WO2003104763A3 - Dispositif et procede de comparaison relative ou quantitative d'echantillons multiples - Google Patents

Dispositif et procede de comparaison relative ou quantitative d'echantillons multiples Download PDF

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Publication number
WO2003104763A3
WO2003104763A3 PCT/US2003/017034 US0317034W WO03104763A3 WO 2003104763 A3 WO2003104763 A3 WO 2003104763A3 US 0317034 W US0317034 W US 0317034W WO 03104763 A3 WO03104763 A3 WO 03104763A3
Authority
WO
WIPO (PCT)
Prior art keywords
multiple samples
relative
quantitative comparison
ionization
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/017034
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English (en)
Other versions
WO2003104763A2 (fr
Inventor
David E Clemmer
Amy E Hilderbrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Priority to AU2003247442A priority Critical patent/AU2003247442A1/en
Publication of WO2003104763A2 publication Critical patent/WO2003104763A2/fr
Publication of WO2003104763A3 publication Critical patent/WO2003104763A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/107—Arrangements for using several ion sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Cette invention concerne un dispositif et un procédé permettant d'effectuer une analyse relative ou quantitative d'échantillons multiples. La démarche peut consister en une post-ionisation et une combinaison en phase gazeuse d'un ou de plusieurs des échantillons multiples avec un ou plusieurs réactifs.
PCT/US2003/017034 2002-06-05 2003-05-30 Dispositif et procede de comparaison relative ou quantitative d'echantillons multiples Ceased WO2003104763A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003247442A AU2003247442A1 (en) 2002-06-05 2003-05-30 Apparatus and method for relative or quantitative comparison of multiple samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38662102P 2002-06-05 2002-06-05
US60/386,621 2002-06-05

Publications (2)

Publication Number Publication Date
WO2003104763A2 WO2003104763A2 (fr) 2003-12-18
WO2003104763A3 true WO2003104763A3 (fr) 2004-03-04

Family

ID=29736187

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017034 Ceased WO2003104763A2 (fr) 2002-06-05 2003-05-30 Dispositif et procede de comparaison relative ou quantitative d'echantillons multiples

Country Status (2)

Country Link
AU (1) AU2003247442A1 (fr)
WO (1) WO2003104763A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4782796B2 (ja) * 2004-11-09 2011-09-28 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 質量分析計用イオン源
US7385190B2 (en) 2005-11-16 2008-06-10 Agilent Technologies, Inc. Reference mass introduction via a capillary
US20080087815A1 (en) * 2006-10-13 2008-04-17 Agilent Technologies, Inc. Time division multiplexing MS with beam converging capillary
GB0704547D0 (en) 2007-03-09 2007-04-18 Smiths Detection Watford Ltd Ion mobility spectrometers
JP5579706B2 (ja) * 2008-05-30 2014-08-27 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 差動移動度分光計用のカーテンガスに調整剤を提供するための方法およびシステム
DE102009037716B4 (de) * 2009-08-17 2013-01-31 Bruker Daltonik Gmbh Atmosphärendruck-Ionenquelle hoher Ausbeute für Vakuum-Ionenspektrometer
GB201118889D0 (en) * 2011-11-02 2011-12-14 Micromass Ltd Multi inlet for solvent assisted inlet ionisation
CN107359104B (zh) * 2017-06-14 2018-07-20 中国科学院地质与地球物理研究所 一种磁质谱分析器与双离子源的联接转换装置
EP4080545A1 (fr) * 2021-04-20 2022-10-26 Tofwerk AG Procédé et appareil d'analyse de masse d'un échantillon

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504326A (en) * 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
WO1999019899A1 (fr) * 1997-10-15 1999-04-22 Analytica Of Branford, Inc. Dispositif d'introduction courbe pour spectrometrie de masse
WO2000052735A1 (fr) * 1999-03-05 2000-09-08 Bruker Daltronics, Inc. Chambre d'ionisation pour spectrometrie de masse par ionisation a pression atmospherique
GB2349270A (en) * 1999-04-15 2000-10-25 Hitachi Ltd A mass spectrometer with plural ion sources
US6207954B1 (en) * 1997-09-12 2001-03-27 Analytica Of Branford, Inc. Multiple sample introduction mass spectrometry
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
WO2001095367A2 (fr) * 2000-06-05 2001-12-13 Pharmacia & Upjohn Company Ionisation a electronebulisation a sources multiples pour la spectrometrie de masse
US20020014586A1 (en) * 1997-06-02 2002-02-07 Clemmer David E. Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6350617B1 (en) * 1998-03-27 2002-02-26 Ole Hindsgaul Device for delivery of multiple liquid sample streams to a mass spectrometer
GB2367685A (en) * 2000-07-26 2002-04-10 Masslab Ltd Mass spectrometer with multiple ion sources
US20020121598A1 (en) * 2001-03-02 2002-09-05 Park Melvin A. Means and method for multiplexing sprays in an electrospray ionization source
US6501073B1 (en) * 2000-10-04 2002-12-31 Thermo Finnigan Llc Mass spectrometer with a plurality of ionization probes

