WO2005007185A3 - Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa) - Google Patents

Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa) Download PDF

Info

Publication number
WO2005007185A3
WO2005007185A3 PCT/DE2004/001635 DE2004001635W WO2005007185A3 WO 2005007185 A3 WO2005007185 A3 WO 2005007185A3 DE 2004001635 W DE2004001635 W DE 2004001635W WO 2005007185 A3 WO2005007185 A3 WO 2005007185A3
Authority
WO
WIPO (PCT)
Prior art keywords
hsa
formulation
serum albumin
human serum
protein pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2004/001635
Other languages
English (en)
French (fr)
Other versions
WO2005007185A2 (de
Inventor
Juergen Frevert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotecon Therapeutics GmbH
Original Assignee
Biotecon Therapeutics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34071833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005007185(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2004257391A priority Critical patent/AU2004257391B2/en
Priority to US10/565,111 priority patent/US7829525B2/en
Priority to CA2532475A priority patent/CA2532475C/en
Priority to ES04762485.3T priority patent/ES2363600T5/es
Priority to BRPI0412241-0A priority patent/BRPI0412241A/pt
Priority to EP04762485.3A priority patent/EP1648485B2/de
Priority to DE502004012418T priority patent/DE502004012418D1/de
Application filed by Biotecon Therapeutics GmbH filed Critical Biotecon Therapeutics GmbH
Priority to JP2006520664A priority patent/JP4912147B2/ja
Priority to KR1020067001593A priority patent/KR101176579B1/ko
Priority to AT04762485T priority patent/ATE506071T1/de
Publication of WO2005007185A2 publication Critical patent/WO2005007185A2/de
Publication of WO2005007185A3 publication Critical patent/WO2005007185A3/de
Priority to IL172835A priority patent/IL172835A/en
Anticipated expiration legal-status Critical
Priority to NO20060772A priority patent/NO20060772L/no
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Zusammensetzung zur Stabilisierung von Protein-Wirkstoffen in Arzneimitteln 1, umfassend die folgenden beiden Komponenten: a) eine oberflächenaktive Substanz, vorzugsweise ein nicht-ionisches Detergens (Tensid); und b) ein Gemisch von mindestens zwei Aminosäuren, wobei die mindestens zwei Aminosäuren entweder Glu und Gln oder Asp und Asn sind.
PCT/DE2004/001635 2003-07-22 2004-07-22 Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa) Ceased WO2005007185A2 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1020067001593A KR101176579B1 (ko) 2003-07-22 2004-07-22 인간 혈청 알부민(ｈｓａ)이 첨가되지 않은 단백질 약제를위한 제제
JP2006520664A JP4912147B2 (ja) 2003-07-22 2004-07-22 ヒト血清アルブミン（ｈｓａ）を添加しないタンパク質医薬のための製剤
CA2532475A CA2532475C (en) 2003-07-22 2004-07-22 Formulation for a protein pharmaceutical without added human serum albumin (hsa)
ES04762485.3T ES2363600T5 (es) 2003-07-22 2004-07-22 Formulación para medicamentos proteicos sin adición de seroalbúmina humana (HSA)
BRPI0412241-0A BRPI0412241A (pt) 2003-07-22 2004-07-22 formulação para medicamentos de proteìna sem adição de albumina de soro humano (hsa)
EP04762485.3A EP1648485B2 (de) 2003-07-22 2004-07-22 Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa)
DE502004012418T DE502004012418D1 (de) 2003-07-22 2004-07-22 Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa)
AU2004257391A AU2004257391B2 (en) 2003-07-22 2004-07-22 Formulation for a protein pharmaceutical without added human serum albumin (HSA)
AT04762485T ATE506071T1 (de) 2003-07-22 2004-07-22 Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa)
US10/565,111 US7829525B2 (en) 2003-07-22 2004-07-22 Formulation for a protein pharmaceutical without added human serum albumin (HSA)
IL172835A IL172835A (en) 2003-07-22 2005-12-26 Composition for stabilizing active protein ingredients in pharmaceutical composition containing at least 2 amino acids
NO20060772A NO20060772L (no) 2003-07-22 2006-02-17 Formulering for et proteinlegemiddel uten tilsatt serum albumin (HSA)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10333317.7 2003-07-22
DE10333317A DE10333317A1 (de) 2003-07-22 2003-07-22 Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)

