WO2009037861A1 - β-グルクロニダーゼ阻害剤 - Google Patents

β-グルクロニダーゼ阻害剤 Download PDF

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Publication number
WO2009037861A1
WO2009037861A1 PCT/JP2008/002602 JP2008002602W WO2009037861A1 WO 2009037861 A1 WO2009037861 A1 WO 2009037861A1 JP 2008002602 W JP2008002602 W JP 2008002602W WO 2009037861 A1 WO2009037861 A1 WO 2009037861A1
Authority
WO
WIPO (PCT)
Prior art keywords
specific
glucuronidase inhibitor
macrocyclic
ketone
glucuronidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/002602
Other languages
English (en)
French (fr)
Inventor
Ichirou Mori
Syunichi Akiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Priority to CN2008801080468A priority Critical patent/CN101802189B/zh
Priority to KR1020107004774A priority patent/KR101530398B1/ko
Priority to EP08831650.0A priority patent/EP2192178B1/en
Priority to JP2009533068A priority patent/JP5548451B2/ja
Priority to US12/679,244 priority patent/US9200269B2/en
Publication of WO2009037861A1 publication Critical patent/WO2009037861A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　特定の大環状ケトン、ケトン、大環状ラクトン、大環状オキサラクトン、エステル、アルデヒド、アルコール及びテルペンから選ばれる化合物からなる新規β-グルクロニダーゼ阻害剤、並びに当該-βグルクロニダーゼ阻害剤を含有する環境衛生製品及びサニタリー製品。並びにβ-グルクロニダーゼ阻害剤を使用した尿臭生成抑制用組成物及び尿臭の生成抑制方法。
PCT/JP2008/002602 2007-09-20 2008-09-19 β-グルクロニダーゼ阻害剤 Ceased WO2009037861A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2008801080468A CN101802189B (zh) 2007-09-20 2008-09-19 β-葡萄糖醛酸苷酶抑制剂
KR1020107004774A KR101530398B1 (ko) 2007-09-20 2008-09-19 β-글루쿠로니다아제 저해제
EP08831650.0A EP2192178B1 (en) 2007-09-20 2008-09-19 B-glucuronidase inhibitor
JP2009533068A JP5548451B2 (ja) 2007-09-20 2008-09-19 β−グルクロニダーゼ阻害剤
US12/679,244 US9200269B2 (en) 2007-09-20 2008-09-19 β-glucuronidase inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-243661 2007-09-20
JP2007243661 2007-09-20

Publications (1)

Publication Number Publication Date
WO2009037861A1 true WO2009037861A1 (ja) 2009-03-26

Family

ID=40467687

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002602 Ceased WO2009037861A1 (ja) 2007-09-20 2008-09-19 β-グルクロニダーゼ阻害剤

Country Status (6)

Country Link
US (1) US9200269B2 (ja)
EP (1) EP2192178B1 (ja)
JP (2) JP5548451B2 (ja)
KR (1) KR101530398B1 (ja)
CN (1) CN101802189B (ja)
WO (1) WO2009037861A1 (ja)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011229894A (ja) * 2010-04-06 2011-11-17 Kao Corp 尿臭生成抑制用組成物
WO2012023444A1 (ja) * 2010-08-18 2012-02-23 住友精化株式会社 吸水性樹脂組成物、吸収体及び吸収性物品
WO2012115238A1 (ja) * 2011-02-25 2012-08-30 花王株式会社 尿臭発生部の視覚的判定方法
JP2013252451A (ja) * 2013-08-29 2013-12-19 Kao Corp β−グルクロニダーゼ阻害剤
JP2014144942A (ja) * 2013-01-30 2014-08-14 Kao Corp 過活動膀胱の予防又は改善剤
JP2015211667A (ja) * 2014-04-14 2015-11-26 花王株式会社 尿臭抑制剤の探索方法
JP2015224273A (ja) * 2014-05-27 2015-12-14 花王株式会社 衣料用臭気抑制剤組成物
JP2016528318A (ja) * 2013-06-17 2016-09-15 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 活性分子を制御放出するための化合物
JP2017039871A (ja) * 2015-08-20 2017-02-23 花王株式会社 粉末洗濯前処理剤組成物
WO2017090518A1 (ja) * 2015-11-24 2017-06-01 花王株式会社 尿臭抑制剤
JP2017101224A (ja) * 2015-11-24 2017-06-08 花王株式会社 尿臭抑制剤
JP2018051555A (ja) * 2016-09-21 2018-04-05 三洋化成工業株式会社 吸着剤組成物及びそれを用いた有害物質の吸着方法
JP2021069330A (ja) * 2019-10-31 2021-05-06 花王株式会社 インドール臭抑制剤の選択方法
WO2021106822A1 (ja) 2019-11-25 2021-06-03 花王株式会社 分岐脂肪酸の代謝制御方法

