WO2007076533A2 - Attache opthalmique et procédé chirurgical associé - Google Patents

Attache opthalmique et procédé chirurgical associé Download PDF

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Publication number
WO2007076533A2
WO2007076533A2 PCT/US2006/062701 US2006062701W WO2007076533A2 WO 2007076533 A2 WO2007076533 A2 WO 2007076533A2 US 2006062701 W US2006062701 W US 2006062701W WO 2007076533 A2 WO2007076533 A2 WO 2007076533A2
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WO
WIPO (PCT)
Prior art keywords
clip
sclera
feet
approximately
opposed
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Ceased
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PCT/US2006/062701
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English (en)
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WO2007076533A3 (fr
Inventor
Nicholas C. Caro
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Individual
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Individual
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Publication of WO2007076533A2 publication Critical patent/WO2007076533A2/fr
Publication of WO2007076533A3 publication Critical patent/WO2007076533A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/122—Clamps or clips, e.g. for the umbilical cord

Definitions

  • the present invention is directed to an ophthalmic clip for treating vision disorders, such as presbyopia and/or glaucoma and an associated surgical method for application of the clip.
  • Presbyopia is a vision disorder associated with aging resulting from the failure of the accommodation mechanism of the eye.
  • the accommodative mechanism is driven principally by parasympathetic inervati ⁇ n of the ciliary smooth muscle. In the non-presbyopic eye, this causes the muscle to slide forward in a unified manner and produces an inward movement of the muscle. The result is a reduction in the diameter of the ciliary muscle collar that instigates a series of events leading to an ability to see near objects clearly-
  • Presbyopia is most frequently treated by the use of reading glasses, bifocals, and progressive multi-focal contact lenses.
  • the inconveniences associated with eyeglasses and contact lenses have prompted investigation into, and the development of, surgical techniques aimed at correcting presbyopia.
  • Glaucoma specifically primary open angle glaucoma, is an eye disease that progressively damages the optic nerve, thus producing certain characteristic defects in the afflicted individual's peripheral vision.
  • Primary open angle glaucoma occurs when the eye' s drainage canals become clogged over time, causing a gradual and irreversible loss of vision. It is most commonly treated with eye drops, such as PILOCARPINE, PROPINE, TIMOLOL and XALATAN, which may have side effects ⁇ Oral medications are also used.
  • eye drops such as PILOCARPINE, PROPINE, TIMOLOL and XALATAN, which may have side effects ⁇ Oral medications are also used.
  • ⁇ method for treating presbyopia and glaucoma and a scleral clip for use in the method are disclosed in my U.S. Patent No. 6,517,555 and U.S. Published Application No.
  • the method involves applying a plurality of clips to the sclera underneath the conjunctiva.
  • the clips In the treatment of presbyopia, the clips -serve to support or reinforce the ciliary muscles so that they may work to alter the lens diameter for focusing on close objects.
  • the tensioning of the sclera with the clips stretches the tissues of the eye that provide for drainage, thus reducing blockage of the drainage canals and facilitating drainage of fluid from the eye.
  • a clip for attachment to the sclera that includes a pair of opposed teeth or feet that are adapted to be received in shallow, complementarily-shaped pockets made in the sclera, thus securing the clip thereto.
  • the clip comprises a body portion having a working length of from approximately 3,5 to 6.0 mm, a width of from approximately 1.0 to 2.5 mm, and a thickness of from 600 ⁇ m to 2.00 mm.
  • feet for securing the clip to the sclera and which have a working length of approximately 200 ⁇ in.
  • the middle portion of the body of the clip is either curved downwardly (i.e., toward a plane defined by the opposed feet) or enlarged ⁇ in thickness) with respect to the ends so that the clip, when secured to the sclera, pushes downwardly thereon to compress the sclera.
  • the working length of the feet is between approximately 1.5 mm and 2.5 mm.
  • an additional foot extends from each end of the body so as to overlie the feet referred to above and define a space therebetween for capturing the portion of the sclera defined by the incision for receiving the first-mentioned feet and the surface of the sclera.
