WO2004013275A3 - Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules - Google Patents

Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules Download PDF

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Publication number
WO2004013275A3
WO2004013275A3 PCT/FR2003/002439 FR0302439W WO2004013275A3 WO 2004013275 A3 WO2004013275 A3 WO 2004013275A3 FR 0302439 W FR0302439 W FR 0302439W WO 2004013275 A3 WO2004013275 A3 WO 2004013275A3
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WIPO (PCT)
Prior art keywords
cells derived
cells
differentiated
derived
stem cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2003/002439
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English (en)
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WO2004013275A8 (fr
WO2004013275A2 (fr
Inventor
Christian Dani
Gerard Ailhaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Yves Saint Laurent Parfums SA
Universite de Nice Sophia Antipolis UNSA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Yves Saint Laurent Parfums SA
Universite de Nice Sophia Antipolis UNSA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0209799A external-priority patent/FR2843123B1/fr
Priority to BR0305721-6A priority Critical patent/BR0305721A/pt
Priority to JP2004525508A priority patent/JP4603883B2/ja
Priority to AU2003278212A priority patent/AU2003278212B2/en
Priority to CA2493532A priority patent/CA2493532C/fr
Priority to ES03766432.3T priority patent/ES2560847T3/es
Application filed by Centre National de la Recherche Scientifique CNRS, Yves Saint Laurent Parfums SA, Universite de Nice Sophia Antipolis UNSA filed Critical Centre National de la Recherche Scientifique CNRS
Priority to EP03766432.3A priority patent/EP1527161B1/fr
Publication of WO2004013275A2 publication Critical patent/WO2004013275A2/fr
Publication of WO2004013275A3 publication Critical patent/WO2004013275A3/fr
Publication of WO2004013275A8 publication Critical patent/WO2004013275A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1305—Adipocytes
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)

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  • Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Wood Science & Technology (AREA)
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  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne des cellules souches humaines multipotentes et adultes, caractérisées en ce qu'elles présentent: i) une activité télomérase significative, ii) un phénotype HLA Classe I négatif, iii) un caryotype normal, iv) une capacité à rentrer en quiescence, v) une capacité d'autorenouvellement conservée pendant au moins 130 doublements de population.
PCT/FR2003/002439 2002-07-31 2003-07-31 Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules Ceased WO2004013275A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP03766432.3A EP1527161B1 (fr) 2002-07-31 2003-07-31 Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules
JP2004525508A JP4603883B2 (ja) 2002-07-31 2003-07-31 脂肪組織由来の幹細胞および前記細胞から分化した細胞
AU2003278212A AU2003278212B2 (en) 2002-07-31 2003-07-31 Stem cells derived from adipous tissue and differentiated cells derived from said cells
CA2493532A CA2493532C (fr) 2002-07-31 2003-07-31 Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules
ES03766432.3T ES2560847T3 (es) 2002-07-31 2003-07-31 Células madre procedentes de tejido adiposo y células diferenciadas procedentes de estas células
BR0305721-6A BR0305721A (pt) 2002-07-31 2003-07-31 Célula-tronco humana, população de células, processo para obtenção de células-tronco, para a produção de células diferenciadas da linhagem mesodérmica, para seleção que permite identificar agentes suscetìveis de apresentar uma atividade lipolìtica e uma atividade insulino-sensibilizante, utilização de uma célula, utilização de células-tronco, composição farmacêutica, célula humana, população celular humana multipotente

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR02/09799 2002-07-31
FR0209799A FR2843123B1 (fr) 2002-07-31 2002-07-31 Cellules souches issues de tissu adipeux humain
FR0302657 2003-02-28
FR03/02657 2003-02-28

Publications (3)

Publication Number Publication Date
WO2004013275A2 WO2004013275A2 (fr) 2004-02-12
WO2004013275A3 true WO2004013275A3 (fr) 2004-04-29
WO2004013275A8 WO2004013275A8 (fr) 2004-10-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/002439 Ceased WO2004013275A2 (fr) 2002-07-31 2003-07-31 Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules

Country Status (8)

Country Link
US (2) US8334135B2 (fr)
EP (1) EP1527161B1 (fr)
JP (1) JP4603883B2 (fr)
AU (1) AU2003278212B2 (fr)
BR (1) BR0305721A (fr)
CA (1) CA2493532C (fr)
ES (1) ES2560847T3 (fr)
WO (1) WO2004013275A2 (fr)

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DK1349918T3 (da) 2000-12-06 2014-11-10 Anthrogenesis Corp Fremgangsmåde til indsamling af stamceller fra moderkagen
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2316919B1 (fr) * 2001-02-14 2015-10-07 Anthrogenesis Corporation Placenta post-gravidique de mammifère, son utilisation et céllules souches placentaires correspondantes
EP3246396B1 (fr) 2001-02-14 2020-01-29 Celularity, Inc. Rénovation et repopulation de tissus décellularisés et d'organes cadavériques par des cellules souches
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
KR100930139B1 (ko) 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US7514075B2 (en) 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
ES2633604T3 (es) * 2003-09-17 2017-09-22 Cytori Therapeutics, Inc. Métodos para usar células regenerativas derivadas de adiposo en el tratamiento de una enfermedad vascular periférica
ES2313805B1 (es) * 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
US20060222634A1 (en) * 2005-03-31 2006-10-05 Clarke Diana L Amnion-derived cell compositions, methods of making and uses thereof
WO2006121428A1 (fr) * 2005-05-05 2006-11-16 Regents Of The University Of Minnesota Utilisation de l'inhibition d'une cellule nk pour faciliter la persistance de cellules negatives mhc-1 greffees
US20080187518A1 (en) * 2005-05-25 2008-08-07 University Of Virginia Patent Foundation Production of Osteoclasts from Adipose Tissues
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US8334135B2 (en) 2012-12-18
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AU2003278212B2 (en) 2009-07-09
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WO2004013275A2 (fr) 2004-02-12
US20130084270A1 (en) 2013-04-04
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CA2493532C (fr) 2014-05-27

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