WO2000067728A3 - Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung - Google Patents

Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung Download PDF

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Publication number
WO2000067728A3
WO2000067728A3 PCT/EP2000/004112 EP0004112W WO0067728A3 WO 2000067728 A3 WO2000067728 A3 WO 2000067728A3 EP 0004112 W EP0004112 W EP 0004112W WO 0067728 A3 WO0067728 A3 WO 0067728A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
liquid
particles
dispersions
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/004112
Other languages
English (en)
French (fr)
Other versions
WO2000067728A2 (de
Inventor
Rainer Helmut Mueller
Volkhard Jenning
Karsten Maeder
Andreas Lippacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmasol GmbH
Original Assignee
Pharmasol GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999138371 external-priority patent/DE19938371A1/de
Priority claimed from DE19945203A external-priority patent/DE19945203A1/de
Priority to MXPA01011343A priority Critical patent/MXPA01011343A/es
Priority to BR0010354-3A priority patent/BR0010354A/pt
Priority to US09/959,732 priority patent/US8663692B1/en
Priority to KR1020017014237A priority patent/KR20020011985A/ko
Application filed by Pharmasol GmbH filed Critical Pharmasol GmbH
Priority to AU49179/00A priority patent/AU4917900A/en
Priority to CA002369594A priority patent/CA2369594A1/en
Priority to JP2000616755A priority patent/JP2002544155A/ja
Priority to EP00931138.2A priority patent/EP1176949B1/de
Publication of WO2000067728A2 publication Critical patent/WO2000067728A2/de
Publication of WO2000067728A3 publication Critical patent/WO2000067728A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Die Erfindung betrifft Wirkstoff-freie und Wirkstoff-beladene Lipidpartikel mit einer gemischten Matrix aus festem und flüssigem Lipid (sog. Fest-flüssig-Partikel), mit ungeordneter Struktur (teilkristallin, überwiegend nicht-kristallin bis zu amorph) im halbfesten bis festen Aggregatzustand sowie Verfahren zur Herstellung dieser Dispersionen, speziell Verfahren zur Herstellung von hochkonzentrierten Lipidpartikeldispersionen mit einem Lipidgehalt von 30 % bis 95 % oder einem Feststoffgehalt von 30 % bis 95 % (Lipid und Stabilisator), bei denen es sich im Gegensatz zu biamphiphilen Cremes um integere Partikel handelt, und/oder bei denen die hochkonzentrierten Partikeldispersionen bei Verdünnen mit der äusseren Phase fliessfähige Partikeldispersionen ergeben.
PCT/EP2000/004112 1999-05-07 2000-05-08 Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung Ceased WO2000067728A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP00931138.2A EP1176949B1 (de) 1999-05-07 2000-05-08 Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung
JP2000616755A JP2002544155A (ja) 1999-05-07 2000-05-08 流体および固体脂質の混合物を基礎とする脂質粒子、およびそれらを製造するための方法
BR0010354-3A BR0010354A (pt) 1999-05-07 2000-05-08 Partìculas de lipìdeo à base em misturas de lipìdeos lìquidos e sólidos e método para a sua produção
US09/959,732 US8663692B1 (en) 1999-05-07 2000-05-08 Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
KR1020017014237A KR20020011985A (ko) 1999-05-07 2000-05-08 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법
MXPA01011343A MXPA01011343A (es) 1999-05-07 2000-05-08 Particulas de lipidos a base de mezclas de lipidos liquidos y solidos asi como procedimiento para su produccion.
AU49179/00A AU4917900A (en) 1999-05-07 2000-05-08 Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
CA002369594A CA2369594A1 (en) 1999-05-07 2000-05-08 Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE19921034 1999-05-07
DE19921034.9 1999-05-07
DE1999138371 DE19938371A1 (de) 1999-08-09 1999-08-09 Zusammensetzung, Herstellung und Verwendung einer Suspension verfestigter, amorpher Öltröpfchen
DE19938371.5 1999-08-09
DE19945203A DE19945203A1 (de) 1999-05-07 1999-09-21 Fest-flüssig (halbfeste) Lipidpartikel (Nano-Compartiment-Carrier-NCC) und Verfahren zur Herstellung hochkonzentrierter Lipidpartikel
DE19945203.2 1999-09-21
DE10016357 2000-03-31
DE10016357.2 2000-03-31

Publications (2)

Publication Number Publication Date
WO2000067728A2 WO2000067728A2 (de) 2000-11-16
WO2000067728A3 true WO2000067728A3 (de) 2001-08-09

Family

ID=27437798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/004112 Ceased WO2000067728A2 (de) 1999-05-07 2000-05-08 Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung

Country Status (8)

Country Link
EP (1) EP1176949B1 (de)
JP (1) JP2002544155A (de)
AU (1) AU4917900A (de)
BR (1) BR0010354A (de)
CA (1) CA2369594A1 (de)
MX (1) MXPA01011343A (de)
TR (1) TR200103188T2 (de)
WO (1) WO2000067728A2 (de)

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Also Published As

Publication number Publication date
EP1176949A2 (de) 2002-02-06
BR0010354A (pt) 2002-03-05
AU4917900A (en) 2000-11-21
WO2000067728A2 (de) 2000-11-16
JP2002544155A (ja) 2002-12-24
MXPA01011343A (es) 2002-06-04
EP1176949B1 (de) 2014-12-10
CA2369594A1 (en) 2000-11-16
TR200103188T2 (tr) 2002-04-22

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