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504326A (en) * 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
US20020014586A1 (en) * 1997-06-02 2002-02-07 Clemmer David E. Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6207954B1 (en) * 1997-09-12 2001-03-27 Analytica Of Branford, Inc. Multiple sample introduction mass spectrometry
WO1999019899A1 (fr) * 1997-10-15 1999-04-22 Analytica Of Branford, Inc. Dispositif d'introduction courbe pour spectrometrie de masse
US6350617B1 (en) * 1998-03-27 2002-02-26 Ole Hindsgaul Device for delivery of multiple liquid sample streams to a mass spectrometer
WO2000052735A1 (fr) * 1999-03-05 2000-09-08 Bruker Daltronics, Inc. Chambre d'ionisation pour spectrometrie de masse par ionisation a pression atmospherique
GB2349270A (en) * 1999-04-15 2000-10-25 Hitachi Ltd A mass spectrometer with plural ion sources
WO2001095367A2 (fr) * 2000-06-05 2001-12-13 Pharmacia & Upjohn Company Ionisation a electronebulisation a sources multiples pour la spectrometrie de masse
GB2367685A (en) * 2000-07-26 2002-04-10 Masslab Ltd Mass spectrometer with multiple ion sources
US6501073B1 (en) * 2000-10-04 2002-12-31 Thermo Finnigan Llc Mass spectrometer with a plurality of ionization probes
US20020121598A1 (en) * 2001-03-02 2002-09-05 Park Melvin A. Means and method for multiplexing sprays in an electrospray ionization source

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHUPAKHIN M.S.: "Introduction of gases to be analyzed into the ion source of a mass spectrometer", JOURNAL OF ANALYTICAL CHEMISTRY, vol. 15, no. 2, March 1960 (1960-03-01) - April 1960 (1960-04-01), pages 175 - 178, XP002971688 *
HASKINS N.J.: "Faster compound analysis by mass spectrometry - the ToF revolution", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 25, 2001, pages 767 - 773, XP002971687 *
KOSTIAINEN R. ET AL.: "Effect of multiple sprayers on dynamic range and flow rate liitations in electrospray and ionspray mass spectrometry", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 8, 1994, pages 549 - 558, XP002929950 *
LEE Y.J. ET AL.: "Development of high-throughput liquid chromatography injected ion mobility", JOURNAL OF CHROMATOGRAPHY B, vol. 782, no. 1-2, 25 December 2002 (2002-12-25), pages 343 - 351, XP004394236 *
NISHI I. ET AL.: "Application of a twin ion source mass spectrometer: simultaneous measurement of respiratory and blood gases", ADVANCES IN MASS SPECTROMETRY, vol. 8B, 1980, pages 1926 - 1933 *
SREBALUS BARNES C.A. ET AL.: "Resolving isomeric peptide mixtures: A combined HPLC/Ion mobility-TOFMS analysis of a 4000-component combinatorial library", ANALYTICAL CHEMISTRY, vol. 74, no. 1, 1 January 2002 (2002-01-01), pages 26 - 36, XP002971689 *
TANG K. ET AL.: "Generation of multiple electrosprays using microfabricated emitter arrays for improved mass spectrometric sensitivity", ANALYTICAL CHEMISTRY, vol. 73, no. 8, 15 April 2001 (2001-04-15), pages 1658 - 1663, XP001030274 *
YANG L. ET AL.: "Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes", ANALYTICAL CHEMISTRY, vol. 73, no. 8, 15 April 2001 (2001-04-15), pages 1740 - 1747, XP002971690 *
ZENG L. ET AL.: "Developments of a fully automated parallel HPLC/mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries", ANALYTICAL CHEMISTRY, vol. 70, no. 20, 15 October 1998 (1998-10-15), pages 4380 - 4388, XP002217928 *

Also Published As

Publication number Publication date
AU2003247442A8 (en) 2003-12-22
WO2003104763A2 (fr) 2003-12-18
AU2003247442A1 (en) 2003-12-22

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