WO2003000842A3 - Nouvelles proteines et acides nucleiques codant pour de telles proteines - Google Patents
Nouvelles proteines et acides nucleiques codant pour de telles proteines Download PDFInfo
- Publication number
- WO2003000842A3 WO2003000842A3 PCT/US2002/017443 US0217443W WO03000842A3 WO 2003000842 A3 WO2003000842 A3 WO 2003000842A3 US 0217443 W US0217443 W US 0217443W WO 03000842 A3 WO03000842 A3 WO 03000842A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- small molecule
- molecule target
- nucleic acids
- acids encoding
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003507229A JP2005518185A (ja) | 2001-06-04 | 2002-06-04 | 新規タンパク質およびそれをコード化する核酸 |
| EP02765778A EP1578905A2 (fr) | 2001-06-04 | 2002-06-04 | Nouvelles proteines et acides nucleiques codant pour de telles proteines |
| CA002447941A CA2447941A1 (fr) | 2001-06-04 | 2002-06-04 | Nouvelles proteines et acides nucleiques codant pour de telles proteines |
Applications Claiming Priority (72)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29560701P | 2001-06-04 | 2001-06-04 | |
| US29566101P | 2001-06-04 | 2001-06-04 | |
| US60/295,607 | 2001-06-04 | ||
| US60/295,661 | 2001-06-04 | ||
| US29641801P | 2001-06-06 | 2001-06-06 | |
| US29640401P | 2001-06-06 | 2001-06-06 | |
| US60/296,418 | 2001-06-06 | ||
| US60/296,404 | 2001-06-06 | ||
| US29657501P | 2001-06-07 | 2001-06-07 | |
| US60/296,575 | 2001-06-07 | ||
| US29741401P | 2001-06-11 | 2001-06-11 | |
| US60/297,414 | 2001-06-11 | ||
| US29756701P | 2001-06-12 | 2001-06-12 | |
| US29757301P | 2001-06-12 | 2001-06-12 | |
| US60/297,567 | 2001-06-12 | ||
| US60/295,573 | 2001-06-12 | ||
| US29828501P | 2001-06-14 | 2001-06-14 | |
| US60/298,285 | 2001-06-14 | ||
| US29852801P | 2001-06-15 | 2001-06-15 | |
| US60/298,528 | 2001-06-15 | ||
| US29913301P | 2001-06-18 | 2001-06-18 | |
| US60/299,133 | 2001-06-18 | ||
| US29923001P | 2001-06-19 | 2001-06-19 | |
| US60/299,230 | 2001-06-19 | ||
| US29994901P | 2001-06-21 | 2001-06-21 | |
| US60/299,949 | 2001-06-21 | ||
| US30017701P | 2001-06-22 | 2001-06-22 | |
| US60/300,177 | 2001-06-22 | ||
| US30088301P | 2001-06-26 | 2001-06-26 | |
| US60/300,883 | 2001-06-26 | ||
| US30153001P | 2001-06-28 | 2001-06-28 | |
| US30155001P | 2001-06-28 | 2001-06-28 | |
| US60/301,550 | 2001-06-28 | ||
| US60/301,530 | 2001-06-28 | ||
| US30295101P | 2001-07-03 | 2001-07-03 | |
| US60/302,951 | 2001-07-03 | ||
| US30889001P | 2001-07-31 | 2001-07-31 | |
| US60/308,890 | 2001-07-31 | ||
| US32229701P | 2001-09-14 | 2001-09-14 | |
| US60/322,297 | 2001-09-14 | ||
| US32466901P | 2001-09-25 | 2001-09-25 | |
| US60/324,669 | 2001-09-25 | ||
| US33747701P | 2001-12-03 | 2001-12-03 | |
| US60/337,477 | 2001-12-03 | ||
| US34156201P | 2001-12-14 | 2001-12-14 | |
| US60/341,562 | 2001-12-14 | ||
| US35912202P | 2002-02-21 | 2002-02-21 | |
| US35865602P | 2002-02-21 | 2002-02-21 | |
| US60/359,122 | 2002-02-21 | ||
| US60/358,656 | 2002-02-21 | ||
| US35912102P | 2002-02-22 | 2002-02-22 | |
| US35897802P | 2002-02-22 | 2002-02-22 | |
| US35903502P | 2002-02-22 | 2002-02-22 | |
| US35903402P | 2002-02-22 | 2002-02-22 | |
| US60/359,035 | 2002-02-22 | ||
| US60/359,121 | 2002-02-22 | ||
| US60/358,978 | 2002-02-22 | ||
| US60/359,034 | 2002-02-22 | ||
| US35996402P | 2002-02-27 | 2002-02-27 | |
| US60/359,964 | 2002-02-27 | ||
