WO2008126784A1 - グルタチオンおよびγ-グルタミルシステインの製造法 - Google Patents

グルタチオンおよびγ-グルタミルシステインの製造法 Download PDF

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Publication number
WO2008126784A1
WO2008126784A1 PCT/JP2008/056759 JP2008056759W WO2008126784A1 WO 2008126784 A1 WO2008126784 A1 WO 2008126784A1 JP 2008056759 W JP2008056759 W JP 2008056759W WO 2008126784 A1 WO2008126784 A1 WO 2008126784A1
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Prior art keywords
glutathione
glutamylcysteine
amino acid
acid sequence
protein
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Ceased
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PCT/JP2008/056759
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English (en)
French (fr)
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Kazuhiko Tabata
Yoshiyuki Yonetani
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Kyowa Hakko Bio Co Ltd
KH Neochem Co Ltd
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Kyowa Hakko Kogyo Co Ltd
Kyowa Hakko Bio Co Ltd
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Priority to US12/594,928 priority Critical patent/US8647839B2/en
Priority to EP08739865A priority patent/EP2143804A4/en
Priority to JP2009509318A priority patent/JP6018357B2/ja
Priority to CN200880019101.6A priority patent/CN101715490B/zh
Publication of WO2008126784A1 publication Critical patent/WO2008126784A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　本発明により、以下のグルタチオンおよびγ－グルタミルシステインの製造法が提供される。 　以下の細胞内のグルタチオンを細胞外へ輸送する活性を有する蛋白質の活性、およびグルタチオンまたはγ-グルタミルシステインの生合成に関わる蛋白質の活性が親株より高い微生物を培地に培養し、該培地中にグルタチオンまたはγ-グルタミルシステインを生成、蓄積させ、培養物中からグルタチオンまたはγ-グルタミルシステインを採取するグルタチオンまたはγ-グルタミルシステインの製造法。 ［１］配列番号１～２６のいずれかで表されるアミノ酸配列を有する蛋白質 ［２］配列番号１～２６のいずれかで表されるアミノ酸配列において、１以上のアミノ酸が欠失、置換または付加したアミノ酸配列からなり、かつグルタチオン輸送活性を有する蛋白質 ［３］配列番号１～２６のいずれかで表されるアミノ酸配列と８０％以上の相同性を有し、かつグルタチオン輸送活性を有する蛋白質
PCT/JP2008/056759 2007-04-06 2008-04-04 グルタチオンおよびγ-グルタミルシステインの製造法 Ceased WO2008126784A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/594,928 US8647839B2 (en) 2007-04-06 2008-04-04 Method for production of glutathione or gamma-glutamylcysteine
EP08739865A EP2143804A4 (en) 2007-04-06 2008-04-04 PROCESS FOR THE PREPARATION OF GLUTATHION OR GAMMA GLUTAMYLCYSTEIN
JP2009509318A JP6018357B2 (ja) 2007-04-06 2008-04-04 グルタチオンおよびγ−グルタミルシステインの製造法
CN200880019101.6A CN101715490B (zh) 2007-04-06 2008-04-04 谷胱甘肽及γ-谷氨酰半胱氨酸的制造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-099957 2007-04-06
JP2007099957 2007-04-06

Publications (1)

Publication Number Publication Date
WO2008126784A1 true WO2008126784A1 (ja) 2008-10-23

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PCT/JP2008/056759 Ceased WO2008126784A1 (ja) 2007-04-06 2008-04-04 グルタチオンおよびγ-グルタミルシステインの製造法

Country Status (5)

Country Link
US (1) US8647839B2 (ja)
EP (2) EP2489741B1 (ja)
JP (1) JP6018357B2 (ja)
CN (1) CN101715490B (ja)
WO (1) WO2008126784A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012085637A (ja) * 2010-09-22 2012-05-10 Ajinomoto Co Inc γ‐Ｇｌｕ‐Ｘ‐Ｙの製造方法
JP2012100622A (ja) * 2010-11-12 2012-05-31 Kaneka Corp グルタチオンの製造方法
JP2013169168A (ja) * 2012-02-20 2013-09-02 Kaneka Corp グルタチオンの製造方法
WO2015115612A1 (ja) * 2014-01-31 2015-08-06 味の素株式会社 変異型グルタミン酸－システインリガーゼ、及び、γ－グルタミルバリルグリシンの製造法
CN106536744A (zh) * 2014-07-29 2017-03-22 株式会社钟化 γ‑谷氨酰半胱氨酸及谷胱甘肽的制造方法
WO2017159555A1 (ja) 2016-03-17 2017-09-21 協和発酵バイオ株式会社 還元型グルタチオンの結晶及びその製造方法
JP2017528126A (ja) * 2014-08-12 2017-09-28 シージェイ チェイルジェダン コーポレーション Ｏ−ホスホセリン生産微生物及びそれを用いたｏ−ホスホセリンまたはｌ−システイン生産方法
JPWO2021100846A1 (ja) * 2019-11-22 2021-05-27
JPWO2021220970A1 (ja) * 2020-04-28 2021-11-04
JPWO2022131323A1 (ja) * 2020-12-17 2022-06-23
JPWO2022168991A1 (ja) * 2021-02-08 2022-08-11

