WO2000067728A3 - Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung - Google Patents

Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung Download PDF

Info

Publication number
WO2000067728A3
WO2000067728A3 PCT/EP2000/004112 EP0004112W WO0067728A3 WO 2000067728 A3 WO2000067728 A3 WO 2000067728A3 EP 0004112 W EP0004112 W EP 0004112W WO 0067728 A3 WO0067728 A3 WO 0067728A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
liquid
particles
dispersions
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/004112
Other languages
English (en)
French (fr)
Other versions
WO2000067728A2 (de
Inventor
Rainer Helmut Mueller
Volkhard Jenning
Karsten Maeder
Andreas Lippacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmasol GmbH
Original Assignee
Pharmasol GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999138371 external-priority patent/DE19938371A1/de
Priority claimed from DE19945203A external-priority patent/DE19945203A1/de
Priority to BR0010354-3A priority Critical patent/BR0010354A/pt
Priority to AU49179/00A priority patent/AU4917900A/en
Priority to JP2000616755A priority patent/JP2002544155A/ja
Priority to KR1020017014237A priority patent/KR20020011985A/ko
Application filed by Pharmasol GmbH filed Critical Pharmasol GmbH
Priority to MXPA01011343A priority patent/MXPA01011343A/es
Priority to CA002369594A priority patent/CA2369594A1/en
Priority to EP00931138.2A priority patent/EP1176949B1/de
Priority to US09/959,732 priority patent/US8663692B1/en
Publication of WO2000067728A2 publication Critical patent/WO2000067728A2/de
Publication of WO2000067728A3 publication Critical patent/WO2000067728A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Die Erfindung betrifft Wirkstoff-freie und Wirkstoff-beladene Lipidpartikel mit einer gemischten Matrix aus festem und flüssigem Lipid (sog. Fest-flüssig-Partikel), mit ungeordneter Struktur (teilkristallin, überwiegend nicht-kristallin bis zu amorph) im halbfesten bis festen Aggregatzustand sowie Verfahren zur Herstellung dieser Dispersionen, speziell Verfahren zur Herstellung von hochkonzentrierten Lipidpartikeldispersionen mit einem Lipidgehalt von 30 % bis 95 % oder einem Feststoffgehalt von 30 % bis 95 % (Lipid und Stabilisator), bei denen es sich im Gegensatz zu biamphiphilen Cremes um integere Partikel handelt, und/oder bei denen die hochkonzentrierten Partikeldispersionen bei Verdünnen mit der äusseren Phase fliessfähige Partikeldispersionen ergeben.
PCT/EP2000/004112 1999-05-07 2000-05-08 Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung Ceased WO2000067728A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US09/959,732 US8663692B1 (en) 1999-05-07 2000-05-08 Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
EP00931138.2A EP1176949B1 (de) 1999-05-07 2000-05-08 Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung
AU49179/00A AU4917900A (en) 1999-05-07 2000-05-08 Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
JP2000616755A JP2002544155A (ja) 1999-05-07 2000-05-08 流体および固体脂質の混合物を基礎とする脂質粒子、およびそれらを製造するための方法
KR1020017014237A KR20020011985A (ko) 1999-05-07 2000-05-08 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법
BR0010354-3A BR0010354A (pt) 1999-05-07 2000-05-08 Partìculas de lipìdeo à base em misturas de lipìdeos lìquidos e sólidos e método para a sua produção
MXPA01011343A MXPA01011343A (es) 1999-05-07 2000-05-08 Particulas de lipidos a base de mezclas de lipidos liquidos y solidos asi como procedimiento para su produccion.
CA002369594A CA2369594A1 (en) 1999-05-07 2000-05-08 Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE19921034 1999-05-07
DE19921034.9 1999-05-07
DE19938371.5 1999-08-09
DE1999138371 DE19938371A1 (de) 1999-08-09 1999-08-09 Zusammensetzung, Herstellung und Verwendung einer Suspension verfestigter, amorpher Öltröpfchen
DE19945203.2 1999-09-21
DE19945203A DE19945203A1 (de) 1999-05-07 1999-09-21 Fest-flüssig (halbfeste) Lipidpartikel (Nano-Compartiment-Carrier-NCC) und Verfahren zur Herstellung hochkonzentrierter Lipidpartikel
DE10016357 2000-03-31
DE10016357.2 2000-03-31

