WO2003016544A1 - Procede d'elaboration d'acide 1,4-dihydroxy-2-naphtoique - Google Patents

Procede d'elaboration d'acide 1,4-dihydroxy-2-naphtoique Download PDF

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Publication number
WO2003016544A1
WO2003016544A1 PCT/JP2002/008010 JP0208010W WO03016544A1 WO 2003016544 A1 WO2003016544 A1 WO 2003016544A1 JP 0208010 W JP0208010 W JP 0208010W WO 03016544 A1 WO03016544 A1 WO 03016544A1
Authority
WO
WIPO (PCT)
Prior art keywords
dihydroxy
naphthoic acid
producing
composition
unpleasantness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008010
Other languages
English (en)
French (fr)
Inventor
Yoshiro Sato
Seiya Makino
Nobuo Yoda
Kakuhei Isawa
Tomonori Kamiyama
Kenichi Hojyo
Mizue Saito
Naoki Taketomo
Keisuke Furuichi
Shuji Ikegami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Dairies Corp
Original Assignee
Meiji Dairies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2003521851A priority Critical patent/JP4070721B2/ja
Priority to EP02755845A priority patent/EP1416052B8/en
Priority to US10/486,421 priority patent/US7374915B2/en
Priority to KR1020047001743A priority patent/KR100899615B1/ko
Priority to CA2457055A priority patent/CA2457055C/en
Priority to NZ531192A priority patent/NZ531192A/en
Application filed by Meiji Dairies Corp filed Critical Meiji Dairies Corp
Priority to AU2002323899A priority patent/AU2002323899B2/en
Publication of WO2003016544A1 publication Critical patent/WO2003016544A1/ja
Anticipated expiration legal-status Critical
Priority to US12/100,075 priority patent/US7629155B2/en
Priority to US12/543,814 priority patent/US7834061B2/en
Priority to US12/877,471 priority patent/US8110607B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PCT/JP2002/008010 2001-08-10 2002-08-06 Procede d'elaboration d'acide 1,4-dihydroxy-2-naphtoique Ceased WO2003016544A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2002323899A AU2002323899B2 (en) 2001-08-10 2002-08-06 Process for producing 1,4-dihydroxy -2-naphthoic acid
EP02755845A EP1416052B8 (en) 2001-08-10 2002-08-06 Process for producing 1,4-dihydroxy-2-naphthoic acid
US10/486,421 US7374915B2 (en) 2001-08-10 2002-08-06 Process for producing 1,4-dihydroxy-2-naphthoic acid
KR1020047001743A KR100899615B1 (ko) 2001-08-10 2002-08-06 1,4-디히드록시-2-나프토산의 제조방법
CA2457055A CA2457055C (en) 2001-08-10 2002-08-06 Process for producing 1,4-dihydroxy-2-naphthoic acid
JP2003521851A JP4070721B2 (ja) 2001-08-10 2002-08-06 １，４−ジヒドロキシ−２−ナフトエ酸の製造法
NZ531192A NZ531192A (en) 2001-08-10 2002-08-06 Process for producing 1,4-dihydroxy-2-naphthoic acid and compositions made therefrom for regulating intestinal function
US12/100,075 US7629155B2 (en) 2001-08-10 2008-04-09 Process for producing 1,4-dihydroxy-2-naphthoic acid
US12/543,814 US7834061B2 (en) 2001-08-10 2009-08-19 Process for producing 1,4-dihydroxy-2-naphthoic acid
US12/877,471 US8110607B2 (en) 2001-08-10 2010-09-08 Process for producing 1,4-dihydroxy-2-naphthoic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-244475 2001-08-10
JP2001244475 2001-08-10

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10486421 A-371-Of-International 2002-08-06
US12/100,075 Division US7629155B2 (en) 2001-08-10 2008-04-09 Process for producing 1,4-dihydroxy-2-naphthoic acid

Publications (1)