| US36085802P | 2002-03-01 | 2002-03-01 | |
| US60/360,858 | 2002-03-01 | ||
| US36343002P | 2002-03-12 | 2002-03-12 | |
| US36367602P | 2002-03-12 | 2002-03-12 | |
| US60/363,676 | 2002-03-12 | ||
| US60/363,430 | 2002-03-12 | ||
| US37134602P | 2002-04-10 | 2002-04-10 | |
| US60/371,346 | 2002-04-10 | ||
| US37944402P | 2002-05-10 | 2002-05-10 | |
| US60/379,444 | 2002-05-10 | ||
| US16061902A | 2002-06-03 | 2002-06-03 | |
| US10/160,619 | 2002-06-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003000842A2 WO2003000842A2 (fr) | 2003-01-03 |
| WO2003000842A3 true WO2003000842A3 (fr) | 2005-11-03 |
Family
ID=34744079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2002/017443 Ceased WO2003000842A2 (fr) | 2001-06-04 | 2002-06-04 | Nouvelles proteines et acides nucleiques codant pour de telles proteines |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2005518185A (fr) |
| WO (1) | WO2003000842A2 (fr) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9056138B2 (en) | 2002-03-01 | 2015-06-16 | Bracco Suisse Sa | Multivalent constructs for therapeutic and diagnostic applications |
| US9295737B2 (en) | 2002-03-01 | 2016-03-29 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US9408926B2 (en) | 2002-03-01 | 2016-08-09 | Bracco Suisse S.A. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US9446155B2 (en) | 2002-03-01 | 2016-09-20 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7041494B2 (en) * | 2000-11-15 | 2006-05-09 | Icagen, Inc. | DNA encoding Slo2 and Slo4, potassium channel |
| US6815181B2 (en) * | 2001-07-09 | 2004-11-09 | Applera Corporation | Nucleic acid molecules encoding human secreted hemopexin-related proteins |
| ES2396368T3 (es) * | 2003-03-03 | 2013-02-21 | Dyax Corporation | Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos |
| EP2478912B1 (fr) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Conjugués d'auristatin avec des anticorps dirigés contre le HER2 ou le CD22 et leur usage thérapeutique |
| NZ579482A (en) | 2004-06-01 | 2011-02-25 | Genentech Inc | Antibody drug conjugates and methods |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| JP2006217859A (ja) * | 2005-02-10 | 2006-08-24 | Japan Health Science Foundation | アルツハイマー病の治療薬または予防薬のスクリーニング方法、およびアルツハイマー病を診断する方法、アルツハイマー病発症の危険度を予測する方法 |
| EP1849877A1 (fr) * | 2006-04-24 | 2007-10-31 | Erasmus University Medical Center Rotterdam | Histoire réplicative de sous-ensembles de lymphocytes T et B |
| DE102007017433A1 (de) * | 2007-04-03 | 2008-10-09 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | PIKfyve als pharmakologisches Target zur Behandlung von glucosestoffwechselassoziierten Krankheiten |
| JP2013504585A (ja) | 2009-09-09 | 2013-02-07 | セントローズ, エルエルシー | 細胞外標的化薬物複合体 |
| SI2528625T1 (sl) | 2010-04-15 | 2013-11-29 | Spirogen Sarl | Pirolobenzodiazepini in njihovi konjugati |
| CA2799540A1 (fr) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Anticorps et conjugues modifies par la cysteine |
| US20120121615A1 (en) | 2010-11-17 | 2012-05-17 | Flygare John A | Alaninyl maytansinol antibody conjugates |
| US9598733B2 (en) | 2011-02-17 | 2017-03-21 | The Trustees Of Columbia University In The City Of New York | Methods for identifying subjects with a genetic risk for developing IgA nephropathy |
| US8679767B2 (en) | 2011-05-12 | 2014-03-25 | Genentech, Inc. | Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides |
