WO2003017975A3 - Verfahren zur herstellung von lösungen - Google Patents

Verfahren zur herstellung von lösungen Download PDF

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Publication number
WO2003017975A3
WO2003017975A3 PCT/EP2002/009776 EP0209776W WO03017975A3 WO 2003017975 A3 WO2003017975 A3 WO 2003017975A3 EP 0209776 W EP0209776 W EP 0209776W WO 03017975 A3 WO03017975 A3 WO 03017975A3
Authority
WO
WIPO (PCT)
Prior art keywords
water
producing solutions
producing
solution
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/009776
Other languages
English (en)
French (fr)
Other versions
WO2003017975A2 (de
Inventor
Ralph E Eckert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular and Clinical Drug Research
Original Assignee
Molecular and Clinical Drug Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular and Clinical Drug Research filed Critical Molecular and Clinical Drug Research
Priority to AU2002340848A priority Critical patent/AU2002340848A1/en
Publication of WO2003017975A2 publication Critical patent/WO2003017975A2/de
Publication of WO2003017975A3 publication Critical patent/WO2003017975A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Verfahren zur Herstellung wässriger Lösungen wasserunlöslicher Substanzen durch Lösung mindestens einer Reinsubstanz in mindestens einem mit Wasser lösbarem Lösungsvermittler und wässriger Verdünnung der so hergestellten Lösung durch Zugabe von Wasser und/oder einer wässrigen Pufferlösung.
PCT/EP2002/009776 2001-08-31 2002-09-02 Verfahren zur herstellung von lösungen Ceased WO2003017975A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002340848A AU2002340848A1 (en) 2001-08-31 2002-09-02 Method for producing solutions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142416.7 2001-08-31
DE2001142416 DE10142416A1 (de) 2001-08-31 2001-08-31 Verfahren zur Herstellung von Lösungen

Publications (2)

Publication Number Publication Date
WO2003017975A2 WO2003017975A2 (de) 2003-03-06
WO2003017975A3 true WO2003017975A3 (de) 2003-12-24

Family

ID=7697053

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009776 Ceased WO2003017975A2 (de) 2001-08-31 2002-09-02 Verfahren zur herstellung von lösungen

Country Status (3)

Country Link
AU (1) AU2002340848A1 (de)
DE (1) DE10142416A1 (de)
WO (1) WO2003017975A2 (de)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117888A1 (de) * 1983-03-03 1984-09-12 Bayer Ag Flüssigzubereitungen von Dihydropyridinen, ein Verfahren zu ihrer Herstellung, sowie ihre Verwendung bei der Bekämpfung von Erkrankungen
EP0278168A1 (de) * 1986-12-12 1988-08-17 Harris Pharmaceuticals Ltd Nifedipinkapseln
EP0315960A1 (de) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Nifedipin enthaltende Kapsel zur sofortigen oralen Freisetzung
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
KR960004019B1 (ko) * 1992-12-10 1996-03-25 보령제약주식회사 니모디핀의 가용화 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58131982A (ja) * 1982-02-01 1983-08-06 Tokyo Tanabe Co Ltd 新規なる１．４−ジヒドロピリジン誘導体
DE3316510A1 (de) * 1983-05-06 1984-11-08 Bayer Ag Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
DE3702105A1 (de) * 1987-01-24 1988-08-04 Bayer Ag Parenterale loesung
DE19757224A1 (de) * 1997-12-22 1999-07-01 Bayer Ag Verfahren und Vorrichtung zur in-situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117888A1 (de) * 1983-03-03 1984-09-12 Bayer Ag Flüssigzubereitungen von Dihydropyridinen, ein Verfahren zu ihrer Herstellung, sowie ihre Verwendung bei der Bekämpfung von Erkrankungen
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
EP0278168A1 (de) * 1986-12-12 1988-08-17 Harris Pharmaceuticals Ltd Nifedipinkapseln
EP0315960A1 (de) * 1987-11-11 1989-05-17 Euro-Celtique S.A. Nifedipin enthaltende Kapsel zur sofortigen oralen Freisetzung
KR960004019B1 (ko) * 1992-12-10 1996-03-25 보령제약주식회사 니모디핀의 가용화 방법

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN, G. ET AL.: "Preparation of nimodipine injection of higher concentration", ZHONGGUO YIYAO GONGYE ZAZHI, vol. 28, no. 6, 1997, China, pages 254 - 256 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002239288, Database accession no. 1997:683820 *
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; XP002239287 *

Also Published As

Publication number Publication date
DE10142416A1 (de) 2003-03-20
WO2003017975A2 (de) 2003-03-06
AU2002340848A1 (en) 2003-03-10

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