Publications (2)

Publication Number Publication Date
WO2005007185A2 WO2005007185A2 (de) 2005-01-27
WO2005007185A3 true WO2005007185A3 (de) 2005-05-12

Family

ID=34071833

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/001635 Ceased WO2005007185A2 (de) 2003-07-22 2004-07-22 Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa)

Country Status (15)

Country Link
US (1) US7829525B2 (de)
EP (1) EP1648485B2 (de)
JP (1) JP4912147B2 (de)
KR (1) KR101176579B1 (de)
CN (1) CN100450542C (de)
AT (1) ATE506071T1 (de)
AU (1) AU2004257391B2 (de)
BR (1) BRPI0412241A (de)
CA (1) CA2532475C (de)
DE (2) DE10333317A1 (de)
ES (1) ES2363600T5 (de)
IL (1) IL172835A (de)
NO (1) NO20060772L (de)
RU (2) RU2491927C2 (de)
WO (1) WO2005007185A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9180081B2 (en) 2005-03-03 2015-11-10 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US11033625B2 (en) 2005-10-06 2021-06-15 Allergan, Inc. Method for stabilizing a toxin

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925739A1 (de) * 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum mit einem Botulinum-Neurotoxin
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
SG150570A1 (en) 2004-03-03 2009-03-30 Revance Therapeutics Inc Compositions and methods for topical diagnostic and therapeutic transport
GB2416122A (en) * 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
DE102005025520A1 (de) 2005-06-03 2006-12-07 Robert Bosch Gmbh Verfahren zur modellbasierten Diagnose eines mechatronischen Systems
ATE501248T1 (de) * 2005-07-02 2011-03-15 Arecor Ltd Stabile wässrige systeme mit proteinen
US8323666B2 (en) * 2005-08-01 2012-12-04 Allergan, Inc. Botulinum toxin compositions
AU2013202329B2 (en) * 2005-10-06 2016-04-14 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
AU2016204034B2 (en) * 2005-10-06 2017-12-21 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
US8137677B2 (en) 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
US20090324647A1 (en) * 2005-10-11 2009-12-31 Borodic Gary E Albumin-Free Botulinum Toxin Based Pharmaceutical Compositions Containing a Hyaluronidase and Methods of Use
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
US8617568B2 (en) 2007-07-10 2013-12-31 Medy-Tox, Inc. Pharmaceutical liquid composition of botulinum toxin with improved stability
EP2198007B1 (de) * 2007-09-14 2017-10-25 Sanofi Pasteur Biologics, LLC Pharmazeutische zusammensetzungen mit clostridium difficile toxoiden a und b
US9107815B2 (en) 2008-02-22 2015-08-18 Allergan, Inc. Sustained release poloxamer containing pharmaceutical compositions
WO2009133408A2 (en) * 2008-05-01 2009-11-05 Arecor Limited Protein formulation
ES2669020T3 (es) 2008-12-31 2018-05-23 Revance Therapeutics, Inc. Formulaciones inyectables de toxina botulínica
EP2248518B1 (de) * 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulierung zur Stabilisierung von Proteinen, Peptiden und deren Mischungen.
JP6043627B2 (ja) 2009-06-25 2016-12-14 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． アルブミン非含有ボツリヌス毒素製剤
AU2010267963B2 (en) 2009-07-02 2015-09-24 Merz Pharma Gmbh & Co. Kgaa Neurotoxins exhibiting shortened biological activity