| JP5864918B2 (ja) * | 2011-07-06 | 2016-02-17 | 国立大学法人東北大学 | オートタキシンアイソフォーム特異的抗体および検出方法 |
| BR112014009050B1 (pt) | 2011-10-14 | 2022-06-21 | Medimmune Limited | Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas |
| WO2013130093A1 (fr) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarqueurs pour un traitement à base de composés chimiothérapeutiques anti-tubuline |
| ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
| RS57694B1 (sr) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Pirolobenzodiazepin - anti-psma konjugati antitela |
| EP2906296B1 (fr) | 2012-10-12 | 2018-03-21 | ADC Therapeutics SA | Conjugués anticorps - pyrrolobenzodiazépine |
| EP2906297B1 (fr) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Conjugués anticorps - pyrrolobenzodiazépine |
| MX338711B (es) | 2012-10-12 | 2016-04-28 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
| HRP20182129T1 (hr) | 2012-10-12 | 2019-02-08 | Adc Therapeutics Sa | Konjugati protutijelo - pirolobenzodiazepin |
| JP6392765B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa | ピロロベンゾジアゼピン−抗体結合体 |
| TWI680766B (zh) | 2013-03-13 | 2020-01-01 | 英商梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
| MX362970B (es) | 2013-03-13 | 2019-02-28 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
| AU2014229529B2 (en) | 2013-03-13 | 2018-02-15 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| US10202647B2 (en) | 2013-04-12 | 2019-02-12 | The Trustees Of Columbia University In The City Of New York | Mutations in DSTYK cause dominant urinary tract malformations |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2015052535A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépine |
| EP3054983B1 (fr) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Conjugués anticorps-pyrrolobenzodiazépines |
| WO2015052534A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépine |
| WO2015095227A2 (fr) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Composés peptidomimétiques et conjugués anticorps-médicament de ceux-ci |
| JP6671292B2 (ja) | 2013-12-16 | 2020-03-25 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
| EP3082876B1 (fr) | 2013-12-16 | 2018-01-17 | Genentech, Inc. | Composés conjugués anticorps-médicament dimérique à base de 1-(chlorométhyl)-2,3-dihydro-1 h-benzo [e]indole, et méthodes d'utilisation et de traitement |
| EP3193940A1 (fr) | 2014-09-10 | 2017-07-26 | Medimmune Limited | Pyrrolobenzodiazépines et leurs conjugués |
| SG11201701128YA (en) | 2014-09-12 | 2017-03-30 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| WO2016040825A1 (fr) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| CN107073136A (zh) | 2014-09-17 | 2017-08-18 | 健泰科生物技术公司 | 吡咯并苯并二氮杂卓及其抗体二硫化物偶联物 |
| SG11201703528YA (en) * | 2014-11-03 | 2017-05-30 | Univ Nanyang Tech | A recombinant expression system that senses pathogenic microorganisms |
| CN107148285B (zh) | 2014-11-25 | 2022-01-04 | Adc治疗股份有限公司 | 吡咯并苯并二氮杂䓬-抗体缀合物 |
| AU2015358532C1 (en) | 2014-12-03 | 2020-10-29 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| CR20180243A (es) | 2015-10-02 | 2018-07-31 | Genentech Inc | Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| EP3365025B1 (fr) | 2015-10-20 | 2020-07-15 | Genentech, Inc. | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN108700598A (zh) | 2016-03-25 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 多路总抗体和抗体缀合的药物量化测定法 |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| EP3465221B1 (fr) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Procédé bioanalytique pour la caractérisation de conjugués anticorps-médicament spécifiques d'un site |