Publication Number Publication Date
WO2003016544A1 true WO2003016544A1 (fr) 2003-02-27

Family

ID=19074394

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008010 Ceased WO2003016544A1 (fr) 2001-08-10 2002-08-06 Procede d'elaboration d'acide 1,4-dihydroxy-2-naphtoique

Country Status (9)

Country Link
US (4) US7374915B2 (ja)
EP (1) EP1416052B8 (ja)
JP (1) JP4070721B2 (ja)
KR (1) KR100899615B1 (ja)
CN (2) CN1312285C (ja)
AU (1) AU2002323899B2 (ja)
CA (1) CA2457055C (ja)
NZ (1) NZ531192A (ja)
WO (1) WO2003016544A1 (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085364A1 (ja) * 2003-03-26 2004-10-07 Meiji Dairies Corporation １,４−ジヒドロキシ−２−ナフトエ酸の安定化方法
WO2005033323A1 (ja) * 2003-10-01 2005-04-14 Meiji Dairies Corporation １，４−ジヒドロキシ−２−ナフトエ酸の製造法
WO2005072718A1 (ja) * 2004-01-28 2005-08-11 Kurume University 乳清発酵物を含有する医薬組成物
JP2005225794A (ja) * 2004-02-12 2005-08-25 Meiji Milk Prod Co Ltd １，４−ジヒドロキシ−２−ナフトエ酸の安定化剤
WO2005099725A1 (ja) * 2004-04-13 2005-10-27 Meiji Dairies Corporation 炎症性腸疾患予防および／または治療剤
WO2006098447A1 (ja) * 2005-03-18 2006-09-21 Meiji Feed. Co., Ltd. ビフィズス菌増殖促進成分を含有する飼料組成物及びその使用方法
WO2008088008A1 (ja) 2007-01-17 2008-07-24 Meiji Dairies Corporation 消化管機能異常症予防及び／又は治療剤
WO2009107380A1 (ja) 2008-02-29 2009-09-03 明治乳業株式会社 抗アレルギー剤
WO2014163031A1 (ja) * 2013-04-01 2014-10-09 株式会社明治 即効性の整腸剤
JP2016020339A (ja) * 2014-06-16 2016-02-04 学校法人産業医科大学 １，４−ジヒドロキシ−２−ナフトエ酸誘導体
JP2016164144A (ja) * 2010-05-21 2016-09-08 株式会社明治 皮膚状態の改善用組成物
KR20170022343A (ko) 2015-08-20 2017-03-02 김태웅 유산균 발효액, 플로랄 워터 및 생약 추출물을 기반으로 하는 피부 알레르기의 예방, 개선제
JP2022054403A (ja) * 2020-09-25 2022-04-06 ライオン株式会社 腸内環境改善剤

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002323899B2 (en) 2001-08-10 2007-06-28 Meiji Dairies Corporation Process for producing 1,4-dihydroxy -2-naphthoic acid
US7241809B2 (en) * 2003-12-22 2007-07-10 Meiji Dairies Corporation Method for treating inflammatory bowel diseases
CN102008460B (zh) * 2005-08-26 2012-09-19 株式会社明治 抗过敏剂
KR20170059011A (ko) * 2007-11-27 2017-05-29 가부시키가이샤 메이지 유산균의 생잔성 향상제 및 생잔성 향상 방법, 및 식품 조성물
EP2300024B1 (en) * 2008-05-26 2013-09-04 Compagnie Gervais Danone Method for decreasing borborygmi by administering a bifidobacterium bacteria.
FR2960001A1 (fr) 2010-05-12 2011-11-18 Univ Rennes Vecteur recombinant pour la production et la secretion de sequences d'acides amines d'interet par les bacteries propioniques et ses applications
KR101342791B1 (ko) 2012-08-16 2013-12-19 주식회사 제이케이뉴트라 1,4-디히드록시-2-나프토산 생산능을 가지는 락토바실러스 카제이 ｌｐ1 균주 및 이의 이용
US11179427B2 (en) 2013-01-21 2021-11-23 Eth Zurich Baby food composition comprising viable propionic acid-producing bacteria
EP2829274A1 (en) 2013-07-25 2015-01-28 Institut National De La Recherche Agronomique Vectors for producing and secreting substance of interest by bacteria and applications thereof
WO2016183535A1 (en) 2015-05-14 2016-11-17 University Of Puerto Rico Methods for restoring microbiota of newborns
US11564667B2 (en) 2015-12-28 2023-01-31 New York University Device and method of restoring microbiota of newborns
KR102127108B1 (ko) * 2018-06-26 2020-06-26 고려대학교산학협력단 프로피오니바크테리움 후레우덴레이키, 이의 배양액 또는 이의 사균체를 유효성분으로 함유하는 골질환의 예방 또는 치료용 조성물