  • the clip is formed of a resilient, biocompatible material.
  • the clip is made entirely of PMMA.
  • the body of the clip may be made from PMMA, while the feet are made from titanium.
  • a method for applying the clip is also provided. Pursuant to the method, the location of the ciliary muscles in the eye are determined, and an incision is made in the conjunctiva to gain access to the sclera overlying the ciliary muscles. The incision is opened to expose the sclera and opposed pockets are made in the surface of the sclera for receiving -A -
  • the clip is attached to the eye by introducing the feet of the clip into the pockets made in the sclera , with the downward curve of the body of the clip compressing the surface of the sclera inwardly.
  • the conjunctiva is then closed over the clip.
  • a fibrin adhesive may be applied to the conjunctiva after it is closed over the clip in order to expedite the healing process.
  • Fig. 1 is a horizontal sectional view of an eyeball .
  • Fig. 2 is an anterior view of the eye showing the extrinsic eye muscles.
  • FIG. 3 is a perspective view of an improved clip in accordance with the present invention.
  • Fig. 4 is a front elevation of the clip of Fig. 3.
  • Fig. 5 is an end view of the clip of Fig. 3.
  • Fig. 6 is a top view of the clip of Fig, 3.
  • Figs. 7-9 are similar views to Figs. 3, 4 and 6, and illustrate a second embodiment of an ophthalmic clip according to the present invention.
  • Figs. 10-12 are similar to Figs. 3 f 4 and 6, and illustrate a third embodiment of an ophthalmic clip according to the present invention.
  • FIGs. 13-15 are perspective views of a fourth, fifth and sixth clip embodiment according to the present invention .
  • Figs. 16A-16D are a perspective view, a top view, a side view, and a bottom view of a seventh clip embodiment.
  • Figs. 17A-17D are a perspective view, a top view, a side view, and a bottom view of an eighth clip embodiment according to the present invention. DETAILED DESCRIPTION
  • the method that utilizes the clip of the present invention is based upon the theory that the cause of presbyopia is the failure of the ciliary body to adjust the lens diameter in order to focus images onto the retina for close objects.
  • the ciliary muscles change the lens diameter by using the sclera as a support or fixation structure.
  • the sclera of the eye weakens due to age, the ciliary muscles lack the support needed to alter the lens diameter for focusing on close objects.
  • the sclera must be supported or reinforced. Accordingly, an improved clip for reinforcing the sclera is provided, so as to form a stronger and more stable support for the ciliary muscles.
  • the clip of the present invention accomplishes this by compressing or depressing the sclera.
  • the sclera is strengthened, and the ciliary muscles are then able to again function properly to provide near vision.
  • the method and its associated clip may also be advantageously used for the treatment of open angle glaucoma.
  • Glaucoma like presbyopia, is an age- related disease and is caused by a buildup of fluid pressure in the eye which damages the optic nerve. Over time, glaucoma destroys peripheral vision, thus shrinking the field of vision.
  • the fluid produced by the ciliary tissues surrounding the lens drains out of the eye through a series of drainage canals around the outer edge of the iris-
  • the ciliary muscles lack support, they are less capable of maintaining these drainage canals in an open condition to allow free drainage of fluid.
  • FIG. 1 With reference to Fig. 1, there is seen a simplified sectional view of a human eye 10 having a lens 12 contained within a lens capsule 14.
  • the ciliary body and ciliary muscle 16 are connected to the lens capsule 14 and also to the choroid 18.
  • the sclera 20 overlies the choroid 18 and, at the front of the eye, the ciliary muscles 16, and terminates in the sclera spur 22 at the cornea 24 of the eye.
  • the conjunctiva 26 surrounds the cornea 24 and overlies the bulbar sheath (or Tenon's capsule) 28 which, in turn, overlies the sclera 20 on the front of the eye 10.
  • Blood is supplied to the sclera by arteries in the superior, inferior, medial and lateral rectus muscles 30, 32, 34, and 36 respectively, best seen in Fig. 2.
  • FIG. 3-6 An improved clip, generally designated 40, for application to the sclera is shown in Figs. 3-6.
  • the clip, generally designated 40 includes a body portion 42, with two opposed feet 44 extending from the opposite ends of the body.
  • the clip 40 should present no sharp edges that would irritate or damage tissue that comes into contact therewith .