Publications (2)

Publication Number Publication Date
WO2000067728A2 WO2000067728A2 (de) 2000-11-16
WO2000067728A3 true WO2000067728A3 (de) 2001-08-09

Family

ID=27437798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/004112 Ceased WO2000067728A2 (de) 1999-05-07 2000-05-08 Lipidpartikel auf der basis von mischungen von flüssigen und festen lipiden und verfahren zu ihrer herstellung

Country Status (8)

Country Link
EP (1) EP1176949B1 (de)
JP (1) JP2002544155A (de)
AU (1) AU4917900A (de)
BR (1) BR0010354A (de)
CA (1) CA2369594A1 (de)
MX (1) MXPA01011343A (de)
TR (1) TR200103188T2 (de)
WO (1) WO2000067728A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL138146A0 (en) 1998-03-12 2001-10-31 Procter & Gamble Disposable absorbent article having a skin care composition containing an enzyme inhibitor
DE50013433D1 (de) 1999-07-13 2006-10-19 Clr Chemisches Lab Dr Kurt Ric Mittel mit uv-strahlung absorbierender und/oder reflektierender wirkung zum schutz vor gesundheitsschädlicher uv-strahlung und stärkung der natürlichen hautbarriere
JP2003516955A (ja) * 1999-12-17 2003-05-20 ザ、プロクター、エンド、ギャンブル、カンパニー 活性成分の有効な放出のための組成物
NZ504526A (en) * 2000-05-12 2003-05-30 Meracol Corp Ltd Treating herpes simplex symptoms using a mixture of cetyl myristate and cetyl palmitate
ES2299484T3 (es) * 2000-05-12 2008-06-01 Meracol Corporation Limited Tratamiento del sindrome o enfermedad de intestino irritable.
US20030153620A1 (en) 2000-05-12 2003-08-14 Meakin Timothy David Treating eczema and/or psoriasis
DE60132008T2 (de) * 2000-05-12 2008-12-11 Meracol Corp. Ltd., Takapuna Cetylmyristat und cetylpalmitat zur behandlung von ekzemen und/oder psoriasis
DE10065217A1 (de) * 2000-12-27 2002-07-18 Pharmasol Gmbh Transfektionskomplexe (TransoPlex) mit reduzierter Toxizität, hoher physikalischer Stabilität und hoher Transfektionseffizienz sowie Verfahren zu ihrer Herstellung
DE10228680A1 (de) * 2002-06-27 2004-01-22 Holden Development Limited, Tortola Grundlage für transdermale Formulierungen (PTF)
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
US20040191207A1 (en) * 2003-03-31 2004-09-30 Lipari John M. Alpha-hydroxy acid ester drug delivery compositions and methods of use
EP1628626B2 (de) * 2003-05-07 2013-12-04 OTC GmbH Zusammensetzungen zur gezielten freisetzung von duftstoffen und aromen
DE10357639A1 (de) 2003-08-27 2005-03-24 Beiersdorf Ag Kosmetische und/oder dermatologische Kapsel
EP1660033B1 (de) 2003-08-27 2010-11-10 Beiersdorf AG Kosmetische kugelförmige zubereitungen zur topischen anwendung
US8741321B2 (en) 2003-08-27 2014-06-03 Beiersdorf Ag Capsule whose envelope is separately imperceptible during the topical use thereof
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
PL2359808T3 (pl) 2006-08-09 2013-10-31 Intarcia Therapeutics Inc Osmotyczne systemy dostawcze i zespoły tłokowe
WO2008058755A1 (en) 2006-11-17 2008-05-22 Abbott Gmbh & Co. Kg Nanocrystals for use in topical cosmetic formulations and method of production thereof
EP2157967B1 (de) 2007-04-23 2013-01-16 Intarcia Therapeutics, Inc Suspensionsformulierungen insulinotroper peptide und ihre verwendung
DE102007055341A1 (de) 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
EP2229936B1 (de) * 2009-03-09 2015-05-06 PharmaSol GmbH Nanonisierte Testosteronformulierungen für verbesserte Bioverfügbarkeit
EP3323423B1 (de) 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Schnelle initiierung und/oder beendigung der verabreichung substantiell stabiler arzneimittel
ES2384060B1 (es) 2010-03-24 2013-09-23 Lipotec S.A. Cápsulas de nanopartículas lipídicas.
EP2441441A1 (de) * 2010-10-14 2012-04-18 Deva Holding Anonim Sirketi Siebverfahren für Cetylmyristat und/oder Cetylpalmitat
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
GB201021937D0 (en) * 2010-12-24 2011-02-02 Reckitt & Colman Overseas Skin sanitizer compositions comprising alcohol based emulsion