Citations (8)

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Publication number Priority date Publication date Assignee Title
JPH0898677A (ja) * 1994-04-26 1996-04-16 Meiji Milk Prod Co Ltd ビフィズス菌増殖促進組成物
JPH0975095A (ja) * 1995-09-14 1997-03-25 Unitika Ltd ２，４−ジヒドロキシ−３−ナフトエ酸の製造方法
JPH1014589A (ja) * 1996-07-08 1998-01-20 Unitika Ltd キャンディダ・リポリティカｈｎａ−１１０株及び２，６−ジヒドロキシ−３−ナフトエ酸の製造方法
JPH11228424A (ja) * 1998-02-06 1999-08-24 Kyodo Milk Ind Co Ltd ビフィズス菌活性化物質とビフィズス菌活性増殖剤とそれを含有する食品
JP2000086525A (ja) * 1998-09-16 2000-03-28 Morishita Jintan Kk カプセル配合打錠剤
JP2000256201A (ja) * 1999-03-02 2000-09-19 Meiji Milk Prod Co Ltd ビフィズス菌によるオリゴ糖利用能改善剤
WO2001028547A1 (en) * 1999-10-19 2001-04-26 Meiji Milk Products Co., Ltd Food materials useful in preventing and ameliorating metabolic bone diseases and preventives/remedies for metabolic bone diseases comprising these materials
JP2001169749A (ja) * 1999-12-21 2001-06-26 Nitto Yakuhin Kogyo Kk 生菌組成物

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JPS5935910B2 (ja) 1981-02-02 1984-08-31 株式会社日本触媒 １，４−ジヒドロオキシ−２−ナフトエ酸の製造方法
JPS59186942A (ja) 1983-04-07 1984-10-23 Kawasaki Kasei Chem Ltd 粗製１，４−ジヒドロキシ−２−ナフトエ酸又はその塩の精製法
JPS60104037A (ja) 1983-11-10 1985-06-08 Kawasaki Kasei Chem Ltd １，４−ジヒドロキシ−２−ナフトエ酸の製造方法
AU2002323899B2 (en) 2001-08-10 2007-06-28 Meiji Dairies Corporation Process for producing 1,4-dihydroxy -2-naphthoic acid

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JPH0898677A (ja) * 1994-04-26 1996-04-16 Meiji Milk Prod Co Ltd ビフィズス菌増殖促進組成物
JPH0975095A (ja) * 1995-09-14 1997-03-25 Unitika Ltd ２，４−ジヒドロキシ−３−ナフトエ酸の製造方法
JPH1014589A (ja) * 1996-07-08 1998-01-20 Unitika Ltd キャンディダ・リポリティカｈｎａ−１１０株及び２，６−ジヒドロキシ−３−ナフトエ酸の製造方法
JPH11228424A (ja) * 1998-02-06 1999-08-24 Kyodo Milk Ind Co Ltd ビフィズス菌活性化物質とビフィズス菌活性増殖剤とそれを含有する食品
JP2000086525A (ja) * 1998-09-16 2000-03-28 Morishita Jintan Kk カプセル配合打錠剤
JP2000256201A (ja) * 1999-03-02 2000-09-19 Meiji Milk Prod Co Ltd ビフィズス菌によるオリゴ糖利用能改善剤
WO2001028547A1 (en) * 1999-10-19 2001-04-26 Meiji Milk Products Co., Ltd Food materials useful in preventing and ameliorating metabolic bone diseases and preventives/remedies for metabolic bone diseases comprising these materials
JP2001169749A (ja) * 1999-12-21 2001-06-26 Nitto Yakuhin Kogyo Kk 生菌組成物