BR112012010058A2 (pt) * 2009-10-30 2016-05-31 Duoject Inc aplicador tópico para um agente paralítico e método para aplicação do agente
SI3295957T1 (sl) 2010-01-15 2020-02-28 Kirin-Amgen, Inc. Formulacija protitelesa proti IL-17RA in terapevtski režim za zdravljenje luskavice
CN102408467B (zh) * 2010-09-26 2014-03-05 海口维瑅瑷生物研究院 真空干燥蛋白的方法、制得的蛋白产品和试剂盒
AU2011316111B2 (en) 2010-10-12 2015-05-28 Merz Pharma Gmbh & Co. Kgaa Formulation suitable for stabilizing proteins, which is free of mammalian excipients
ES2636680T5 (es) 2011-03-31 2023-10-31 Medy Tox Inc Preparación liofilizada de toxina botulínica
AU2012250924B2 (en) 2011-05-02 2017-05-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
EP2524701A3 (de) 2011-05-20 2012-12-19 Nitto Denko Corporation Pharmazeutische Zusammensetzung und Herstellungsverfahren dafür
WO2013001044A1 (en) * 2011-06-28 2013-01-03 Leukocare Ag Method for preventing the unfolding of a (poly) peptide and/or inducing the (re- ) folding of a (poly) peptide
CA2853112C (en) 2011-10-25 2018-08-21 Onclave Therapeutics Limited Antibody formulations and methods
WO2013068476A1 (en) 2011-11-09 2013-05-16 Merz Pharma Gmbh & Co. Kgaa Neurotoxins exhibiting shortened biological activity
CN102441172B (zh) * 2011-12-06 2014-05-07 中国医学科学院输血研究所 高纯度凝血酶原复合物制品冷冻干燥稳定剂
AR091902A1 (es) 2012-07-25 2015-03-11 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de insulina de accion prolongada
AR092862A1 (es) * 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
JP6608357B2 (ja) 2013-06-28 2019-11-20 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー 細胞において神経毒ポリペプチドの生物活性を決定する手段及び方法
US9480731B2 (en) * 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
AU2015367329B2 (en) 2014-12-19 2021-02-18 Merz Pharma Gmbh & Co. Kgaa Means and methods for the determination of the biological activity of BoNT/E in cells
RU2694820C9 (ru) * 2014-12-23 2019-08-12 Мерц Фарма Гмбх Унд Ко. Кгаа Контейнер, предварительно заполненный ботулиновым токсином
JP6813492B2 (ja) * 2015-02-03 2021-01-13 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン ボツリヌス毒素充填済み容器
ES2893838T3 (es) 2016-03-02 2022-02-10 Merz Pharma Gmbh & Co Kgaa Composición que comprende toxina botulínica
IL285190B (en) 2016-05-27 2022-07-01 Galderma Holding SA A liquid neurotoxin preparation stabilized by tryptophan or tyrosine
WO2018038585A1 (ko) * 2016-08-26 2018-03-01 주식회사 에이비바이오 보툴리눔 독소 및 안정화제를 포함하는 액상 제형 및 이의 제조방법
WO2018038301A1 (en) * 2016-08-26 2018-03-01 Hugel Inc. Stabilized liquid formulation of botulinum toxin and preparation method thereof
EP3290437A1 (de) 2016-08-31 2018-03-07 Merz Pharma GmbH & Co. KGaA Neuartige rekombinante clostridienneurotoxine mit verkürzter wirkungsdauer
IL265109B2 (en) 2016-09-13 2024-05-01 Allergan Inc Stabilized non-protein clostridial toxin compositions
US20190216925A1 (en) 2016-09-16 2019-07-18 Leukocare Ag A Novel Method for Stabilization of a Biopharmaceutical Drug Product During Processing
EP3512496B1 (de) 2016-09-16 2025-07-30 Leukocare Ag Neuartiges verfahren zur herstellung von niedrigviskosen und hochkonzentrierten biopharmazeutischen wirkstoffprodukten in flüssiger formulierung
