WO1991009121A3 - Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides - Google Patents

Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides Download PDF

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Publication number
WO1991009121A3
WO1991009121A3 PCT/EP1990/002154 EP9002154W WO9109121A3 WO 1991009121 A3 WO1991009121 A3 WO 1991009121A3 EP 9002154 W EP9002154 W EP 9002154W WO 9109121 A3 WO9109121 A3 WO 9109121A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
thyrotropin
receptor activity
receptors
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1990/002154
Other languages
English (en)
Other versions
WO1991009121A2 (fr
Inventor
Marc Parmentier
Frederic Libert
Jacques Dumont
Gilbert Vassart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henning Berlin GmbH Chemie- und Pharmawerk
Original Assignee
Henning Berlin GmbH Chemie- und Pharmawerk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henning Berlin GmbH Chemie- und Pharmawerk filed Critical Henning Berlin GmbH Chemie- und Pharmawerk
Priority to EP91901286A priority Critical patent/EP0458940B1/fr
Priority to CA002046917A priority patent/CA2046917C/fr
Priority to US07/741,453 priority patent/US6228597B1/en
Priority to DE69028695T priority patent/DE69028695T2/de
Priority to JP03501671A priority patent/JP3090682B2/ja
Publication of WO1991009121A2 publication Critical patent/WO1991009121A2/fr
Publication of WO1991009121A3 publication Critical patent/WO1991009121A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/854—Glands

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Polypeptide possédant des récepteurs actifs de thyrotropine, caractérisé en ce qu'il comprend la séquence aminoacide (représentée par la Fig. 11), ou un fragment de celle-ci, ou une séquence aminmoacide dérivée de cette séquence par la substitution ou la délétion d'un des résidus aminoacides (indiqués dans la Fig. 11), ou par l'insertion de résidus aminoacides supplémentaires.
PCT/EP1990/002154 1989-12-14 1990-12-12 Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides Ceased WO1991009121A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP91901286A EP0458940B1 (fr) 1989-12-14 1990-12-12 Methode pour la detection quantitative de la thyrotropine (tsh) ou d'autoanticorps contre le recepteur de la thyrotropine (anti-tshr) utilsant un recepteur recombinant de la thyrotropine et kit pour la performance de ladite methode
CA002046917A CA2046917C (fr) 1989-12-14 1990-12-12 Polypeptides presentant une activite a l'egard de la thyreotropine, codage de sequences d'acide nucleique pour de tels recepteurs et des polypeptides et applications de ces polypeptides
US07/741,453 US6228597B1 (en) 1989-12-14 1990-12-12 Polypeptides having thyrotropin-receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
DE69028695T DE69028695T2 (de) 1989-12-14 1990-12-12 Methode zur quantitativen bestimmung von thyrotropin (tsh) oder anti-thryrotropin-rezeptor autoantikörper (anti-tshr) unter verwendung eines rekombinanten thyrotropin rezeptor polypeptides und kit zur durchführung dieser methode
JP03501671A JP3090682B2 (ja) 1989-12-14 1990-12-12 チロトロピンレセプター活性を有するポリペプチド、このレセプターとポリペプチドとをコードする核酸、そしてこのようなペプチドの利用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP89403493.3 1989-12-14
EP89403493A EP0433509B1 (fr) 1989-12-14 1989-12-14 Polypeptides possédant l'activité réceptrice de la thyrotropine, séquences d'acides nucléiques codant pour de tels récepteurs et polypeptides, et applications de ces polypeptides

Publications (2)

Publication Number Publication Date
WO1991009121A2 WO1991009121A2 (fr) 1991-06-27
WO1991009121A3 true WO1991009121A3 (fr) 1991-09-19

Family

ID=8203015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1990/002154 Ceased WO1991009121A2 (fr) 1989-12-14 1990-12-12 Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides

Country Status (10)

