WO2004067498A3 - Derives d’ arylalkylcarbamates, leur preparation et leur application en therapeutique - Google Patents

Derives d’ arylalkylcarbamates, leur preparation et leur application en therapeutique Download PDF

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Publication number
WO2004067498A3
WO2004067498A3 PCT/FR2004/000139 FR2004000139W WO2004067498A3 WO 2004067498 A3 WO2004067498 A3 WO 2004067498A3 FR 2004000139 W FR2004000139 W FR 2004000139W WO 2004067498 A3 WO2004067498 A3 WO 2004067498A3
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Prior art keywords
cycloalkyl
alkyl
therapy
alkylene
optionally substituted
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PCT/FR2004/000139
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English (en)
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WO2004067498A2 (fr
Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Antoine Ravet
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Sanofi Aventis France
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Sanofi Aventis France
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Priority to AT04704251T priority Critical patent/ATE465990T1/de
Priority to MXPA05007848A priority patent/MXPA05007848A/es
Priority to NZ541148A priority patent/NZ541148A/en
Priority to BR0406901-3A priority patent/BRPI0406901A/pt
Priority to JP2006502114A priority patent/JP4617292B2/ja
Priority to AU2004207657A priority patent/AU2004207657B2/en
Priority to CA002511941A priority patent/CA2511941A1/fr
Priority to HR20050631A priority patent/HRP20050631A2/xx
Priority to SI200431464T priority patent/SI1590321T1/sl
Priority to EA200500979A priority patent/EA008801B1/ru
Priority to EP04704251A priority patent/EP1590321B1/fr
Priority to HK06105197.4A priority patent/HK1085193B/xx
Priority to MEP-213/08A priority patent/MEP21308A/xx
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to DE602004026826T priority patent/DE602004026826D1/de
Priority to YUP-2005/0562A priority patent/RS20050562A/sr
Priority to DK04704251.0T priority patent/DK1590321T3/da
Publication of WO2004067498A2 publication Critical patent/WO2004067498A2/fr
Publication of WO2004067498A3 publication Critical patent/WO2004067498A3/fr
Priority to IS7916A priority patent/IS7916A/is
Priority to IL169444A priority patent/IL169444A/en
Priority to TNP2005000172A priority patent/TNSN05172A1/fr
Priority to US11/186,242 priority patent/US7632850B2/en
Priority to NO20053593A priority patent/NO20053593L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Abstract

