WO2007111994A3 - Composés et méthodes pour traitement de troubles associés à un stress du réticulum endoplasmique - Google Patents
Composés et méthodes pour traitement de troubles associés à un stress du réticulum endoplasmique Download PDFInfo
- Publication number
- WO2007111994A3 WO2007111994A3 PCT/US2007/007228 US2007007228W WO2007111994A3 WO 2007111994 A3 WO2007111994 A3 WO 2007111994A3 US 2007007228 W US2007007228 W US 2007007228W WO 2007111994 A3 WO2007111994 A3 WO 2007111994A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stress
- methods
- compounds
- treatment
- disorders associated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002681639A CA2681639A1 (fr) | 2006-03-22 | 2007-03-22 | Composes et methodes pour traitement de troubles associes a un stress du reticulum endoplasmique |
| US12/294,029 US20090131384A1 (en) | 2006-03-22 | 2007-03-22 | Compounds and methods for treatment of disorders associated with er stress |
| JP2009501576A JP2009530399A (ja) | 2006-03-22 | 2007-03-22 | Erストレスに関連する疾病の治療のための化合物及び方法 |
| AU2007230991A AU2007230991A1 (en) | 2006-03-22 | 2007-03-22 | Compounds and methods for treatment of disorders associated with ER stress |
| EP07753824A EP2001897A2 (fr) | 2006-03-22 | 2007-03-22 | Composés et méthodes pour traitement de troubles associés à un stress du réticulum endoplasmique |
Applications Claiming Priority (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78515406P | 2006-03-22 | 2006-03-22 | |
| US78533506P | 2006-03-22 | 2006-03-22 | |
| US78500706P | 2006-03-22 | 2006-03-22 | |
| US78533806P | 2006-03-22 | 2006-03-22 | |
| US78503406P | 2006-03-22 | 2006-03-22 | |
| US78523506P | 2006-03-22 | 2006-03-22 | |
| US78518506P | 2006-03-22 | 2006-03-22 | |
| US78532806P | 2006-03-22 | 2006-03-22 | |
| US78503506P | 2006-03-22 | 2006-03-22 | |
| US78518206P | 2006-03-22 | 2006-03-22 | |
| US60/785,034 | 2006-03-22 | ||
| US60/785,235 | 2006-03-22 | ||
| US60/785,328 | 2006-03-22 | ||
| US60/785,007 | 2006-03-22 | ||
| US60/785,035 | 2006-03-22 | ||
| US60/785,154 | 2006-03-22 | ||
| US60/785,182 | 2006-03-22 | ||
| US60/785,185 | 2006-03-22 | ||
| US60/785,335 | 2006-03-22 | ||
| US60/785,338 | 2006-03-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2007111994A2 WO2007111994A2 (fr) | 2007-10-04 |
| WO2007111994A3 true WO2007111994A3 (fr) | 2008-06-12 |
Family
ID=38541676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2007/007228 Ceased WO2007111994A2 (fr) | 2006-03-22 | 2007-03-22 | Composés et méthodes pour traitement de troubles associés à un stress du réticulum endoplasmique |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090131384A1 (fr) |
| EP (1) | EP2001897A2 (fr) |
| JP (1) | JP2009530399A (fr) |
| AU (1) | AU2007230991A1 (fr) |
| CA (1) | CA2681639A1 (fr) |
| WO (1) | WO2007111994A2 (fr) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0518278B1 (pt) | 2004-10-26 | 2018-04-24 | Dolby Laboratories Licensing Corporation | Método e aparelho para controlar uma característica de sonoridade particular de um sinal de áudio |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US20110092554A1 (en) * | 2007-11-19 | 2011-04-21 | Richard Chesworth | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
| BRPI0819847B1 (pt) | 2007-11-27 | 2022-01-11 | Ardea Biosciences, Inc | Compostos e composições |
| WO2009086277A1 (fr) | 2007-12-20 | 2009-07-09 | Envivo Pharmaceuticals, Inc. | Benzènes tétrasubstitués |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| EP2367839A4 (fr) * | 2008-11-03 | 2012-07-04 | Univ Tufts | Procédés et compositions permettant d'empêcher la germination et l'excroissance des spores de c. difficile |
| EP2255813A1 (fr) * | 2009-05-29 | 2010-12-01 | The Royal College of Surgeons in Ireland | Dérivés d'acide ursodésoxycholique pour le traitement de la diarrhée |
| PL2519100T3 (pl) | 2009-12-29 | 2017-09-29 | Mapi Pharma Limited | Związki pośrednie i sposoby wytwarzania tapentadolu i pokrewnych związków |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| AR081930A1 (es) | 2010-06-16 | 2012-10-31 | Ardea Biosciences Inc | Compuestos de tioacetato |
| TWI499412B (zh) | 2010-06-16 | 2015-09-11 | 亞德生化公司 | 苯基硫乙酸酯組合物及其使用方法 |
| WO2012120054A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| WO2012120056A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| EP2766349B1 (fr) | 2011-03-08 | 2016-06-01 | Sanofi | Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation |
| WO2012120055A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| EP2683704B1 (fr) | 2011-03-08 | 2014-12-17 | Sanofi | Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation |
| EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
