NO20040189L - Nye antitumorderivater av ET-743 - Google Patents

Nye antitumorderivater av ET-743

Info

Publication number: NO20040189L
Authority: NO; Norway
Prior art keywords: substituted; unsubstituted; alkenyl; alkyl; alkynyl
Prior art date: 2001-07-17

Application number

NO20040189A

Other languages

English (en)

Other versions

NO335262B1 (no

Inventor

Carmen Cuevas

Pilar Gallego

Ignacio Manzanares

Maria Flores

Simon Munt

Valentin Martinez

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2004-01-16

Publication date

2004-03-16

2004-01-16 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2004-03-16 Publication of NO20040189L publication Critical patent/NO20040189L/no

2014-10-27 Publication of NO335262B1 publication Critical patent/NO335262B1/no

Links

230000000259 anti-tumor effect Effects 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 6
125000003342 alkenyl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000304 alkynyl group Chemical group 0.000 abstract 5
229910052799 carbon Inorganic materials 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004151 quinonyl group Chemical group 0.000 abstract 1
125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20040189A 2001-07-17 2004-01-16 Nye antitumorderivater av ET-743, anvendelse derav for fremstilling av et medikament, og farmasøytisk preparat omfattende forbindelsen NO335262B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0117402.8A GB0117402D0 (en)	2001-07-17	2001-07-17	New antitumoral derivatives of et-743
PCT/GB2002/003288 WO2003008423A1 (en)	2001-07-17	2002-07-17	New antitumoral derivatives of et-743

Publications (2)

Publication Number	Publication Date
NO20040189L true NO20040189L (no)	2004-03-16
NO335262B1 NO335262B1 (no)	2014-10-27

Family

ID=9918658

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20040189A NO335262B1 (no)	2001-07-17	2004-01-16	Nye antitumorderivater av ET-743, anvendelse derav for fremstilling av et medikament, og farmasøytisk preparat omfattende forbindelsen
NO20140711A NO340213B1 (no)	2001-07-17	2014-06-06	Nye antitumorderivater av ecteinascidinen ET-743, farmasøytisk preparat derav og anvendelse derav ved fremstillingen av et medikament for behandling av en kreftsykdom

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20140711A NO340213B1 (no)	2001-07-17	2014-06-06	Nye antitumorderivater av ecteinascidinen ET-743, farmasøytisk preparat derav og anvendelse derav ved fremstillingen av et medikament for behandling av en kreftsykdom

Country Status (16)

Country	Link
US (2)	US7759345B2 (no)
EP (3)	EP1406907B1 (no)
JP (1)	JP4653950B2 (no)
AT (1)	ATE371661T1 (no)
AU (2)	AU2002317967C1 (no)
CA (1)	CA2453991C (no)
CY (2)	CY1107809T1 (no)
DE (1)	DE60222135T2 (no)
DK (3)	DK1854800T3 (no)
ES (3)	ES2291479T3 (no)
GB (1)	GB0117402D0 (no)
MX (1)	MXPA04000506A (no)
NO (2)	NO335262B1 (no)
PT (3)	PT1406907E (no)
SI (2)	SI1854800T1 (no)
WO (1)	WO2003008423A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
WO2006035244A2 (en) *	2004-09-29	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
GB0521536D0 (en) *	2005-10-22	2005-11-30	Invibio Ltd	Fiducial marker
WO2011147828A1 (en)	2010-05-25	2011-12-01	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds
LT3615544T (lt) *	2017-04-27	2023-05-10	Pharma Mar S.A.	Priešnavikiniai junginiai
TWI824043B (zh)	2018-10-25	2023-12-01	西班牙商瑪製藥股份有限公司	藥物抗體共軛物
WO2024186263A1 (en) *	2023-03-07	2024-09-12	Axcynsis Therapeutics Pte. Ltd.	Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
CN119591621A (zh) *	2023-09-11	2025-03-11	泰诚思(上海)生物医药有限公司	新型海鞘素衍生物、其制备方法及用途、抗体药物偶联物及其应用
CN121986103A (zh)	2023-10-09	2026-05-05	法马马有限公司	用于制造海鞘素化合物的合成方法
WO2025168077A1 (zh) *	2024-02-08	2025-08-14	映恩生物科技(上海)有限公司	海鞘素类化合物及其应用
TW202610629A (zh)	2024-07-26	2026-03-16	西班牙商瑪製藥股份有限公司	用於製造海鞘素化合物的合成方法
WO2026098585A1 (zh) *	2024-11-08	2026-05-15	映恩生物科技(上海)有限公司	海鞘类化合物、其偶联物及其制备方法和用途