Composé répondant à la formule générale (I) ayant un effet inhibiteur de l’enzyme FAAH (Fatly Acid Amido hydrolase).
PCT/FR2004/000139 2003-01-23 2004-01-22 Derives d’ arylalkylcarbamates, leur preparation et leur application en therapeutique Ceased WO2004067498A2 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
MEP-213/08A MEP21308A (en) 2003-01-23 2004-01-22 Ryl alkyl carbamate derivatives production and use thereof in therapy
NZ541148A NZ541148A (en) 2003-01-23 2004-01-22 Aryl alkyl carbamate derivatives production and use thereof in therapy
BR0406901-3A BRPI0406901A (pt) 2003-01-23 2004-01-22 Derivados de arilalquilcarbamatos, a respectiva preparação e a respectiva aplicação em terapêutica
JP2006502114A JP4617292B2 (ja) 2003-01-23 2004-01-22 アリールアルキルカルバメート誘導体の製造およびそれらの治療用途
AU2004207657A AU2004207657B2 (en) 2003-01-23 2004-01-22 Aryl alkyl carbamate derivatives production and use thereof in therapy
CA002511941A CA2511941A1 (fr) 2003-01-23 2004-01-22 Derives d' arylalkylcarbamates, leur preparation et leur application en therapeutique
HR20050631A HRP20050631A2 (en) 2003-01-23 2004-01-22 Aryl alkyl carbamate derivatives production and use thereof in therapy
SI200431464T SI1590321T1 (sl) 2003-01-23 2004-01-22 Arilalkilkarbamatni derivati, njihova priprava in njihova terapevtska uporaba
MXPA05007848A MXPA05007848A (es) 2003-01-23 2004-01-22 Derivados de arilalquilcarbamatos, su preparacion y su aplicacion en terapeutica.
EP04704251A EP1590321B1 (fr) 2003-01-23 2004-01-22 Derives d' arylalkylcarbamates, leur preparation et leur application en therapeutique
HK06105197.4A HK1085193B (en) 2003-01-23 2004-01-22 Aryl alkyl carbamate derivatives production and use thereof in therapy
AT04704251T ATE465990T1 (de) 2003-01-23 2004-01-22 Arylalkylcarbamatderivate, verfahren zur ihrer herstellung und deren therapeutischen anwendungen
DE602004026826T DE602004026826D1 (de) 2003-01-23 2004-01-22 Arylalkylcarbamatderivate, verfahren zur ihrer herstellung und deren therapeutischen anwendungen
EA200500979A EA008801B1 (ru) 2003-01-23 2004-01-22 Получение арилалкилкарбаматных производных и их применение в терапии
YUP-2005/0562A RS20050562A (sr) 2003-01-23 2004-01-22 Derivati arilalkilkarbamata, njihovo dobijanje i upotreba u terapiji
DK04704251.0T DK1590321T3 (da) 2003-01-23 2004-01-22 Arylalkylcarbamat-derivater, fremstilling og terapeutisk anvendelse deraf
IS7916A IS7916A (is) 2003-01-23 2005-06-27 Arýl alkýl karbamat afleiður framleiðslu og notkun þeirra í meðferð
IL169444A IL169444A (en) 2003-01-23 2005-06-28 Arylalkyl carbamate derivatives, process for preparing said derivatives, pharmaceutical compositions and use thereof
TNP2005000172A TNSN05172A1 (fr) 2003-01-23 2005-06-30 Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
US11/186,242 US7632850B2 (en) 2003-01-23 2005-07-21 Arylalkylcarbamate derivatives and production thereof
NO20053593A NO20053593L (no) 2003-01-23 2005-07-22 Arylalkylkarbamat-derivater, fremgangsmate og anvendelse derav i terapi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0300704A FR2850377B1 (fr) 2003-01-23 2003-01-23 Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
FR03/00704 2003-01-23

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US11/186,242 Continuation US7632850B2 (en) 2003-01-23 2005-07-21 Arylalkylcarbamate derivatives and production thereof

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WO2004067498A2 WO2004067498A2 (fr) 2004-08-12
WO2004067498A3 true WO2004067498A3 (fr) 2004-11-04

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PCT/FR2004/000139 Ceased WO2004067498A2 (fr) 2003-01-23 2004-01-22 Derives d’ arylalkylcarbamates, leur preparation et leur application en therapeutique