| ES2704233T3 (es) | 2011-11-03 | 2019-03-15 | Ardea Biosciences Inc | Compuesto de piridina 3,4-di-sustituido, procedimientos de uso y composiciones que comprenden el mismo |
| EP2844257A4 (fr) | 2012-05-01 | 2016-06-01 | Catabasis Pharmaceuticals Inc | Conjugués d'acide gras de statine et d'agonistes de fxr ; compositions et procédés d'utilisation |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| CN111529535A (zh) | 2012-09-27 | 2020-08-14 | 儿童医学中心公司 | 用于治疗肥胖症的化合物和其使用方法 |
| ES2736599T3 (es) | 2013-03-14 | 2020-01-03 | Univ Macau | Nuevos compuestos naturales antineurodegenerativos aislados a partir de Alpiniae oxyphyllae fructus y síntesis total de los mismos |
| PL3925607T5 (pl) | 2014-04-15 | 2026-06-01 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa |
| BR112017009657A2 (pt) * | 2014-11-06 | 2018-01-23 | Enanta Pharmaceuticals, Inc | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos |
| RU2017121457A (ru) | 2014-11-26 | 2018-12-26 | Энанта Фармасьютикалс, Инк. | Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| WO2016086115A1 (fr) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Dérivés de tétrazole d'acides biliaires utilisés en tant qu'agonistes de fxr/tgr5 et leurs procédés d'utilisation |
| AU2016219266A1 (en) | 2015-02-11 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as FXR/TGR5 agonists and methods of use thereof |
| RU2712099C2 (ru) | 2015-03-31 | 2020-01-24 | Энанта Фармасьютикалс, Инк. | Производные желчных кислот в качестве агонистов fxr/tgr5 и способы их применения |
| US10323060B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof |
| US10364267B2 (en) | 2016-02-23 | 2019-07-30 | Enanta Pharmaceuticals, Inc. | Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| WO2017147174A1 (fr) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Analogues de l'acide biliaire contenant de l'hétéroaryle utilisés comme agonistes de fxr/tgr5 et leurs méthodes d'utilisation |
| DE102017005884A1 (de) * | 2016-07-07 | 2018-01-11 | Merck Patent Gmbh | Elektronisches Schaltelement |
| AU2017368069B2 (en) | 2016-11-29 | 2021-07-08 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
| US10472386B2 (en) | 2017-02-14 | 2019-11-12 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR agonists and methods of use thereof |
| MX388300B (es) | 2017-04-07 | 2025-03-19 | Enanta Pharm Inc | Proceso para la preparación de derivados de ácidos biliares de sulfonil carbamato |
| DE102018004733B4 (de) * | 2018-06-14 | 2026-06-11 | Merck Patent Gmbh | Verfahren zur Herstellung eines elektronischen Bauteils enthaltend eine selbstorganisierte Monolage |
| CN116925168A (zh) | 2019-08-23 | 2023-10-24 | 深圳云合医药科技合伙企业(有限合伙) | 胆汁酸衍生物及其组合物和应用 |
| JP2024529444A (ja) * | 2021-07-26 | 2024-08-06 | シャペロン インク. | TNF-α生成及び炎症複合体活性抑制新規化合物及びその製造方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0100983A1 (fr) * | 1982-08-17 | 1984-02-22 | PROTER S.p.A. | Stéroides à activité cholérétique, leur procédé de préparation et compositions thérapeutiques les contenant |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60161996A (ja) * | 1984-02-01 | 1985-08-23 | Eisai Co Ltd | ケノデオキシコ−ル酸またはウルソデオキシコ−ル酸誘導体およびその製造法ならびにそれを含有する医薬 |
| JP2616845B2 (ja) * | 1991-02-21 | 1997-06-04 | 清水化学株式会社 | システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤 |
| JPH0959162A (ja) * | 1995-08-28 | 1997-03-04 | Makoto Takahashi | 胆石溶解剤 |
| WO2001076531A2 (fr) * | 2000-04-07 | 2001-10-18 | University Of Maryland, Baltimore | Promedicaments contenant un acide biliaire et presentant une meilleure biodisponibilite |
| AU2002230398A1 (en) * | 2000-10-06 | 2002-04-29 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
-
2007
- 2007-03-22 EP EP07753824A patent/EP2001897A2/fr not_active Withdrawn
- 2007-03-22 JP JP2009501576A patent/JP2009530399A/ja active Pending
- 2007-03-22 WO PCT/US2007/007228 patent/WO2007111994A2/fr not_active Ceased
- 2007-03-22 AU AU2007230991A patent/AU2007230991A1/en not_active Abandoned
- 2007-03-22 US US12/294,029 patent/US20090131384A1/en not_active Abandoned
- 2007-03-22 CA CA002681639A patent/CA2681639A1/fr not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0100983A1 (fr) * | 1982-08-17 | 1984-02-22 | PROTER S.p.A. | Stéroides à activité cholérétique, leur procédé de préparation et compositions thérapeutiques les contenant |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009530399A (ja) | 2009-08-27 |
| US20090131384A1 (en) | 2009-05-21 |
| AU2007230991A1 (en) | 2007-10-04 |
| WO2007111994A2 (fr) | 2007-10-04 |
| CA2681639A1 (fr) | 2007-10-04 |
| EP2001897A2 (fr) | 2008-12-17 |
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