gum tragacanth greatly affects the adhesive property and there exists the optimum amount to be added for the barium sulfate concentration.
  • contrast medium obtained by such knowledges as described above can be also used as extremely excellent contrast medium in computed tomography (X-ray CT).
  • X-ray CT computed tomography
  • the contrast medium created by the present inventors because barium sulfate at lower concentrations can be coated uniformly on intestinal tube through its excellent coating ability enables examination, even in computed tomography (X-ray CT), without formation of artifact (artificial product) which interferes with diagnosis.
  • the contrast medium of the present invention comprises an aqueous suspension containing barium sulfate at a low concentration of 15 to 35 W/V % and 2.0 to 0.5 W/V % of gum tragacanth.
  • the concentration of gum tragacanth used is generally reduced in response to the increase in concentration of barium sulfate.
  • X-ray CT computed tomography
  • the contrast medium is coated on all the internal circumferences of the whole large intestine under the extended state, not only identification of large intestine and of surrounding lesional sites can be performed with ease, but also the relationship between intestinal tract walls and surrounding tissues can be clearly visualized for every large intestine site, whereby an extremely precise large intestine examination is rendered possible.
  • the contrast medium of the present invention may also contain various additives generally known in the art in addition to the above components, such as humectants, defoaming agents, preservatives, etc.
  • suspending agents such as sodium carboxymethyl cellulose, sodium alginate, sodium chondroitin sulfate, gum arabic, methyl cellulose, gelatin, etc. can be used in combination.
  • the suspension was sterilized by heating, cooled and then 0.01 kg of silicone resin as a defoaming agent was aseptically added and after the resulting mixture was thoroughly mixed, it was filled into a contrast medium injecting vessel in an amount of 400 ml (see, for example, Japanese Utility Model Publication No. 7245/1988).
  • Viscosity curve is shown in FIG. 2 E-type viscometer (Tokyo Keiki) Model EMD (cone plate 1.34"), measurement temperature 25° C.
  • the suspension was sterilized by heating, cooled and then 0.01 kg of silicone resin as a defoaming agent was aseptically added and after the resulting mixture was thoroughly mixed, it was filled into a contrast medium injecting vessel in an amount of 400 ml (see, for example, Japanese Utility Model Publication No. 7245/1988).
  • Viscosity curve is shown in FIG. 4 E-type viscometer (Tokyo Keiki) Model EMD (cone plate 1.34"),measurement temperature 25° C.
  • the suspension was sterilized by heating, cooled and then 0.01 kg of silicone resin as a defoaming agent was aseptically added and after the resulting mixture was thoroughly mixed, it was filled into a contrast medium injecting vessel in an amount of 400 ml (see, for example, Japanese Utility Model Publication No. 7245/1988).
  • Viscosity curve is shown in FIG. 6 E-type viscometer (Tokyo Keiki) Model EMD (cone plate 1.34"), measurement temperature 25° C.
  • each contrast medium of the respective Examples Although an amount of 400 ml of each contrast medium of the respective Examples was used, because most are coated onto the intestine wall, there were few pools to give a double contrast image of wide range, and even if a pool may be formed, it did not interfere with diagnosis due to optimum transmissibility.
  • Coating with contrast medium can be effected simultaneously with its passage through intestinal tract, and no excessive postural change is required.
  • Computed tomography is possible without formation of artifact (artificial product) which interferes with diagnosis, and examination of the afflicted portion can be made immediately subsequent to enema with double contrast method.
  • FIG. 1 is a graph showing the flow curve of the contrast medium of the present invention obtained in Example 1,
  • FIG. 2 is a graph showing the viscosity curve of the same contrast medium (Example 1)
  • FIG. 3 is a graph showing the flow curve of the contrast medium of the present invention obtained in Example 2,
  • FIG. 4 is a graph showing the viscosity curve of the same contrast medium (Example 2)
  • FIG. 5 is a graph showing the flow curve of the contrast medium of the present invention obtained in Example 3,
  • FIG. 6 is a graph showing the viscosity curve of the same contrast medium (Example 3).

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
US07/409,296 1988-09-22 1989-09-19 Barium sulfate contrast medium for x-ray examination of the large intestine Expired - Fee Related US5160724A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63236272A JP2722218B2 (ja) 1988-09-22 1988-09-22 大腸ｘ線検査用硫酸バリウム造影剤
JP63-236272 1988-09-22