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DE102013209274A1 (de) 2013-05-17 2014-11-20 Wacker Chemie Ag Mikroorganismus und Verfahren zur fermentativen Überproduktion von Gamma-Glutamylcystein und Derivaten dieses Dipeptids
DE102013218232A1 (de) * 2013-09-11 2015-03-12 Wacker Chemie Ag Verfahren zur fermentativen Herstellung von Gamma-Glutamyl-cystein und Derivaten dieses Dipeptids
DE102013219016A1 (de) * 2013-09-20 2015-03-26 Wacker Chemie Ag Verfahren zur fermentativen Herstellung von Gamma-Glutamylcystein und Derivaten dieses Dipeptids
WO2015133547A1 (ja) * 2014-03-05 2015-09-11 味の素株式会社 γ－グルタミルバリン合成酵素、及び、γ－グルタミルバリルグリシンの製造法
CN105581344A (zh) * 2015-12-16 2016-05-18 开平牵牛生化制药有限公司 一种含还原型谷胱甘肽的益生菌产品及其制备方法
CN109923209A (zh) * 2016-11-01 2019-06-21 株式会社钟化 修饰型酶及其利用
CN112646768B (zh) * 2020-12-31 2023-05-23 上海青平药业有限公司 一种重组谷氨酸棒杆菌及谷胱甘肽的制备方法
CN118813659A (zh) * 2021-04-14 2024-10-22 上海凯赛生物技术股份有限公司 用于发酵生产1,5-戊二胺的重组dna、菌株及其用途
US20250162987A1 (en) * 2022-04-04 2025-05-22 Children's National Medical Center Preparation of gamma-glutamylcysteine, a precursor of glutathione
CN116769738B (zh) * 2023-06-13 2026-05-12 江苏集萃工业生物技术研究所有限公司 一种谷氨酰半胱氨酸合成酶突变体及其在谷胱甘肽合成中的应用

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JP2012085637A (ja) * 2010-09-22 2012-05-10 Ajinomoto Co Inc γ‐Ｇｌｕ‐Ｘ‐Ｙの製造方法
JP2012100622A (ja) * 2010-11-12 2012-05-31 Kaneka Corp グルタチオンの製造方法
JP2013169168A (ja) * 2012-02-20 2013-09-02 Kaneka Corp グルタチオンの製造方法
WO2015115612A1 (ja) * 2014-01-31 2015-08-06 味の素株式会社 変異型グルタミン酸－システインリガーゼ、及び、γ－グルタミルバリルグリシンの製造法
JPWO2015115612A1 (ja) * 2014-01-31 2017-03-23 味の素株式会社 変異型グルタミン酸−システインリガーゼ、及び、γ−グルタミルバリルグリシンの製造法
CN106536744A (zh) * 2014-07-29 2017-03-22 株式会社钟化 γ‑谷氨酰半胱氨酸及谷胱甘肽的制造方法
JP2017528126A (ja) * 2014-08-12 2017-09-28 シージェイ チェイルジェダン コーポレーション Ｏ−ホスホセリン生産微生物及びそれを用いたｏ−ホスホセリンまたはｌ−システイン生産方法
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JPWO2021100846A1 (ja) * 2019-11-22 2021-05-27
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JPWO2022131323A1 (ja) * 2020-12-17 2022-06-23
WO2022131323A1 (ja) * 2020-12-17 2022-06-23 株式会社カネカ 有用物質を製造する微生物、および製造方法
JP7808047B2 (ja) 2020-12-17 2026-01-28 株式会社カネカ 有用物質を製造する微生物、および製造方法
JPWO2022168991A1 (ja) * 2021-02-08 2022-08-11
EP4289955A4 (en) * 2021-02-08 2025-06-11 Kyowa Hakko Bio Co., Ltd. Protein with fucose-containing sugar transport activity and process for producing fucose-containing sugar

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CN101715490A (zh) 2010-05-26
CN101715490B (zh) 2014-02-05
US8647839B2 (en) 2014-02-11
EP2489741B1 (en) 2016-06-08
EP2489741A1 (en) 2012-08-22
JP6018357B2 (ja) 2016-11-02
EP2143804A1 (en) 2010-01-13
EP2143804A4 (en) 2010-05-12
JPWO2008126784A1 (ja) 2010-07-22

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