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CN105579075A (zh) 2013-08-01 2016-05-11 宝洁公司 包含恶臭减少组合物的制品
ES2726919T3 (es) * 2014-12-18 2019-10-10 Firmenich & Cie Cetona macrocíclica como ingrediente para contrarrestar el mal olor
CN111514144B (zh) * 2015-05-26 2021-10-26 高雄医学大学 具抑制细菌葡萄糖醛酸酶活性的吡唑并[4，3-c]喹啉衍生物
KR101822929B1 (ko) 2016-05-16 2018-01-29 윤혜진 의류 및 섬유용 탈취제 및 이의 제조방법
CN106822070A (zh) * 2017-01-22 2017-06-13 新乡医学院 一种治疗动脉粥样硬化的药物组合物与应用
CN112203699B (zh) * 2018-07-13 2022-11-29 花王株式会社 抑制臭味生成的方法
CN111122268A (zh) * 2019-12-31 2020-05-08 华南理工大学 一种保存液体样品中硫酸酯结合体和葡萄糖苷醛酸结合体的方法
CN111419843B (zh) * 2020-05-14 2021-07-27 浙江工业大学 氰基亚胺噻唑烷呋喃甲酰胺类化合物在制备β-葡萄糖醛酸苷酶抑制剂中的应用
CN113384562B (zh) * 2021-04-07 2022-05-24 浙江工业大学 一种二萜类化合物在制备β-葡萄糖醛酸苷酶活性抑制剂中的应用
CN117298031B (zh) * 2023-10-11 2026-02-06 五峰赤诚生物科技股份有限公司 一种含有五倍子提取物的紧致抗皱乳液

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0543469A (ja) * 1991-08-09 1993-02-23 Tsumura & Co β−グルクロニダーゼ阻害剤
JPH0930944A (ja) * 1995-07-21 1997-02-04 Pola Chem Ind Inc 芳香剤及びこれを含有する衣類
JP2002255776A (ja) 2001-03-01 2002-09-11 Kao Corp デオドラント剤
JP2003501384A (ja) * 1999-06-07 2003-01-14 ペー アー ツェット アルツナイミッテルエントヴィックルングスゲゼルシャフト ミット ベシュレンクテル ハフツング ヒトの組織におけるβ−グルクロニダーゼの阻害作用を有する薬剤の製造のためのベラパミル及びベラパミル誘導体の使用
JP2005162756A (ja) 2003-11-05 2005-06-23 Katsutoshi Terasawa β−グルクロニダーゼ阻害剤
JP2006045188A (ja) * 2004-02-23 2006-02-16 Nagase & Co Ltd β−グルクロニダーゼ阻害剤
JP2007176868A (ja) * 2005-12-28 2007-07-12 Nagase Chemtex Corp β−グルクロニダーゼ阻害剤
JP2007518814A (ja) * 2004-01-20 2007-07-12 ザ・スクリップス・リサーチ・インスティテュート グリコシダーゼ阻害剤によるほ乳類での変性軟骨症の治療

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011229894A (ja) * 2010-04-06 2011-11-17 Kao Corp 尿臭生成抑制用組成物
WO2012023444A1 (ja) * 2010-08-18 2012-02-23 住友精化株式会社 吸水性樹脂組成物、吸収体及び吸収性物品
WO2012115238A1 (ja) * 2011-02-25 2012-08-30 花王株式会社 尿臭発生部の視覚的判定方法
JP2012187101A (ja) * 2011-02-25 2012-10-04 Kao Corp 尿臭発生部の視覚的判定方法
RU2598718C2 (ru) * 2011-02-25 2016-09-27 Као Корпорейшн Способ визуального определения местонахождения источника образования запаха мочи и скрининг ингибиторов образования запаха мочи
JP2014144942A (ja) * 2013-01-30 2014-08-14 Kao Corp 過活動膀胱の予防又は改善剤
JP2016528318A (ja) * 2013-06-17 2016-09-15 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 活性分子を制御放出するための化合物
US10590365B2 (en) 2013-06-17 2020-03-17 Firmenich Sa Compounds for a controlled release of active molecules
JP2013252451A (ja) * 2013-08-29 2013-12-19 Kao Corp β−グルクロニダーゼ阻害剤
JP2015211667A (ja) * 2014-04-14 2015-11-26 花王株式会社 尿臭抑制剤の探索方法
JP2015224273A (ja) * 2014-05-27 2015-12-14 花王株式会社 衣料用臭気抑制剤組成物
JP2017039871A (ja) * 2015-08-20 2017-02-23 花王株式会社 粉末洗濯前処理剤組成物
WO2017090518A1 (ja) * 2015-11-24 2017-06-01 花王株式会社 尿臭抑制剤
JP2017101224A (ja) * 2015-11-24 2017-06-08 花王株式会社 尿臭抑制剤
CN108289973A (zh) * 2015-11-24 2018-07-17 花王株式会社 尿臭抑制剂
JP2018051555A (ja) * 2016-09-21 2018-04-05 三洋化成工業株式会社 吸着剤組成物及びそれを用いた有害物質の吸着方法
JP2021069330A (ja) * 2019-10-31 2021-05-06 花王株式会社 インドール臭抑制剤の選択方法
JP7383453B2 (ja) 2019-10-31 2023-11-20 花王株式会社 インドール臭抑制剤の選択方法
WO2021106822A1 (ja) 2019-11-25 2021-06-03 花王株式会社 分岐脂肪酸の代謝制御方法

Also Published As

Publication number Publication date
CN101802189B (zh) 2013-03-27
US9200269B2 (en) 2015-12-01
JP2014195696A (ja) 2014-10-16
EP2192178A4 (en) 2010-10-27
EP2192178A1 (en) 2010-06-02
JP5719951B2 (ja) 2015-05-20
US20100247475A1 (en) 2010-09-30
JPWO2009037861A1 (ja) 2011-01-06
JP5548451B2 (ja) 2014-07-16
KR101530398B1 (ko) 2015-06-19
KR20100056484A (ko) 2010-05-27
EP2192178B1 (en) 2015-11-18
CN101802189A (zh) 2010-08-11

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