CA2821061A1 (en) 2010-12-28 2012-07-05 Unilever Plc Method for production of an emulsion
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN103442700B (zh) * 2011-03-24 2016-04-06 利奥制药有限公司 含有脂质纳米颗粒和皮质类固醇或维生素d衍生物的组合物
WO2013049749A2 (en) 2011-09-29 2013-04-04 Plx Pharma Inc. pH DEPENDENT CARRIERS FOR TARGETED RELEASE OF PHARMACEUTICALS ALONG THE GASTROINTESTINAL TRACT, COMPOSITIONS THEREFROM, AND MAKING AND USING SAME
CN102688152A (zh) * 2012-06-05 2012-09-26 东南大学 复合防晒剂纳米结构脂质载体及其制备方法
JP6474732B2 (ja) * 2013-01-14 2019-02-27 インファースト ヘルスケア リミテッド 激痛治療用組成物と方法
MX377877B (es) * 2013-01-14 2025-03-11 Infirst Healthcare Ltd Composiciones de solución sólida y su uso en el tratamiento del dolor intenso.
CN105120900A (zh) * 2013-02-04 2015-12-02 因佛斯特医疗有限公司 用于治疗慢性炎症和炎性疾病的组合物及方法
DE102013224627A1 (de) 2013-11-29 2015-06-03 Andreas Lauterbach Pharmazeutische Formulierung mit Lipidmikropartikeln und Herstellungsverfahren
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CA2974208A1 (en) * 2015-01-21 2017-04-06 Michael WILLINSKY Composition and methods to improve stability, dosing, pharmacodynamics and product shelf life of endocannabinoids, phytocannabinoids and synthetic cannabinoids delivered by nasal inhaler
ES2968262T3 (es) 2015-06-03 2024-05-08 I2O Therapeutics Inc Sistemas de colocación de implantes
EP3228359A1 (de) * 2016-04-06 2017-10-11 Infinitec Activos, S.L. Chlorella-zusammensetzungen und verwendung davon zur verringerung von dunklen augenringen
KR20240037175A (ko) 2016-05-16 2024-03-21 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
AU2018206539A1 (en) 2017-01-03 2019-07-18 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
EA201992178A1 (ru) 2017-03-15 2020-05-22 Сересин Инк. Фармацевтические композиции с высоким содержанием лекарственного средства из среднецепочечных триглицеридов и способы, связанные c ними
WO2019178482A1 (en) * 2018-03-15 2019-09-19 Cerecin Inc. Pharmaceutical compositions having high drug loadings of medium chain triglycerides and methods related thereto
KR102037354B1 (ko) * 2018-12-07 2019-10-28 (주) 바이노텍 생리활성물질 봉입을 위한 나노지질전달체 및 이의 제조방법
WO2021119271A1 (en) * 2019-12-10 2021-06-17 Capsugel Belgium Nv Particles containing a lipid matrix core and active ingredient
KR20220158031A (ko) 2020-03-26 2022-11-29 피엘엑스 옵코 인코포레이티드 pH 의존성 재구성이 가능한 제약 담체 및 그의 제조 및 사용 방법
DE102023103292A1 (de) * 2023-02-10 2024-08-14 Cineolux Gmbh Dispersion und Zubereitung zur topischen Anwendung
CN116406663A (zh) * 2023-04-11 2023-07-11 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种含草蒿脑的果蝇驱避剂及其制备方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448930A1 (de) * 1990-03-30 1991-10-02 American Cyanamid Company Stabile Zusammensetzungen zur parenteralen Anwendung und Verfahren zu ihrer Herstellung
EP0525307A1 (de) * 1991-07-23 1993-02-03 American Cyanamid Company Stabile Zusammensetzungen für parenterale Verabrechung und ihre Verwendung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
JPH08505367A (ja) * 1992-10-16 1996-06-11 スミスクライン・ビーチャム・コーポレイション 医薬用エマルジョン組成物
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
JP3454385B2 (ja) * 1993-10-15 2003-10-06 啓次郎 佐藤 Ｏ／ｗ型皮膚用クリームの製造方法
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
JPH09151112A (ja) * 1995-11-30 1997-06-10 Noevir Co Ltd 微細エマルション組成物
FR2775441B1 (fr) * 1998-02-27 2000-04-28 Serobiologiques Lab Sa Matrice pour la preparation de microparticules ou de nanoparticules, procede de fabrication de telles particules et particules obtenues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448930A1 (de) * 1990-03-30 1991-10-02 American Cyanamid Company Stabile Zusammensetzungen zur parenteralen Anwendung und Verfahren zu ihrer Herstellung
EP0525307A1 (de) * 1991-07-23 1993-02-03 American Cyanamid Company Stabile Zusammensetzungen für parenterale Verabrechung und ihre Verwendung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