  • the body 42 has a length that may vary from approximately 3,5 mm to 6.0 mm, depending on the desired degree of compression of the sclera. Where less compression is indicated, most likely in younger patients, a shorter clip is used. Conversely, where more compression is indicated, most likely in older patients, a longer clip is used. As can be appreciated, the length of the body 42 also generally defines the working length of the clip.
  • the body 42 has a width of from approximately 1.0 mm to 2-5 mm, and a thickness of from between approximately 600 ⁇ m to 2.00 mm.
  • the opposed feet 44 are generally L-shaped ⁇ as seen in Fig.
  • the feet 44 have a working length, as defined by the long leg 46 of the L, of approximately 200 ⁇ ro.
  • the short leg 48 of the L measures between approximately 100 ⁇ m in length and 200 ⁇ m in length.
  • the overall length of the clip 40 is the sum of the length of the two feet AA and the length of the body 42, and consequently ranges from approximately 4.0 mm to 6,5 mm.
  • the body 42 of the clip 40 is formed with a reverse bend (i.e., the body curves downwardly) so that, when the clip 40 is applied to the eye, the clip 40 pushes down on or compresses the sclera, thus causing additional deformation of the sclera.
  • the central portion of the body 42 of the clip 40 may be greater in thickness than the ends to achieve the same effect.
  • the amount of the reverse bend is generally the same as the length of the leg 48 of the feet 44, i.e., from 100 ⁇ m to 200 ⁇ m, but may be more or less depending upon the amount of scleral compression needed.
  • the reverse bend exerts an inward force to assist the failing contraction of an aging ciliary body, thus providing what is known as the "Ba ⁇ koff wedge effect," named after George Baikoff, M. D. More specifically, the pressure created by the reverse bend pushes the ciliary muscle inward and forward, modifying the position of the ciliary processes and the location of the zonular plexus, and thus releasing the tension of the zonule and provoking the deformation of the crystalline lens by allowing the lens to move forward and increase its anterior curvature- This allows for an increase in the lenticular power, thus causing the lens to accommodate.
  • the clip body could be enlarged in the central area between the points to provide the same effect .
  • the clip 40 may be made of a variety of suitable biocompatible materials, including titanium and polymethyl methacrylate (PMMA) . Preferably,- the entire clip is molded from PMMA. Alternatively, the body 42 of the clip 40 may be molded from PMMA, while the feet 44 are made from titanium. The titanium feet 44 are secured to the body 42 by overmolding the body with the feet 44 in situ, so that the molten PMMA flows around securement legs 50 that extend from the short leg 48 of the feet 44. The securement legs 50 may be as much as 500 ⁇ m in length, to insure that a sufficient length is received in the body 42 to maintain structural integrity.
  • the clip may also be coated with appropriate bioactive materials, such as sytostatic drugs which have anti-inflammatory characteristics .
  • Figs. 7-9 a further embodiment of an ophthalmic clip 40 according to the present invention is shown.
  • the clip is similar, except dimensionally, to that shown in Figs. 3-6, and identical reference numerals are used-
  • the body 42 has a length that may vary from approximately 2.0 mm to 5.0 ram (preferably approximately 2,5 mm), depending on the desired degree of compression of the sclera.
  • the clip 40 has a width of from approximately 1.0 mm to 2.5 mm (preferably approximately 1.0 mm), and a thickness of from between approximately 200 ⁇ m to 1.00 mm ⁇ preferably approximately 250 ⁇ m) ,
  • the opposed feet 44 are generally L-shaped (as seen in Fig. 8), with the free end of the long leg 46 of the L having a curved or semi-circular configuration (best seen _ g_
  • the feet 44 have a working length, as defined by the long leg 46 of the L, of approximately 1.5 mm to 2.5 mm (preferably approximately 2.5 mm), the longer length helping to maintain the clip in the pockets in the sclera.
  • the short leg 48 of the L measures between approximately 800 ⁇ m in length and 1.5 mm in length and is preferably approximately 800 ⁇ m in length-
  • the overall length of the clip 40 ranges from approximately 5.0 mm to 7.5 mm.
  • the body 42 of the clip 40 is formed with a reverse bend (i.e., the body curves downwardly) so that, when the clip 40 is applied to the eye, the clip 40 pushes down on or compresses the sclera, thus causing additional deformation of the sclera.
  • the reverse bend has a radius of curvature of between 6,0 mm and about 9.0 mm and is preferably approximately 7,5 ram.
