WO2003020217A3 - Nouveaux analogues de pyrazole agissant sur les recepteurs cannabinoides - Google Patents

Nouveaux analogues de pyrazole agissant sur les recepteurs cannabinoides Download PDF

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Publication number
WO2003020217A3
WO2003020217A3 PCT/US2002/027644 US0227644W WO03020217A3 WO 2003020217 A3 WO2003020217 A3 WO 2003020217A3 US 0227644 W US0227644 W US 0227644W WO 03020217 A3 WO03020217 A3 WO 03020217A3
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WIPO (PCT)
Prior art keywords
pyrazole analogs
cannabinoid receptors
analogs
concerned
novel pyrazole
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Ceased
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PCT/US2002/027644
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WO2003020217A2 (fr
Inventor
Alexandros Makriyannis
Qian Liu
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University of Connecticut
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University of Connecticut
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Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Priority to JP2003524531A priority Critical patent/JP2005507875A/ja
Priority to CA002457922A priority patent/CA2457922A1/fr
Priority to EP02768751A priority patent/EP1421077A4/fr
Priority to AU2002331766A priority patent/AU2002331766A1/en
Publication of WO2003020217A2 publication Critical patent/WO2003020217A2/fr
Publication of WO2003020217A3 publication Critical patent/WO2003020217A3/fr
Anticipated expiration legal-status Critical
Priority to US10/790,498 priority patent/US7393842B2/en
Priority to US11/166,835 priority patent/US8084467B2/en
Priority to US11/244,770 priority patent/US7745440B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des analogues de pyrazole cannabimimétiques. L'invention concerne également de nouveaux analogues de pyrazole améliorés présentant de hautes affinités et/ou sélectivités pour le récepteur cannabinoïde GB1. L'invention concerne en outre des préparations pharmaceutiques dans lesquelles sont utilisées les analogues de l'invention, ainsi que des méthodes d'administration de quantités efficaces d'un point de vue thérapeutique des analogues de l'invention afin d'obtenir un effet physiologique.
PCT/US2002/027644 1999-10-18 2002-08-29 Nouveaux analogues de pyrazole agissant sur les recepteurs cannabinoides Ceased WO2003020217A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2003524531A JP2005507875A (ja) 2001-08-31 2002-08-29 カンナビノイド受容体に作用する新規なピラゾール類似体
CA002457922A CA2457922A1 (fr) 2001-08-31 2002-08-29 Nouveaux analogues de pyrazole agissant sur les recepteurs cannabinoides
EP02768751A EP1421077A4 (fr) 2001-08-31 2002-08-29 Nouveaux analogues de pyrazole agissant sur les recepteurs cannabinoides
AU2002331766A AU2002331766A1 (en) 2001-08-31 2002-08-29 Novel pyrazole analogs acting on cannabinoid receptors
US10/790,498 US7393842B2 (en) 2001-08-31 2004-03-01 Pyrazole analogs acting on cannabinoid receptors
US11/166,835 US8084467B2 (en) 1999-10-18 2005-06-24 Pyrazole derivatives as cannabinoid receptor antagonists
US11/244,770 US7745440B2 (en) 1999-10-18 2005-10-06 Pyrazole analogs acting on cannabinoid receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31651501P 2001-08-31 2001-08-31
US60/316,515 2001-08-31

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US10110865 Continuation 2000-10-18
PCT/US2000/041239 Continuation WO2001029007A1 (fr) 1999-10-18 2000-10-18 Derives de pyrazole comme antagonistes des recepteurs des cannabinoides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/790,498 Continuation-In-Part US7393842B2 (en) 1999-10-18 2004-03-01 Pyrazole analogs acting on cannabinoid receptors

Publications (2)

Publication Number Publication Date
WO2003020217A2 WO2003020217A2 (fr) 2003-03-13
WO2003020217A3 true WO2003020217A3 (fr) 2003-08-21

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PCT/US2002/027644 Ceased WO2003020217A2 (fr) 1999-10-18 2002-08-29 Nouveaux analogues de pyrazole agissant sur les recepteurs cannabinoides

Country Status (5)

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EP (1) EP1421077A4 (fr)
JP (1) JP2005507875A (fr)
AU (1) AU2002331766A1 (fr)
CA (1) CA2457922A1 (fr)
WO (1) WO2003020217A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7173027B2 (en) 2001-01-29 2007-02-06 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
US7241799B2 (en) 1999-10-18 2007-07-10 University Of Connecticut Cannabimimetic indole derivatives
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7285683B2 (en) 2001-07-13 2007-10-23 University Of Connecticut Bicyclic and tricyclic cannabinoids
US7329651B2 (en) 2001-01-26 2008-02-12 University Of Connecticut Cannabimimetic ligands
US7550489B2 (en) 2002-03-12 2009-06-23 Merck & Co., Inc. Substituted pyridyoxy amides
US7589220B2 (en) 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter

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CA2387764A1 (fr) 1999-10-18 2001-04-26 University Of Connecticut Ligands selectifs de recepteurs (cb2) de cannabinoides peripheriques
AU2003265663A1 (en) 2002-08-23 2004-03-11 University Of Connecticut Keto cannabinoids with therapeutic indications
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
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JP2008526887A (ja) * 2005-01-10 2008-07-24 ユニバーシティ オブ コネチカット カンナビノイド受容体に作用する新規なヘテロピロール類似体
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US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
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EP1951678A1 (fr) 2005-10-21 2008-08-06 Mitsubishi Tanabe Pharma Corporation Composes pyrazole presentant une activite antagoniste du recepteur cannabinoide (cb1)
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JP2008019205A (ja) * 2006-07-12 2008-01-31 Sanofi-Aventis Ｎ−［（１，５−ジフェニル−１ｈ−ピラゾール−３−イル）メチル］スルホンアミド誘導体、その調製法および治療におけるその応用
CA2673177A1 (fr) 2006-12-18 2008-06-26 7Tm Pharma A/S Modulateurs de recepteurs cb1
PE20081849A1 (es) 2007-01-04 2009-01-26 Prosidion Ltd Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr
US20100048625A1 (en) 2007-01-04 2010-02-25 Matthew Colin Thor Fyfe Piperidine gpcr agonists
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JP2005507875A (ja) 2005-03-24
EP1421077A4 (fr) 2004-11-17
AU2002331766A1 (en) 2003-03-18
WO2003020217A2 (fr) 2003-03-13
CA2457922A1 (fr) 2003-03-13
EP1421077A2 (fr) 2004-05-26

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