Country Link
US (1) US6228597B1 (fr)
EP (2) EP0433509B1 (fr)
JP (1) JP3090682B2 (fr)
AT (2) ATE145240T1 (fr)
AU (1) AU641209B2 (fr)
CA (1) CA2046917C (fr)
DE (2) DE68927461T2 (fr)
DK (1) DK0458940T3 (fr)
ES (2) ES2092998T3 (fr)
WO (1) WO1991009121A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
EP1199361A3 (fr) * 1989-05-05 2004-03-10 Genentech Inc. Molécules réceptrices des hormones glycoprotéiques. Leurs utilisations
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
EP0493434A4 (en) * 1989-09-08 1993-05-05 New England Medical Center Hospitals, Inc. Tsh receptor
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor
EP0482598A3 (en) * 1990-10-24 1993-05-19 Ishihara Sangyo Kaisha, Ltd. Peptide analog of human tsh receptor affective against autoimmune hyperthyroidism
EP0719858A3 (fr) * 1994-12-27 1997-12-29 Tosoh Corporation Lignée cellulaire de myélome exprimant le récepteur humain recombinant pour l'hormone stimulatrice de la thyroide
DE19728991A1 (de) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
DE19801154A1 (de) * 1998-01-14 1999-07-15 Brahms Diagnostica Gmbh Verfahren zur Herstellung von gereinigten und gegebenenfalls markierten TSH-Rezeptor-Präparaten, neue radioiodierte TSH-Rezeptor-Präparate, und die Verwendung derartiger Präparate in Diagnostik und Therapie
DE19907094C1 (de) 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
EP1224473B1 (fr) * 1999-10-12 2005-08-17 Ulrich Loos Procede de determination d'autoanticorps contre le recepteur de tsh
AU2002231353A1 (en) * 2000-10-26 2002-05-06 Deltagen, Inc. Knockout mice thyroid stimulating hormone receptor (tsh-r) gene
GB2376016A (en) * 2001-05-30 2002-12-04 Nadir R Farid Thyrotropin receptor (TSHR) domain cleavage catalysed by the metalloprotease ADAM 10
ES2736165T3 (es) 2001-08-23 2019-12-26 Rsr Ltd Regiones epítopo de un receptor de tirotropina (TSH), sus usos y anticuerpos para las mismas
DE50306067D1 (de) 2002-11-26 2007-02-01 Brahms Ag Nachweis von tsh-rezeptor-autoantikörpern mit affinitätsgereinigten antikörpern
CA2613160A1 (fr) 2005-06-24 2006-12-28 Bayer Bioscience N.V. Methodes servant a modifier la reactivite de parois cellulaires de plantes
US8097699B2 (en) 2006-08-30 2012-01-17 Rsr Limited Crystal structure of thyroid stimulating hormone receptor
US8350012B2 (en) * 2007-01-25 2013-01-08 Cedars-Sinai Medical Center Inverse agonist monoclonal antibody that suppresses thyrotropin receptor constitutive activity
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides
CN115925966A (zh) * 2021-09-22 2023-04-07 厦门英博迈生物科技有限公司 一种重组促甲状腺激素受体蛋白、制备方法及应用
WO2026028159A1 (fr) 2024-07-31 2026-02-05 Biohaven Therapeutics Ltd. Agents de dégradation bifonctionnels pour le traitement d'une maladie de graves