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MEGANATHAN R. ET AL.: "Menaquinone (vitamin K2) bio-synthesis: conversion of omicron-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by mycobacterium phylei enzymes", J. BACTERIOL., vol. 140, no. 1, October 1979 (1979-10-01), pages 92 - 98, XP002957395 *

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8277860B2 (en) 2003-03-26 2012-10-02 Meiji Co., Ltd. Method of stabilizing 1,4-dihydroxy-2-naphthoic acid
WO2004085364A1 (ja) * 2003-03-26 2004-10-07 Meiji Dairies Corporation １,４−ジヒドロキシ−２−ナフトエ酸の安定化方法
KR101003344B1 (ko) * 2003-03-26 2010-12-23 메이지 데어리스 코포레이션 1,4-디히드록시-2-나프토산의 안정화 방법
JP4579158B2 (ja) * 2003-03-26 2010-11-10 明治乳業株式会社 １，４−ジヒドロキシ−２−ナフトエ酸の安定化方法
JP2010233577A (ja) * 2003-03-26 2010-10-21 Meiji Milk Prod Co Ltd １，４−ジヒドロキシ−２−ナフトエ酸（ｄｈｎａ）を含有する飲食品の製造方法
JPWO2004085364A1 (ja) * 2003-03-26 2006-06-29 明治乳業株式会社 １，４−ジヒドロキシ−２−ナフトエ酸の安定化方法
JPWO2005033323A1 (ja) * 2003-10-01 2007-11-15 明治乳業株式会社 １，４−ジヒドロキシ−２−ナフトエ酸の製造法
EP2463376A3 (en) * 2003-10-01 2013-01-30 Meiji Co, Ltd. Food and beverages for treating metabolic osteopathy
KR101116244B1 (ko) * 2003-10-01 2012-03-09 가부시키가이샤 메이지 1,4-디히드록시-2-나프토산의 제조법
EP2463375A3 (en) * 2003-10-01 2013-01-30 Meiji Co., Ltd. Food and beverages for treating abdominal discomfort
EP2463375A2 (en) 2003-10-01 2012-06-13 Meiji Co., Ltd. Food and beverages for treating abdominal discomfort
CN100422337C (zh) * 2003-10-01 2008-10-01 明治乳业株式会社 1,4-二羟基-2-萘甲酸的制造方法
US7507563B2 (en) 2003-10-01 2009-03-24 Meiji Dairies Corporation Process for producing 1, 4-dihydroxy-2-naphthoic acid
EP2463376A2 (en) 2003-10-01 2012-06-13 Meiji Co, Ltd. Food and beverages for treating metabolic osteopathy
US8758842B2 (en) 2003-10-01 2014-06-24 Meiji Co., Ltd. Process for producing 1,4-dihydroxy-2-naphthoic acid
JP4613132B2 (ja) * 2003-10-01 2011-01-12 明治乳業株式会社 １，４−ジヒドロキシ−２−ナフトエ酸の製造法
WO2005033323A1 (ja) * 2003-10-01 2005-04-14 Meiji Dairies Corporation １，４−ジヒドロキシ−２−ナフトエ酸の製造法
WO2005072718A1 (ja) * 2004-01-28 2005-08-11 Kurume University 乳清発酵物を含有する医薬組成物
JP2005225794A (ja) * 2004-02-12 2005-08-25 Meiji Milk Prod Co Ltd １，４−ジヒドロキシ−２−ナフトエ酸の安定化剤