WO2018050874A1 (en) 2016-09-16 2018-03-22 Leukocare Ag A novel method of producing a liquid biopharmaceutical drug product
EP3312193A1 (de) 2016-10-19 2018-04-25 Merz Pharma GmbH & Co. KGaA Neuartige rekombinante botulinumneurotoxine mit beschleunigter wirkung
EP3333179A1 (de) 2016-12-07 2018-06-13 Merz Pharma GmbH & Co. KGaA Neuartiges rekombinantes botulinumneurotoxin mit beschleunigtem wirkungseintritt
EP3335719A1 (de) 2016-12-14 2018-06-20 Merz Pharma GmbH & Co. KGaA Neuartige rekombinante botulinumneurotoxine mit einer stabilisierten leichten kette
IL268688B2 (en) 2017-03-24 2024-01-01 Merz Pharma Gmbh & Co Kgaa Improved use of botulinum neurotoxin in the treatment of sialorrhea
CN110352201A (zh) 2017-04-03 2019-10-18 免疫医疗公司 用于癌症疗法的抗体药物缀合物的皮下施用
WO2018233813A1 (en) 2017-06-20 2018-12-27 Merz Pharma Gmbh & Co. Kgaa NOVEL RECOMBINANT BOTULINUM TOXINS WITH INCREASED DURATION
US11155802B2 (en) 2017-07-06 2021-10-26 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum neurotoxins with increased duration of effect
US20210008156A1 (en) 2017-10-26 2021-01-14 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum neurotoxins with increased duration of effect
WO2019101308A1 (en) 2017-11-22 2019-05-31 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum toxin with increased duration of effect
KR102063475B1 (ko) * 2018-02-22 2020-01-09 주식회사 에이비바이오 보툴리눔 독소, 안정화제, 및 국소마취제를 포함하는 액상 제형 및 이의 제조방법
WO2020070017A1 (en) 2018-10-02 2020-04-09 Merz Pharma Gmbh & Co. Kgaa Novel uses of botulinum neurotoxin for treating lipoedema
KR102259423B1 (ko) 2018-11-30 2021-06-02 주식회사 휴온스바이오파마 보툴리눔 독소의 안정화 액상 조성물
WO2020111852A1 (ko) 2018-11-30 2020-06-04 주식회사 휴온스글로벌 보툴리눔 독소의 안정화 액상 조성물
CN109602705A (zh) * 2018-12-26 2019-04-12 安徽安科生物工程（集团）股份有限公司 一种重组人干扰素α2b喷雾剂
JP7646555B2 (ja) 2019-02-21 2025-03-17 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン 振戦治療のためのボツリヌス神経毒素の新規用途
WO2021152121A1 (en) 2020-01-30 2021-08-05 Leukocare Ag Reduction of adsorption
KR20230020961A (ko) 2020-06-05 2023-02-13 메르츠 파마 게엠베하 운트 코. 카가아 안면 주름의 고용량 및 저용적 보툴리눔 독소 치료
CN112168789B (zh) * 2020-09-25 2022-08-16 广州一品红制药有限公司 一种包含氨基酸的注射用乙酰谷酰胺药物组合物及其应用
CN114642729B (zh) * 2020-12-21 2023-12-15 舒泰神（北京）生物制药股份有限公司 一种凝血因子x激活剂组合物
TW202400122A (zh) 2022-02-28 2024-01-01 德商梅茲製藥有限兩合公司 肉毒桿菌毒素用於降低皮膚毛孔尺寸及／或皮脂產生之用途、以及降低皮膚毛孔尺寸及／或皮脂產生的方法
AU2023400491A1 (en) 2022-11-28 2025-04-10 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin injection in platysma for lower face and neck rejuvenation
WO2024115413A1 (en) 2022-11-28 2024-06-06 Merz Pharma Gmbh & Co. Kgaa High concentration botulinum toxin treatment for neck rejuvenation
WO2024194181A1 (en) 2023-03-20 2024-09-26 Merz Therapeutics GmbH Nh3 scavenger for use in the treatment of mobility disability in a post-stroke patient
WO2024240868A1 (en) 2023-05-23 2024-11-28 Merz Therapeutics GmbH Botulinum toxin for treating peripheral neuropathic pain
KR20250003215A (ko) 2023-06-30 2025-01-07 주식회사 휴온스바이오파마 폴리솔베이트 20 및 세린을 포함하는 보툴리눔 독소의 안정화 액상 조성물
CN121511091A (zh) 2023-07-12 2026-02-10 莫茨药物股份两合公司 通过肉毒杆菌毒素的色素沉着过度病况治疗