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005703A1 (fr) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US4448764A (en) * 1982-07-06 1984-05-15 Pierce Chemical Company Direct-acting iodinating reagent
US5144007A (en) * 1988-11-03 1992-09-01 La Jolla Cancer Research Foundation Thyroid hormone receptor
US5614363A (en) 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
EP0493434A4 (en) * 1989-09-08 1993-05-05 New England Medical Center Hospitals, Inc. Tsh receptor
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005703A1 (fr) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
64th Meeting of the American Thyroid Association, abstract T-51, 1989, Frazier-Seabrook et al.: "Isolation of a thyroid-specific cDNA with over 80% amino acid homology with the luteinizing hormone receptor" *
Biochemical and Biophysical Research Communications, vol. 165, no. 3, 29 December 1989, Academic Press, Inc. (Duluth, MN, US) Y. Nagayama et al.: "Molecular cloning, sequence and functional expression of the cDNA for the human thryrotropin receptor", pages 11-84-1190 *
Biochemical and Biophysical Research Communications, vol. 165, no. 3, 29 December 1989, Academic Press, Inc., (Duluth, MN, US) F. Libert et al.: "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor. Evidence for binding of autoantibodies", pages 1250-1255 *
Chemical Abstracts, vol. 108, 1988 (Columbus, Ohio, US) see page 349 *
Clinical Chemistry, vol. 32, no. 7, 1986 (New York, US) C. Massart et al.: "Assays for thyrotropin receptor binding and thyroid - stimulating antibodies in sera from patients with Graves' disease", pages 1332-1335 *
Clinical Research, vol. 29, no. 2, 1981 (New York, US) M.N. Islam et al.: "Purification of the human thyrotropin receptor", page 294A *
Endocrinology, vol. 110, no. 4, 1982 The Endocrine Society, (Springfield, US) Y. Koizumi et al.: "Solubilization, purification, and partial characterization of thyrotropin receptor from bovine and human thyroid glands", pages 1381-1391 *
Endocrinology, vol. 122, no. 6, 1988 The Endocrine Society (Springfield, US) B.L. Hill et al.: "Monoclonal antibodies to the thyrotropin receptor raised by an autoantiidiotypic protocol and their relationship to monoclonal autoantibodies form Graves patients", pages 2840-2850 *
Molecular and Cellular Endocrinology, vol. 73, no. 1, 1 October 1990, Elsevier Scientific Publishers ireland Ltd. M. Ludgate et al.: "Use of the recombinant human thyrotropin receptor (TSH-R) expressed in mammalian cell lines to assay TSH-R autoantibodies", pages R13-R18 *
Proceedings of the National Academy of Sciences, vol. 79, November 1982, Medical Sciences, (Washington, US) W.A. Valente et al.: Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves Disease" pages 6680-6684 *
Radioimmunoassay and Related Procedures in Medicine 1982, Proceedings of a symposium Vienna 21-25 June 1982 P. Kotulla et al.: "Radioligand receptor assay (RRA) for thyroid stimulating hormone (TSH) using triton X-100 solubilized receptor preparation" pages 297-305 *
Science, vol. 245, 4 August 1989 (Washington, US) H. Loosfelt et al.: "Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domain", pages 525-527 *
Science, vol. 246, 22 December 1989 (Washington, US) M. Parmentier et al.: "Molecular cloning of the thyrotropin receptor", pages 1620-1622 *

Also Published As

Publication number Publication date
ES2092998T3 (es) 1996-12-16
AU641209B2 (en) 1993-09-16
DK0458940T3 (da) 1996-11-11
DE68927461D1 (de) 1996-12-19
ATE143375T1 (de) 1996-10-15
EP0458940A1 (fr) 1991-12-04
WO1991009121A2 (fr) 1991-06-27
DE69028695T2 (de) 1997-02-20
EP0433509A3 (en) 1991-07-24
AU7038691A (en) 1991-07-18
EP0458940B1 (fr) 1996-09-25
JP3090682B2 (ja) 2000-09-25
ES2091317T3 (es) 1996-11-01
DE69028695D1 (de) 1996-10-31
JPH04506752A (ja) 1992-11-26
US6228597B1 (en) 2001-05-08
EP0433509B1 (fr) 1996-11-13
ATE145240T1 (de) 1996-11-15
CA2046917A1 (fr) 1991-06-15
CA2046917C (fr) 2003-07-01
EP0433509A2 (fr) 1991-06-26
DE68927461T2 (de) 1997-03-20

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