Also Published As

Publication number Publication date
JP2002544155A (ja) 2002-12-24
EP1176949B1 (de) 2014-12-10
CA2369594A1 (en) 2000-11-16
EP1176949A2 (de) 2002-02-06
BR0010354A (pt) 2002-03-05
MXPA01011343A (es) 2002-06-04
TR200103188T2 (tr) 2002-04-22
WO2000067728A2 (de) 2000-11-16
AU4917900A (en) 2000-11-21

Similar Documents

Publication Publication Date Title
EP0835908A4 (de) Harzzusammensetzung und harzzusammensetzung für sekundärbatterie
AU5482298A (en) Epoxy resin-amine addition products for use as emulsifiers for epoxy resins; aqueous based epoxy resin dispersions and process for producing the same
CA2271636A1 (en) Disinfecting microemulsions
AU2002223130A1 (en) Granular inorganic filler, process for producing the filler and resin compositions containing the same
EP0965343A3 (de) Ziprasidonhaltige Arzneimittel
AU9307798A (en) System and method for reducing material
AU2166097A (en) Composite gel microparticles as active principle carriers
AU2941100A (en) Epoxy resin composition, epoxy resin composition for fiber-reinforced composite,and fiber-reinforced composite containing the same
CA2247103A1 (en) Iscom or iscom-matrix comprising hydrophobic receptor molecules for antigenic substances
AU3011799A (en) Microspheres as a delivery vehicle for bio-active agents useful in agricultural applications
AU6566300A (en) Detergent for glass-ceramic surfaces
WO2001038708A3 (en) Manual control apparatus
Liu et al. Breathing mode compactifications and supersymmetry of the brane-world
CA2241033A1 (en) Combined nut and flange fastener
WO1999034919A3 (fr) Dispositif d'enrobage pour granules a absorber par voie orale
CA2342632A1 (en) Preparation agents
GB9005498D0 (en) Composition
AU1145400A (en) Process for hydrophobicizing particles, and their use in polymer dispersions
AU3244093A (en) Dispersing agents for comminuted solids
AU6315300A (en) Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same
WO2001005246A3 (en) A process for the preparation of a composition comprising at least one emulsifier and at least one edible fibre
AU1145200A (en) Process for hydrophobicizing particles, and their use in dispersions
EP1123695A3 (de) Orale Zusammensetzungen aus Kapseln, die Keratin enthalten
EP1006038A3 (de) Montageanordnung für eine Lenkeinrichtung
AU1205592A (en) Homogeneous, finely dispersed, pulverulent solid dispersions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2001/08794

Country of ref document: ZA

Ref document number: 200108794

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2001/01342/MU

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 515266

Country of ref document: NZ

ENP Entry into the national phase

Ref document number: 2369594

Country of ref document: CA

Ref document number: 2369594

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2000 616755

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/011343

Country of ref document: MX

Ref document number: 1020017014237

Country of ref document: KR

Ref document number: 2001/03188

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 2000931138

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 49179/00

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2000931138

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020017014237

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 09959732

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1020017014237

Country of ref document: KR