| WO2017214024A1 (fr) | 2016-06-06 | 2017-12-14 | Genentech, Inc. | Médicaments conjugués d'anticorps silvestrol et procédés d'utilisation |
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| JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
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| CN110582505B (zh) | 2017-04-18 | 2021-04-02 | 免疫医疗有限公司 | 吡咯并苯并二氮杂*缀合物 |
| WO2018193102A1 (fr) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Polythérapie avec un conjugué anticorps anti-axl-médicament |
| CA3064804A1 (fr) | 2017-06-14 | 2018-12-20 | Adc Therapeutics Sa | Regimes posologiques pour l'administration d'un cam anti-cd19 |
| KR102270107B1 (ko) | 2017-08-18 | 2021-06-30 | 메디뮨 리미티드 | 피롤로벤조디아제핀 컨쥬게이트 |
| EP3684773B1 (fr) | 2017-09-20 | 2026-04-29 | pH Pharma Co., Ltd. | Analogues de thailanstatine |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| JP7708662B2 (ja) | 2018-10-24 | 2025-07-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | コンジュゲート化された化学的分解誘導物質および使用方法 |
| JP2022513198A (ja) | 2018-12-10 | 2022-02-07 | ジェネンテック, インコーポレイテッド | Fc含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| CN113631560B (zh) | 2019-03-15 | 2025-02-18 | 麦迪穆有限责任公司 | 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物 |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| EP4426727A2 (fr) | 2021-11-03 | 2024-09-11 | Hangzhou Dac Biotech Co., Ltd. | Conjugaison spécifique d'un anticorps |
| WO2024138128A2 (fr) | 2022-12-23 | 2024-06-27 | Genentech, Inc. | Conjugués d'agent de dégradation de céréblon et leurs utilisations |
| KR20260012304A (ko) | 2023-04-17 | 2026-01-26 | 피크 바이오, 인크. | 항체 및 항체-약물 접합체 및 사용 방법 및 합성 공정 및 중간체 |
| WO2026006689A2 (fr) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Conjugués anticorps-dégradeur de bcl-xl et leurs utilisations |
| WO2026006688A2 (fr) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Conjugués d'anticorps de dégradation et leurs utilisations |
-
2002
- 2002-06-04 JP JP2003507229A patent/JP2005518185A/ja active Pending
- 2002-06-04 WO PCT/US2002/017443 patent/WO2003000842A2/fr not_active Ceased
Non-Patent Citations (2)
| Title |
|---|
| BIOCHEM. BIOPHYS. ACTA 1519, vol. 1-2, 2001, pages 117 - 121 * |
| DATABASE GENBANK [online] VIGETTI D. ET AL: "Molecular cloning of mouse allantoicase cDNA", XP002991050, Database accession no. (AF278712) * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9056138B2 (en) | 2002-03-01 | 2015-06-16 | Bracco Suisse Sa | Multivalent constructs for therapeutic and diagnostic applications |
| US9295737B2 (en) | 2002-03-01 | 2016-03-29 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US9381258B2 (en) | 2002-03-01 | 2016-07-05 | Bracco Suisse S.A. | Targeting vector-phospholipid conjugates |
| US9408926B2 (en) | 2002-03-01 | 2016-08-09 | Bracco Suisse S.A. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US9446155B2 (en) | 2002-03-01 | 2016-09-20 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005518185A (ja) | 2005-06-23 |
| WO2003000842A2 (fr) | 2003-01-03 |
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