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EP (1) EP0360266B1 (de)
JP (1) JP2722218B2 (de)
DE (1) DE68902206T2 (de)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5518711A (en) * 1992-10-02 1996-05-21 Ohta Seiyaku Kabushiki Kaisha X-ray contrast medium comprising barium and xanthan gum for examination of large intestine and small intestine
US6001334A (en) * 1995-12-08 1999-12-14 Fushimi Pharmaceutical Co., Ltd. Extremely high density barium suspension as a contrast medium for upper gastrointestinal examination
US20050074405A1 (en) * 2003-10-03 2005-04-07 Williams Archie B. Contrast media for use in medical and diagnostic procedures and methods of using the same
US20060144834A1 (en) * 2003-03-18 2006-07-06 Denney Paul E Containment plenum for laser irradiation and removal of material from a surface of a structure
US20120101360A1 (en) * 2009-07-01 2012-04-26 Koninklijke Philips Electronics N.V. Colonography
CN113456835A (zh) * 2021-06-16 2021-10-01 博迈医疗科技(常州)有限公司 一种排粪造影剂及其制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948387A (en) * 1990-06-01 1999-09-07 Imarx Pharmaceutical Corp. Contrast media for ultrasonic imaging
ES2112859T3 (es) * 1990-06-01 1998-04-16 Imarx Pharmaceutical Corp Medios de contraste para la formacion de imagenes ecograficas.
US5420176A (en) * 1990-06-01 1995-05-30 Imarx Pharmaceutical Corp. Contrast media for ultrasonic imaging
JP2909876B2 (ja) * 1994-01-24 1999-06-23 恭弘 小川 造影剤
ES2081764B1 (es) * 1994-03-03 1996-10-01 Cesar Jose Taveira Un producto para aumentar el contraste de las imagenes radiologicas.
KR100339485B1 (ko) * 1999-04-07 2002-06-05 이태영 씨티촬영용 조영제

Citations (6)

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Publication number Priority date Publication date Assignee Title
US3689630A (en) * 1968-09-09 1972-09-05 Sakai Chemical Industry Co Barium sulfate contrast media
US4069306A (en) * 1974-03-14 1978-01-17 Pharmacia Aktiebolag X-ray contrast preparation containing a hydrophilic polymer containing amino groups
US4120946A (en) * 1976-05-26 1978-10-17 Andre Queuille Pharmaceutical compositions for barium opacification and method of preparing them
JPS55127327A (en) * 1979-03-27 1980-10-02 Nippon Soda Co Ltd Simultaneous preparation of substituted benzaldehyde and benzoic acid
WO1984004888A1 (en) * 1983-06-09 1984-12-20 Field Group Chemicals Radiopaque medium
JPS6069041A (ja) * 1983-09-26 1985-04-19 Otsuka Pharmaceut Factory Inc Ｘ線用硫酸バリウム造影剤

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JPS54163827A (en) * 1978-06-13 1979-12-26 Otsuka Pharma Co Ltd Xxray barium sulphate contrast medium
JPS55127322A (en) * 1979-03-26 1980-10-02 Otsuka Pharmaceut Factory Inc Barium sulfate contrast medium for x-ray radiography
IT1164372B (it) * 1983-08-04 1987-04-08 Bracco Ind Chimica Spa Procedimento per la preparazione di solfato di bario con fluidita' e densita' accresciute, adatto quale componente opacizzante nei mezzi di contrasto, prodotto ottenuto con questo procedimento e relativi mezzi di contrasto allestiti

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3689630A (en) * 1968-09-09 1972-09-05 Sakai Chemical Industry Co Barium sulfate contrast media
US4069306A (en) * 1974-03-14 1978-01-17 Pharmacia Aktiebolag X-ray contrast preparation containing a hydrophilic polymer containing amino groups
US4120946A (en) * 1976-05-26 1978-10-17 Andre Queuille Pharmaceutical compositions for barium opacification and method of preparing them
JPS55127327A (en) * 1979-03-27 1980-10-02 Nippon Soda Co Ltd Simultaneous preparation of substituted benzaldehyde and benzoic acid
WO1984004888A1 (en) * 1983-06-09 1984-12-20 Field Group Chemicals Radiopaque medium
JPS6069041A (ja) * 1983-09-26 1985-04-19 Otsuka Pharmaceut Factory Inc Ｘ線用硫酸バリウム造影剤

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5518711A (en) * 1992-10-02 1996-05-21 Ohta Seiyaku Kabushiki Kaisha X-ray contrast medium comprising barium and xanthan gum for examination of large intestine and small intestine
US6001334A (en) * 1995-12-08 1999-12-14 Fushimi Pharmaceutical Co., Ltd. Extremely high density barium suspension as a contrast medium for upper gastrointestinal examination
US20060144834A1 (en) * 2003-03-18 2006-07-06 Denney Paul E Containment plenum for laser irradiation and removal of material from a surface of a structure
US20050074405A1 (en) * 2003-10-03 2005-04-07 Williams Archie B. Contrast media for use in medical and diagnostic procedures and methods of using the same
US7498018B2 (en) 2003-10-03 2009-03-03 Bracco Diagnostics Inc. Contrast media for use in medical and diagnostic procedures and methods of using the same
US20090136426A1 (en) * 2003-10-03 2009-05-28 Bracco Diagnostics Inc. Contrast media for using in medical and diagnostic procedures and methods of using the same
US20120101360A1 (en) * 2009-07-01 2012-04-26 Koninklijke Philips Electronics N.V. Colonography
US9020578B2 (en) * 2009-07-01 2015-04-28 Koninklijke Philips N.V. Colonography
CN113456835A (zh) * 2021-06-16 2021-10-01 博迈医疗科技(常州)有限公司 一种排粪造影剂及其制备方法

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DE68902206D1 (de) 1992-08-27
EP0360266B1 (de) 1992-07-22
JPH0285217A (ja) 1990-03-26
JP2722218B2 (ja) 1998-03-04
EP0360266A3 (en) 1990-11-07
EP0360266A2 (de) 1990-03-28
DE68902206T2 (de) 1993-02-25

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