US8025911B2 (en) 2004-04-13 2011-09-27 Meiji Dairies Corporation Preventive and/or remedy for inflammatory bowel diseases
WO2005099725A1 (ja) * 2004-04-13 2005-10-27 Meiji Dairies Corporation 炎症性腸疾患予防および／または治療剤
US8241684B2 (en) 2004-04-13 2012-08-14 Meiji Co., Ltd. Preventive and/or therapeutic agent for inflammatory bowel diseases
JPWO2005099725A1 (ja) * 2004-04-13 2008-03-06 明治乳業株式会社 炎症性腸疾患予防および／または治療剤
WO2006098447A1 (ja) * 2005-03-18 2006-09-21 Meiji Feed. Co., Ltd. ビフィズス菌増殖促進成分を含有する飼料組成物及びその使用方法
JP2006254841A (ja) * 2005-03-18 2006-09-28 Meiji Shiryo Kk ビフィズス菌増殖促進成分を含有する飼料組成物とその使用方法
US9675647B2 (en) 2007-01-17 2017-06-13 Meiji Co., Ltd. Prophylactic and/or therapeutic agent for functional gastrointestinal disorders
WO2008088008A1 (ja) 2007-01-17 2008-07-24 Meiji Dairies Corporation 消化管機能異常症予防及び／又は治療剤
WO2009107380A1 (ja) 2008-02-29 2009-09-03 明治乳業株式会社 抗アレルギー剤
JP2016164144A (ja) * 2010-05-21 2016-09-08 株式会社明治 皮膚状態の改善用組成物
WO2014163031A1 (ja) * 2013-04-01 2014-10-09 株式会社明治 即効性の整腸剤
JPWO2014163031A1 (ja) * 2013-04-01 2017-02-16 株式会社明治 即効性の整腸剤
JP2016020339A (ja) * 2014-06-16 2016-02-04 学校法人産業医科大学 １，４−ジヒドロキシ−２−ナフトエ酸誘導体
JP2020010703A (ja) * 2014-06-16 2020-01-23 学校法人産業医科大学 １，４−ジヒドロキシ−２−ナフトエ酸誘導体
KR20170022343A (ko) 2015-08-20 2017-03-02 김태웅 유산균 발효액, 플로랄 워터 및 생약 추출물을 기반으로 하는 피부 알레르기의 예방, 개선제
JP2022054403A (ja) * 2020-09-25 2022-04-06 ライオン株式会社 腸内環境改善剤
JP7720734B2 (ja) 2020-09-25 2025-08-08 ライオン株式会社 腸内環境改善剤

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AU2002323899B2 (en) 2007-06-28
KR100899615B1 (ko) 2009-05-27
CN1820741A (zh) 2006-08-23
KR20040032886A (ko) 2004-04-17
CA2457055A1 (en) 2003-02-27
US7629155B2 (en) 2009-12-08
US20040241815A1 (en) 2004-12-02
US20110009491A1 (en) 2011-01-13
EP1416052B8 (en) 2013-01-09
EP1416052B1 (en) 2012-09-12
AU2002323899B9 (en) 2003-03-03
US20080194688A1 (en) 2008-08-14
EP1416052A1 (en) 2004-05-06
NZ531192A (en) 2005-07-29
CN1539019A (zh) 2004-10-20
JP4070721B2 (ja) 2008-04-02
JPWO2003016544A1 (ja) 2004-12-02
US8110607B2 (en) 2012-02-07
US7374915B2 (en) 2008-05-20
CA2457055C (en) 2013-10-08
US7834061B2 (en) 2010-11-16
EP1416052A4 (en) 2005-10-12
CN1312285C (zh) 2007-04-25

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