  • a third embodiment of a clip 54 according to the present invention is shown.
  • the clip 54 is similar to that shown in Figs. 7-9, so that identical reference numerals are used for corresponding structure.
  • the clip 54 includes an additional foot 56 extending from each end of the body and overlying the foot 46 so as to define a space 58 therebetween.
  • the space 58 is adapted to receive therein the portion of the sclera defined by the incision for making the pocket 52 for receiving the foot 46 and the surface of the sclera, and measures approximately 300-400 ⁇ m.
  • the clip 60 comprises two parts 62,64, The fixst part 62 is similar to the clip 40 shown in Figs- 7-9- The second part 64 overlays the first part 62 and includes a series of retaining pegs (3 shown) 66a, b, c that are received in mating apertures 68a, b,c in the feet and body of the first part 62.
  • a fifth embodiment of the clip is shown in Fig. 14. f and is generally designated 70.
  • the clip 70 is generally similar to that shown in Figs.
  • a screw 74 has a point that, upon insertion into the central aperture 72, bites into the sclera to a depth of, e.g., approximately 100 ⁇ m to secure the clip 70 thereto.
  • the shank of the screw 74 may include, e.g., a spiral thread or hook to positively secure the clip to the sclera.
  • a sixth embodiment of the clip, generally designated 80 that also has means for ensuring that the clip stays in place on the sclera.
  • the clip 80 is similar to that shown in Figs. 7-9, except that each foot has at least one aperture 82 therein through which scleral tissue will grow after application of the clip 80 to the eye as part of the healing response to making the incision for the pockets that receive the feet of the clip.
  • the tissue that grows through apertures 82 thus serves to hold the clip in place on the eye.
  • each foot 92 includes a hook-like retaining portion 94 with a single point to assist in holding the clip in the pocket in the sclera.
  • the clip 90 has an overall length of from approximately 8-0 mm to 9.0 mm, with an overall width r exclusive of the width of the hooks, of from approximately 1.0 mm to 3.0 mm.
  • the opposed feet 92 have a length of from approximately 2,5 mm to 3.0 mm, and the width of the feet 92 at the hooks 94 is from 2,0 ram to 3.5 mm.
  • the preferred dimensions for the clip are as follows.
  • the clip has an overall length of 7.937 mm and a width, without reference to the width of the retaining hook, of 1.016 mm.
  • the overall length of each foot is 2.5 mm, As noted above, these are specific dimensions for a preferred embodiment.
  • the clip 90 is similar to the clips described above.
  • FIGs. 17A-17D show an eighth embodiment of a clip 100 according to the present invention.
  • This embodiment is similar to the clip 90 shown in Figs. 16A-D, except that each foot 102 includes a double retaining hook 104 with opposed points.
  • the dimensions for the preferred embodiment of clip 100 are the same as those for the clip 90 shown in Figs. 16A-D, except for the width of each foot at the double retaining hook. This width is approximately 3»0 mm.
  • the clip 100 is similar to the clips described above.
  • a method of applying the clip of the present invention to the eye will now jbe set forth.
  • the eyelid is held open with a lid speculum and a topical anesthetic, such as a sub-conjunctival lidocaine, is applied to the eye-
  • a topical anesthetic such as a sub-conjunctival lidocaine
  • the location of the ciliary body is determined, for example, by using commercially-available ultrasound equipment.
  • an incision 38 is then made in the conjunctiva parallel to the scleral- limbal junction so as to dissect the conjunctiva bypassing the Tenon's capsule 28.
  • the incision is then deepened into the episclera.
  • Opposed pockets 52 are made in the surface of the sclera for receiving the opposed feet of the clip using a preset marker-
  • the openings of the pockets are spaced approximately 3.5 to 6.0 mm apart, depending on the length of the clip body, and have a depth (in a direction generally parallel to or concentric with the surface of the sclera) that corresponds to the length of the foot, i.e., from between approximately 200 ⁇ m to 2.5 mm.
  • the pockets extend no deeper into the sclera from the surface thereof than approximately 50 percent of its thickness, i.e., no deeper than about 350 ⁇ m, and preferably extend no deeper than approximately 200 ⁇ m. If the clips shown in Figs. 16A-K or Figs. 17A-E are to be used, the opening of the pockets should have a width approximately .5 mm less than the width of the clip at the retaining hook.