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
JPS6084288A (ja)	1983-10-13	1985-05-13	Shionogi & Co Ltd	シアノキノナミンアセテ−ト類およびその製造法
US5256663A (en)	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
EP0309477B1 (en)	1986-06-09	1991-11-06	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5089273A (en)	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) *	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
US5478932A (en)	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US20040059112A1 (en) *	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
US5721362A (en)	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en)	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
BR9909488B1 (pt) *	1998-04-06	2011-02-08		ecteinascidinas semi-sintéticas e composição farmacêutica.
DK1076486T3 (da)	1998-05-05	2006-01-09	Pharma Mar Sa	Dyrkning af sessile marine dyr
IL139607A0 (en)	1998-05-11	2002-02-10	Pharma Mar Sa	Metabolites of ecteinascidin 743
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
MY130271A (en)	1999-05-14	2007-06-29	Pharma Mar Sa	Hemisynthetic method and new compounds
EP1254140A4 (en)	2000-01-19	2003-03-12	Univ Columbia	SAFRAMYCIN-ECTEINASCIDIN SERIES COMPOUNDS, USAGE AND SYNTHESIS THEREOF
US6815544B2 (en)	2000-02-11	2004-11-09	President And Fellows Of Harvard College	Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en)	2000-02-22	2003-05-27	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
KR100886496B1 (ko)	2000-04-12	2009-03-05	파르마 마르, 에스.에이.	항종양성 엑티나시딘 유도체
US7919493B2 (en) *	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es)	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
WO2002036135A2 (en) *	2000-11-06	2002-05-10	Pharma Mar, S.A.	Compositions for antitumour treatment containing ecteinascidin 743
PL368458A1 (en) *	2001-10-19	2005-03-21	Pharmamar S.A.	Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en)	2002-08-13	2002-09-18	Pharma Mar Sa	DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) *	2002-12-20	2003-01-29	Pharma Mar Sa	The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
JP2007511499A (ja)	2003-11-13	2007-05-10	ファーマ・マール・エス・アー・ウー	コンビネーション
JP2007511509A (ja) *	2003-11-14	2007-05-10	ファルマ・マール・ソシエダード・アノニマ	Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
JP2008505862A (ja) *	2004-07-09	2008-02-28	ファルマ、マール、ソシエダード、アノニマ	予後分子マーカー
WO2006035244A2 (en) *	2004-09-29	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
RS50822B (sr) *	2004-10-26	2010-08-31	Pharma Mar S.A., Sociedad Unipersonal	Pegilovani lipozomalni doksorubicin u kombinaciji sa ekteinescidinom 743
KR101188691B1 (ko) *	2004-10-29	2012-10-09	파르마 마르 에스.에이.	엑티나시딘 및 디사카라이드를 포함하는 제제
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
JP2009517403A (ja) *	2005-11-25	2009-04-30	ユニバーシティーオブメディシンアンドデンティストリーオブニュージャージー	Ｐａｒｐ−１阻害剤の使用
WO2007134203A2 (en) *	2006-05-12	2007-11-22	Pharma Mar, S.A.	Anticancer treatments with a combination of docetaxel and ecteinascidin
WO2009050303A1 (en)	2007-10-19	2009-04-23	Pharma Mar, S.A.	Prognostic molecular markers for et-743 treatment
EP2307003A2 (en)	2008-05-16	2011-04-13	Pharma Mar S.A.	Combination therapy with pm00104 and another antitumor agent
AU2009248039B2 (en)	2008-05-16	2014-07-31	Pharma Mar, S.A.	Multiple myeloma treatments