WO2025228877A1 (en) 2024-04-29 2025-11-06 Merz Therapeutics GmbH Botulinum toxin for the preventive treatment of migraine
WO2026021713A1 (en) 2024-07-23 2026-01-29 Merz Therapeutics GmbH Uses of magnetic nerve stimulation associated with botulinum neurotoxin administration
KR102823973B1 (ko) * 2024-09-27 2025-06-24 주식회사 휴온스바이오파마 보툴리눔 독소 안정화 액상 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512547A (en) * 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3033932C2 (de) * 1980-09-10 1984-05-24 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Kaltsterilisation von Blutgerinnungsfaktor VIII enthaltenden Präparaten
US4895716A (en) * 1987-06-09 1990-01-23 Biogen, Inc. Stabilized formulations of gamma interferons
JPH01246226A (ja) * 1988-03-28 1989-10-02 Sumitomo Pharmaceut Co Ltd 安定な修飾アスパラギナーゼ含有組成物
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
DE4111393A1 (de) † 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
DK204791D0 (da) 1991-12-20 1991-12-20 Novo Nordisk As Hidtil ukendt farmaceutisk praeparat
US5762993A (en) * 1992-02-19 1998-06-09 Kraft Foods, Inc. Process for preparing reduced fat meat
JP2886061B2 (ja) * 1993-10-29 1999-04-26 財団法人化学及血清療法研究所 プロテインｃもしくは活性化プロテインｃの安定化方法及び安定化組成物
FR2719479B1 (fr) * 1994-05-04 1996-07-26 Sanofi Elf Formulation stable lyophilisée comprenant une protéine: kit de dosage.
DE4431833C1 (de) * 1994-09-07 1995-05-18 Blutspendedienst Der Drk Lande Verfahren zur Herstellung eines AHF-Konzentrates
GB9418092D0 (en) * 1994-09-08 1994-10-26 Red Cross Found Cent Lab Blood Organic compounds
DE19508192A1 (de) * 1995-03-09 1996-09-12 Behringwerke Ag Stabile Transglutaminasepräparate und Verfahren zu ihrer Herstellung
TW426523B (en) * 1995-04-06 2001-03-21 Hoffmann La Roche Interferon solution
EP0837883B1 (de) * 1995-06-07 2005-08-10 Chiron Corporation Methode zur lösung, reinigung und rückfaltung von protein
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
TR199800811T2 (xx) * 1995-11-07 1998-07-21 Genentech,Inc. NGF i�in stabilize edici form�lasyonlar.
US20020077461A1 (en) 1996-04-24 2002-06-20 Soren Bjorn Pharmaceutical formulation
TW518219B (en) * 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
EP2311436A1 (de) * 1998-04-27 2011-04-20 Altus Pharmaceuticals Inc. Stabilisierte Protein-Kristalle, diese enthaltende Formulierungen und ihre Herstellungsverfahren
JP2000072873A (ja) * 1998-06-18 2000-03-07 Kao Corp 含窒素高分子化合物
US6136294C1 (en) * 1998-09-22 2002-09-24 Aeropharm Technology Inc Amino acid stabilized medical aerosol formulation
CA2634663C (en) * 1999-02-22 2009-08-25 University Of Connecticut Novel albumin-free factor viii formulations
JP2000247903A (ja) * 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
ATE401908T1 (de) * 1999-04-09 2008-08-15 Ortho Mcneil Pharm Inc Pharmazeutische zusammensetzungen von erythropoietin
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
AU2002335046A1 (en) * 2001-10-19 2003-05-06 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
US7005144B2 (en) * 2002-06-07 2006-02-28 Eve Szu-Ju Chen Antler composition and its manufacturing process