  • the clip is then loaded onto an application tool, which may simply comprise a grasping forceps, which grips the short legs of the feet to apply an axially compressive force to the clip along its body, thus bending the body and moving the feet toward each other.
  • the feet are then introduced into the pockets 52 made in the sclera. If the clip 54 according to Figs. 10-12 is used, the portion of the sclera between the incision for the pocket 52 and the surface of the sclera is received in the space 58 between in the feet 46 and 56. If the clip 60 according to Fig. 13 is used, additional pin holes are made in the pockets for receipt of the pegs 66a, 66c.
  • the second part of the clip 62 is assembled onto the first part of the clip 62. If the clip 70 according to Fig. 14 is used, the screw 74 is inserted into the aperture 72 and manipulated so that the point thereof bites into the sclera,
  • the applied clips have a generally low profile, closely adhering to the curvature of the eye, thus providing reinforcement to the sclera.
  • the Tenon's capsule 28 is then reapposed over the clip and the conjunctiva closed. No suturing is needed as the conjunctiva self seals.
  • a fibrin adhesive such as Tisseel® VH fibrin sealant available from Baxter Healthcare Corporation, may be applied over the closed conjunction to accelerate healing.
  • the procedure is then repeated for each of the four quadrants, as deemed necessary by the surgeon, so that the clips are applied to the eye equally spaced about the cornea 24 between the adjacent rectus muscles. An ointment is applied to the eye, which is then patched for 24 hours.
  • the procedure can be simply reversed by merely again gaining access to the sclera by making an incision in the conjunctiva over the clip, moving the Tenon's capsule to expose the clip, and then removing the clip.
  • each clip should deform the uvea and move the sclera inwardly approximately 0.5 mm, for a total of 2 mm if four clips are applied. This will increase the amplitude of accommodation, thus reversing the effects of presbyopia. This inward movement of the sclera should also increase the angle of the canals of Schlemn, thus increasing the aqueous flow and decreasing the intraocular pressure, to ameliorate the effects of glaucoma. [00048]
  • a method and a clip for performing the method have been provided that fully meet the objects of the present invention. While the invention has been described in terms of a preferred ophthalmic clip and method, there is no intent to limit the invention, to the same. Indeed/ the clip may have application to medical procedures in addition to that described above. Instead, the invention is defined by the scope of the following claims.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L’invention concerne un procédé et une attache de traitement de presbyopie et/ou de glaucome à angle ouvert où la sclérotique est supportée ou renforcée, tout en maintenant sensiblement la relation spatiale entre le muscle ciliaire et le cristallin. Le procédé consiste à pratiquer une incision dans la conjonctive pour accéder à la sclérotique recouvrant le muscle ciliaire. Les capsules de Tenon sont déplacées latéralement pour exposer la sclérotique, et des poches creuses opposées sont pratiquées dans la sclérotique. Une attache R, ou une série d’attaches, est prévue présentant deux pieds opposés, qui sont reçus dans les poches opposées dans la sclérotique. Les capsules de Tenon glissent alors au-dessus de l’attache et la conjonctive est fermée.
PCT/US2006/062701 2005-12-29 2006-12-29 Attache opthalmique et procédé chirurgical associé Ceased WO2007076533A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75500805P 2005-12-29 2005-12-29
US60/755,008 2005-12-29

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WO2007076533A2 true WO2007076533A2 (fr) 2007-07-05
WO2007076533A3 WO2007076533A3 (fr) 2008-03-27

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463540B2 (en) 2013-12-23 2019-11-05 Quantel Medical, Inc. System and device for multi spot photocoagulation
EP3984504A1 (fr) * 2020-10-13 2022-04-20 GlauVue, Inc. Dispositif scléral pour le traitement d'un glaucome à angle ouvert

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007578A (en) * 1997-10-08 1999-12-28 Ras Holding Corp Scleral prosthesis for treatment of presbyopia and other eye disorders
US6517555B1 (en) * 2000-09-05 2003-02-11 Clear Sight, Inc. Method for treating presbyopia

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10463540B2 (en) 2013-12-23 2019-11-05 Quantel Medical, Inc. System and device for multi spot photocoagulation
EP3984504A1 (fr) * 2020-10-13 2022-04-20 GlauVue, Inc. Dispositif scléral pour le traitement d'un glaucome à angle ouvert

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