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JP (1) JP4617292B2 (fr)
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AU (1) AU2004207657B2 (fr)
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CY (1) CY1110216T1 (fr)
DE (1) DE602004026826D1 (fr)
DK (1) DK1590321T3 (fr)
EA (1) EA008801B1 (fr)
ES (1) ES2344454T3 (fr)
FR (1) FR2850377B1 (fr)
HR (1) HRP20050631A2 (fr)
IL (1) IL169444A (fr)
IS (1) IS7916A (fr)
MA (1) MA27609A1 (fr)
ME (1) MEP21308A (fr)
MX (1) MXPA05007848A (fr)
NO (1) NO20053593L (fr)
NZ (1) NZ541148A (fr)
PL (1) PL378022A1 (fr)
PT (1) PT1590321E (fr)
RS (1) RS20050562A (fr)
SI (1) SI1590321T1 (fr)
TN (1) TNSN05172A1 (fr)
TW (1) TWI330628B (fr)
UA (1) UA86013C2 (fr)
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FR2865205B1 (fr) 2004-01-16 2006-02-24 Sanofi Synthelabo Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
DE102004039326A1 (de) * 2004-08-12 2006-02-16 Abbott Gmbh & Co. Kg Neue medizinische Verwendungen und Verfahren
WO2006074025A1 (fr) * 2004-12-30 2006-07-13 Janssen Pharmaceutica N.V. Urees piperazinyle et piperidinyle en tant que modulateurs de l’amide hydrolase d’acides gras
US20070155707A1 (en) * 2005-12-29 2007-07-05 Kadmus Pharmaceuticals, Inc. Ionizable inhibitors of fatty acid amide hydrolase
US20080089845A1 (en) * 2006-09-07 2008-04-17 N.V. Organon Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo
US20090099240A1 (en) * 2006-10-02 2009-04-16 N.V. Organon Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity
EP2096915A1 (fr) * 2006-11-20 2009-09-09 N.V. Organon Inhibiteurs stabilisés métaboliquement d'hydrolase d'amides d'acide gras
WO2009009041A2 (fr) * 2007-07-06 2009-01-15 Kinex Pharmaceuticals, Llc Compositions et procédés permettant de moduler une cascade de kinases
TW200948805A (en) * 2008-03-07 2009-12-01 Sigma Tau Ind Farmaceuti Enol carbamate derivatives as modulators of fatty acid amide hydrolase
CN101538245B (zh) * 2008-03-18 2011-02-16 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和制备药物的用途
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
EP2598477B1 (fr) * 2010-07-28 2016-03-02 The Regents of The University of California Inhibiteurs de la faah à restriction périphérique
JP6092870B2 (ja) 2011-08-19 2017-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア メタ置換ビフェニル末梢に限局されたｆａａｈ阻害剤
US9926273B2 (en) 2012-08-30 2018-03-27 Athenex, Inc. Composition and methods for modulating a kinase cascade
ES2908240T3 (es) 2014-04-07 2022-04-28 Univ California Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos
BR112021007830A2 (pt) * 2018-11-20 2021-08-03 Bayer Aktiengesellschaft antagonistas do adrenoceptor-alfa2 do subtipo c (al-fa-2c) para o tratamento da apneia do sono
CN118515624B (zh) * 2024-04-29 2025-01-24 聊城金歌合成材料有限公司 一种含三氟甲基多取代恶唑烷-4-酮的合成方法及应用

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PL378022A1 (pl) 2006-02-20
AU2004207657B2 (en) 2010-09-16
TW200503993A (en) 2005-02-01
IS7916A (is) 2005-06-27
RS20050562A (sr) 2007-12-31
HK1085193A1 (zh) 2006-08-18
FR2850377A1 (fr) 2004-07-30
EP1590321A2 (fr) 2005-11-02
JP2006517218A (ja) 2006-07-20
WO2004067498A2 (fr) 2004-08-12
ES2344454T3 (es) 2010-08-27
AR042746A1 (es) 2005-06-29
IL169444A0 (en) 2007-07-04
MA27609A1 (fr) 2005-11-01
JP4617292B2 (ja) 2011-01-19
ZA200505351B (en) 2006-09-27
MEP21308A (en) 2010-06-10
HRP20050631A2 (en) 2005-08-31
AU2004207657A1 (en) 2004-08-12
BRPI0406901A (pt) 2005-12-13
CN1741990A (zh) 2006-03-01
CN101058564A (zh) 2007-10-24
US7632850B2 (en) 2009-12-15
CA2511941A1 (fr) 2004-08-12
PT1590321E (pt) 2010-07-06
TNSN05172A1 (fr) 2007-05-14
CN101058564B (zh) 2010-05-26
DE602004026826D1 (de) 2010-06-10
ATE465990T1 (de) 2010-05-15
CN100506788C (zh) 2009-07-01
FR2850377B1 (fr) 2009-02-20
CY1110216T1 (el) 2015-01-14
NO20053593D0 (no) 2005-07-22
TWI330628B (en) 2010-09-21
SI1590321T1 (sl) 2010-08-31
US20060014830A1 (en) 2006-01-19
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IL169444A (en) 2011-06-30
UA86013C2 (ru) 2009-03-25
NZ541148A (en) 2009-01-31
DK1590321T3 (da) 2010-08-09
MXPA05007848A (es) 2005-10-18
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