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512547A (en) * 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
H. DOOTZ: "Rote Liste 2003", 1 January 2003, ROTE LISTE SERVICE GMBH, AULENDORF, XP002319956 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9180081B2 (en) 2005-03-03 2015-11-10 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US9314416B2 (en) 2005-03-03 2016-04-19 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US11033625B2 (en) 2005-10-06 2021-06-15 Allergan, Inc. Method for stabilizing a toxin
US11147878B2 (en) 2005-10-06 2021-10-19 Allergan, Inc. Animal protein-free pharmaceutical compositions
US11285216B2 (en) 2005-10-06 2022-03-29 Allergan, Inc. Animal protein-free pharmaceutical compositions
US11446382B2 (en) 2005-10-06 2022-09-20 Allergan, Inc. Animal protein-free pharmaceutical compositions
US11524075B2 (en) 2005-10-06 2022-12-13 Allergan, Inc. Animal protein-free pharmaceutical compositions

Also Published As

Publication number Publication date
CA2532475A1 (en) 2005-01-27
RU2491927C2 (ru) 2013-09-10
ES2363600T5 (es) 2014-12-05
RU2354366C2 (ru) 2009-05-10
BRPI0412241A (pt) 2006-10-17
DE502004012418D1 (de) 2011-06-01
RU2008147818A (ru) 2010-06-10
NO20060772L (no) 2006-04-19
WO2005007185A2 (de) 2005-01-27
JP2006528137A (ja) 2006-12-14
DE10333317A1 (de) 2005-02-17
CN1826132A (zh) 2006-08-30
US7829525B2 (en) 2010-11-09
CA2532475C (en) 2013-05-28
EP1648485B2 (de) 2014-09-24
KR101176579B1 (ko) 2012-08-23
AU2004257391A1 (en) 2005-01-27
ES2363600T3 (es) 2011-08-10
IL172835A0 (en) 2006-06-11
ATE506071T1 (de) 2011-05-15
KR20060031697A (ko) 2006-04-12
EP1648485B1 (de) 2011-04-20
IL172835A (en) 2010-06-16
CN100450542C (zh) 2009-01-14
EP1648485A2 (de) 2006-04-26
US20070134199A1 (en) 2007-06-14
RU2006101589A (ru) 2006-09-10
AU2004257391B2 (en) 2010-02-11
JP4912147B2 (ja) 2012-04-11

Similar Documents

Publication Publication Date Title
DE502004012418D1 (de) Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa)
CA2269923A1 (en) Pharmaceutical compositions containing plasma protein
IL160641A0 (en) Carbohydrate binding domain containing fusion proteins for delivery of therapeutic and other agents, and compositions containing them
WO2006020580A3 (en) Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
WO2002051390A3 (en) Amphiphilic lipid nanoparticles for peptide and/or protein incorporation
HRP20041200B1 (hr) Kiseli inzulinski pripravci poboljšane postojanosti
WO2002055098A3 (en) Latency associated peptide for providing latency to pharmaceutically active proteins
IE882671L (en) Stabilised human protein formulation
BR0214496A (pt) Métodos e composições a base de peroxigênio para limpeza ou sanitização de tapete ou estofamento
WO2001087329A8 (en) Liquid pharmaceutical composition containing an erythropoietin derivate
CA2319308A1 (en) Pharmaceutical agents
CA2203033A1 (en) Compounds and compositions for delivering active agents
WO2002085311A3 (en) Hcg formulation
MA29273B1 (fr) Combinaison synergique de xolair/omalizumab/e25 et d'un agent immunosuppresseur
CA2361402A1 (en) Bis-sulfonamides
EP1466602A4 (de) Organfibroseinhibitoren
WO2002024883A3 (en) Lactic acid bacteria capable of reducing an individual's tendency to develop allergic reactions
FI941046A0 (fi) Farmaseuttinen menetelmä
WO2001034641A8 (en) Antimicrobial activity of the first cationic cluster of human lactoferrin
JP2004513093A5 (de)
WO2002024665A8 (en) Arylalkane-sulfonamides having endothelin-antagonist activity
PL379272A1 (pl) Stabilny wodny roztwór ludzkiej erytropoetyny niezawierający albuminy surowiczej
EE200200493A (et) Lipiidne kandesüsteem, selle kasutamine ravimpreparaatide valmistamiseks ning seda sisaldav farmatseutiline kompositsioon
MXPA05009135A (es) Formulaciones liquidas de las proteinas de union del factor necrosis del tumor.
WO2007089334A3 (en) Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480021141.6

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004257391

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 172835

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: PA/a/2006/000501

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2532475

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2004257391

Country of ref document: AU

Date of ref document: 20040722

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004257391

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2006520664

Country of ref document: JP

Ref document number: 1020067001593

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2004762485

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006101589

Country of ref document: RU

WWP Wipo information: published in national office

Ref document number: 1020067001593

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2004762485

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0412241

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 2007134199

Country of ref document: US

Ref document number: 10565111

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10565111

Country of ref document: US