2001
- 2001-07-17 GB GBGB0117402.8A patent/GB0117402D0/en not_active Ceased
2002
- 2002-07-17 JP JP2003513982A patent/JP4653950B2/ja not_active Expired - Lifetime
- 2002-07-17 ES ES02747577T patent/ES2291479T3/es not_active Expired - Lifetime
- 2002-07-17 PT PT02747577T patent/PT1406907E/pt unknown
- 2002-07-17 EP EP02747577A patent/EP1406907B1/en not_active Expired - Lifetime
- 2002-07-17 DK DK07011446.7T patent/DK1854800T3/da active
- 2002-07-17 WO PCT/GB2002/003288 patent/WO2003008423A1/en not_active Ceased
- 2002-07-17 US US10/484,060 patent/US7759345B2/en not_active Expired - Lifetime
- 2002-07-17 AU AU2002317967A patent/AU2002317967C1/en not_active Expired
- 2002-07-17 SI SI200231003T patent/SI1854800T1/sl unknown
- 2002-07-17 EP EP10180049A patent/EP2298780B1/en not_active Expired - Lifetime
- 2002-07-17 EP EP07011446A patent/EP1854800B1/en not_active Expired - Lifetime
- 2002-07-17 SI SI200231015T patent/SI2298780T1/sl unknown
- 2002-07-17 ES ES10180049T patent/ES2394772T3/es not_active Expired - Lifetime
- 2002-07-17 DE DE60222135T patent/DE60222135T2/de not_active Expired - Lifetime
- 2002-07-17 ES ES07011446T patent/ES2389671T3/es not_active Expired - Lifetime
- 2002-07-17 DK DK02747577T patent/DK1406907T3/da active
- 2002-07-17 PT PT07011446T patent/PT1854800E/pt unknown
- 2002-07-17 MX MXPA04000506A patent/MXPA04000506A/es active IP Right Grant
- 2002-07-17 CA CA2453991A patent/CA2453991C/en not_active Expired - Lifetime
- 2002-07-17 PT PT101800498T patent/PT2298780E/pt unknown
- 2002-07-17 AT AT02747577T patent/ATE371661T1/de active
- 2002-07-17 DK DK10180049.8T patent/DK2298780T3/da active
2004
- 2004-01-16 NO NO20040189A patent/NO335262B1/no not_active IP Right Cessation
2007
- 2007-11-21 CY CY20071101494T patent/CY1107809T1/el unknown
2008
- 2008-08-20 AU AU2008207381A patent/AU2008207381B2/en not_active Expired
2010
- 2010-04-06 US US12/755,218 patent/US8076337B2/en not_active Expired - Fee Related
2012
- 2012-09-20 CY CY20121100864T patent/CY1113359T1/el unknown
2014
- 2014-06-06 NO NO20140711A patent/NO340213B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4653950B2 (ja)	2011-03-16
DE60222135T2 (de)	2008-05-21
MXPA04000506A (es)	2004-07-23
US8076337B2 (en)	2011-12-13
CY1113359T1 (el)	2016-06-22
AU2008207381B2 (en)	2011-07-14
ES2389671T3 (es)	2012-10-30
GB0117402D0 (en)	2001-09-05
US20100197695A1 (en)	2010-08-05
ES2291479T3 (es)	2008-03-01
ES2394772T3 (es)	2013-02-05
JP2004536132A (ja)	2004-12-02
EP1854800A1 (en)	2007-11-14
NO20140711L (no)	2004-03-16
DE60222135D1 (de)	2007-10-11
NO335262B1 (no)	2014-10-27
PT1406907E (pt)	2007-12-10
EP2298780A1 (en)	2011-03-23
DK2298780T3 (da)	2013-01-07
CA2453991C (en)	2011-12-20
EP1406907B1 (en)	2007-08-29
NO340213B1 (no)	2017-03-20
WO2003008423A1 (en)	2003-01-30
CA2453991A1 (en)	2003-01-30
SI1854800T1 (sl)	2012-11-30
ATE371661T1 (de)	2007-09-15
EP2298780B1 (en)	2012-09-12
US7759345B2 (en)	2010-07-20
CY1107809T1 (el)	2013-06-19
EP1406907A1 (en)	2004-04-14
US20060106021A1 (en)	2006-05-18
EP1854800B1 (en)	2012-06-27
DK1854800T3 (da)	2012-10-01
SI2298780T1 (sl)	2013-01-31
AU2002317967C1 (en)	2009-01-22
DK1406907T3 (da)	2008-02-04
PT1854800E (pt)	2012-09-25
AU2008207381A1 (en)	2008-09-11
PT2298780E (pt)	2012-12-17
AU2002317967B2 (en)	2008-06-05

Legal Events

Date	Code	Title	Description
2022-08-15	MK1K	Patent expired

Publication	Publication Date	Title
CY1113359T1 (el)	2016-06-22	Αντι-νεοπλασιακα παραγωγα του et-743
ATE356117T1 (de)	2007-03-15	Derivate des n-((chinolinyl)oxy)-phenyl)- harnstoffs und des n-((chinazolinyl)oxy)-phenyl)- harnstoffs mit antitumor aktivität
DK1117297T3 (da)	2006-01-09	Syntetiske analoger af ecteinascidin-743
NO20040961L (no)	2004-03-05	Antitumoranaloger
NO307255B1 (no)	2000-03-06	Nye forbindelser og antitumormidler
PT1280809E (pt)	2005-11-30	Derivados antitumorais de ecteinascidina
TW325473B (en)	1998-01-21	Azoamine derivative having methylene or substituted methylene on the amino ring
CY1108313T1 (el)	2014-02-12	Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
ATE167473T1 (de)	1998-07-15	Sulfonamid-derivate
ATE88714T1 (de)	1993-05-15	2'-desoxy-5-fluoruridinderivate.
ES8601146A1 (es)	1985-11-01	Procedimiento para preparar derivados azolicos
DE60027131D1 (de)	2006-05-18	Inhibitoren für asparagin-proteasen
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
GB9012223D0 (en)	1990-07-18	Amines
GB0116966D0 (en)	2001-09-05	Anittumoral compounds
HUP0001245A1 (hu)	2000-09-28	Új eritromicinszármazékok, eljárás a vegyületek előállítására és gyógyszerként történő alkalmazásuk
NO961537D0 (no)	1996-04-18	Salpetersyreestere fra derivater av 2-(2,6-dihalofenylamino)-fenylacetoksyeddiksyre, og deres fremstillingsprosedyrer
TW200510300A (en)	2005-03-16	Amino alcohol compounds
HUP9900895A2 (hu)	1999-07-28	Simaizom sejtburjánzást gátló 2-szubsztituált benzimidazolszármazékok
NO20051037L (no)	2005-04-13	Totalsyntese av myriaporoner